Combined therapeutic potential of meso-2,3-dimercaptosuccinic acid and calcium disodium edetate on the mobilization and distribution of lead in experimental lead intoxication in rats

Toxicological Sciences

Volumn 25, Issue 2, 1995, Pages 233-240

  Flora, S J S ^a   Bhattacharya, R ^a   Vijayaraghavan, R ^a  

^a DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; CREATININE; EDETATE CALCIUM DISODIUM; LEAD; SUCCIMER; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; INTRAPERITONEAL DRUG ADMINISTRATION; LEAD POISONING; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; TISSUE LEVEL; TOXICOKINETICS; URINARY EXCRETION;

ANIMALIA;

EID: 77957177450     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/25.2.233     Document Type: Article

References (29)

1. Andersen, O. (1987). Chelation of cadmium in vivo. In Proceeding of the Second International Symposium on Chelating Agents in Pharmacology. Toxicology and Therapeutics (V. Eybl, Ed.), abstract 8. The Czechoslovak Medical Society, J. E. Purtyne, Pilsen.
2. Angle, C. R. (1993). Childhood lead poisoning and its treatment. Annu. Rev. Pharmacol. Toxicol., 32, 409-434.
3. Berlin, A., and Schaller, K. H. (1974). European standardized method for the determination of δ-aminolevulinic acid dehydratase activity in blood. Z. Klin. Chem. Klin Biochem., 12, 389-390.
4. Castellino, N., and Aloj, S. (1965). Effects of calcium sodium ethylenediamine tetraacetate on the kinetics of distribution and excretion of lead in rat. Br. J. Ind. Med., 22, 172-180.
5. Cherian, M. G. (1980). Chelation of cadmium with BAL and DTPA in rats. Nature 207, 871-872.
6. Chisolm, J. J. (1974). Chelate therapy in children with plumbism. J. Pediatr., 53, 441-445.
7. Chisolm, J. J., Jr. (1989). Evaluation of the potential role of chelation therapy in treatment of low to moderate lead exposure. Environ. Health Perspect., 89, 67-74.
8. Chisolm, J. J., Mellits, E. D., and Barrett, M. D. (1976). Interrelationship among blood lead concentration quantitative daily ALAD and urinary lead output following calcium EDTA. In Effects and Dose-Response Relationship for toxic metal (G. S. Nordberg Ed.), pp. 426-433. Elsevier, Amsterdam.
9. Cory-Slechta, D. A., Weiss, B., and Cox, C. (1987). Mobilization and distribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy. J Pharmacol. Exp. Ther., 293, 804-813.
10. Cory-Slechta, D. A. (1988). Mobilization of lead over the course of DMSA chelation therapy and long term efficacy. J. Pharmacol. Exp. Ther., 246, 84-91.
11. Davis, J. R., Abrahams, R. H., Fishbein, W. I., and Fabrega, E. A. (1968). Urinary delta aminolevulinic acid (ALA) levels in lead poisoning II. correlation of ALA values with clinical findings in 250 children with suspected lead ingestion. Arch. Environ. Health 17, 164-171.
12. Doolan, P. D., Schwartz, S. K., Hayes, J. R., Mullen, J. C., and Cummings, N. B. (1967). An evaluation of the nephrotoxicity of ethylenediamine tetraacetate and diethyltriamine pentaacetate in the rat. Toxicol. Appl. Pharmacol., 10, 481-500.
13. Flora, S. J. S., and Tandon, S. K. (1990). Beneficial effect of zinc supplementation during chelation treatment of lead intoxication in rats. Toxicology 64, 129-139.
14. Flora, S. J. S., Dhawan, M., and Tandon, S. K. (1990). Influence of copper supplementation during chelation of lead. Clin. Chem. Enzymol. Commun., 3, 97-105.
15. Flora, S. J. S., Bhattacharya, R., and Sachan, S. R. S. (1994). Dose dependent effects of zinc supplementation during chelation of lead in rats. Pharmacol. Toxicol., 74, 330-333.
16. Flora, S. J. S. (1991). Influence of simultaneous supplementation of zinc and copper during chelation of lead in rats. Hum. Exp. Toxicol., 10, 331-336.
17. Grandjean, P. (1979). Occupational lead exposure in Denmark: Screening with haematofluorometer. Br. J. Ind. Med., 36, 52-58.
18. Graziano, J. H., Siris, E. S., Loiacono, N. J., Silverberg, S. J., and Turgeon, L. (1985). 2, 3-Dimercaptosuccinic acid as an antidote for lead intoxication. Clin. Pharmacol. Ther., 37, 431-438.
19. Hammond, P. B., Aronson, A. L., and Olson, W. C. (1967). The mechanism of mobilization of lead by ethylenediamine tetraacetate. J. Pharmacol. Exp. Ther., 157, 196-206.
20. Jones, M. M. (1983). Therapeutic chelating agents. In Metal Ions in Biological System (H. Siegel, Ed.), Vol. 16, Chap. 3. Dekker, New York.
21. Kopito, L., and Schwachman, H. (1967). Determination of lead in urine by atomic absorption spectroscopy using coprecipitation with bismuth. J. Lab. Clin. Med., 70, 326-332.
22. Parker, M. M., Hummoler, F. L., and Mahler, D. J. (1967). Determination of copper and zinc in biological material. Clin. Chem., 13, 40-48.
23. Piomelli, S., Rosen, J. F., Chisolm, J. J., and Graef, J. W. (1984). Management of childhood lead poisoning. J. Pediatr., 105, 523-527.
24. Reiders, F., Dunnigton, W. G., and Breiger, H. (1955). The efficacy of edathamil calcium disodium in the treatment of occupational lead poisoning. Ind. Med. Surg., 24, 195-202.
25. Rcitman, S., and Frankel, S. (1957). A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol., 28, 56-63.
26. Tandon, S. K., Flora, S. J. S., and Singh, S. (1986). Chelation in metal intoxication, XIV. Effects of thiol and amino chelators on lead poisoned rats with normal or damaged kidneys. Toxicol. Appl. Pharmacol., 79, 204-210.
27. 239Pu nitrate in the rat. Health Phys., 29, 61-68.
28. Wright, P. J., Leathwood, P. D., and Plummer, D. T. (1972). Enzyme in rat urine; alkaline phosphatase. Enzymologia 42, 317-327.
29. Yeager, D. W., Cholak, J., and Hendersen, E. W. (1971). Determination of lead in biological and related material by atomic absorption spectrophotometry. Environ. Sci. Technol., 5, 1020-1022.