How to manage the patient with early-age-of-onset (<50 years) colorectal cancer?

Surgical Oncology Clinics of North America

Volumn 19, Issue 4, 2010, Pages 725-731

  Liang, Jennifer ^a   Church, James ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Colorectal cancer; Early age of onset; Genetic abnormalities; Young patient

Indexed keywords

ADVANCED CANCER; CANCER DIAGNOSIS; CANCER RISK; CANCER STAGING; CARCINOGENESIS; COLITIS; COLON RESECTION; COLONOSCOPY; COLORECTAL CANCER; FAMILY HISTORY; GENETIC ANALYSIS; GENETIC PREDISPOSITION; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HUMAN; MICROSATELLITE INSTABILITY; ONSET AGE; POLYPOSIS; PROGNOSIS; REVIEW;

ADULT; AGE OF ONSET; COLORECTAL NEOPLASMS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED;

EID: 77957124871     PISSN: 10553207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.soc.2010.07.007     Document Type: Review

References (15)

1. Winawer S.J., Zauber A.G., Ho M.N., et al. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med 1993, 329(27):1977-1981.
2. Surveillance, Epidemiology, and End Results (SEER) Program SEER*Stat Database: Incidence - SEER 11 Regs Public-Use, Nov 2001 Sub (1992-1999) Available at:, Accessed July 31, 2010. http://www.seer.cancer.gov.
3. O'Connell J.B., Maggard M.A., Livingston E.H., et al. Colorectal cancer in the young. Am J Surg 2004, 187:343-348.
4. Mitchell R.J., Campbell H., Farrington S.M., et al. Prevalence of family history of colorectal cancer in the general population. Br J Surg 2005, 92(9):1161-1164.
5. O'Connell J.B., Maggard M.A., Liu J.H., et al. Do young colon cancer patients have worse outcomes?. World J Surg 2004, 28:558-562.
6. Murff H.J., Greevy R.A., Syngal S. The comprehensiveness of family cancer history assessments in primary care. Community Genet 2007, 10(3):174-180.
7. Church J., McGannon E. Family history of colorectal cancer: how often and how accurately is it recorded?. Dis Colon Rectum 2000, 43(11):1540-1544.
8. Mitchell R.J., Brewster D., Campbell H., et al. Accuracy of reporting of family history of colorectal cancer. Gut 2004, 53(2):291-295.
9. Church J.M. A scoring system for the strength of a family history of colorectal cancer. Dis Colon Rectum 2005, 48(5):889-896.
10. Johns L.E., Houlston R.S. A systematic review and meta-analysis of familial colorectal cancer risk. Am J Gastroenterol 2001, 96(10):2992-3003.
11. Boparai K.S., Dekker E., Van Eeden S., et al. Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis. Gastroenterology 2008, 135(6):2014-2018.
12. Balaguer F., Castellví-Bel S., Castells A., et al. Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study. Clin Gastroenterol Hepatol 2007, 5(3):379-387.
13. Sanchez J.A., Krumroy L., Plummer S., et al. Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer. Br J Surg 2009, 96(10):1196-1204.
14. Greenson J.K., Huang S.C., Herron C., et al. Pathologic predictors of microsatellite instability in colorectal cancer. Am J Surg Pathol 2009, 33(1):126-133.
15. Natarajan N., Watson P., Silva-Lopez E., et al. Comparison of extended colectomy and limited resection in patients with Lynch syndrome. Dis Colon Rectum 2010, 53(1):77-82.