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Preliminary calculations (geometry optimization, by molecular mechanics, semiempirical and DFT methods) indicate that compound 4a is more stable than the corresponding isomer 4a′ by around 23 kJ/mol.
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b) The use of unprotected anthranilic aldehyde led to complex mixtures.
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77957171695
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Around 237,000 substances with this core are listed in SciFinder (2010), most being in biomedical patents
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Around 237,000 substances with this core are listed in SciFinder (2010), most being in biomedical patents.
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77957143380
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Although in this study only two salicylic aldehydes and one anthranilic aldehyde have been, used, taking into account the reactivity precedents on related MBH-type reactions, we believe the methodology has a general application range, including substrates with different substituents and substitution patterns on the aromatic ring
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Although in this study only two salicylic aldehydes and one anthranilic aldehyde have been, used, taking into account the reactivity precedents on related MBH-type reactions, we believe the methodology has a general application range, including substrates with different substituents and substitution patterns on the aromatic ring.
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2 reagent was prepared accordingly to a literature procedure, see: A. K. Chakraborti, R. Gulhane, Tetrahedron Lett, 2003, 44, 3521-3525.
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