Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 1, 2010, Pages 124-132

  Walker, Q David ^a   Morris, Sarah E ^a   Arrant, Andrew E ^a   Nagel, Jacqueline M ^a   Parylak, Sarah ^a   Zhou, Guiying ^a   Caster, Joseph M ^a   Kuhn, Cynthia M ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; DOPAMINE; METHYLPHENIDATE; NOMIFENSINE; VANOXERINE; AMPHETAMINE DERIVATIVE; DOPAMINE UPTAKE INHIBITOR; PIPERAZINE DERIVATIVE;

ADOLESCENT; AGE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG RESPONSE; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT; STEREOTYPY; AGING; ANIMAL; ANIMAL BEHAVIOR; BRAIN LEVEL; DRUG EFFECTS; ELECTROPHYSIOLOGY; METABOLISM; MOTOR ACTIVITY; NEOSTRIATUM; PHYSIOLOGY;

AGING; AMPHETAMINES; ANIMALS; BEHAVIOR, ANIMAL; BRAIN CHEMISTRY; DOPAMINE; DOPAMINE UPTAKE INHIBITORS; ELECTROPHYSIOLOGY; MALE; METHYLPHENIDATE; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEOSTRIATUM; NOMIFENSINE; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77957243879     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.167320     Document Type: Article

References (41)

1. Andersen SL (2003) Trajectories of brain development: point of vulnerability or window of opportunity? Neurosci Biobehav Rev 27:3-18.
2. Badanich KA, Adler KJ, and Kirstein CL (2006) Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi. Eur J Pharmacol 550:95-106.
3. Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, et al. (2008) The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nat Neurosci 11:780-789.
4. Bolanos CA, Glatt SJ, and Jackson D (1998) Subsensitivity to dopaminergic drugs in periadolescent rats: a behavioral and neurochemical analysis. Brain Res Dev Brain Res 111:25-33.
5. Briegleb SK, Gulley JM, Hoover BR, and Zahniser NR (2004) Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: contribution of the dopamine transporter. Neuropsychopharmacology 29:2168-2179.
6. Cao J, Lotfipour S, Loughlin SE, and Leslie FM (2007) Adolescent maturation of cocaine-sensitive neural mechanisms. Neuropsychopharmacology 32:2279-2289. (Pubitemid 47587668)
7. Carboni E, Imperato A, Perezzani L, and Di Chiara G (1989) Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats. Neuroscience 28:653-661.
8. Carlsson A, Fuxe K, Hamberger B, and Lindqvist M (1966) Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons. Acta Physiol Scand 67:481-497.
9. Caster JM, Walker QD, and Kuhn CM (2005) Enhanced behavioral response to repeated-dose cocaine in adolescent rats. Psychopharmacology (Berl) 183:218-225. (Pubitemid 41609274)
10. Caster JM, Walker QD, and Kuhn CM (2007) A single high dose of cocaine induces differential sensitization to specific behaviors across adolescence. Psychopharmacology (Berl) 193:247-260.
11. Chambers RA, Taylor JR, and Potenza MN (2003) Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. Am J Psychiatry 160:1041-1052.
12. Dersch CM, Akunne HC, Partilla JS, Char GU, de Costa BR, Rice KC, Carroll FI, and Rothman RB (1994) Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains. Neurochem Res 19:201-208.
13. España RA, Roberts DC, and Jones SR (2008) Short-acting cocaine and long-acting GBR-12909 both elicit rapid dopamine uptake inhibition following intravenous delivery. Neuroscience 155:250-257.
14. Frantz KJ, O'Dell LE, and Parsons LH (2007) Behavioral and neurochemical responses to cocaine in periadolescent and adult rats. Neuropsychopharmacology 32:625-637. (Pubitemid 46271057)
15. Gainetdinov RR, Wetsel WC, Jones SR, Levin ED, Jaber M, and Caron MG (1999) Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science 283:397-401. (Pubitemid 129501103)
16. Galineau L, Kodas E, Guilloteau D, Vilar MP, and Chalon S (2004) Ontogeny of the dopamine and serotonin transporters in the rat brain: an autoradiographic study. Neurosci Lett 363:266-271. (Pubitemid 38746526)
17. Garris PA, Budygin EA, Phillips PE, Venton BJ, Robinson DL, Bergstrom BP, Rebec GV, and Wightman RM (2003) A role for presynaptic mechanisms in the actions of nomifensine and haloperidol. Neuroscience 118:819-829. (Pubitemid 36506968)
18. Greco PG and Garris PA (2003) In vivo interaction of cocaine with the dopamine transporter as measured by voltammetry. Eur J Pharmacol 479:117-125.
19. Kuczenski R and Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. J Neurochem 68:2032-2037. (Pubitemid 27176139)
20. Kuhn C, Johnson M, Thomae A, Luo B, Simon SA, Zhou G, and Walker QD (2010) The emergence of gonadal hormone influences on dopaminergic function during puberty. Horm Behav 58:122-137.
21. Li LB, Chen N, Ramamoorthy S, Chi L, Cui XN, Wang LC, and Reith ME (2004) The role of N-glycosylation in function and surface trafficking of the human dopamine transporter. J Biol Chem 279:21012-21020.
22. McCutcheon JE and Marinelli M (2009) Age matters. Eur J Neurosci 29:997-1014.
23. McMillen BA (1983) CNS stimulants: two distinct mechanisms of action for amphetamine-like drugs. Trends Pharmacol Sci 4:429-432.
24. Moll GH, Mehnert C, Wicker M, Bock N, Rothenberger A, Rüther E, and Huether G (2000) Age-associated changes in the densities of presynaptic monoamine transporters in different regions of the rat brain from early juvenile life to late adulthood. Brain Res Dev Brain Res 119:251-257.
25. Nomikos GG, Damsma G, Wenkstern D, and Fibiger HC (1990) In vivo characterization of locally applied dopamine uptake inhibitors by striatal microdialysis. Synapse 6:106-112.
26. Parylak SL, Caster JM, Walker QD, and Kuhn CM (2008) Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats. Pharmacol Biochem Behav 89:314-323.
27. Patel AP, Cerruti C, Vaughan RA, and Kuhar MJ (1994) Developmentally regulated glycosylation of dopamine transporter. Brain Res Dev Brain Res 83:53-58.
28. Schramm-Sapyta NL, Walker QD, Caster JM, Levin ED, and Kuhn CM (2009) Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. Psychopharmacology (Berl) 206:1-121.
29. Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417-463.
30. Spear LP (2007) Assessment of adolescent neurotoxicity: rationale and methodological considerations. Neurotoxicol Teratol 29:1-9.
31. Spear LP and Brake SC (1983) Periadolescence: age-dependent behavior and psychopharmacological responsivity in rats. Dev Psychobiol 16:83-109.
32. Stamford JA (1989) Development and ageing of the rat nigrostriatal dopamine system studied with fast cyclic voltammetry. J Neurochem 52:1582-1589.
33. Vasilev V, Veskov R, Janać B, Rakić Lj, and Stojiljković M (2003) Age-related differences in MK-801- and amphetamine-induced locomotor and stereotypic activities of rats. Neurobiol Aging 24:715-723.
34. Velázquez-Sánchez C, Ferragud A, Hernández-Rabaza V, Nácher A, Merino V, Cardá M, Murga J, and Canales JJ (2009) The dopamine uptake inhibitor 3 alpha-[bis(4′-fluorophenyl)methoxy]-tropane reduces cocaine-induced early-gene expression, locomotor activity, and conditioned reward. Neuropsychopharmacology 34:2497-2507.
35. Walker QD, Cabassa J, Kaplan K, Li ST, Haroon J, Spohr HA, and Kuhn CM (2001) Sex differences in cocaine-stimulated motor behavior: disparate effects of gonadectomy. Neuropsychopharmacology 25:118-130.
36. Walker QD and Kuhn CM (2008) Cocaine increases stimulated dopamine release more in periadolescent than adult rats. Neurotoxicol Teratol 30:412-418.
37. Walker QD, Schramm-Sapyta NL, Caster JM, Waller ST, Brooks MP, and Kuhn CM (2009) Novelty-induced locomotion is positively associated with cocaine ingestion in adolescent rats; anxiety is correlated in adults. Pharmacol Biochem Behav 91:398-408.
38. Wayment H, Meiergerd SM, and Schenk JO (1998) Relationships between the catechol substrate binding site and amphetamine, cocaine, and mazindol binding sites in a kinetic model of the striatal transporter of dopamine in vitro. J Neurochem 70:1941-1949.
39. Weissman A, Koe BK, and Tenen SS (1966) Antiamphetamine effects following inhibition of tyrosine hydroxylase. J Pharmacol Exp Ther 151:339-352.
40. Westerink BH, Tuntler J, Damsma G, Rollema H, and de Vries JB (1987) The use of tetrodotoxin for the characterization of drug-enhanced dopamine release in conscious rats studied by brain dialysis. Naunyn Schmiedebergs Arch Pharmacol 336:502-507.
41. Wooters TE, Dwoskin LP, and Bardo MT (2006) Age and sex differences in the locomotor effect of repeated methylphenidate in rats classified as high or low novelty responders. Psychopharmacology (Berl) 188:18-27.