Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: Genetic evidence of impaired tissue response to Fgf8

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 5, 2010, Pages 836-840

  Vitelli, Francesca ^a   Lania, Gabriella ^b   Huynh, Tuong ^a   Baldini, Antonio ^a,b  

^a TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^b INSTITUTE OF GENETICS AND BIOPHYSICS ADRIANO BUZZATI TRAVERSO   (Italy)

Author keywords

Cardiac outflow tract septation; Cardiac progenitors; DiGeorge syndrome; FGF signaling pathway; T box

Indexed keywords

FIBROBLAST GROWTH FACTOR 8; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MUTANT PROTEIN; PROTEIN RSK1; T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTERIAL TRUNK; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIGEORGE SYNDROME; EMBRYO; FIBROBLAST; GENE EXPRESSION; HEART OUTFLOW TRACT OBSTRUCTION; HEART VENTRICLE SEPTUM DEFECT; LIGAND BINDING; MOUSE; NONHUMAN; PERSISTENT TRUNCUS ARTERIOSUS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; TISSUE CULTURE;

ANIMALS; BLOTTING, WESTERN; FIBROBLAST GROWTH FACTOR 8; FIBROBLASTS; MICE; MUTATION; MYOCARDIUM; PHENOTYPE; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; T-BOX DOMAIN PROTEINS;

MUS;

EID: 77957237693     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.08.023     Document Type: Article

References (16)

1. Prall O.W., Elliott D.A., Harvey R.P. Developmental paradigms in heart disease: insights from tinman. Ann. Med. 2002, 34:148-156.
2. Chen L., Fulcoli F.G., Tang S., Baldini A. Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ. Res. 2009, 105:842-851.
3. Fulcoli F.G., Huynh T., Scambler P.J., Baldini A. Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS ONE 2009, 4:e6049.
4. Prall O.W., Menon M.K., Solloway M.J., Watanabe Y., Zaffran S., Bajolle F., Biben C., McBride J.J., Robertson B.R., Chaulet H., Stennard F.A., Wise N., Schaft D., Wolstein O., Furtado M.B., Shiratori H., Chien K.R., Hamada H., Black B.L., Saga Y., Robertson E.J., Buckingham M.E., Harvey R.P. An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell 2007, 128:947-959.
5. Vitelli F., Taddei I., Morishima M., Meyers E.N., Lindsay E.A., Baldini A. A genetic link between Tbx1 and fibroblast growth factor signaling. Development 2002, 129:4605-4611.
6. Vitelli F., Zhang Z., Huynh T., Sobotka A., Mupo A., Baldini A. Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev. Biol. 2006, 295:559-570.
7. Lania G., Zhang Z., Huynh T., Caprio C., Moon A.M., Vitelli F., Baldini A. Early thyroid development requires a Tbx1-Fgf8 pathway. Dev. Biol. 2009, 328:109-117.
8. Huynh T., Chen L., Terrell P., Baldini A. A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis 2007, 45:470-475.
9. Zhang Z., Huynh T., Baldini A. Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development 2006, 133:3587-3595.
10. Meyers E.N., Lewandoski M., Martin G.R. An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat. Genet. 1998, 18:136-141.
11. Brown C.B., Wenning J.M., Lu M.M., Epstein D.J., Meyers E.N., Epstein J.A. Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev. Biol. 2004, 267:190-202.
12. Zhang Z., Baldini A. In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum. Mol. Genet. 2008, 17:150-157.
13. Firnberg N., Neubuser A. FGF signaling regulates expression of Tbx2, Erm, Pea3, and Pax3 in the early nasal region. Dev. Biol. 2002, 247:237-250.
14. Zhang J., Lin Y., Zhang Y., Lan Y., Lin C., Moon A.M., Schwartz R.J., Martin J.F., Wang F. Frs2alpha-deficiency in cardiac progenitors disrupts a subset of FGF signals required for outflow tract morphogenesis. Development 2008, 135:3611-3622.
15. Guris D.L., Duester G., Papaioannou V.E., Imamoto A. Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev. Cell 2006, 10:81-92.
16. Park E.J., Ogden L.A., Talbot A., Evans S., Cai C.L., Black B.L., Frank D.U., Moon A.M. Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development 2006, 133:2419-2433.