-
1
-
-
77957201023
-
The phosphatidylinositol 3-kinase-delta inhibitor CAL-101 demonstrates promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals
-
Herman SE, Gordon AL, Wagner AJ, et al. The phosphatidylinositol 3-kinase-delta inhibitor CAL-101 demonstrates promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals. Blood. 2010;116(12):2078-2088.
-
(2010)
Blood
, vol.116
, Issue.12
, pp. 2078-2088
-
-
Herman, S.E.1
Gordon, A.L.2
Wagner, A.J.3
-
4
-
-
70349562920
-
Molecular and cellular mechanisms of CLL: Novel therapeutic approaches
-
Pleyer L, Egle A, Hartmann TN, Greil R. Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nat Rev Clin Oncol. 2009;6(7):405-418.
-
(2009)
Nat Rev Clin Oncol
, vol.6
, Issue.7
, pp. 405-418
-
-
Pleyer, L.1
Egle, A.2
Hartmann, T.N.3
Greil, R.4
-
5
-
-
43249129993
-
The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development
-
Kulathu Y, Hobeika E, Turchinovich G, RethM.The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development.EMBOJ. 2008;27(9):1333-1344.
-
(2008)
EMBOJ
, vol.27
, Issue.9
, pp. 1333-1344
-
-
Kulathu, Y.1
Hobeika, E.2
Turchinovich, G.3
Reth, M.4
-
6
-
-
67650458526
-
Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia
-
Buchner M, Fuchs S, Prinz G, et al. Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia. Cancer Res. 2009;69(13):5424-5432.
-
(2009)
Cancer Res
, vol.69
, Issue.13
, pp. 5424-5432
-
-
Buchner, M.1
Fuchs, S.2
Prinz, G.3
-
7
-
-
70349237504
-
B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: Specific targeting with a novel spleen tyrosine kinase inhibitor, R406
-
Quiroga MP, Balakrishnan K, Kurtova AV, et al. B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406. Blood. 2009; 114(5):1029-1037.
-
(2009)
Blood
, vol.114
, Issue.5
, pp. 1029-1037
-
-
Quiroga, M.P.1
Balakrishnan, K.2
Kurtova, A.V.3
-
8
-
-
61849183478
-
Bruton's tyrosine kinase (Btk): Function, regulation, and transformation with special emphasis on the PH domain
-
Mohamed AJ, Yu L, Bäckesjö CM, et al. Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain. Immunol Rev. 2009;228(1):58-73.
-
(2009)
Immunol Rev
, vol.228
, Issue.1
, pp. 58-73
-
-
Mohamed, A.J.1
Yu, L.2
Bäckesjö, C.M.3
-
9
-
-
38349158386
-
Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival
-
Woodland RT, Fox CJ, Schmidt MR, et al. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 2008;111(2):750-760.
-
(2008)
Blood
, vol.111
, Issue.2
, pp. 750-760
-
-
Woodland, R.T.1
Fox, C.J.2
Schmidt, M.R.3
-
10
-
-
61849096108
-
Mcl-1: The 1 in CLL
-
comment
-
Gandhi V, Balakrishnan K, Chen LS. Mcl-1: the 1 in CLL [comment]. Blood. 2008;112(9):3538-3540.
-
(2008)
Blood
, vol.112
, Issue.9
, pp. 3538-3540
-
-
Gandhi, V.1
Balakrishnan, K.2
Chen, L.S.3
-
11
-
-
77950538522
-
Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells
-
Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi V. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2009;114(19):4150-4157.
-
(2009)
Blood
, vol.114
, Issue.19
, pp. 4150-4157
-
-
Chen, L.S.1
Redkar, S.2
Bearss, D.3
Wierda, W.G.4
Gandhi, V.5
-
12
-
-
77950457187
-
PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
-
Soond DR, Bjørgo E, Moltu K, et al. PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans. Blood. 2010;115(11):2203-2213.
-
(2010)
Blood
, vol.115
, Issue.11
, pp. 2203-2213
-
-
Soond, D.R.1
Bjørgo, E.2
Moltu, K.3
-
13
-
-
77951002653
-
Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia
-
Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. 2010;115(13):2578-2585.
-
(2010)
Blood
, vol.115
, Issue.13
, pp. 2578-2585
-
-
Friedberg, J.W.1
Sharman, J.2
Sweetenham, J.3
-
14
-
-
78649797979
-
Btk inhibitor PCI-32765 monotherapy induces objective responses in patients with relapsed aggressive NHL: Evidence of antitumor activity from a phase I study
-
abstract
-
Advani R, Sharman J, Smith S, et al. Btk inhibitor PCI-32765 monotherapy induces objective responses in patients with relapsed aggressive NHL: evidence of antitumor activity from a phase I study [abstract]. J Clin Oncol. 2010;28:576s.
-
(2010)
J Clin Oncol
, vol.28
-
-
Advani, R.1
Sharman, J.2
Smith, S.3
-
15
-
-
77957203544
-
Interim results from a phase I study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110δd isoform, in patients with relapsed or refractory hematologic malignancies
-
abstract
-
Furman R, Byrd J, Flinn I, et al. Interim results from a phase I study of CAL-101, a selective oral inhibitor of phosphatidylinositol 3-kinase p110δd isoform, in patients with relapsed or refractory hematologic malignancies [abstract]. J Clin Oncol. 2010;28:15s.
-
(2010)
J Clin Oncol
, vol.28
-
-
Furman, R.1
Byrd, J.2
Flinn, I.3
|