Effects of reversible inactivation of the dorsomedial hypothalamus on panic-and anxiety-related responses in rats

Brazilian Journal of Medical and Biological Research

Volumn 43, Issue 9, 2010, Pages 869-873

  Nascimento, J O G ^a   Zangrossi, H ^b   Viana, M B ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Dorsomedial hypothalamus; Elevated t maze; Generalized anxiety disorder; Muscimol; Panic disorder

Indexed keywords

MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; HISTOPATHOLOGY; HYPOTHALAMUS NUCLEUS; LOCOMOTION; MALE; MAZE TEST; MOTOR DYSFUNCTION; NONHUMAN; PANIC; RAT;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 77957087838     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2010007500075     Document Type: Article

References (20)

1. Canteras NS. The medial hypothalamic defensive system: hodological organization and functional implications. Pharmacol Biochem Behav 2002; 71: 481-491.
2. Silveira MC, Graeff FG. Defense reaction elicited by microinjection of kainic acid into the medial hypothalamus of the rat: antagonism by a GABAA receptor agonist. Behav Neural Biol 1992; 57: 226-232.
3. Shekhar A, Keim SR. The circumventricular organs form a potential neural pathway for lactate sensitivity: implications for panic disorder. J Neurosci 1997; 17: 9726-9735.
4. Santos JM, Macedo CE, Brandao ML. Gabaergic mechanisms of hypothalamic nuclei in the expression of conditioned fear. Neurobiol Learn Mem 2008; 90: 560-568.
5. Hess WR, Brugger M. [Das subkortikale Zentrum der affek-tiven abwehrreacktion]. Helv Physiol Pharmacol Acta 1943; 1: 33-52.
6. Fernandez de Molina A., Hunsperger RW. Organization of the subcortical system governing defence and fight reactions in the cat. J Physiol 1962; 160: 200-213.
7. Bailey TW, Dimicco JA. Chemical stimulation of the dorso-medial hypothalamus elevates plasma ACTH in conscious rats. Am J Physiol Regul Integr Comp Physiol 2001; 280: R8-R15.
8. Schmitt P, Di Scala G, Brandao ML, Karli P. Behavioral effects of microinjections of SR 95103, a new GABA-A antagonist, into the medial hypothalamus or the mesencephalic central gray. Eur J Pharmacol 1985; 117: 149-158.
9. Soltis RP, Dimicco JA. GABAA and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats. Am J Physiol 1991; 260: R13-R20.
10. Blanchard DC, Griebel G, Blanchard RJ. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neurosci Biobehav Rev 2001; 25: 205-218.
11. Graeff FG. Serotonin, the periaqueductal gray and panic. Neurosci Biobehav Rev 2004; 28: 239-259.
12. McNaughton N, Corr PJ. A two-dimensional neuropsychol-ogy of defense: fear/anxiety and defensive distance. Neu-rosci Biobehav Rev 2004; 28: 285-305.
13. Shekhar A, Keim SR. LY354740, a potent group II me-tabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats. Neuro-pharmacology 2000; 39: 1139-1146.
14. Viana MB, Tomaz C, Graeff FG. The elevated T-maze: a new animal model of anxiety and memory. Pharmacol Biochem Behav 1994; 49: 549-554.
15. Teixeira RC, Zangrossi H, Graeff FG. Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety. Pharmacol Biochem Behav 2000; 65: 571-576.
16. Poltronieri SC, Zangrossi H Jr, de Barros V. Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze. Behav Brain Res 2003; 147: 185-192.
17. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Sidney: Academic Press; 1998.
18. Sena LM, Bueno C, Pobbe RL, Andrade TG, Zangrossi H Jr, Viana MB. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav Brain Res 2003; 142: 125-133.
19. Bueno CH, Zangrossi H Jr, Nogueira RL, Soares VP, Viana MB. Panicolytic-like effect induced by the stimulation of GABAA and GABAB receptors in the dorsal periaqueductal grey of rats. Eur J Pharmacol 2005; 516: 239-246.
20. Bueno CH, Zangrossi H Jr, Viana MB. The inactivation of the basolateral nucleus of the rat amygdala has an anxiolytic effect in the elevated T-maze and light/dark transition tests. Braz J Med Biol Res 2005; 38: 1697-1701.