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Volumn 6, Issue C, 2005, Pages 1-37

Chapter 1 The total synthesis of luzopeptins

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EID: 77957080395     PISSN: 18746004     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1874-6004(05)80024-3     Document Type: Article
Times cited : (2)

References (111)
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    • Interestingly, anti-RT activity appears to be limited to luzopeptins and actinomycin D. Quinoxaline antibiotics such as triostin A and echinomycin are inactive, despite their structural similarity to luzopeptins: see ref. 1-2 as well as. Wang A.H.-J., Ughetto G., Quigley G.J., Hakoshima T., van der Marel G.A., van Boom J.H., and Rich A. Science 225 (1985) 1115
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    • The reported activity of luzopeptin A against P388 leukemia is more than 100 times greater than that of mytomycin C, a clinically used anticancer agent. In addition, luzopeptin A is roughly 3-times as potent as luzopeptin B, while luzopeptin C is much less active
    • The reported activity of luzopeptin A against P388 leukemia is more than 100 times greater than that of mytomycin C, a clinically used anticancer agent. Ohkuma H., Sakai F., Nishiyama Y., Ohbayashi M., Imanishi H., Konishi M., Miyaki T., Koshiyama H., and Kawaguchi H. J. Antibiot. 33 (1980) 1087. In addition, luzopeptin A is roughly 3-times as potent as luzopeptin B, while luzopeptin C is much less active
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    • For related structures such as echinomycine, triostine, thiocoraline and BE-22179 see, e.g. Boger D.L., Ichikawa S., Tse W.C., Hendrick M.P., and Jin W. and references cited therein. J. Am. Chem. Soc. 123 (2001) 561
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