Chapter 7 Micropollutants in Water Recycling: A Case Study of N-Nitrosodimethylamine (NDMA) Exposure from Water versus Food

Sustainability Science and Engineering

Volumn 2, Issue C, 2010, Pages 203-228

  Schäfer, Andrea I ^a   Mitch, William ^b   Walewijk, Sophie ^c   Munoz, Albert ^d   Teuten, Emma ^a   Reinhard, Martin ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Yale University   (United States)

^c Stanford University   (United States)

^d UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

Advanced oxidation; Exposure; Membrane filtration; N Nitrosodimethylamine (NDMA); Regulation; Risk assessment

Indexed keywords

EID: 77957100098     PISSN: 18712711     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1871-2711(09)00207-4     Document Type: Review

References (99)

1. World Health Organization International Agency for Research on Cancer, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs, Vols. 1-42, Lyon, 1987.
2. D.B. Jobb, R.B. Hunsinger, O. Meresz, V.Y. Taguchi, A Study of the Occurrence and Inhibition of Formation of N-Nitrosodimethylamine (NDMA) in the Ohsweken Water Supply, in: Proceedings of 5th National Conference on Drinking Water on Disinfection Dilemma - Microbiological Control versus By-products, September 13-15, 1992, Winnipeg, Canada, 1993, pp. 241-252.
3. Mitch W.A., Sharp J.O., Trussell R.R., Valentine R.L., Alvarez-Cohen L., and Sedlak D.L. N-Nitrosodimethylamine (NDMA) as a drinking water contaminant: a review. Environ. Eng. Sci. 20 (2003) 389-404
4. Charrois J.W.A., Boyd J.M., Froese K.L., and Hrudey S.E. Occurrence of N-nitrosamines in Alberta public drinking-water distribution systems. J. Environ. Sci. Eng. 6 (2007) 103-114
5. Fristachi A., and Rice G. Estimation of the total daily oral intake of NDMA attributable to drinking water. J. Water Health 5 (2007) 341-355
6. Doyle T.J., Zheng W., Cerhan J.R., Hong C.P., Sellers T.A., Kushi L.H., and Folsom A.R. The association of drinking water source and chlorination by-products with cancer incidence among postmenopausal women in Iowa: a prospective cohort study. Am. J. Public Health 87 (1997) 1168-1176
7. Koivusalo M., Pukkala E., Vartiainen T., Jaakkola J.J., and Hakulinen T. Drinking water chlorination and cancer a historical cohort study in Finland. Cancer Causes Control 8 (1997) 192-200
8. Villanueva C.M., Fernández F., Malats N., Grimalt J.O., and Kogevinas M. Meta-analysis of studies on individual consumption of chlorinated drinking water and bladder cancer. J. Epidemiol. Community Health 57 (2005) 166-173
9. World Health Organization, N-Nitrosodimethylamine in Drinking -Water, Geneva, 2006.
10. United States Environmental Protection Agency, Ambient Quality Criteria for Nitrosamines, Office of Water Regulations: Standards Criteria and Standards Division, Washington, DC, 1980.
11. Ontario Ministry of the Environment. Scientific Criteria Document for Multimedia Standard Development No. 01-90; N-Nitrosodimethylamine (1991), Hazardous Contaminants Coordination Branch, Toronto, Ont.
12. R.C. Weast, CRC Handbook of Chemistry and Physics, CRC Press Inc., Boca Raton, FL, 1983.
13. Mirvish S.S., Issenberg I., and Sornson H.C. Air-water and ether-water distribution of N-nitroso compound: implications for laboratory safety, analytic methodology, and carcinogenicity for the rat esophagus, nose and liver. J. Natl. Cancer Inst. 56 (1976) 1125-1129
14. C. Hansch, A.J. Leo, Medchem Project Issue No. 26, Pomona College, Claremont, CA, 1985.
15. Thomas R.G. Volatilization from water. In: Lyman W.J., Reehl W.F., and Rosenblatt D.H. (Eds). Handbook of Chemical Property Estimation Methods (1982), McGraw-Hill, New York 15-27
16. Schmidt C.K., and Brauch H.J. N,N-Dimethylsulfamide as precursor for N-nitrosodimethylamine (NDMA) formation upon ozonation and its fate during water treatment. Environ. Sci. Technol. 42 (2008) 6340-6346
17. Schreiber I.M., and Mitch W. Enhanced nitrogenous disinfection byproduct formation near the breakpoint: implications for nitrification control. Environ. Sci. Technol. 41 (2007) 7039-7046
18. Mirvish S.S. Kinetics of nitrosamide formation from alkylureas, N-alkylurethans, and alkylguanidines: possible implications for the etiology of known gastric cancer. J. Natl. Cancer Inst. 46 (1971) 1183-1193
19. Casado J., González-AlaTorre G., Izquierdo C., and Brunner C. The nitrosation of N-alkylureas: evidence for a proton-transfer mechanism. Int. J. Chem. Kinet. 28 (1996) 307
20. Fan T.Y., and Tannenbaum S.R. Factors influencing the rate of formation of nitrosomorpholine from morpholine and nitrite: acceleration by thiocyanate and other anions. J. Agric. Food Chem. 21 (1973) 237-240
21. Choi J., and Valentine R.L. Formation of N-nitrosodimethylamine (NDMA) from reaction of monochloroamine: a new disinfection by-product. Water Res. 36 (2002) 817-824
22. Mitch W.A., and Sedlak D.L. Formation of N-nitrosodimethylamine (NDMA) from dimethylamine during chlorination. Environ. Sci. Technol. 36 (2002) 588-595
23. Schreiber I.M., and Mitch W.A. Nitrosamine formation pathway revisited: the importance of dichloramine and dissolved oxygen. Environ. Sci. Technol. 40 (2006) 6007-6014
24. Choi J., and Valentine R.L. N-Nitrosodimethylamine formation by free-chlorine-enhanced nitrosation of dimethylamine. Environ. Sci. Technol. 37 (2003) 4871-4876
25. Walse S.S., and Mitch W.A. Nitrosamine carcinogens also swim in chlorinated pools. Environ. Sci. Technol. 42 (2008) 1032-1037
26. Westerhoff P., and Mash H. Dissolved organic nitrogen in drinking water supplies: a review. J. Water SRT - Aqua 51 (2002) 415-448
27. Gerecke A.C., and Sedlak D.L. Precursors of N-nitrosodimethylamine in natural waters. Environ. Sci. Technol. 37 (2003) 1331-1336
28. Mitch W.A., and Sedlak D.L. Characterization and fate of N-nitrosodimethylamine precursors in municipal wastewater treatment plants. Environ. Sci. Technol. 38 (2004) 1445-1454
29. Mitch W.A., and Schreiber I.M. Degradation of tertiary alkylamines during chlorination/chloramination: implications for formation of aldehydes, nitriles, halonitroalkanes and nitrosamines. Environ. Sci. Technol. 42 (2008) 4811-4817
30. Kosaka K., Asami M., Konno Y., Oya M., and Kunikane S. Identification of antiyellowing agents as precursors of N-nitrosodimethylamine production on ozonation from sewage treatment plant influent. Environ. Sci. Technol. 407 11 (2009) 3540-3545
31. Park S.-H., Wei S., Mizaikoff B., Taylor A.E., Favero C., and Huang C.-H. Degradation of amine-based water treatment polymers during chloramination as N-nitrosodimethylamine (NDMA) precursors. Environ. Sci. Technol. 43 (2009) 1360-1366
32. Kemper J.M., Westerhoff P., Dotson A., and Mitch W.A. Nitrosamine, dimethylnitramine, and chloropicrin formation during strong-base anion-exchange treatment. Environ. Sci. Technol. 43 (2009) 466-472
33. Orange County Water District, Water Factory 21, Orange Country, CA, Orange County Water District, 2001.
34. Ontario Ministry of the Environment and Energy, Removal of N-Nitrosodimethylamine from the Ohsweken (Six Nations) Water Supply, Toronto, Ont., 1994.
35. G. Dillon, S. Blake, P. Rumsby, L. Rockett, T. Hall, P. Jackson, A. Rawlinson, NDMA - Concentrations in drinking water and factors affecting its formation (CSA7240/WT02049/DWI 70/2/210), Defra 7348 Final Report, March 2008.
36. Asami M., Oya M., and Kosaka K. A nationwide survey of NDMA in raw and drinking water in Japan. Sci. Total Environ. 407 (2009) 3540-3545
37. Sedlak D.L., Deeb R.A., Hawley E.L., Mitch W.A., Turbin T.D., Mowbray S., and Carr S. Sources and fate of nitrosodimethylamine and its precursors in municipal wastewater treatment plants. Water Environ. Res. 77 (2005) 32-39
38. Anderson J. The environmental benefits of water recycling and reuse. Water Sci. Technol.: Water Supply 3 (2003) 1
39. J. Drewes, C. Bellona, P. Xu, G. Amy, G. Filteau, G. Oelker, Comparing nanofiltration and reverse osmosis for treating recycled water, AWWARF Report 91212, 2008.
40. D.L. Sedlak, M. Kavanaugh, Removal and Destruction of NDMA and NDMA Precursors during Wastewater Treatment, Final Report to the Water Reuse Foundation, Project 01-002, 2005.
41. Lijinsky W. N-Nitroso compounds in the diet. Mutat. Res. 443 (1999) 129-138
42. Fazio T., Damico J.N., Howard J.W., White R.H., and Watts J.O. Gas chromatographic determination and mass spectrometric confirmation of N-nitrosodimethylamine in smoke-processed marine fish. J. Agric. Food Chem. 19 (1971) 250-253
43. Yurchenko S., and Mölder U. Volatile N-nitrosamines in various fish products. Food Chem. 100 (2007) 1713-1721
44. Sen W.P., Iyengar J.R., Donaldson B.D., Panalaks T., and Miles W.F. The analysis and occurrence of volatile nitrosamines in cured meat products. International Agency for Research on Cancer (IARC) Sci. Publ. 9 (1975) 49-52
45. Byun M.W., Ahn H.J., Kim J.H., Lee J.W., Yook H.S., and Han S.B. Determination of volatile N-nitrosamines in irradiated fermented sausage by gas chromatography coupled to a thermal energy analyzer. J. Chromatogr. A 1054 (2004) 403-407
46. Sen N.P., Donaldson B., Iyengar J.R., and Panalaks T. Nitrosopyrrolidine and dimethylnitrosamine in bacon. Nature 241 (1973) 473-474
47. Glória M.B.A., Barbour J.F., and Scanlan R.A. Volatile nitrosamines in fried bacon. J. Agric. Food Chem. 45 (1997) 1816-1818
48. Gough T.A., Webb K.S., and Coleman R.F. Estimate of the volatile nitrosamine content in U.K. food. Nature 272 (1978) 161
49. Dellisanti A., Cerutti G., and Airoldi L. Volatile N-nitrosamines in selected Italian cheeses. Bull. Environ. Contam. Toxicol. 57 (1996) 16-21
50. Lakritz L., and Pensabene J.W. Survey of fluid and nonfat dry milks for N-nitrosamines. J. Dairy Sci. 64 (1981) 371-374
51. Oliveira C.P., Beatriz M., Gloria A., Barbour J.F., and Scanlan R.A. Nitrate, nitrite, and volatile nitrosamines in whey-containing food products. J. Agric. Food Chem. 43 (1995) 967-969
52. D.W. Lachenmeier, D. Fügel, Reduction of nitrosamines in beer: review of a success story, Brewing Sci. 297 (May/June) (2007) 84-89.
53. Anderson L.M., Carter J.P., Logsdon D.L., Driver C.L., and Kovatch R.M. Characterization of ethanol's enhancement of tumorigenesis by N-nitrosodimethylamine in mice. Carcinogenesis 13 (1992) 2107-2111
54. Hietanen E., Bartsch H., Bereziat J.C., Ahotupa M., Camus A.M., Cabral J.R., and Laitinen M. Quantity and saturation degree of dietary fats as modulators of oxidative stress and chemically-induced liver tumors in rats. Int. J. Cancer 46 (1990) 640-647
55. Wade G.G., Mandel R., and Ryser H.J.-P. Marked synergism of dimethylnitrosamine carcinogenesis in rats exposed to cadmium. Cancer Res. 47 (1987) 6606-6613
56. Choi S.Y., Chung M.J., Lee S.-J., Shin J.H., and Sung N.K. N-Nitrosamine inhibition by strawberry, garlic, kale, and the effects of nitrite-scavenging and N-nitrosamine formation by functional compounds in strawberry and garlic. Food Control 18 (2007) 485-491
57. Choi S.Y., Chung M.J., and Sung N.J. Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB. et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate. Food Chem. Toxicol. 43 (2002) 949-957
58. Fitzgerald D.J., and Robinson N.I. Development of a tolerable daily intake for N-nitrosodimethylamine using a modified benchmark dose methodology. J. Toxicol. Environ. Health Part A 70 (2007) 1670-1678
59. Tricker A.R., Ditrich D., and Preussmann R. N-Nitroso compounds in cigarette tobacco and their occurrence in mainstream tobacco smoke. Carcinogenesis 12 (1991) 257-261
60. Biaudet H., Mavelle T., and Debry G. Mean daily intake of N-nitrosodimethylamine from foods and beverages in France in 1987-1992. Food Chem. Toxicol. 32 (1994) 417-421
61. A. Munoz, A Comparison of N-Nitrosodimethylamine Human Health Risks from Water and Other Sources, MEng Thesis, University of Wollongong, Australia, 2005.
62. Ministry of Agriculture Fisheries and Food (MAFF), Nitrate, nitrite and N-nitroso compounds in foods, Food Surveillance Paper, 20, 1987.
63. Stephany R.W., and Schuller P.L. Daily dietary intakes of nitrate, nitrite and volatile N-nitrosamines in the Netherlands using the duplicate portion sampling technique. Oncology 37 (1980) 203-210
64. Ellen G., Egmond E., Loon J.W.V., Sahertian E.T., and Tolsma K. Dietary intakes of some essential metals and non-essential trace elements, nitrate, nitrite and N-nitrosamines, by Dutch adults: estimated via 24-hour duplicate portion study. Food Addit. Contam. 7 (1990) 207-221
65. Spiegelhalder B., Eisenbrand G., and Preussmann R. Occurrence of volatile nitrosamines in food: a survey of the West German market. IARC Sci. Publ. 31 (1980) 467-479
66. Spiegelhalder B., and Preussmann R.C. Occupational nitrosamine exposure. 1. Rubber and tyre industry. Carcinogenesis 4 (1983) 1147
67. Maki T., Tamura Y., Shimamura Y., and Naoi Y. Estimate of the volatile nitrosamine content of Japanese food. Bull. Environ. Contam. Toxicol. 25 (1980) 257-261
68. Yamamoto M., Iwata R., Ishiwata H., Yamada T., and Tanimura A. Determination of volatile nitrosamine levels in foods and estimation of their daily intake in Japan. Food Chem. Toxicol. 22 (1984) 61-64
69. Österdahl B.G. Volatile nitrosamines in foods on the Swedish market and estimation of their daily intake. Food Addit. Contam. 5 (1988) 587-595
70. Pentilla P.L., Räsänen L., and Kimppa S. Nitrate, nitrite and N-nitroso compounds in Finnish foods and estimation of the dietary intakes. Food Sci. Technol. 190 (1990) 336-340
71. Glória M.B.A., Barbour J.F., and Scanlan R.A. N-Nitrosodimethylamine in Brazilian, U.S. domestic, and U.S. imported beers. J. Agric. Food Chem. 1997 (1997) 814-816
72. Ministry of Agriculture Fisheries and Food (MAFF), UK, NDMA and ATNC in retail malt whisky, Food Surveillance Information Sheet, Number 57, February 1995, http://archive.food.gov.uk/maff/archive/food/infsheet/1995/no57/57whisky.htm, retrieved 06.17.2009.
73. Spiegelhalder B., and Preussmann R. Contamination of toiletries and cosmetic products with volatile and nonvolatile N-nitroso carcinogens. J. Cancer Res. Clin. Oncol. 108 (1984) 160-163
74. Brain K.R., Walters K.A., James V.J., Dressler W.E., Howes D., Kelling C.K., Moloney S.J., and Gettings S.D. Percutaneous penetration of dimethylnitrosamine through human skin in vitro: application from cosmetic vehicles. Food Chem. Toxicol. 33 (1995) 315-322
75. Stehlik G., Richter O., and Altmann H. Concentration of dimethylnitrosamine in the air of smoke-filled rooms. Ecotoxicol. Environ. Saf. 6 (1982) 495-500
76. United States Environmental Protection Agency, Fact Sheet: Emerging Contaminant - N-Nitroso-dimethylamine (NDMA), 2008.
77. Umweltbundesamt. Bewertung der Anwesenheit teil- oder nicht bewertbarer Stoffe im Trinkwasser aus gesundheitlicher Sicht. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 46 (2003) S249-S251
78. Wilczak A., Assadi-Rad A., Lai H.H., Hoover L.L., Smith J.F., Berger R., Rodigari F., Beland J.W., Lazzelle L.J., Kinicannon E.G., Baker H., and Heaney C.T. Formation of NDMA in chloraminated water coagulated with DADMAC cationic polymer. J. Am. Water Works Assoc. 95 (2003) 94-106
79. Schreiber I.M., and Mitch W.A. Influence of the order of reagent addition on NDMA formation during chloramination. Environ. Sci. Technol. 38 (2005) 1445-1454
80. Lee C., Schmidt C., Yoon J., and VonGunten U. Oxidation of N-nitrosodimethylamine (NDMA) precursors with ozone and chlorine dioxide: kinetics and effect on NDMA formation potential. Environ. Sci. Technol. 41 (2007) 2056-2063
81. Mitch W.A., Oelker G.L., Hawley E.L., Deeb R.A., and Sedlak D.L. Minimization of NDMA formation during chlorine disinfection of municipal wastewater by application of pre-formed chloramines. Environ. Eng. Sci. 22 (2005) 882-890
82. Glater J. The early history of reverse osmosis membrane development. Desalination 117 (1998) 297-309
83. Verliefde. Priority organic micropollutants in water sources in Flanders and the Netherlands and assessment of removal possibilities with nanofiltration. Environ. Pollut. 146 (2007) 281-289
84. R. Deeb, E. Hawley, D. Sedlak, J. Loveland, M. Kavanaugh, Removal and destruction of NDMA and precursors during wastewater treatment, Water Environmental Federation's Annual Technical Exhibition and Conference, 2006.
85. Bellona C., Drewes J.E., Oelker G., Luna J., Filteau G., and Amy G. Comparing nanofiltration and reverse osmosis for drinking water augmentation. J. Am. Water Works Assoc. 100 (2008) 102
86. Plumlee M.H., López-Mesas M., Heidlberger A., Ishida K.P., and Reinhard M. N-Nitrosodimethylamine (NDMA) removal by reverse osmosis and UV treatment and analysis via LC-MS/MS. Water Res. 42 (2008) 347-355
87. Steinle-Darling E., Zedda M., Plumlee M.H., Ridgway H.F., and Reinhard M. Evaluating the impacts of membrane type, coating, fouling, chemical properties and water chemistry on reverse osmosis rejection of seven nitrosoalklyamines, including NDMA. Water Res. 41 (2007) 3959-3967
88. Wijmans J.G., and Baker R.W. The solution-diffusion model: a review. J. Membr. Sci. 107 (1995) 1-21
89. Bellona C., Drewes J.E., Xu P., and Amy G. Factors affecting the rejection of organic solutes during NF/RO treatment: a literature review. Water Res. 38 (2004) 2795
90. Nghiem L.D., Schäfer A.I., and Elimelech M. Removal of natural hormones by nanofiltration membranes: measurement, modeling, and mechanisms. Environ. Sci. Technol. 38 (2004) 1888-1896
91. Novasep, http://www.novasep.com/misc/glossary.asp?defId=139&lookfor=&search=M, retrieved 04.03.2009.
92. Lee C., Lee Y., Schmidt C., Yoon J., and VonGunten U. Oxidation of suspected N-nitrosodimethylamine (NDMA) precursors by ferrate (VI): kinetics and effect on the NDMA formation potential of natural waters. Water Res. 42 (2008) 433-441
93. Fonseca A.C., Summers R.S., Greenberg A.R., and Hernandez M.T. Extra-cellular polysaccharides, soluble microbial products, and natural organic matter impact on nanofiltration membranes flux decline. Environ. Sci. Technol. 41 (2007) 2491-2497
94. Kim J., DiGiano F.A., and Reardon R.D. Autopsy of high-pressure membranes to compare effectiveness of MF and UF pretreatment in water reclamation. Water Res. 42 (2008) 697-707
95. Drewes J.E., Bellona C., Oedekoven M., Xu P., K T.-U., and Amy G. Rejection of wastewater-derived micropollutants in high-pressure membrane applications leading to indirect potable reuse. Environ. Prog. 24 (2005) 400-409
96. Ng H.Y., and Elimelech M. Influence of colloidal fouling on rejection of trace organic contaminants by reverse osmosis. J. Membr. Sci. 244 (2004) 215-226
97. Zhu X., and Elimelech M. Colloidal fouling of reverse osmosis membranes: measurements and fouling mechanisms. Environ. Sci. Technol. 31 (1997) 3654-3662
98. Tang C.Y., Kwon Y.-N., and Leckie J.O. Fouling of reverse osmosis and nanofiltration membranes by humic acid: effects of solution composition and hydrodynamic conditions. J. Membr. Sci. 290 (2007) 86-94
99. 2 assisted UV photodegradation of N-nitrosodimethylamine in simulated drinking water. Environ. Sci. Technol. 37 (2003) 1933-1940