Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14

European Journal of Human Genetics

Volumn 18, Issue 10, 2010, Pages 1141-1147

  Fitzgerald, Liesel M ^a   McDonnell, Shannon K ^b   Carlson, Erin E ^b   Langeberg, Wendy ^a   McIntosh, Laura M ^a   Deutsch, Kerry ^c   Ostrander, Elaine A ^d   Schaid, Daniel J ^b   Stanford, Janet L ^a,e  

^a Fred Hutchinson Cancer Research Center   (United States)

^b MAYO CLINIC   (United States)

^c INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

^d NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

colon cancer; hereditary; linkage analysis; pleiotropic effects; prostate cancer

Indexed keywords

ARTICLE; CHROMOSOME 15Q; COLON CANCER; FAMILIAL CANCER; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 15; COLONIC NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FAMILY; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC LINKAGE; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LOD SCORE; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77957105586     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.49     Document Type: Article

References (57)

1. Ostrander EA, Markianos K, Stanford JL: Finding prostate cancer susceptibility genes. Annu Rev Genomics Hum Genet 2004; 5: 151-175.
2. Schaid DJ: The complex genetic epidemiology of prostate cancer. Hum Mol Genet 2004; 13 (Spec No 1): R103-R121.
3. Chang BL, Isaacs SD, Wiley KE et al: Genome-wide screen for prostate cancer susceptibility genes in men with clinically significant disease. Prostate 2005; 64: 356-361.
4. Stanford JL, McDonnell SK, Friedrichsen DM et al: Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness. Prostate 2006; 66: 317-325.
5. Fearon ER: Human cancer syndromes: clues to the origin and nature of cancer. Science 1997; 278: 1043-1050.
6. Damber L, Gronberg H, Damber JE: Familial prostate cancer and possible associated malignancies: nation-wide register cohort study in Sweden. Int J Cancer 1998; 78: 293-297.
7. Hall JM, Lee MK, Newman B et al: Linkage of early-onset familial breast cancer to chromosome 17q21. Science 1990; 250: 1684-1689.
8. Miki Y, Swensen J, Shattuck-Eidens D et al: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994; 266: 66-71.
9. Thorlacius S, Tryggvadottir L, Olafsdottir GH et al: Linkage to BRCA2 region in hereditary male breast cancer. Lancet 1995; 346: 544-545.
10. Wooster R, Bignell G, Lancaster J et al: Identification of the breast cancer susceptibility gene BRCA2. Nature 1995; 378: 789-792.
11. Gibbs M, Stanford JL, McIndoe RA et al: Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet 1999; 64: 776-787.
12. Matsui H, Suzuki K, Ohtake N et al: Genomewide linkage analysis of familial prostate cancer in the Japanese population. J Hum Genet 2004; 49: 9-15.
13. Badzioch M, Eeles R, Leblanc G et al: Suggestive evidence for a site specific prostate cancer gene on chromosome 1p36. The CRC/BPG UK Familial Prostate Cancer Study Coordinators and Collaborators. The EU Biomed Collaborators. J Med Genet 2000; 37: 947-949.
14. Johanneson B, Deutsch K, McIntosh L et al: Suggestive genetic linkage to chromosome 11p11.2-q12.2 in hereditary prostate cancer families with primary kidney cancer. Prostate 2007; 67: 732-742.
15. Pierce BL, Friedrichsen-Karyadi DM, McIntosh L et al: Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer. Prostate 2007; 67: 410-415.
16. Suarez BK, Lin J, Burmester JK et al: A genome screen of multiplex sibships with prostate cancer. Am J Hum Genet 2000; 66: 933-944.
17. Witte JS, Suarez BK, Thiel B et al: Genome-wide scan of brothers: replication and fine mapping of prostate cancer susceptibility and aggressiveness loci. Prostate 2003; 57: 298-308.
18. Albright LA, Schwab A, Camp NJ, Farnham JS, Thomas A: Population-based risk assessment for other cancers in relatives of hereditary prostate cancer (HPC) cases. Prostate 2005; 64: 347-355.
19. Enblad P, Adami HO, Glimelius B, Krusemo U, Pahlman L: The risk of subsequent primary malignant diseases after cancers of the colon and rectum. A nationwide cohort study. Cancer 1990; 65: 2091-2100.
20. Haiman CA, Le Marchand L, Yamamato J et al: A common genetic risk factor for colorectal and prostate cancer. Nat Genet 2007; 39: 954-956.
21. Larson GP, Ding Y, Cheng LS et al: Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. Cancer Res 2005; 65: 805-814.
22. Amundadottir LT, Sulem P, Gudmundsson J et al: A common variant associated with prostate cancer in European and African populations. Nat Genet 2006; 38: 652-658.
23. Maier C, Herkommer K, Hoegel J, Vogel W, Paiss T: A genomewide linkage analysis for prostate cancer susceptibility genes in families from Germany. Eur J Hum Genet 2005; 13: 352-360.
24. Stanford JL, FitzGerald LM, McDonnell SK et al: Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. Hum Mol Genet 2009; 18: 1839-1848.
25. Daley D, Lewis S, Platzer P et al: Identification of susceptibility genes for cancer in a genome-wide scan: results from the colon neoplasia sibling study. Am J Hum Genet 2008; 82: 723-736.
26. Ohta M, Inoue H, Cotticelli MG et al: The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 1996; 84: 587-597.
27. Tomlinson I, Rahman N, Frayling I et al: Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22. Gastroenter-ology 1999; 116: 789-795.
28. Janer M, Friedrichsen DM, Stanford JL et al: Genomic scan of 254 hereditary prostate cancer families. Prostate 2003; 57: 309-319.
29. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
30. Kong A, Cox NJ: Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 1997; 61: 1179-1188.
31. Abecasis GR, Wigginton JE: Handling marker-marker linkage disequilibrium: pedigree analysis with clustered markers. Am J Hum Genet 2005; 77: 754-767.
32. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA: Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004; 74: 106-120.
33. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
34. Schaid DJ, McDonnell SK, Zarfas KE et al: Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics. Hum Genet 2006; 120: 471-485.
35. Schleutker J, Baffoe-Bonnie AB, Gillanders E et al: Genome-wide scan for linkage in Finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26. Prostate 2003; 57: 280-289.
36. Eeles RA, Kote-Jarai Z, Giles GG et al: Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet 2008; 40: 316-321.
37. Slager SL, Schaid DJ, Cunningham JM et al: Confirmation of linkage of prostate cancer aggressiveness with chromosome 19q. Am J Hum Genet 2003; 72: 759-762.
38. Xu J, Dimitrov L, Chang BL et al: A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics. Am J Hum Genet 2005; 77: 219-229.
39. Ozden N, Saruc M, Smith LM, Sanjeevi A, Roy HK: Increased cumulative incidence of prostate malignancies in colorectal cancer patients. Int J Gastrointest Cancer 2003; 34: 49-54.
40. Burmester JK, Suarez BK, Lin JH et al: Analysis of candidate genes for prostate cancer. Hum Hered 2004; 57: 172-178.
41. Hirata H, Hinoda Y, Kawamoto K et al: Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer. J Urol 2008; 179: 2020-2024.
42. Curtin K, Lin WY, George R et al: Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21. Cancer Epidemiol Biomarkers Prev 2009; 18: 616-621.
43. Tomlinson I, Webb E, Carvajal-Carmona L et al: A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 2007; 39: 984-988.
44. Jaeger E, Webb E, Howarth K et al: Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk. Nat Genet 2008; 40: 26-28.
45. Wallar BJ, Alberts AS: The formins: active scaffolds that remodel the cytoskeleton. Trends Cell Biol 2003; 13: 435-446.
46. Zhou F, Leder P, Martin SS: Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Exp Cell Res 2006; 312: 1119-1126.
47. Djureinovic T, Skoglund J, Vandrovcova J et al: A genome wide linkage analysis in Swedish families with hereditary non-familial adenomatous polyposis/non-hereditary non-polyposis colorectal cancer. Gut 2006; 55: 362-366.
48. Cui Y, Ying Y, van Hasselt A et al: OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS ONE 2008; 3: e2990.
49. Frattini M, Balestra D, Suardi S et al: Different genetic features associated with colon and rectal carcinogenesis. Clin Cancer Res 2004; 10: 4015-4021.
50. Ueda T, Komiya A, Emi M et al: Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer. Genes Chromosomes Cancer 1997; 20: 140-147.
51. Broderick P, Carvajal-Carmona L, Pittman AM et al: A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk. Nat Genet 2007; 39: 1315-1317.
52. Navarro C, Chirlaque MD, Tormo MJ et al: Validity of self reported diagnoses of cancer in a major Spanish prospective cohort study. J Epidemiol Community Health 2006; 60: 593-599.
53. Sijmons RH, Boonstra AE, Reefhuis J et al: Accuracy of family history of cancer: clinical genetic implications. Eur J Hum Genet 2000; 8: 181-186.
54. Chang ET, Smedby KE, Hjalgrim H, Glimelius B, Adami HO: Reliability of self-reported family history of cancer in a large case-control study of lymphoma. J Natl Cancer Inst 2006; 98: 61-68.
55. Theis B, Boyd N, Lockwood G, Tritchler D: Accuracy of family cancer history in breast cancer patients. Eur J Cancer Prev 1994; 3: 321-327.
56. Rapiti E, Fioretta G, Verkooijen HM et al: Increased risk of colon cancer after external radiation therapy for prostate cancer. Int J Cancer 2008; 123: 1141-1145.
57. Bostrom PJ, Soloway MS: Secondary cancer after radiotherapy for prostate cancer: should we be more aware of the risk? Eur Urol 2007; 52: 973-982.