Vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (Vertos II): An open-label randomised trial

The Lancet

Volumn 376, Issue 9746, 2010, Pages 1085-1092

  Klazen, Caroline A H ^a,c   Lohle, Paul N M ^a   De Vries, Jolanda ^a   Jansen, Frits H ^b   Tielbeek, Alexander V ^b   Blonk, Marion C ^b   Venmans, Alexander ^a   Van Rooij, Willem Jan J ^a   Schoemaker, Marinus C ^a   Juttmann, Job R ^a   Lo, Tjoen H ^c   Verhaar, Harald J J ^c   Van Der Graaf, Yolanda ^c   Van Everdingen, Kaspar J ^d   Muller, Alex F ^d   Elgersma, Otto E H ^e   Halkema, Dirk R ^e   Fransen, Hendrik ^f   Janssens, Xavier ^g   Buskens, Erik ^h   Mali, Willem P Th M ^c   more..

^a CPRLab   (Netherlands)

^b CATHARINA HOSPITAL   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d DEPARTMENT OF SURGERY   (Netherlands)

^e ALBERT SCHWEITZER HOSPITAL   (Netherlands)

^f Instititut Moderne   (Belgium)

^g Rheumatology   (Belgium)

^h UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; BONE CEMENT; CALCIUM; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PARACETAMOL; VITAMIN D;

ACUTE DISEASE; AGED; ARTICLE; BACKACHE; BELGIUM; BONE DENSITY; CHRONIC PAIN; CLINICAL TRIAL; COMPRESSION FRACTURE; CONSERVATIVE TREATMENT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DISABILITY; EDEMA; FEMALE; FOLLOW UP; FUNCTIONAL ASSESSMENT; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NETHERLANDS; NUCLEAR MAGNETIC RESONANCE IMAGING; OPEN STUDY; OSTEOPOROSIS; OUTCOME ASSESSMENT; PERCUTANEOUS VERTEBROPLASTY; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; QUALITY OF LIFE; QUESTIONNAIRE; RADIOLOGY DEPARTMENT; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SPINE RADIOGRAPHY; TREATMENT OUTCOME; VERTEBRA FRACTURE; VISUAL ANALOG SCALE; ANALGESIA; COMPARATIVE STUDY; COMPLICATION; COST BENEFIT ANALYSIS; ECONOMICS; FRACTURES, COMPRESSION; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PROSPECTIVE STUDY; SPINAL FRACTURES; TIME; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BELGIUM; BONE CEMENTS; COST-BENEFIT ANALYSIS; FEMALE; FRACTURES, COMPRESSION; HUMANS; MALE; MIDDLE AGED; NETHERLANDS; OSTEOPOROSIS; PAIN; PAIN MANAGEMENT; PAIN MEASUREMENT; PROSPECTIVE STUDIES; QUALITY-ADJUSTED LIFE YEARS; QUESTIONNAIRES; SPINAL FRACTURES; TIME FACTORS; TREATMENT OUTCOME; VERTEBROPLASTY;

EID: 77957204960     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(10)60954-3     Document Type: Article

References (28)

1. O Johnell, JA Kanis An estimate of the worldwide prevalence and disability associated with osteoporotic fractures Osteoporos Int 17 2006 1726 1733 (Pubitemid 44607392)
2. DM Black, SR Cummings, DB Karpf for the Fracture Intervention Trial Research Group Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures Lancet 348 1996 1535 1541 (Pubitemid 26411651)
3. PA Hulme, J Krebs, SJ Ferguson, U Berlemann Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies Spine 31 2006 1983 2001 (Pubitemid 44297781)
4. GH Zoarski, P Snow, WJ Olan Percutaneous vertebroplasty for osteoporotic compression fractures: quantitative prospective evaluation of long-term outcomes J Vasc Interv Radiol 13 2002 139 148 (Pubitemid 34160375)
5. JK McGraw, JA Lippert, KD Minkus, PM Rami, TM Davis, RF Budzik Prospective evaluation of pain relief in 100 patients undergoing percutaneous vertebroplasty: results and follow-up J Vasc Interv Radiol 13 2002 883 886
6. I Legroux-Gerot, C Lormeau, N Boutry, A Cotten, B Duquesnoy, B Cortet Long-term follow-up of vertebral osteoporotic fractures treated by percutaneous vertebroplasty Clin Rheumatol 23 2004 310 317 (Pubitemid 39193786)
7. MH Voormolen, PN Lohle, LE Lampmann Prospective clinical follow-up after percutaneous vertebroplasty in patients with painful osteoporotic vertebral compression fractures J Vasc Interv Radiol 17 2006 1313 1320 (Pubitemid 44259014)
8. GC Anselmetti, G Corrao, PD Monica Pain relief following percutaneous vertebroplasty: results of a series of 283 consecutive patients treated in a single institution Cardiovasc Intervent Radiol 30 2007 441 447 (Pubitemid 46599097)
9. AJ Evans, ME Jensen, KE Kip Vertebral compression fractures: pain reduction and improvement in functional mobility after percutaneous polymethylmethacrylate vertebroplasty retrospective report of 245 cases Radiology 226 2003 366 372
10. L Alvarez, M Alcaraz, A Perez-Higueras Percutaneous vertebroplasty: functional improvement in patients with osteoporotic compression fractures Spine 31 2006 1113 1118
11. A Perez-Higueras, L Alvarez, RE Rossi, D Quinones, I Al-Assir Percutaneous vertebroplasty: long-term clinical and radiological outcome Neuroradiology 44 2002 950 954 (Pubitemid 36067899)
12. JC Eck, D Nachtigall, SC Humphreys, SD Hodges Comparison of vertebroplasty and balloon kyphoplasty for treatment of vertebral compression fractures: a meta-analysis of the literature Spine J 8 2008 488 497 (Pubitemid 351608967)
13. DF Kallmes, BA Comstock, PJ Heagerty A randomized trial of vertebroplasty for osteoporotic spinal fractures N Engl J Med 361 2009 569 579
14. R Buchbinder, RH Osborne, PR Ebeling A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures N Engl J Med 361 2009 557 568
15. W Clark, S Lyon, J Burnes Trials of vertebroplasty for vertebral fractures N Engl J Med 361 2009 2097 2100
16. CA Klazen, HJ Verhaar, LE Lampmann VERTOS II: percutaneous vertebroplasty versus conservative therapy in patients with painful osteoporotic vertebral compression fractures; rationale, objectives and design of a multicenter randomized controlled trial Trials 8 2007 33
17. GA McHugh, KA Luker, M Campbell, PR Kay, AJ Silman A longitudinal study exploring pain control, treatment and service provision for individuals with end-stage lower limb osteoarthritis Rheumatology (Oxford) 46 2007 631 637 (Pubitemid 46523309)
18. HK Genant, CY Wu, KC van, MC Nevitt Vertebral fracture assessment using a semiquantitative technique J Bone Miner Res 8 1993 1137 1148 (Pubitemid 23261108)
19. EC Huskisson Measurement of pain Lancet 2 1974 1127 1131
20. JB Oostenbrink, CAM Bouwmans, MA Koopmanschap, FFH Rutten Dutch guidelines for cost evaluation in health care. Dutch Health Insurance Board http://www.cvz.nl/binaries/live/CVZ-Internet/hst-content/nl/documenten/ rubriek+zorgpakket/cfh/handleiding+kostenonderzoek.pdf 2004 (accessed July 22, 2010).
21. P Dolan Modeling valuations for EuroQol health states Med Care 35 1997 1095 1108 (Pubitemid 127453463)
22. LM Lamers, PF Stalmeier, J McDonnell, PF Krabbe, JJ van Busschbach Measuring the quality of life in economic evaluations: the Dutch EQ-5D tariff Ned Tijdschr Geneeskd 149 2005 1574 1578 (in Dutch). (Pubitemid 40978328)
23. P Lips, C Cooper, D Agnusdei Quality of life in patients with vertebral fractures: validation of the Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO) Osteoporos Int 10 1999 150 160 (Pubitemid 29462204)
24. M Roland, R Morris A study of the natural history of low-back pain. Part II: development of guidelines for trials of treatment in primary care Spine 8 1983 145 150 (Pubitemid 13089566)
25. D Wardlaw, SR Cummings, J Van Meirhaeghe Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial Lancet 373 2009 1016 1024
26. MH Voormolen, WP Mali, PN Lohle Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study AJNR Am J Neuroradiol 28 2007 555 560
27. JT Liu, WJ Liao, WC Tan Balloon kyphoplasty versus vertebroplasty for treatment of osteoporotic vertebral compression fracture: a prospective, comparative, and randomized clinical study Osteoporos Int 21 2010 359 364
28. JM Mathis, AO Ortiz, GH Zoarski Vertebroplasty versus kyphoplasty: a comparison and contrast AJNR Am J Neuroradiol 25 2004 840 845