Facing up to toxic epidermal necrolysis

Expert Opinion on Pharmacotherapy

Volumn 11, Issue 15, 2010, Pages 2443-2446

  Piérard, Gérald E ^a   Paquet, Philippe ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Adverse drug reaction; Apoptosis; Necrosis; Toxic epidermal necrolysis

Indexed keywords

ACETYLCYSTEINE; ALLOPURINOL; ANTIBIOTIC AGENT; CARBAMAZEPINE; COTRIMOXAZOLE; CYCLOOXYGENASE 2 INHIBITOR; GLUCOCORTICOID; IMMUNOGLOBULIN; ISOXICAM; LAMOTRIGINE; NEVIRAPINE; OXYPHENBUTAZONE; PANTOPRAZOLE; PHENOBARBITAL; PHENYLBUTAZONE; PHENYTOIN; PIROXICAM; SERTRALINE; TRAMADOL; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

APOPTOSIS; CELL DEATH; DISEASE COURSE; DRUG METABOLISM; EPIDERMIS; GENITAL SYSTEM; HUMAN; KERATINOCYTE; MACROPHAGE; MOUTH; PATHOGENESIS; PROTEIN EXPRESSION; REVIEW; SKIN DEFECT; T LYMPHOCYTE; TOXIC EPIDERMAL NECROLYSIS;

DRUG TOXICITY; EPIDERMAL NECROLYSIS, TOXIC; HUMANS; KERATINOCYTES; PHARMACOGENETICS;

EID: 77957092502     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.2010.512915     Document Type: Review

References (20)

1. Wolf R, Wolf D, Davidovici B. In the pursuit of classifying severe cutaneous adverse reactions. Clin Dermatol 2007;25:438-439
2. Lissia M, Mulas P, Bulla A, et al. Toxic epidermal necrolysis (Lyells disease). Burns 2010;36:152-163
3. Paquet P, Pierard GE. New insights in toxic epidermal necrolysis (Lyells syndrome). Clinical considerations, pathobiology and targeted treatments revisited. Drug Saf 2010;33:189-212
4. Mockenhaupt M, Viboud C, Dunant A, et al. Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 2008;128:35-44
5. Stone N, Sheerin S, Burge S. Toxic epidermal necrolysis and graft vs host disease: a clinical spectrum but a diagnostic dilemma. Clin Exp Dermatol 1999;24:260-262
6. Paquet P, Arrese JE, Beguin Y, et al. Clinicopathological differential diagnosis of drug-induced toxic epidermal necrolysis (Lyells syndrome) and acute graft-versus-host reaction. Curr Top Pathol 2001;94:49-63
7. Chung WH, Hung Si, Hong HS, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004;428:486
8. Paquet P, Pierard GE. Toxic epidermal necrolysis: revisiting the tentative link between early apoptosis and late necrosis. Int J Mol Med 2007;19:3-10
9. Paquet P, Nikkels A, Arrese J, et al. Macrophages and tumor necrosis factor alpha in toxic epidermal necrolysis. Arch Dermatol 1994;130:605-608
10. Viard I, Wehrli P, Bullani R, et al. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 1998;282:490-493
11. Paquet P, Pierard GE. Epidermal calprotectin in drug-induced toxic epidermal necrolysis. J Cutan Pathol 1999;26:301-305
12. Paquet P, Pierard GE. Glutathione-S-transferase phi expression in toxic epidermal necrolysis: a marker of putative oxidative stress in keratinocytes. Skin Pharmacol Physiol 2007;20:66-70
13. Nassif A, Bensussan A, Bournsell L, et al. Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells. J Allergy Clin Immunol 2004;114:1209-1215
14. Paquet P, Jacob E, Damas P, et al. Analytical quantification of the inflammatory cell infiltrate and CD95R expression during treatment of drug-induced toxic epidermal necrolysis. Arch Dermatol Res 2005;297:266-273
15. Chung WH, Hung SI, Yang JY, et al. Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 2008;14:1343-1350
16. Paquet P, De Groote D, Pierard GE. Functionally-active macrophage-derived myeloperoxidase in the skin of drug-induced toxic epidermal necrolysis. Dermatology 2010;220:201-207
17. Paquet P, Pierard GE, Quatresooz P. Novel treatments for drug-induced toxic epidermal necrolysis (Lyells syndrome). Int Arch Allergy Immunol 2005;136:205-216 (Pubitemid 40529192)
18. Fischer M, Fiedler E, Marsch WC, Wohlrab J. Antitumour necrosis factor-alpha antibodies (infliximab) in the treatment of a patient with toxic epidermal necrolysis. Br J Dermatol 2002;146:707-708
19. Famularo G, Di Dona B, Canzona F, et al. Etanercept for toxic epidermal necrolysis. Ann Pharmacother 2007;41:1083-1084
20. Paquet P, Pierard GE. Topical treatment options for drug-induced toxic epidermal necrolysis (TEN). Expert Opin Pharmacother 2010;11:2447-2458