High Neuroticism and low Conscientiousness are associated with interleukin-6

Psychological Medicine

Volumn 40, Issue 9, 2010, Pages 1485-1493

  Sutin, A R ^a   Terracciano, A ^a   Deiana, B ^b   Naitza, S ^b   Ferrucci, L ^a   Uda, M ^b   Schlessinger, D ^a   Costa, P T ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b CNR   (Italy)

Author keywords

C reactive protein; health; impulsivity; inflammation; interleukin 6; personality

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 6;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD; CLINICAL TRIAL; FEMALE; HEALTH BEHAVIOR; HEALTH STATUS; HUMAN; IMPULSIVENESS; INFLAMMATION; ITALY; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; NEUROSIS; PERSONALITY; PHYSIOLOGY; STATISTICAL MODEL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; FEMALE; HEALTH BEHAVIOR; HEALTH STATUS; HUMANS; IMPULSIVE BEHAVIOR; INFLAMMATION; INTERLEUKIN-6; ITALY; LOGISTIC MODELS; MALE; MIDDLE AGED; NEUROTIC DISORDERS; PERSONALITY;

EID: 77957132981     PISSN: 00332917     EISSN: 14698978     Source Type: Journal    
DOI: 10.1017/S0033291709992029     Document Type: Article

References (39)

1. Adler N, Matthews K (1994). Health psychology: Why do some people get sick and some stay well? Annual Review of Psychology 45, 229-259.
2. Aiken LS, West SG (1991). Multiple Regression: Testing and Interpreting Interactions. Sage: Thousand Oaks, CA.
3. Bouchard G, Lussier Y, Sabourin S (1999). Personality and marital adjustment: Utility of the five-factor model of personality. Journal of Marriage and Family 61, 651-660.
4. Bremmer MA, Beekman ATF, Deeg DJH, Penninx BWJH, Dik MG, Hack CE, Hoogendijk WJG (2008). Inflammatory markers in late-life depression: Results from a population-based study. Journal of Affective Disorders 106, 249-255.
5. Chapman BP, Khan A, Harper M, Stockman D, Fiscella K, Walton J, Duberstein P, Talbot N, Lyness JM, Moynihan J (2009). Gender, race/ethnicity, personality, and interleukin-6 in urban primary care patients. Brain, Behavior, and Immunity 23, 636-642.
6. Chida Y, Hamer M (2008). Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: A quantitative review of 30 years of investigations. Psychological Bulletin 134, 829-885.
7. Costa Jr. PT, McCrae RR (1992). Revised NEO Personality Inventory (NEO-PI-R) and the NEO Five-Factor Inventory (NEO-FFI) Professional Manual. Psychological Assessment Resources: Odessa, FL.
8. Costa Jr. PT, Terracciano A, Uda M, Vacca L, Mameli C, Pilia G, Zonderman AB, Lakatta E, Schlessinger D, McCrae RR (2007). Personality traits in Sardinia: Testing founder population effects on trait means and variances. Behavior Genetics 37, 376-387.
9. Davidson KW, Schwartz JE, Kirkland SA, Mostofsky E, Fink D, Guernsey D, Shimbo D (2009). Relation of inflammation to depression and incident coronary heart disease (from the Canadian Nova Scotia Health Survey [NSHS95] Prospective Population Study). American Journal of Cardiology 103, 755-761.
10. Doyle WJ, Gentile DA, Cohen S (2006). Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure. Brain, Behavior, and Immunity 20, 175-181. (Pubitemid 43202083)
11. Gimeno D, Kivimäki M, Brunner EJ, Elovainio M, de Vogli R, Steptoe A, Kumari M, Lowe GD, Rumley A, Marmot MG, Ferrie JE (2009). Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychological Medicine 39, 413-423.
12. Goodwin RD, Friedman HS (2006). Health status and the five-factor personality traits in a nationally representative sample. Journal of Health Psychology 11, 643-654.
13. Harris TB, Ferrucci L, Tracy RP, Corti MC, Wacholder S, Ettinger Jr. WH, Heimovitz H, Cohen HJ, Wallace R (1999). Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. American Journal of Medicine 106, 506-512.
14. Judge TA, Higgins CA, Thoresen CJ, Barrick MR (1999). The big five personality traits, general mental ability, and career success across the life span. Personnel Psychology 52, 621-652.
15. Löckenhoff CE, Sutin AR, Ferrucci L, Costa Jr. PT (2008). Personality traits and subjective health in the later years: The association between NEO-PI-R and SF-36 in advanced age is influenced by health status. Journal of Research in Personality 42, 1334-1346.
16. Macy EM, Hayes TE, Tracy RP (1997). Variability in the measurement of C-reactive protein in healthy subjects: Implications for reference intervals and epidemiological applications. Clinical Chemistry 43, 52-58.
17. Maggio M, Guralnik JM, Longo DL, Ferrucci L (2006). Interleukin-6 in aging and chronic disease: a magnificent pathway. Journals of Gerontology, Series A: Biological Sciences and Medical Sciences 61, 575-584.
18. Mangold DL, Wand GS (2006). Cortisol and adrenocorticotropic hormone responses to naloxone in subjects with high and low neuroticism. Biological Psychiatry 60, 850-855.
19. Marsland AL, Prather AA, Petersen KL, Cohen S, Manuck SB (2008). Antagonistic characteristics are positively associated with inflammatory markers independently of trait negative emotionality. Brain, Behavior, and Immunity 22, 753-761.
20. Martin LR, Friedman HS, Schwartz JE (2007). Personality and mortality risk across the life span: The importance of conscientiousness as a biopsychosocial attribute. Health Psychology 26, 428-436.
21. Miller GE, Rohleder N, Cole SW (2009). Chronic interpersonal stress predicts activation of pro-and anti-inflammatory signaling pathways 6 months later. Psychosomatic Medicine 71, 57-62.
22. Ozer DJ, Benet-Martinez V (2006). Personality and the prediction of consequential outcomes. Annual Review of Psychology 57, 401-421.
23. Penninx BWJH, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M (2003). Inflammatory markers and depressed mood in older persons: Results from the health, aging and body composition study. Biological Psychiatry 54, 566-572.
24. Pilia G, Chen WM, Scuteri A, Orrú M, Albai G, Dei M, Lai S, Usala G, Lai M, Loi P, Mameli C, Vacca L, Deiana M, Olla N, Masala M, Cao A, Najjar SS, Terracciano A, Nedorezov T, Sharov A, Zonderman AB, Abecasis GR, Costa P, Lakatta E, Schlessinger D (2006). Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genetics 2, 1207-1223.
25. Preacher KJ, Hayes AF (2008). Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behavior Research Methods 40, 879-891.
26. Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T (2001). Cytokine-associated emotional and cognitive disturbances in humans. Archives of General Psychiatry 58, 445-452.
27. Rohleder N, Marin TJ, Ma R, Miller GE (2009). Biologic cost of caring for a cancer patient: Dysregulation of pro-and anti-inflammatory signaling pathways. Journal of Clinical Oncology 27, 2909-2915.
28. Sjögren E, Leanderson P, Kristenson M, Ernerudh J (2006). Interleukin-6 levels in relation to psychosocial factors: Studies on serum, saliva, and in vitro production by blood mononuclear cells. Brain, Behavior, and Immunity 20, 270-278.
29. Stewart JC, Rand KL, Muldoon MF, Kamarck TW (2009). A prospective evaluation of the directionality of the depression-inflammation relationship. Brain, Behavior, and Immunity 23, 936-944.
30. Sutin AR, Costa Jr. PT, Miech R, Eaton WW (2009). Personality and career success: Concurrent and longitudinal relations. European Journal of Personality 23, 71-84.
31. Sutin AR, Costa Jr. PT (in press). Reciprocal influences of personality and job characteristics across middle adulthood. Journal of Personality.
32. Terracciano A (2003). The Italian version of the NEO PI-R: Conceptual and empirical support for the use of targeted rotation. Personality and Individual Differences 35, 1859-1872.
33. Terracciano A, Löckenhoff CE, Crum RM, Bienvenu OJ, Costa Jr. PT (2008a). Five-factor model personality profiles of drug users. BMC Psychiatry 8, 22.
34. Terracciano A, Löckenhoff CE, Zonderman AB, Ferrucci L, Costa Jr. PT (2008b). Personality predictors of longevity: Activity, emotional stability, and conscientiousness. Psychosomatic Medicine 70, 621-627.
35. Terracciano A, McCrae RR, Brant LJ, Costa Jr. PT (2005). Hierarchical linear modeling analyses of the NEO-PI-R scales in the Baltimore Longitudinal Study of Aging. Psychology and Aging 20, 493-506.
36. Terracciano A, Sutin AR, McCrae RR, Deiana B, Ferrucci L, Schlessinger D, Uda M, Costa Jr. PT (2009). Facets of personality linked to underweight and overweight. Psychosomatic Medicine 71, 682-689.
37. Tyrka AR, Wier LM, Price LH, Rikhye K, Ross NS, Anderson GM, Wilkinson CW, Carpenter LL (2008). Cortisol and ACTH responses to the Dex/CRH Test: Influence of temperament. Hormones and Behavior 53, 518-525.
38. Wilson RS, Mendes de Leon CF, Bienias JL, Evans DA, Bennett DA (2004). Personality and mortality in old age. Journals of Gerontology, Series B: Psychological Sciences and Social Sciences 59, 110-116.
39. Zobel A, Barkow K, Schulze-Rauschenbach S, von Widdern O, Metten M, Pfeiffer U, Schnell S, Wagner M, Maier W (2004). High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic-pituitary-adrenocortical system in healthy volunteers. Acta Psychiatrica Scandinavica 109, 392-399.