Cataractogenesis in rats induced by in Utero exposure to RG 12915, a 5-HT3 antagonist

Toxicological Sciences

Volumn 27, Issue 2, 1995, Pages 270-276

  Lerman, S A ^a   Delongeas, J L ^a,b   Plard, J P ^a,b   Veneziale, R W ^a,b   Clark, R L ^a,b   Rubin, L ^c   Sanders, J E ^a  

^a SANOFI   (France)

^b School of Veterinary Medicine ^*  (France)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 5A,6,7,8,9,9A HEXAHYDRO N (3 QUINUCLIDINYL)DIBENZOFURAN 4 CARBOXAMIDE; SEROTONIN 3 ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CATARACT; CATARACTOGENESIS; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; FETUS; GROWTH RETARDATION; INTRAGASTRIC DRUG ADMINISTRATION; NEWBORN; NONHUMAN; ORAL DRUG ADMINISTRATION; POSTNATAL DEVELOPMENT; PROGENY; RAT; REPRODUCTIVE TOXICITY;

ANIMAL; BENZOFURANS; BICYCLO COMPOUNDS, HETEROCYCLIC; BODY WEIGHT; CATARACT; FEMALE; LENS, CRYSTALLINE; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; SEROTONIN ANTAGONISTS;

EID: 77957187257     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/27.2.270     Document Type: Article

References (19)

1. Armstrong, R. C., and Monie, I. W, (1966). Congenital eye defects in rats following maternal folic-acid deficiency during pregnancy. J. Embryol. Exp. Morph., 16(3), 531-542.
2. Balinsky, B I. (1975). An Introduction to Embryology, 4th ed., p. 330. SCP.
3. Bunce, G. E., Hess, J. L., and Fillnow, G. M. (1978). Investigation of low tryptophan induced cataract in weanling rats. Exp. Eye Res., 26, 399-405
4. Candia. O. A., Lanzetta. P. A., Alvarez, L. J., and Gaines. W. (1980). Inhibition of ionic transport and ATPase activities by serotonin analogues in the isolated toad lens. Biochim. Biophvs. Acia 602, 389-400.
5. Chemoff, N., Linder, R. E., Scotti, T. M., Rogers, E. H., Carver. B. D., and Kavlock, R. J. (1979). Fetotoxicity and cataractogenicity of mirex in rats and mice with notes on kepone. Environ. Res., 18, 257-269.
6. Clinton, J. M., and Lang. P. L. (1991). Spontaneaous Ophthalmic Lesions in the Crl:CD®BR Rat., Monograph published by Charles River Laboratories.
7. Dietze, U., and Tilgner, S. (1973). Reversible linsentrlibungen Wistar-ratten nach einmaliger Applikation von Serotonin. (Reversible lens opacities in Wistar rats following a single subcutaneous injection of serotonin.) Ophthalmologica 166(1), 76-80.
8. FOI Services Inc. (1991). FDA Pharmacologist’s Review for the Drug Zofran (Ondansetron HC1 Injection), NDA 20-007, p. 12.
9. Gralla, E. J., and Rubin, L. (1970). Ocular studies with para-chlorophenylalanine in rats and monkeys. Arch. Ophthalmol., 83, 734-740.
10. Hanaway, J. K. (1969). Lysergic acid diethylamide: Effects on the developing mouse lens. Science 164, 574-575.
11. 3 antagonist. Fundam. Appl. Toxicol., 21, 393-401.
12. Lauder, J. M. (1988). Neurotransmitters as morphogens. In Progress in Brain Research, Vol. 73, Chap. 24, pp. 365-388.
13. McAvoy, J. W. (1980). Induction of the eye lens. Differentiation 17, 137-149.
14. Pitel, M., and Lerman, S. (1962). Studies on the fetal rat lens. Effects of intrauterine adrenalin and noradrenalin. Invest. Ophthalmol., 1, 406-412
15. Rogers, J. M., and Grabowski, C. T. (1983). Mirex-induced fetal cataracts: Lens growth, histology and cation balance, and relationship to edema. Teratology 27, 343-349.
16. Tuchmann-Duplessis, H., and Mercier-Parot, L. (1963). Action du chlorhydrate de cyclizine sur la gestation et le développement embryonnaire du rat, de la souris et du lapin. C. R. Acad. Sci. Paris 256, 3359-3362.
17. Tuchmann-Duplessis, H., and Mercier-Parot. L. (1964). Production de malformations des membres chez le lapin par administration d’un antimetabolite: l’azathioprine. C. R. Acad. Sci. Paris 259(12), 3648-3651.
18. Wagner, N., Kanai, A., Harrington, J. S., Kaufman. H. E., and Nakamoto. T. (1983). Cataract formation in newborn rats from feeding a liquid protein diet. Exp. Eye Res., 37, 129-138.
19. Zimmerman, E. F., Clark, R. L., Ganguli, S., and Venkatasubramanian, K. (1983). Serotonin regulation of palatal cell motility and metabolism. J. Craniofacial Genet. Dev. Biol., 3, 371-385.