Comparative carcinogenicity of ethylene thiourea with or without perinatal exposure in rats and mice

Toxicological Sciences

Volumn 18, Issue 3, 1992, Pages 405-417

  Chhabra, R S ^a   Eustis, S ^a   Haseman, J K ^a   Kurtz, P J ^a,b   Carlton, B D ^a,b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b BATTELLE MEMORIAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 IMIDAZOLIDINETHIONE;

ANIMAL EXPERIMENT; ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONTROLLED STUDY; FEMALE; MALE; MOUSE; NONHUMAN; PERINATAL PERIOD; RAT; THYROID TUMOR;

ANIMAL; BODY WEIGHT; CARCINOGENS; COMPARATIVE STUDY; DIET; ETHYLENETHIOUREA; FEMALE; HORMONES; MICE; MICE, INBRED C57BL; NEOPLASMS, EXPERIMENTAL; ORGAN WEIGHT; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, INBRED F344; SPECIES SPECIFICITY; THYROID HORMONES; THYROID NEOPLASMS;

ANIMALIA;

EID: 77957174895     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/18.3.405     Document Type: Article

References (45)

1. Alexandrov, V. A. (1983). Role of the maternal organism in transplacental carcinogenesis. In Modulators of Experimental Carcinogenesis (V. Turosov and R. Montesano, Eds.). International Agency for Research on Cancer, Lyon.
2. Armitage, P. (1971). Statistical Methods in Medical Research, pp. 362-365. Wiley, New York.
3. Capen, C. C., and Martin, S. L. (1989). The effects of xenobiotics on the structure and function of thyroid follicular and c-cells. Toxicol. Pathol., 17, 266.
4. Chhabra, R. S., Huff, J. E, Schwetz, B. S., and Selkirk, J. (1990). An overview of prechronic and chronic toxicity/carcinogenicity experimental study designs and criteria used by the National Toxicology Program. Environ. Health Perspect., 86, 313-321.
5. Cox, D. R. (1972). Regression models and life tables. J. R. Stat. Soc., B34, 187-220.
6. Dinse, G. E, and Haseman, J. K. (1986). Logistic regression analysis of incidental tumor data from animal carcinogenicity studies. Fundam. Appl. Toxicol., 6, 44-52.
7. Druckery, H., Ivankovic, S., and Preussmann, R. (1966). Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant rats. Nature 210, 1378-1379.
8. Dunnett, C. W. (1980). Pairwise multiple comparisons in the unequal variance case. J. Am. Stat. Assoc., 75, 796-800.
9. Furth, J., Moy, P., Hershman, J. M., and Ueda, G. (1973). Thyrotropic tumor syndrome. A multiglandular disease induced by sustained deficiency of thyroid hormones. Arch. Pathol., 96, 217-226.
10. Gak, J.-C, Graillot, C, and Truhaut, R. (1976). Difference de sensibilite du hamster et du rat vis-a-vis des effects de l’administration a long terme de l’ethylene thiouree. Eur. J. Toxicol., 9, 303-312.
11. Gart, J. J., Chu, K. C., and Tarone, R. E. (1979). Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J. Natl. Cancer Inst., 62, 957-974.
12. Graham, S. L., Hansen, W. H., Davis, K. J., and Perry, C. J. (1973). Effects of one-year administration of ethylenethiourea upon the thyroid of the rat J. Agric. Food Chem., 21, 324-329.
13. Graham, S. L., Davis, K. J., Hansen, W. H., and Graham, C. H. (1975). Effects of prolonged ethylene thiourea ingestion on the thyroid of the rat Food Cosmet. Toxicol., 13, 493-499.
14. Greenwood, F. C., Hunter, W. M., and Glover, J. S. (1963). The preparation of 1-131-labeled human growth hormone of high specific radioactivity. Biochem. J., 89, 114-123.
15. Grufferman, S., Delzell, E. S., Maile, M. C, and Michalopoulos, G. (1983). Parents’ cigarette smoking and childhood cancer. Med. Hypotheses 12, 17-20.
16. Hill, R. N., Erdreich, L. S., Paynter, O. E., Roberts, P. A., Rosenthal, S. L, and Wilkinson, C. F. (1989). Thyroid follicular cell carcinogenesis. Fundam. Appl. Toxicol 12, 629-697.
17. Innes, J. R. M., Ulland, B. M., Valerio, M. G., Petrucelli, L., Fishbein, L, Hart, E. R., Pallotta, A. J., Bates, R. R., Falk, H. L., Gart, J. J., Klein, M., Mitchell, I., and Peters, J. (1969). Bioassay of pesticides and industrial & chemicals for tumorogenicity in mice: A preliminary note. J. Natl. Cancer Inst., 42, 1101-1114.
18. International Agency for Research on Cancer (LARC) (1974). Ethylenethiourea. Some Anti-Thyroid and Related Substances, Nitrofurans and Industrial Chemicals. IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man, Vol 7, pp. 45-52. IARC, World Health Organization, Lyon, France.
19. Kaplan, E. L., and Meier, P. (1958). Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc., 53, 457-481.
20. Larsen, C. C. (1947). Pulmonary tumor induction by transplacental exposure to urethane. J. Natl. Cancer Inst., 8, 63-69.
21. Lewerenz, H. J. (1982). Xenobiotics in the environment of the fetus and the food of the infant and consequences for later life. Bibl. Nutr. Dieta., 31, 83-94.
22. Lowengart, R. A., Peters, J. M., Cicioni, C, Buckley, J., Bernstein, L, PrestonMartin, S., and Rappaport, E. (1987). Childhood leukemia and parents’ occupational and home exposures. J. Natl. Cancer Inst., 79, 39-46.
23. McClain, R. M. (1989). The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid y, gland neoplasia. Toxicol. Pathol., 17, 294.
24. McClain, R. M., Posch, R. C, Bosakowski, T., and Armstrong, J. M. (1988). Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital. Toxicol. Appl. Pharmacol., 94, 254-265.
25. Miller, R. K. (1983). Perinatal toxicology: Its recognition and fundamentals. Am. J. Ind. Med., 4, 205-244.
26. Moller, P. C., Chang, J. P., and Partridge, L. R. (1986). The effects of ethylene thiourea administration upon rat liver cells. J. Environ. Pathol. Toxicol. Oncol., 6, 127-142.
27. National Cancer Institute (NCI) (1979). Perinatal Carcinogenesis., NCI Monograph 51. DHEW Publication (NIH) 79-1633. U.S. Department of Health, Education, and Welfare, Public Health Service, National Institute of Health, Bethesda, MD.
28. National Toxicology Program (NTP) (1990). NTP Technical Report on the Perinatal Toxicity and Carcinogenicity Studies of Ethylene Thiourea in F/344 Rats and B6C3F1 Mice., NTP Technical Report 388. U.S. Department of Health and Human Services, Public Health Services, National Institutes of Health, Bethesda, MD.
29. Nomura, T. (1982). Parental exposure to X rays and chemicals induces heritable tumors and anomalies in mice. Nature 296, 575-577.
30. Pershagen, G. (1989). Childhood cancer and malignancies other than lung cancer related to passive smoking Mutat. Res., 222, 129-135.
31. Peters, J. M., Preston-Martin, S., and Yu, M. C. (1981). Brain tumors in children and occupational exposure of parents. Science 213, 235-237.
32. Pietra, G., Spencer, K., and Shubik, P. (1959). Response of newly born mice to a chemical carcinogen. Nature 183, 1689.
33. Pietra, G., Rappaport, H., and Shubik, P. (1961). The effects of carcinogenic chemicals in newborn mice. Cancer 14, 308-317.
34. Rice, J. M., Rehm, S., Donovan, P. J., and Perantoni, A. O. (1989). Comparative transplacental carcinogenesis by direct-acting and metabolism-dependent alkylating agents in rodents and nonhuman primates. In Perinatal and Multigeneration Carcinogenesis (N. P. Napalkov, J. M. Rice, L. Tomatis, and H. Yamasaki, Eds.). International Agency for Research on Cancer, Lyon.
35. Ruddick, J. A., Newsome, W. H., and Iverson, F. (1977). A comparison of the distribution, metabolism and excretion of ethylenethiourea in the pregnant mouse and rat. Teratology 16, 159-162.
36. Schardein, J. L., and Keller, K. A. (1989). Potential human developmental toxicants and the role of animal testing in their identification and characterization. CRC Crit. Rev. Toxicol., 19, 251-339.
37. Sontag, J. M., Page, N. P., and Saffiotti, U. (1976). Gwdelines for Carcinogen Bioassay in Small Rodents., U.S. Dept of Health and Human Services Publication (N1H 76-801), National Cancer Institute, Bethesda, MD.
38. Stjernfeldt, M., Berglund, K., Lindsten, J., and Ludvigsson, J. (1986). Maternal smoking during pregnancy and risk of childhood cancer. Lancet, 1350-1352.
39. Swenberg, J. A. (1979). Incorporation of transplacental exposure into routine carcinogenicity bioassays. Natl. Cancer Inst. Monograph 51, 265-268.
40. Tarone, R. E. (1975). Tests for trend in life table analysis. Biometrika 62, 679-682.
41. Ulland, B. L. (1972). Thyroid cancer in rats from ethylene thiourea intake. J. Natl. Cancer Inst., 49, 483-485.
42. U.S. Environmental Protection Agency (USEPA) (1982). Portions of EPA Health Effects Test Guidelines and FDA Toxicology Principles for the Safety Assessment of Direct Food Additives and Color Additives Used in Food., Publication PB82-232984, p. 205.
43. Vesselinovitch, S. D., Rao, K. V. N., and Mihailovich, N. (1979). Neoplastic response of mouse tissues during perinatal age periods and its significance in chemical carcinogenesis. Natl. Cancer Inst. Monogr., 51, 239-249.
44. Weisburger, E. K., Ulland, B. M., Nam, J.-M., Gart, J. J., and Weisburger, J. H. (1981). Carcinogenicity tests of certain environmental and industrial chemicals. J. Natl. Cancer Inst., 67, 75-88.
45. Yamasaki, H., Hollstein, M., Martel, N., Cabral, J. R. P., Galendo, D., and Tomatis, L. (1987). Transplacental induction of a specific mutation in fetal Ha-ras and its critical role in post-natal carcinogenesis. Int. J. Cancer 40, 818-822.