Nck adaptors are positive regulators of the size and sensitivity of the T-cell repertoire

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 35, 2010, Pages 15529-15534

  Roy, Edwige ^a,b   Togbe, Dieudonnée ^a,b   Holdorf, Amy D ^c,d   Trubetskoy, Dmitry ^a,b   Nabti, Sabrina ^a,b   Küblbeck, Günter ^e   Klevenz, Alexandra ^e   Kopp Schneider, Annette ^e   Leithäuser, Frank ^f   Möller, Peter ^f   Bladt, Friedhelm ^c,d   Hämmerling, Günter ^e   Arnold, Bernd ^e   Pawson, Tony ^c,d   Tafuri, Anna ^a,b,e  

^a INSERM   (France)

^b INSTITUT CURIE   (France)

^c MOUNT SINAI HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^f UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Immunodeficiency; Repertoire development; Signal transduction; T cell activation; T cell receptor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; NCK PROTEIN; PROTEIN SH2; PROTEIN SH3; T LYMPHOCYTE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CELL MATURATION; CELL SIZE; CONTROLLED STUDY; FEMALE; LYMPHOCYTOPENIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL PROLIFERATION; CELLS, CULTURED; DENDRITIC CELLS; FEMALE; FLOW CYTOMETRY; LYMPHOPENIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; ONCOGENE PROTEINS; PHOSPHORYLATION; RECEPTORS, ANTIGEN, T-CELL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES;

EID: 77957255138     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1009743107     Document Type: Article

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