Triiodothyronine supplementation in infants and children undergoing cardiopulmonary bypass (TRICC): A multicenter placebo-controlled randomized trial: Age analysis

Circulation

Volumn 122, Issue 11 SUPPL. 1, 2010, Pages

  Portman, Michael A ^a   Slee, April ^g   Olson, Aaron K ^a   Cohen, Gordon ^a   Karl, Tom ^b   Tong, Elizabeth ⁱ   Hastings, Laura ^c   Patel, Hitendra ^d   Reinhartz, Olaf ^d   Mott, Antonio R ^e   Mainwaring, Richard ^f   Linam, Justin ⁱ   Danzi, Sara ^h  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

^d CHILDREN S HOSPITAL OAKLAND   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f Sutter Medical Center   (United States)

^g Axio Research Corporation   (United States)

^h NORTH SHORE UNIVERSITY HOSPITAL   (United States)

ⁱ NONE

Author keywords

cardiopulmonary bypass; congenital heart surgery; thyroid hormone

Indexed keywords

INOTROPIC AGENT; LIOTHYRONINE; PLACEBO;

AGE DISTRIBUTION; ARTICLE; CARDIOPULMONARY BYPASS; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; ECHOCARDIOGRAPHY; EXTUBATION; FEMALE; HEART FUNCTION; HEART VENTRICLE TACHYCARDIA; HORMONE SUBSTITUTION; HUMAN; HYPOTHYROIDISM; INFANT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; POSTOPERATIVE PERIOD; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUPRAVENTRICULAR TACHYCARDIA; TACHYCARDIA; TREATMENT OUTCOME; AGE; CHEMICALLY INDUCED; HEART ARRHYTHMIA; HEART DEFECTS, CONGENITAL; NEWBORN; PROPORTIONAL HAZARDS MODEL; PROSPECTIVE STUDY; TIME;

AGE FACTORS; ARRHYTHMIAS, CARDIAC; CARDIOPULMONARY BYPASS; CHILD, PRESCHOOL; DOUBLE-BLIND METHOD; FEMALE; HEART DEFECTS, CONGENITAL; HUMANS; INFANT; INFANT, NEWBORN; MALE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; TIME FACTORS; TRIIODOTHYRONINE;

EID: 77957244180     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.926394     Document Type: Article

References (28)

1. Bettendorf M, Schmidt KG, Tiefenbacher U, Grulich-Henn J, Heinrich UE, Schonberg DK. Transient secondary hypothyroidism in children after cardiac surgery. Pediatr Res. 1997;41:375-379.
2. Klemperer JD, Klein I, Gomez M, Helm RE, Ojamaa K, Thomas SJ, Isom OW, Krieger K. Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med. 1995;333:1522-1527.
3. Klemperer JD, Klein IL, Ojamaa K, Helm RE, Gomez M, Isom OW, Krieger KH. Triiodothyronine therapy lowers the incidence of atrial fibrillation after cardiac operations. Ann Thorac Surg. 1996;61: 1323-1327, discussion 1328-1329.
4. Mullis-Jansson SL, Argenziano M, Corwin S, Homma S, Weinberg AD, Williams M, Rose EA, Smith CR. A randomized double-blind study of the effect of triiodothyronine on cardiac function and morbidity after coronary bypass surgery. J Thorac Cardiovasc Surg. 1999;117:1128-1134.
5. Plumpton K, Haas NA. Identifying infants at risk of marked thyroid suppression post-cardiopulmonary bypass. Intensive Care Med. 2005;31: 581-587.
6. Portman MA, Fearneyhough C, Ning X, Duncan B, Rosenthal G, Lupinetti F. Triiodothyronine repletion in infants during cardiopulmonary bypass for congenital heart surgery. J Thorac Cardiovasc Surg. 2000; 120:604-608.
7. Bettendorf M, Schmidt KG, Grulich-Henn J, Ulmer HE, Heinrich UE. Tri-iodothyronine treatment in children after cardiac surgery: a double-blind, randomised, placebo-controlled study. Lancet. 2000;356:529-534.
8. Chowdhury D, Ojamaa K, Parnell VA, McMahon C, Sison CP, Klein I. A prospective randomized clinical study of thyroid hormone treatment after operations for complex congenital heart disease. J Thorac Cardiovasc Surg. 2001;122:1023-1025.
9. Mackie AS, Booth KL, Newburger JW, Gauvreau K, Huang SA, Laussen PC, DiNardo JA, del Nido PJ, Mayer JE Jr, Jonas RA, McGrath E, Elder J, Roth SJ. A randomized, double-blind, placebo-controlled pilot trial of triiodothyronine in neonatal heart surgery. J Thorac Cardiovasc Surg. 2005;130:810-816.
10. Mainwaring RD, Capparelli E, Schell K, Acosta M, Nelson JC. Pharma-cokinetic Evaluation of Triiodothyronine Supplementation in Children After Modified Fontan Procedure. Circulation. 2000;101:1423-1429.
11. Gidding SS. The importance of randomized controlled trials in pediatric cardiology. JAMA. 2007;298:1214-1216.
12. Hoffman TM, Wernovsky G, Atz AM, Kulik TJ, Nelson DP, Chang AC, Bailey JM, Akbary A, Kocsis JF, Kaczmarek R, Spray TL, Wessel DL. Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation. 2003;107:996-1002.
13. Portman MA, Fearneyhough C, Karl TR, Tong E, Seidel K, Mott A, Cohen G, Tacy T, Lewin M, Permut L, Schlater M, Azakie A. The Triiodothyronine for Infants and Children Undergoing Cardiopulmonary Bypass (TRICC) study: design and rationale. Am Heart J. 2004;148:393-398.
14. Heinle JS, Diaz LK, Fox LS. Early extubation after cardiac operations in neonates and young infants. J Thorac Cardiovasc Surg. 1997;114:413-418.
15. Lacour-Gayet F, Clarke D, Jacobs J, Comas J, Daebritz S, Daenen W, Gaynor W, Hamilton L, Jacobs M, Maruszsewski B, Pozzi M, Spray T, Stellin G, Tchervenkov C, Mavroudis C. The Aristotle score: a complexity-adjusted method to evaluate surgical results. Eur J Cardiothorac Surg. 2004;25:911-924.
16. Tei C, Nishimura RA, Seward JB, Tajik AJ. Noninvasive Doppler-derived myocardial performance index: correlation with simultaneous measurements of cardiac catheterization measurements. J Am Soc Echocardiogr. 1997;10: 169-178.
17. Wernovsky G, Wypij D, Jonas RA, Mayer JE, Jr., Hanley FL, Hickey PR, Walsh AZ, Chang AC, Castaneda AR, Newburger JW. Postoperative course and hemodynamic profile after the arterial switch operation in neonates and infants. A comparison of low-flow cardiopulmonary bypass and circulatory arrest. Circulation. 1995;92:2226-2235.
18. Kratzsch J, Schubert G, Pulzer F, Pfaeffle R, Koerner A, Dietz A, Rauh M, Kiess W, Thiery J. Reference intervals for TSH and thyroid hormones are mainly affected by age, body mass index and number of blood leucocytes, but hardly by gender and thyroid autoantibodies during the first decades of life. Clin Biochem. 2008;41:1091-1098.
19. Morales DL, Carberry KE, Heinle JS, McKenzie ED, Fraser CD Jr, Diaz LK. Extubation in the operating room after Fontan's procedure: effect on practice and outcomes. Ann Thorac Surg. 2008;86:576-581, discussion 581-1572
20. Chang RK, Chen AY, Klitzner TS. Factors associated with age at operation for children with congenital heart disease. Pediatrics. 2000; 105:1073-1081.
21. Danzi S, Dubon P, Klein I. Effect of serum triiodothyronine on regulation of cardiac gene expression: role of histone acetylation. Am J Physiol Heart Circ Physiol. 2005;289:H1506-H1511.
22. Hyyti OM, Ning XH, Buroker NE, Ge M, Portman MA. Thyroid hormone controls myocardial substrate metabolism through nuclear receptor-mediated and rapid posttranscriptional mechanisms. Am J Physiol Endocrinol Metab. 2006;290:E372-E379.
23. Wang YG, Dedkova EN, Fiening JP, Ojamaa K, Blatter LA, Lipsius SL. Acute exposure to thyroid hormone increases Na+ current and intracellular Ca2+ in cat atrial myocytes. J Physiol. 2003;546:491-499.
24. Danzi S, Klein I, Portman MA. Effect of triiodothyronine on gene transcription during cardiopulmonary bypass in infants with ventricular septal defect. Am J Cardiol. 2005;95:787-789.
25. Novotny J, Bourova L, Malkova O, Svoboda P, Kolar F. G proteins, beta-adrenoreceptors and beta-adrenergic responsiveness in immature and adult rat ventricular myocardium: influence of neonatal hypo-and hyperthyroidism. J Mol Cell Cardiol. 1999;31:761-772.
26. Hoit BD, Khoury SF, Shao Y, Gabel M, Liggett SB, Walsh RA. Effects of thyroid hormone on cardiac beta-adrenergic responsiveness in conscious baboons. Circulation. 1997;96:592-598.
27. Portman MA, Qian K, Krueger JJ, Ning XH. Direct Action of T3 on Phosphorylation Potential in the Sheep Heart in vivo. Am J Physiol Heart Circ Physiol. 2005;288:2484-2490.
28. Doin FL, Borges Mda R, Campos O, de Camargo Carvalho AC, de Paola AA, Paiva MG, Abucham J, Moises VA. Effect of central hypothyroidism on Doppler-derived myocardial performance index. J Am Soc Echocardiogr. 2004;17:622-629.