Distinct regulatory mechanism of immunoglobulin gene transcription in epithelial cancer cells

Cellular and Molecular Immunology

Volumn 7, Issue 4, 2010, Pages 279-287

  Zhu, Xiaohui ^a   Wu, Lina ^a   Zhang, Li ^a   Hao, Peng ^a   Zhang, Shuai ^a   Huang, Jing ^a   Zheng, Jie ^a   Liu, Yinan ^b   Li, Wenjun ^a   Zhang, Yingmei ^a   Zhou, Chunyan ^b   Zhang, Youhui ^c   Yin, C Cameron ^d   Qiu, Xiaoyan ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Ig gene transcription; Oct 1; promoter; transcription regulation; VH4 59

Indexed keywords

IMMUNOGLOBULIN; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR PAX5; POU2F1 PROTEIN, HUMAN; POU2F2 PROTEIN, HUMAN;

ARTICLE; CELL STRAIN HEPG2; CELL STRAIN HT29; CONTROLLED STUDY; DAUDI CELL; ENHANCER REGION; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; GENOME SIZE; HELA CELL; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; LEUKEMIA CELL LINE; LUNG CANCER; OSTEOSARCOMA CELL; PROMOTER REGION; PROTEIN BINDING; REGULATORY SEQUENCE; SOLID TUMOR; TRANSCRIPTION REGULATION; B LYMPHOCYTE; CHROMATIN IMMUNOPRECIPITATION; DNA FLANKING REGION; EPITHELIUM CELL; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; NEOPLASM; PATHOLOGY;

5' FLANKING REGION; B-LYMPHOCYTES; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, IMMUNOGLOBULIN; HELA CELLS; HT29 CELLS; HUMANS; NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-1; OCTAMER TRANSCRIPTION FACTOR-2; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; TRANSCRIPTION, GENETIC;

EID: 77957252636     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.13     Document Type: Article

References (39)

1. Henderson A, Calame K. Transcriptional regulation during B cell development. Annu Rev Immunol 1998; 16: 163-200. (Pubitemid 28183363)
2. Qiu XY, Yang GZ. Study on the characteristics of Ig-like protein from malignant tumor cytoplasm and analysis of Ig gene structure. Chin J Immunol 1996; 5: 296.
3. Qiu XY, Yang GZ. Ig-like protein present in epithelial malignant tumor cells. J Norman Bethune Univ Med Sci 1996; 6: 572-575.
4. Wang DS, Qiu XY, Zhu XH, Lv P, Jiang N, Lv P et al. Purification and Western-blot analysis of Ig-like protein. J Beijing Med Univ 2000; 32: 310-312.
5. Qiu X, Zhu X, Zhang L, Mao Y, Zhang J, Hao P et al. Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells. Cancer Res 2003; 63: 6488-6495. (Pubitemid 37255201)
6. Huang J, Sun X, Mao Y, Zhu X, Zhang P, Zhang L et al. Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons. Int J Biochem Cell Biol 2008; 40: 1604-1615.
7. Zhu X, Li C, Sun X, Mao Y, Li G, Liu X et al. Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells. Appl Immunohistochem Mol Morphol 2008; 16: 232-238. (Pubitemid 351589554)
8. Huang J, Zhang L, Ma T, Zhang P, Qiu X. Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse testis and epididymis. J Histochem Cytochem 2009; 57: 339-349.
9. Zheng J, Huang J, Mao Y, Liu S, Sun X, Zhu X et al. Immunoglobulin gene transcripts have distinct VHDJH recombination characteristics in human epithelial cancer cells. J Biol Chem 2009; 284: 13610-13619.
10. Kimoto Y. Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines. Genes Chromosomes Cancer 1998; 22: 83-86. (Pubitemid 28217811)
11. Li M, Feng DY, Ren W, Zheng L, Zheng H, TangMet al. Expression of immunoglobulin kappa light chain constant region in abnormal human cervical epithelial cells. Int J Biochem Cell Biol 2004; 36: 2250-2257. (Pubitemid 39094446)
12. Babbage G, Ottensmeier CH, Blaydes J, Stevenson FK, Sahota SS. Immunoglobulin heavy chain locus events and expression of activation-induced cytidine deaminase in epithelial breast cancer cell lines. Cancer Res 2006; 66: 3996-4000.
13. Chen Z, Gu J. Immunoglobulin G expression in carcinomas and cancer cell lines. FASEB J 2007; 21: 2931-2938. (Pubitemid 47372759)
14. Liu HD, Zheng H, Li M, Hu DS, Tang M, Cao Y. Upregulated expression of kappa light chain by Epstein-Barr virus encoded latent membrane protein 1 in nasopharyngeal carcinoma cells via NF-kappaB and AP-1 pathways. Cell Signal 2007; 19: 419-427. (Pubitemid 46001832)
15. Zheng H, Li M, Ren W, Zeng L, Liu HD, Hu D et al. Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells. Mol Immunol 2007; 44: 2221-2227. (Pubitemid 46097112)
16. Lee G, Laflamme E, Chien CH, Ting HH. Molecular identity of a pan cancer marker, CA215. Cancer Biol Ther 2008; 7: 2007-2014.
17. Lee G. Cancer cell-expressed immunoglobulins: CA215 as a pan cancer marker and its diagnostic applications. Cancer Biomark 2009; 5: 137-142.
18. Lin H, Grosschedl R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 1995; 376: 263-267.
19. Quong MW, Martensson A, Langerak AW, Rivera RR, Nemazee D, Murre C. Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A. J Exp Med 2004; 199: 1101-1112. (Pubitemid 38619906)
20. Yabuki M, Ordinario EC, Cummings WJ, Fujii MM, Maizels N. E2A acts in cis in G1 phase of cell cycle to promote Ig gene diversification. J Immunol 2009; 182: 408-415.
21. Pawlitzky I, Angeles CV, Siegel AM, Stanton ML, Riblet R, Brodeur PH. Identification of a candidate regulatory element within the 59 flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A. J Immunol 2006; 176: 6839-6851. (Pubitemid 43791970)
22. Nakayama M, Suzuki H, Yamamoto-Nagamatsu N, Barman HK, Kikuchi H, Takami Y et al. HDAC2 controls IgM H- and L-chain gene expressions via EBF1, Pax5, Ikaros, Aiolos and E2A gene expressions. Genes Cells 2007; 12: 359-373. (Pubitemid 46359589)
23. Kim U, Qin XF, Gong S, Stevens S, Luo Y, Nussenzweig M et al. The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature 1996; 383: 542-547. (Pubitemid 26346183)
24. Schubart K, Massa S, Schubart D, Corcoran LM, Rolink AG, Matthias P. B cell development and immunoglobulin gene transcription in the absence of Oct-2 and OBF-1. Nat Immunol 2001; 2: 69-74. (Pubitemid 33704956)
25. Ju Z, Volpi SA, Hassan R, Martinez N, Giannini SL, Gold T et al. Evidence for physical interaction between the immunoglobulin heavy chain variable region and the 39 regulatory region. J Biol Chem 2007; 282: 35169-35178. (Pubitemid 350232409)
26. Laumen H, Nielsen PJ, Wirth T. The BOB.1/OBF.1 co-activator is essential for octamer-dependent transcription in B cells. Eur J Immunol 2000; 30: 458-469. (Pubitemid 30098838)
27. Poellinger L, Yoza BK, Roeder RG. Functional cooperativity between protein molecules bound at two distinct sequence elements of the immunoglobulin heavychain promoter. Nature 1989; 337: 573-576. (Pubitemid 19045545)
28. Kunkel GR, Pederson T. Upstream elements required for efficient transcription of a human U6 RNA gene resemble those of U1 and U2 genes even though a different polymerase is used. Genes Dev 1988; 2: 196-204.
29. Nakajima N, Horikoshi M, Roeder RG. Factors involved in specific transcription by mammalian RNA polymerase II: purification, genetic specificity, and TATA boxpromoter interactions of TFIID. Mol Cell Biol 1988; 8: 4028-4040.
30. Yang J, Muller-Immergluck MM, Seipel K, Janson L, Westin G, SchaffnerWet al. Both Oct-1 and Oct-2A contain domains which can activate the ubiquitously expressed U2 snRNA genes. EMBO J 1991; 10: 2291-2296. (Pubitemid 21905702)
31. Hinkley C, Perry M. Histone H2B gene transcription during Xenopus early development requires functional cooperation between proteins bound to the CCAAT and octamer motifs. Mol Cell Biol 1992; 12: 4400-4411.
32. Sun Z, Kitchingman GR. Bidirectional transcription from the human immunoglobulin VH6 gene promoter. Nucleic Acids Res 1994; 22: 861-868.
33. Gstaiger M, Georgiev O, van Leeuwen H, van der Vliet P, Schaffner W. The B cell coactivator Bob1 shows DNA sequence-dependent complex formation with Oct-1/Oct- factors, leading to differential promoter activation. EMBO J 1996; 15: 2781-2790. (Pubitemid 26176255)
34. Massa S, Junker S, Schubart K, Matthias G, Matthias P. The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter. Eur J Immunol 2003; 33: 2864-2874. (Pubitemid 37337152)
35. Bartholdy B, Du Roure C, Bordon A, Emslie D, Corcoran LM, Matthias P. The Ets factor Spi-B is a direct critical target of the coactivator OBF-1. Proc Natl Acad Sci USA 2006; 103: 11665-11670. (Pubitemid 44182508)
36. Corcoran LM, Karvelas M, Nossal GJ, Ye ZS, Jacks T, Baltimore D. Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev 1993; 7: 570-582. (Pubitemid 23125258)
37. Corcoran LM, Hasbold J, Dietrich W, Hawkins E, Kallies A, Nutt SL et al. Differential requirement for OBF-1 during antibody-secreting cell differentiation. J Exp Med 2005; 201: 1385-1396. (Pubitemid 40664083)
38. Tanaka M, HerrW. Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell 1990; 60: 375-386.
39. Delacroix L, Begon D, Chatel G, Jackers P, Winkler R. Distal ERBB2 promoter fragment displays specific transcriptional and nuclear binding activities in ERBB2 overexpressing breast cancer cells. DNA Cell Biol 2005; 24: 582-594. (Pubitemid 41339044)