Characterization of disulfoton-induced behavioral and neurochemical effects following repeated exposure

Toxicological Sciences

Volumn 20, Issue 2, 1993, Pages 163-169

  Llorens, Jordi ^c   Crofton, Kevin M ^a   Tilson, Hugh A ^a   Ali, Syed F ^b   Mundy, William R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b National Center for Toxicological Research   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; DISULFOTON; MUSCARINIC RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; COGNITION; CONTROLLED STUDY; MALE; MEMORY; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; RAT;

ANIMALIA; ZEA MAYS;

EID: 77957175603     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/20.2.163     Document Type: Article

References (24)

1. Ali, S. F., Slikker, W., Jr., Newport, G. D., and Good, P. T. (1986). Cholinergic and dopaminergic alterations in the mouse central nervous system following acute trimethyltin exposure. Acta. Pharmacol. Toxicol. 59, 179-188.
2. Bradford, M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
3. Bushnell, P. J., Padilla, S. S., Ward, T., Pope, C. N., and Olszyk, V. B. (1991). Behavioral and neurochemical changes in rats dosed repeatedly with diisopropylfluorophosphate. J. Pharmacol. Exp. Ther 256, 741-750.
4. Collins, A. C., Smolen, T. N., Smolen, A., and Medhurst, L. J. (1987). Cross-tolerance between muscarinic agonists: Role of muscarinic receptors. Pharmacol. Biochem Behav. 26, 173-182.
5. 3H]quinuclidinyl benzilate binding to muscarinic receptors in disulfoton tolerant mice. Toxicol. Appl. Pharmacol. 60, 441-450.
6. Costa, L. G., and Murphy, S. D. (1982). Passive avoidance retention in mice tolerant to the organophosphorus insecticide disulfoton. Toxicol. Appl. Pharmacol 65, 451-458.
7. Costa, L. G., Kaylor, G., and Murphy, S. D. (1986). Carbachol-and norepinephrine-stimulated phosphoinositide metabolism in rat brain: Effect of chronic cholinesterase inhibition. J. Pharmacol. Exp. Ther. 239, 32-37.
8. Ecobichon, D. J. (1991). Pesticides. In Casarett and Doull’s Toxicology: The Basic Science of Poisons (M. O. Amdur, J. Doull, and C. D. Klaas-sen, Eds.), pp. 580-592. Pergamon, New York.
9. Gonzales, R. A., and Crews, F. T. (1984). Characterization of the cholinergic stimulation of phosphoinositide hydrolysis in rat brain slices. J. Neurosci. 4, 3120-3127.
10. Hoskins, B., and Ho, I. K. (1992). Tolerance to organophosphorus cholinesterase inhibitors. In Organophosphates: Chemistry, Fate, and Effects (J. E. Chambers and P. E. Levi, Eds.), pp. 285-297. Academic Press, San Diego.
11. Johnson, C. D., and Russell, R. L. (1975). A rapid, simple radiometric assay for cholinesterase, suitable for multiple determinations. Anal. Biochem. 64, 229-238.
12. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, J. R. (1951). Protein measurements with the Folin phenol reagent. J. Biol Chem. 193, 265-275.
13. McDonald, B. E., Costa, L. G., and Murphy, S. D. (1988). Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates. Toxicol. Lett. 40, 47-56.
14. Morris, R. G. M. (1981). Spatial localization does not depend on the presence of local cues. Leant. Motiv. 12, 236-260.
15. Mundy, W. R., and Tilson, H. A. (1988). Behavioral impairment in the rat after colchicine lesions of the hippocampus and nucleus basalis. Neurotoxicology 9, 511-520.
16. Norton, S., Culver, B., and Mullenix, P. (1975). Measurement of the effects of drugs on activity of permanent groups of rats. Psychopharmacol. Commun. 1, 131-138.
17. Peele, D. B., Allison, S. D., and Crofton, K. M. (1990). Learning and memory deficits in rats following exposure to 3,3'-immodipropionitrile. Toxicol. Appl. Pharmacol. 105, 321-332.
18. Reiter, L. W., Anderson, G. E., Laskey, J. W., and Cahill, D. F. (1975). Developmental and behavioral changes in the rat during chronic exposure to lead. Environ Health Perspect. 12, 119-123.
19. Russell, R. W., Overstreet, D. H., Cotman, C. W., Carson, V. G., Doyle, L., Dalglish, F. W., and Vasquez, B. S. (1975). Experimental tests of hypotheses about neurochemical mechanisms underlying behavioral tolerance to the anticholinesterase, DFP. J. Pharmacol. Exp. Ther. 192, 73-85.
20. Russell, R. W., Booth, R. A., Smith, C. A., Jenden, D. J., Roch, M., Rice, K. M., and Lauretz, S. D. (1989). Roles of neurotransmitter receptors in behavior Recovery of function following decreases in muscarinic receptor density induced by cholinesterase inhibition. Behav Neurosci. 103, 881-892.
21. Sivam, S. P., Norris, J. C., Lim, D. K., Hoskins, B., and Ho, I. K. (1983). Effects of acute and chronic cholinesterase inhibitors with diisopropylfluorophosphate on muscarinic, dopamine, and GABA receptors of the rat striatum. J. Neurochem. 40, 1414-1422.
22. Smit, M. F., Ehlert, F. J., Yamamura, S., Roeske, W. R., and Yamamura, I. H. (1980). Differential regulation of muscarinic agonist binding sites following chronic cholinesterase inhibition. Eur. J. Pharmacol. 66, 379-380.
23. Smolen, T. N., Smolen, A., and Collins, A. C. (1986). Dissociation of decreased numbers of muscarinic receptors from tolerance to DFP. Pharmacol. Biochem. Behav. 25, 1293-1301.
24. Tilson, H. A., Veronesi, B., McLamb, R. L., and Matthews, H. B. (1990). Acute exposure to tris(2-chloroethyl) phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol. Appl. Pharmacol. 106, 254-269.