Pulmonary response to toner upon chronic inhalation exposure in rats

Toxicological Sciences

Volumn 17, Issue 2, 1991, Pages 280-299

  Muhle, H ^a   Bellmann, B ^a   Creutzenberg, O ^a   Dasenbrock, C ^a   Ernst, H ^a   Kilpper, R ^b   Mackenzie, J C ^b   Morrow, P ^c   Mohr, U ^a   Takenaka, S ^a   Mermelstein, R ^b  

^a Geslischaft für Strahlen und Umweltforschung ^*  (Germany)

^b XEROX CORPORATION   (United States)

^c UNIVERSITY OF ROCHESTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SILICON DIOXIDE; TITANIUM DIOXIDE;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG TOXICITY; FEMALE; INHALATION; LUNG FIBROSIS; LUNG TOXICITY; MALE; NONHUMAN; PARTICULATE MATTER; RAT;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMAL; BODY WEIGHT; BRONCHOALVEOLAR LAVAGE FLUID; CARCINOGENS; FEMALE; LUNG; LUNG DISEASES; LUNG NEOPLASMS; LYMPH NODES; MALE; ORGAN WEIGHT; PULMONARY FIBROSIS; RATS; RATS, INBRED F344; SILICON DIOXIDE; TITANIUM;

ANIMALIA;

EID: 77957181417     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/17.2.280     Document Type: Article

References (39)

1. Bellmann, B., Muhle, H., Creutzenberg, O., Das-Enbrock, C., Kllpper, R., Mackenzie, S., Morrow, P., and Mermelstein, R. (1991). Lung clearance and retention of toner, utilizing a tracer technique during chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17, 300-313.
2. Butler, M. A., Evans, D. L., Giammarise, A. T., Kjri-Azides, D. K., Marsh, D., McCoy, E. G, Mermel, Stein, R., Murphy, C. B., and Rosenkranz, H. S. (1982). Application of the Salmonella assay to carbon blacks and toners. In Polynudear Aromatic Hydrocarbons: Seventh International Symposium on Formation, Metabolism and Measurement (M. W. Cooke and A. J. Dennis, Eds.), pp. 225-241. Battelle Press, Columbus, OH.
3. Chan, T. L., Lee, P. S., and Hering, E. E. (1984). Pulmonary retention of inhaled diesel particles after prolonged exposures to diesel exhaust. Fundam. Appl. Toxicol. 4, 624-631.
4. Dagle, G. E., Wehner, A. P., Clark, M. L., and Buschbom, R. L. (1986). Chronic inhalation exposure of rats to quartz. In Silica, Silicosis and Cancer (D. F. Goldsmith, D. M. Winn, and C. M. Shy, Eds.), pp. 255-266. Praeger, New York.
5. Environmental Protection Agency (EPA). (1986). Draft policy. Chemical Regulation Reporter, May 9, p. 158 (BNA).
6. Groth, D. H., Stettler, L. B., Platek, S. F., Lal, J. B., and Burg, J. R. (1986). Lung tumors in rats treated with quartz by intratracheal instillation. In Silica, Silicosis and Cancer (D. F. Goldsmith, D. M. Winn, and C. M. Shy, Eds.), pp. 243-253. Praeger, New York.
7. Heinrich, U., Muhle, H., Hoymann, H. G., and Mer-Melstein, R. (1989). Pulmonary function changes in rats after chronic and subchronic inhalation exposure to various particulate matter. Exp. Pathol. 37, 248-252.
8. Heinrich, U., Muhle, H., Koch, W., and Mohr, U. (1985). Long-term inhalation studies with rodents. In Safety Evaluation and Regulation of Chemicals (F. Homburger, Ed.), pp. 239-250. Karger, Basel.
9. Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., Mohr, U., Pott, F., and Stober, W. (1986). Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J. Appl Toxicol 6, 383-395.
10. Henderson, R. F., Benson, J. M., Hahn, F. F., Hobbs, C. H., Johns, R. K., Mauderly, J. L., McClellan, R. O., and Pickrell, J. A. (1985). New approaches for the evaluation of pulmonary toxicity bronchoalveolar lavage fluid analysis. Fundam. Appl. Toxicol. 5, 451-458.
11. Henderson, R. F., Mauderly, J. L, Pickrell, J. A., Hahn, R. F., Muhle, H., and Rebar, A. H. (1987). Comparative study of bronchoalveolar lavage fluid: Effect of species, age and method of lavage. Exp. Lung Res. 13, 329-342.
12. Henderson, R. F., Pickrell, J. A., Jones, R. K., Sun, J. D., Benson, J. M., Mauderly, J. L., and McClellan, R. O. (1988). Response of rodents to inhaled diluted diesel exhaust: Biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue. Fundam. Appl. Toxicol. 11, 546-565.
13. Holland, L. M., Wilson, J. S., Tillery, M. I., and Smith, D. M. (1986). Lung cancer in rats exposed to fibrogenic dusts. In Silica, Silicosis and Cancer (D. F. Goldsmith, D. M. Winn, and C. M. Shy, Eds.), pp. 267-279. Praeger, New York.
14. Ishinishi, N., Koizumi, A., McClellan, R. O., and Stöber, W. (Eds.) (1986). Carcinogenic and Mutagenic Effects of Diesel Engine Exhaust. Elsevier, Amsterdam/ New York.
15. Klonne, D. R., Burns, J. M., Halder, C. A., Hold-Sworth, C. E., and Ulrich, C. E. (1987). Two-year inhalation toxicity study of petroleum coke in rats and monkeys. Am. J. Ind. Med. II, 375-379.
16. Klosterkötter, W., and Bonemann, G. (1959). Untersuchungen über die Ausscheidung inhalierter Stäube im Tierexperiment. Beitr. Silikose-Forsch. Sonderband 3, 145-155.
17. Koch, W., Lödding, H., Oennjng, G., and Muhle, H. (1986). The generation and measurement of dry aerosols in large-scale inhalation experiments. J Aerosol Sei. 3, 499-504.
18. 2) by inhalation for two years. Toxicol. Appl. Pharmacol 79, 179-192.
19. Mauderly, J. L., Jones, R. K., Griffith, W. C., Henderson, R. F., and McClellan, R. O. (1987). Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. Appl Toxicol 9, 208-221.
20. Mermelstein, R., Creutzenberg, O., Dasenbrock, C., Kilpper, R., Morrow, P., and Muhle, H. (1990). Long-term inhalation study of a test toner in hamsters. Toxicologist 10, № 802.
21. Mermelstein, R., Mohr, U., Koch, Dasenbrock, C., Kjlpper, R., Mackenzie, J., Morrow, P., and Muhle, H. (1988). Long-term inhalation study of a test toner in rats. Toxicologist 8, № 271.
22. Morrow, P. E. (1986). The setting of particulate exposure levels for chronic inhalation toxicity studies. J. Am. Coll Toxicol 5, 533-544.
23. Morrow, P. E. (1988). Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. Toxicol 10, 369-384.
24. Morrow, P. E., and Mermelstein, R. (1988). Chronic inhalation toxicity studies: Protocols and pitfalls. In Inhalation Toxicology. The Design and Interpretation of Inhalation Studies and Their Use in Risk Assessment (D. Dungworth et al., Eds.), pp. 103-117. Springer-Verlag, New York.
25. Morrow, P. E., Muhle, H., and Mermelstein, R. (1991). Chronic inhalation study findings as a basis for proposing a new occupational dust exposure limit. J. Am. Coll. Toxicol. 10, 279-290.
26. Muhle, H., Bellmann, B., Creutzenberg, O., Fuhst, R., Kjlpper, R., Koch, W., Mackenzie, J. C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. (1990a). Subchronic inhalation study of toner in rats. Inhal. Toxicol. 2, 341-359.
27. Muhle, H., Bellmann, B., Creutzenberg, O., Heinrich, U., and Mermelstein, R. (1990b). Dust overloading of lungs: Investigations of various materials, species differences and irreversibility of effects. J. Aerosol Med 3, S111-S128.
28. Muhle, H., Bellmann, B., Creutzenberg, O., Stöber, W., Kilpper, R., Mackenzie, J. C., Morrow, P., and Mermelstein, R. (1988). Pulmonary deposition clearance and retention of test toner, TiO and quartz during a long-term inhalation study in rats. Toxicologist 8, № 272.
29. Muhle, H., Takenaka, S., Mohr, U., Dasenbrock, C., and Mermelstein, R. (1989). Lung tumor induction upon long-term low-level inhalation of crystalline silica. Am. J Ind. Med. 15, 343-346.
30. Robock, K. (1973). Standard quartz DQ 12 5 fim for experimental pneumoconiosis research projects in the Federal Republic of Germany. Ann. Occup. Hyg. 16, 61-64.
31. Rosenkranz, H. S., McCoy, E. C., Sanders, D. R., Butler, M., Kiriazides, D. K., and Mermelstein, R. (1980). Nitropyrene isolation, identification and reduction of mutagenic impurities in carbon black and toners. Science 209, 1039-1043.
32. SAS Institute (1985) SAS User’s Guide. Statistics, Version 5 ed. SAS Institute Inc. Cary, NC.
33. Solleveld, H. A., Haseman, J. K., and McConnell, E. E. (1984). Natural history of body weight gain, survival and neoplasms in the F344 rat. J Nall. Cancer Inst 72, 929-940.
34. Vincent, J H., Johnston, A. Y., Jones, A. D., Bolton, R. E., and Addison, J. (1985). Kinetics of deposition and clearance of inhaled mineral dusts during chronic exposure. Br. J. Ind. Med. 42, 707-715.
35. Vostal, J. J. (1986). Factors limiting the evidence for chemical carcinogenicity of diesel emissions in long-term inhalation experiments. In Carcinogenic and Miaagenic Effects of Diesel Engine Exhaust (N. Ishinishi, A. Koizumi, R. O. McClellan, and W. Stöber, Eds.), pp. 381-396. Elsevier, Amsterdam/New York.
36. Vostal, J. J., Schreck, R. M., Lee, P. S., Chan, T. L., and Soderholm, S. C. (1982a). Deposition and clearance of diesel particles from the lungs. In Toxicology of Diesel Exhaust Emissions (J. Lewtas Ed.), pp. 143-159. Elsevier Biomedical, New York.
37. Vostal, J. J., White, H. J., Strom, K. A., Siak, J. S., Chen, K. C., and Dziedzic, D. (1982b). Response of the pulmonary defense system to diesel particulate exposure. In Toxicology of Diesel Exhaust Emissions (J. Lewtas, Ed.), pp. 201-221. Elsevier Biomedical, New York.
38. Wagner, J. C. (1990). Experimental asbestosis. In Models of Lung Disease Microscopy and Structural Methods (J. Gil, Ed.), pp. 761-799. Marcel Dekker, New York.
39. Wolff, R. K., Henderson, R. F., Snipes, M. B., Griffith, W. C., Mauderly, J. L., Cuddihy, R. G., and McClellan, R. O. (1987). Alterations in particle accumulation and clearance in lungs of rats chronically exposed to diesel exhaust. Fundam Appl Toxicol. 9, 154-166.