In vitro pharmacological evaluation and phenolic content of ten South African medicinal plants used as anthelmintics

South African Journal of Botany

Volumn 76, Issue 3, 2010, Pages 558-566

  Aremu, A O ^a   Ndhlala, A R ^a   Fawole, O A ^a   Light, M E ^a   Finnie, J F ^a   Van Staden, J ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Anthelmintic; Antimicrobial; Cyclooxygenase inhibition; Phenolic content; South African medicinal plants; Tannin

Indexed keywords

DRUG; ENZYME ACTIVITY; INFECTIOUS DISEASE; MEDICINAL PLANT; PARASITIC DISEASE; PHENOLIC COMPOUND; PLANT EXTRACT; RURAL AREA; TANNIN;

SOUTH AFRICA;

ACOKANTHERA OPPOSITIFOLIA; CAENORHABDITIS ELEGANS; COTYLEDON ORBICULATA; CYATHEA; FELICIA ERIGEROIDES; HYPOXIS; OCIMUM; OCIMUM BASILICUM; SENNA; VERMES;

EID: 77957194790     PISSN: 02546299     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sajb.2010.04.009     Document Type: Article

References (46)

1. Aligiannis N., Kalpoutzakis E., Mitaku S., Chinou I.B. Composition and antimicrobial activity of the essential oils of two Origanum species. Journal of Agricultural and Food Chemistry 2001, 49:4168-4170.
2. Balunas M.J., Kinghorn A.D. Drug discovery from medicinal plants. Life Sciences 2005, 78:431-441.
3. Bentwich Z., Kalinkovich A., Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunology Today 1995, 16:187-191.
4. Botting R.M. Cyclooxygenase: past, present and future. A tribute to John R. Vane (1927-2004). Journal of Thermal Biology 2006, 31:208-219.
5. Brenner S. The genetics of Caenorhabditis elegans. Genetics 1974, 77:71-94.
6. Brooker S., Bethony J., Hotez P.J. Human hookworm infection in the 21st century. Advances in Parasitology 2004, 58:197-288.
7. Brooker S., Alexander N., Geiger S., Moyeed R.A., Stander J., Fleming F., Hotez P.J., Correa-Oliveira R., Bethony J. Contrasting patterns in the small-scale heterogeneity of human helminth infections in urban and rural environments in Brazil. International Journal of Parasitology 2006, 36:1143-1151.
8. Buwa L.V., Van Staden J. Antibacterial and antifungal activity of traditional medicinal plants used against venereal diseases in South Africa. Journal of Ethnopharmacology 2006, 103:139-142.
9. Clements J.M., Coignard F., Johnson I., Chandler S., Palan S., Waller A., Wijkmans J., Hunter M.G. Antibacterial activities and characterization of novel inhibitors of LpxC. Antimicrobial Agents and Chemotherapy 2002, 46:1793-1799.
10. Deacon J.W. Fungal Biology 2006, Blackwell Publishing, Oxford, United Kingdom.
11. Elgorashi E.E., Van Staden J. Pharmacological screening of six Amaryllidaceae species. Journal of Ethnopharmacology 2004, 90:27-32.
12. Eloff J.N. A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria. Planta Medica 1998, 64:711-713.
13. Eloff J.N. Which extractant should be used for the screening and isolation of antimicrobial components from plants?. Journal of Ethnopharmacology 1998, 60:1-8.
14. Erdèlyi K., Kiss A., Bakondi E., Bai P., Szabó C., Gergely P., Erdo{double acute}di F., Virág L. Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells. Molecular Pharmacology 2005, 68:895-904.
15. Fawole O.A., Finnie J.F., Van Staden J. Antimicrobial activity and mutagenic effects of twelve traditional medicinal plants used to treat ailments related to the gastro-intestinal tract in South Africa. South African Journal of Botany 2009, 75:356-362.
16. Geary T.G., Sangster N.C., Thompson D.P. Frontiers in anthelmintic pharmacology. Veterinary Parasitology 1999, 84:275-295.
17. Gurib-Fakim A. Medicinal plants: traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine 2006, 27:1-93.
18. Hagerman A.E. Tannin Chemistry 2002, Miami University Press, Oxford, USA.
19. Hewson M.G. Traditional healers in Southern Africa. Annals of Internal Medicine 1998, 128:1029-1034.
20. Houghton P.J., Hylands P.J., Mensah A.Y., Hensel A., Deters A.M. In vitro tests and ethnopharmacological investigations: wound healing as an example. Journal of Ethnopharmacology 2005, 100:100-107.
21. Houghton P.J., Howes M.J., Lee C.C., Steventon G. Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant. Journal of Ethnopharmacology 2007, 110:391-400.
22. Hutchings A., Scott A.H., Lewis G., Cunningham A. Zulu Medicinal Plants. An Inventory 1996, University of Natal Press, Pietermaritzburg, South Africa.
23. Ijagbone I.F., Olagunju F.T. Intestinal helminth parasites in school children in Iragbiji, Boripe Local Government, Osun State, Nigeria. African Journal of Biomedical Research 2006, 9:63-66.
24. Jäger A.K., Hutchings A., Van Staden J. Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors. Journal of Ethnopharmacology 1996, 52:95-100.
25. James C.E., Davey M.W. A rapid colorimetric assay for the quantitation of the viability of free-living larvae of nematodes in vitro. Parasitology Research 2007, 101:975-980.
26. James C.E., Davey M.W. Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegans. International Journal for Parasitology 2009, 39:213-220.
27. Jinabhai C.C., Taylor M., Coutsoudis A., Coovadia H.M., Tomkins A.M., Sullivan K.R. Epidemiology of helminth infections: implications for parasite control programmes, a South African perspective. Public Health Nutrition 2001, 4:1211-1219.
28. Light M.E., Sparg S.G., Stafford G.I., Van Staden J. Riding the wave: South Africa's contribution to ethnopharmacological research over the last 25years. Journal of Ethnopharmacology 2005, 100:127-130.
29. Lin J., Opoku A.R., Geheeb-Keller M., Hutchings A.D., Terblanche S.E., Jäger A.K., Van Staden J. Preliminary screening of some traditional Zulu medicinal plants for anti-inflammatory and anti-microbial activities. Journal of Ethnopharmacology 1999, 68:267-274.
30. Makkar H.P.S. Quantification of tannins in tree foliage. A laboratory manual for the FAO/IAEA co-ordinated research project on 'Use of nuclear and related techniques to develop simple tannin assays for predicting and improving the safety and efficiency of feeding ruminants on tanniniferous tree foliage' 2000, Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture, Vienna, Austria.
31. Masoko P., Picard J., Eloff J.N. The antifungal activity of twenty-four southern African Combretum species (Combretaceae). South African Journal of Botany 2007, 73:173-183.
32. McGaw L.J., Van der Merwe D., Eloff J.N. In vitro anthelmintic, antibacterial and cytotoxic effects of extracts from plants used in South African ethnoveterinary medicine. The Veterinary Journal 2007, 173:366-372.
33. Ndhlala A.R., Kasiyamhuru A., Mupure C., Chitindingu K., Benhura M.A., Muchuweti M. Phenolic composition of Flacourtia indica, Opuntia megacantha and Sclerocarya birrea. Food Chemistry 2007, 103:82-87.
34. Okujagu T.F., Etatuvie S.O., Eze I., Jimoh B., Nwokeke C., Mbaoji C., Mohammed Z. Medicinal Plants of Nigeria: South West Nigeria. Nigerian Natural Medicine Development Agency 2006, Regent Press, Lagos, Nigeria.
35. Polya G. Biochemical Targets of Plant Bioactive Compounds: a Pharmacological Reference Guide to Sites of Action and Biological Effects 2003, CRC Press, Florida, USA.
36. Pooley E. A Field Guide to Wild Flowers: KwaZulu-Natal and the Eastern Regions 1998, Natal Flora Publications Trust, Durban, South Africa.
37. Sleigh D.J., Timburg M.C. Notes on Medical Bacteriology 1998, Churchill Livingstone, Edinburgh, United Kingdom.
38. Talukdar S. Lesotho. Southern African Plant Red Data Lists. Southern African Botanical Diversity Network Report No. 14:21-30 2002, SABONET, Pretoria, South Africa. J. Golding (Ed.).
39. Taylor J.L.S., Rabe T., McGaw L.J., Jäger A.K., Van Staden J. Towards the scientific validation of traditional medicinal plants. Plant Growth Regulation 2001, 34:23-37.
40. Tshikalange T.E., Meyer J.J.M., Hussein A.A. Antimicrobial activity, toxicity and the isolation of a bioactive compound from plants used to treat sexually transmitted diseases. Journal of Ethnopharmacology 2005, 96:515-519.
41. Tunón H., Olavsdotter C., Bohlin L. Evaluation of anti-inflammatory activity of some Swedish medicinal plants. Inhibition of prostaglandin biosynthesis and PAF-induced exocytosis. Journal of Ethnopharmacology 1995, 48:61-76.
42. Van Wyk B.-E., Van Oudtshoorn B., Gericke N. Medicinal Plants of South Africa 1997, Briza Publications, Pretoria, South Africa.
43. Waller P.J., Bernes G., Thamsborg S.M., Sukura A., Richter S.H., Ingebrigtsen K., Hoglund J. Plants as de-worming agents of livestock in the nordic countries: historical perspective, popular beliefs and prospects for the future. Acta Veterinaria Scandinavica 2001, 42:31-44.
44. Watt J.M., Breyer-Brandwijk M.G. The Medicinal and Poisonous Plants of Southern and Eastern Africa 1962, Livingstone, London, United Kingdom.
45. Zschocke S., Van Staden J. Cryptocarya species - substitute plants for Ocotea bullata? A pharmacological investigation in terms of cyclooxygenase-1 and -2 inhibition. Journal of Ethnopharmacology 2000, 71:473-478.
46. Zschocke S., Rabe T., Taylor J.L.S., Jäger A.K., Van Staden J. Plant part substitution - a way to conserve endangered medicinal plants?. Journal of Ethnopharmacology 2000, 71:281-292.