The degradation properties of co-continuous calcium phosphate polyester composites: Insights with synchrotron micro-computer tomography

Journal of the Royal Society Interface

Volumn 7, Issue SUPPL. 5, 2010, Pages

  Ehrenfried, Lisa M ^a   Farrar, David ^b   Cameron, Ruth E ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Smith and Nephew Research Centre   (United Kingdom)

Author keywords

Calcium phosphate; Composite; Degradation; In vitro test; Poly(lactic) acid

Indexed keywords

BIODEGRADATION; CALCIUM; DEGRADATION; FOAMS; GRAFTS; LACTIC ACID; ORGANIC ACIDS; PHOSPHATES; POLYMERS; SPHERES; SYNCHROTRONS; TOMOGRAPHY;

BONE REPAIR; BULK SAMPLES; COMPOSITE; GRENOBLE; IN-SITU; IN-SITU POLYMERIZATION; IN-VITRO; IN-VITRO TESTS; MANUFACTURING METHODS; MICRO-COMPUTER TOMOGRAPHIES; POLY(LACTIC) ACID; POLYESTER COMPOSITES; POLYMER PHASE; POLYMER SPHERES; POROUS TRICALCIUM PHOSPHATE; PROPERTIES OF COMPOSITES; ROYAL SOCIETY;

CALCIUM PHOSPHATE;

CALCIUM PHOSPHATE;

ARTICLE; BONE REMODELING; IN SITU HYBRIDIZATION; IN VITRO STUDY; MICRO-COMPUTED TOMOGRAPHY; MOLECULAR WEIGHT; WATER TRANSPORT;

EID: 77957174151     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2010.0014.focus     Document Type: Article

References (50)

1. Agrawal, C. M. & Athanasiou, K. A. 1997 Technique to control pH in vicinity of biodegrading PLA-PGA implants. J. Biomed. Mater. Res. 38, 105-114. (doi:10.1002/(SICI)1097-4636(199722)38:2〈105::AID-JBM4〉3.0.CO;2-U)
2. Aizawa, M., Ito, M., Takeoka, Y., Rikukawa, M. & Okada, I. 2004 Fabrication of porous tricalcium phosphate ceramics from calcium-phosphate fibers for a matrix of biodegradable ceramics/polymer hybrids. Phosphorus Res. Bull. 17, 213-214.
3. An, Y. H., Woolf, S. K. & Friedman, R. J. 2000 Pre-clinical in vivo evaluation of orthopaedic bioabsorbable devices. Biomaterials 21, 2635-2652. (doi:10.1016/S0142-9612(00)00132-0)
4. Ara, M., Watanabe, M. & Imai, Y. 2002 Effect of blending calcium compounds on hydrolytic degradation of poly (DL-lactic acid-co-glycolic acid). Biomaterials 23, 2479-2483. (doi:10.1016/S0142-9612(01)00382-9) (Pubitemid 34288489)
5. Bonfield, W., Grynpas, M. D. & Tully, A. E. 1981 Hydroxyapatite reinforced polyethylene - a mechanically compatible implant material for bone replacement. Biomaterials 2, 185-186. (doi:10.1016/0142-9612(81)90050-8) (Pubitemid 11045313)
6. Daculsi, G., Laboux, O., Malard, O. & Weiss, P. 2003 Current state of the art of biphasic calcium phosphate bioceramics. J. Mater. Sci.-Mater. Med. 14, 195-200. (doi:10.1023/A:1022842404495)
7. Ehrenfried, L. M. 2009 Co-continuous degradable polyestercalcium- phosphate composite for bone-replacement applications. PhD thesis, University of Cambridge, Cambridge, UK.
8. Ehrenfried, L. M., Farrar, D., Morsley, D. & Cameron, R. E. 2007. Accelerated degradation by increased temperature to study degradable polymer-bioceramic composites. In Proc. 21st ESB Conference, European Society of Biomaterials, Brighton, UK, 10-13 September 2007.
9. Farrar, D. F., Brown, M., Hall, M., Brunelle, J. E., Cotton, N. J., Berube, R. & Lipchitz, J. 2007 Tissue repair and replacement. US 2007/0129810 A1.
10. Fedors, R. F. 1979 Osmotic effects in water absorption by polymers. Polymer 21, 207-212. (doi:10.1016/0032-3861(80)90062-2)
11. Fu, K., Pack, D. W., Klibanov, A. M. & Langer, R. 2000 Visual evidence of acidic environment within degrading poly(lacticco- glycolic acid) (PLGA) microspheres. Pharm. Res. 17, 100-106. (doi:10.1023/A:1007582911958)
12. Galois, L., Mainard, D. & Delagoutte, J. P. 2002 Beta-tricalcium phosphate ceramic as a bone substitute in orthopaedic surgery. Int. Orthop. 26, 109-115.
13. Grizzi, I., Garreau, H., Li, S. & Vert, M. 1995 Hydrolytic degradation of devices based on poly (DL-lactic acid) size-dependance. Biomaterials 16, 305-311. (doi:10.1016/ 0142-9612(95)93258-F)
14. Heidemann, W., Jeschkeit, S., Ruffieux, K., Fischer, J. H., Wagner, M., Kruger, G., Wintermantel, E. & Gerlach, K. L. 2001 Degradation of poly(D,L)lactide implants with or without addition of calcium phosphates in vivo. Biomaterials 22, 2371-2381. (doi:10.1016/S0142-9612(00)00424-5) (Pubitemid 32672859)
15. Horch, H. H., Sader, R., Pautke, C., Neff, A., Deppe, H. & Kolk, A. 2006 Synthetic, pure-phase betatricalcium phosphate granules (Cerasorb (R)) regeneration in the ceramic for bone reconstructive surgery of the jaws. Int. J. Oral Maxillofac. Surg. 35, 708-713. (doi:10.1016/j.ijom.2006.03.017)
16. 2 foaming with PU sponge and modified with PLGA and bioactive glass. J. Biomater. Appl. 21, 351-375.
17. Hurrell, S., Milroy, G. E. & Cameron, R. E. 2003 The degradation of polyglycolide in water and deuterium oxide. Part 1: the effect of reaction rate. Polymer 44, 1421-1424. (doi:10.1016/S0032-3861(02)00883-2)
18. Hutmacher, D. W., Schantz, J. T., Lam, C. X. F., Tan, K. C. & Lim, T. C. 2007 State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. J. Tissue Eng. Regen. Med. 1, 245-260. (doi:10.1002/term.24)
19. Ignatius, A. A., Augat, P. & Claes, L. E. 2001 Degradation behaviour of composite pins made of tricalcium phosphate and poly (D,L-lactide). J. Biomater. Sci. Polym. Ed. 12, 185-194. (doi:10.1163/156856201750180915)
20. Imai, Y., Nagai, M. & Watanabe, M. 1999 Degradation of composite materials composed of tricalcium phosphate and a new type of block polyester containing a poly (L-lactic acid) segment. J. Biomater. Sci. Polym. Ed. 10, 421-432. (doi:10.1163/156856299X00180)
21. Jin, H. H., Min, S. H., Hwang, K. H., Park, I. M., Park, H. C. & Yoon, S. Y. 2006 Synthesis of biodegradable beta- TCP/PLGA composites using microwave energy. Mater. Sci. Forum 510-511, 758-761. (doi:10.4028/www.scienti- fic.net/MSF.510-511.758)
22. Kikuchi, M., Koyama, Y., Takakuda, K., Miyairi, H., Shirahama, N. & Tanaka, J. 2002 In vitro change in mechanical strength of beta-tricalcium phosphate/copolymerized PLA composites and their application for guided bone regeneration. J. Biomed. Mater. Res. 62, 265-272. (doi:10.1002/jbm.10248)
23. Leonard, D. J., Pick, L. T., Farrar, D. F., Dickson, G. R., Orr, J. F. & Buchanan, F. J. 2009 The modification of PLA and PLGA using electron-beam radiation. J. Biomed. Mater. Res. Part A 89A, 567-574. (doi:10.1002/jbm.a.31998)
24. Li, S. M. & Vert, M. 1994 Morphological changes resulting from the hydrolytic degradation of stereocopolymers derived from L-lactides and DL-lactides. Macromolecules 27, 3107-3110. (doi:10.1021/ma00089a031)
25. Li, S. M., Garreau, H. & Vert, M. 1990a Structure-property relationships in the case of the degradation of massive aliphatic poly-(a-hydroxy acids) in aqueous media. Part 1: poly (DL-lactic acid). J. Mater. Sci. Mater. Med. 1, 123-130. (doi:10.1007/BF00700871)
26. Li, S. M., Garreau, H. & Vert, M. 1990b Structure-property relationships in the case of the degradation of massive poly-(a-hydroxy acids) in aqueous media. Part 2: degradation of lactide-glycolide copolymers: PLA 37.5GA25 and PLA75GA25. J. Mater. Sci. Mater. Med. 1, 131-139. (doi:10.1007/BF00700872)
27. Li, S. M., Garreau, H. & Vert, M. 1990c Structure-property relationships in the case of the degradation of massive poly-(a-hydroxy acids) in aqueous media. Part 3: influence of the morphology of poly(L-lactic acid). J. Mater. Sci. Mater. Med. 1, 198-206. (doi:10.1007/BF00701077)
28. Li, S. H., de Wijn, J. R., Layrolle, P. & de Groot, K. 2003 Toughening of HA through interpenetrating organic/ inorganic microstructure. Key Eng. Mater. 240-242, 147-150. (doi:10.4028/www.scientific.net/KEM.240-242.147)
29. Lu, L. C., Garcia, C. A.& Mikos, A. G. 1999 In vitro degradation of thin poly(DL-lactic-co-glycolic acid) films. J. Biomed. Mater. Res. 46, 236-244. (doi:10.1002/(SICI)1097-4636(199908)46:2〈236::AID-JBM13〉3.0.CO;2-F)
30. Miao, X., Lim, W. K., Huang, X. & Chen, Y. 2005 Preparation and characterization of interpenetrating phased TCP/HA/ PLGA composites. Mater. Lett. 59 (doi:10.1016/j.matlet.2005.07.062)
31. Miao, X., Tan, L. P., Tan, L. S. & Huang, X. 2007 Porous calcium phosphate ceramics modified with PLGA-bioactive glass. Mater. Sci. Eng. C Biomimet. Supramol. Syst. 27, 274-279.
32. Nakahira, A., Tamai, M., Miki, S. & Pezzotti, G. 2002 Fracture behaviour and biocompatibility evaluation of nylon-infiltrated porous HA. J. Mater. Sci. 37, 4425-4430. (doi:10.1023/A:1020681309572)
33. Niemela, T. 2005 Effect of beta-tricalcium phosphate addition on the in vitro degradation of self-reinforced poly-L,D-lactide. Polym. Degrad. Stab. 89, 492-500. (doi:10.1016/j.polymdegradstab.2005.02.003)
34. Niemela, T., Kellomaki, M. & Tormala, P. 2004a In vitro degradation of osteoconductive poly-L/DL-lactide beta- TCP composites. In Proc. 16th Int. Symp. on Ceramics in Medicine, Porto, Portugal, 69 November 2003. Key Engineering Materials, vol. 254-2, pp. 509-512. Zurich, Switzerland: Trans Tech.
35. Niemela, T., Kellomaki, M. & Törmälä, P. 2004b Self-reinforced composites of bTCPand bioabsorbable polymer in vitro: comparison of two matrix polymers. In Proc. 7th World Biomaterials Congress 2004, Sydney, Australia, 17-21 May 2004. Red Hook, NY: Curran Associates.
36. Paivarinta, U., Bostman, O., Majola, A., Toivonen, T., Tormala, P. & Rokkanen, P. 1993 Intraosseous cellular-response to biodegradable fracture fixation screws made of polyglycolide or polylactide. Arch. Orthop. Trauma Surg. 112, 71-74. (doi:10.1007/BF00420258)
37. Park, T. G. 1994 Degradation of poly(D,L-lactic acid) microspheres: effect of molecular-weight. J. Controll. Rel. 30, 161-173. (doi:10.1016/0168- 3659(94)90263-1)
38. Park, T. G. 1995 Degradation of poly(lactic-co-glycolic acid) microspheres: effect of copolymer composition. Biomaterials 16, 1123-1130. (doi:10.1016/0142-9612(95) 93575-X)
39. Pezzotti, G., Asmus, S. M., Ferroni, L. P. & Miki, S. 2002 In situ polymerization into porous ceramics: a novel route to tough biomimetic materials. J. Mater. Sci. Mater. Med. 13, 783-787. (doi:10.1023/A:1016127209117)
40. Rahman, F. F. 2004 Composites of poly(ethylmethacrylate) tetrahydrofurfuryl methacrylate with tricalcium phosphate and hydroxyapatite for bone scaffolds. PhD thesis, University of Cambridge, Cambridge, UK.
41. Renouf-Glauser, A. C., Rose, J., Farrar, D. & Cameron, R. E. 2005 A degradation study of PLLA containing lauric acid. Biomaterials 26, 2415-2422. (Pubitemid 39600695)
42. Renouf-Glauser, A. C., Rose, J., Farrar, D. F. & Cameron, R. E. 2006 Comparison of the hydrolytic degradation and deformation properties of a PLLA-lauric acid based family of biomaterials. Biomacromolecules 7, 612-617. (doi:10.1021/bm050746v)
43. Schliecker, G., Schmidt, C., Fuchs, S., Wombacher, R. & Kissel, T. 2003 Hydrolytic degradation of poly(lactide-co-glycolide) films: effect of oligomers on degradation rate and crystallinity. Int. J. Pharm. 266, 39. (doi:10. 1016/S0378-5173(03)00379-X)
44. Sharma, L. & Pezzotti, G. 2003 Biomimetic hybrids: an advancement for biomaterials. Key Eng. Mater. 240-242, 143-146. (doi:10.4028/www.scientific. net/ KEM.240-242.143)
45. Suchanek, W. & Yoshimura, M. 1998 Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J. Mater. Res. 13, 94-117. (doi:10.1557/JMR.1998.0015)
46. Sugiyama, N., Kunibu, R., Yoshizawa-Fujita, M., Takeoka, Y., Aizawa, M. & Rikukawa, M. 2007 Ring-opening bulk polymerization of L-lactide in porous hydroxyapatite. Chem. Lett. 36, 1476-1477. (doi:10.1246/cl.2007.1476)
47. Vert, M., Li, S. & Garreau, H. 1991 More about the degradation of LA/GA-derived matrices in aqueous media. J. Controll. Rel. 16, 15-26. (doi:10.1016/0168-3659(91)90027-B)
48. Witt, C. & Kissel, T. 2001 Morphological characterization of microspheres, films and implants prepared from poly (lactide-co-glycolide) and ABA triblock copolymers: is the erosion controlled by degradation, swelling or diffusion? Eur. J. Pharm. Biopharm. 51, 171-181. (doi:10.1016/S0939-6411(01) 00130-8)
49. Yunos, M., Bretcanu, O. & Boccaccini, A. R. 2008 Polymer-bioceramic composites for tissue engineering scaffolds. J. Mater. Sci. 43, 4433-4442.
50. Zhang, Y. & Zhang, M. Q. 2002 Three-dimensional macroporous calcium phosphate bioceramics with nested chitosan sponges for load-bearing bone implants. J. Biomed. Mater. Res. 61, 1-8. (doi:10.1002/jbm.10176)