Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 33, 2010, Pages 14915-14920

  Prestele, Jakob ^a   Hierl, Georg ^a   Scherling, Christian ^b   Hetkamp, Stefan ^a   Schwechheimer, Claus ^a   Isono, Erika ^a   Weckwerth, Wolfram ^c   Wanner, Gerhard ^d   Gietl, Christine ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^c UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Glyoxysome; Metabolomics; Thr Leu Gly Glu Glu Tyr motif in peroxin PEX10

Indexed keywords

CARBON DIOXIDE; CELL PROTEIN; MATRIX PROTEIN; MUTANT PROTEIN; PEROXIN; PROTEIN PEX10; PROTEIN PEX12; PROTEIN PEX2; RING FINGER PROTEIN; UNCLASSIFIED DRUG; ARABIDOPSIS PROTEIN; CARRIER PROTEIN; CELL RECEPTOR; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; PEROXIN 12 PROTEIN, ARABIDOPSIS; PEROXISOME TARGETING SIGNAL 1 RECEPTOR; PEROXISOME-TARGETING SIGNAL 1 RECEPTOR; PEX10 PROTEIN, ARABIDOPSIS; SCLEROPROTEIN; TED3 PROTEIN, ARABIDOPSIS; ZINC FINGER PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARABIDOPSIS; ARTICLE; BIOGENESIS; CELL ORGANELLE; CELL STRUCTURE; CHLOROPLAST; EMBRYO; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GERMINATION; GROWTH; HEART; INFLORESCENCE; LETHALITY; METABOLITE; MITOCHONDRION; MOBILIZATION; MUTANT; NONHUMAN; PEROXISOME; PHENOTYPE; PHOTORESPIRATION; PLANT; PLANT DEVELOPMENT; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TRANSPORT; RUMINANT STOMACH; UBIQUITINATION; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CONFOCAL MICROSCOPY; ELECTRON MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; METABOLOMICS; METHODOLOGY; MICROBODY; MOLECULAR GENETICS; MUTATION; PHOTOSYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RING FINGER MOTIF; SEQUENCE HOMOLOGY; TRANSGENIC PLANT; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE;

ARABIDOPSIS;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BIOLOGICAL TRANSPORT; CARBON DIOXIDE; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, PLANT; GLYOXYSOMES; GREEN FLUORESCENT PROTEINS; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; METABOLOMICS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; PEROXISOMES; PHOTOSYNTHESIS; PLANTS, GENETICALLY MODIFIED; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RING FINGER DOMAINS; SEQUENCE HOMOLOGY, AMINO ACID; ZINC FINGERS;

EID: 77957060296     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1009174107     Document Type: Article

References (25)

1. Brown LA, Baker A (2008) Shuttles and cycles: Transport of proteins into the peroxisome matrix (review). Mol Membr Biol 25:363-375.
2. Somerville CR (2001) An early Arabidopsis demonstration. Resolving a few issues concerning photorespiration. Plant Physiol 125:20-24.
3. Reumann S, Weber AP (2006) Plant peroxisomes respire in the light: Some gaps of the photorespiratory C2 cycle have become filled - others remain. Biochim Biophys Acta 1763:1496-1510.
4. Hayashi M, Nishimura M (2006) Arabidopsis thaliana - a model organism to study plant peroxisomes. Biochim Biophys Acta 1763:1382-1391.
5. Mano S, Nishimura M (2005) Plant peroxisomes. Vitam Horm 72:111-154.
6. Eckert JH, Erdmann R (2003) Peroxisome biogenesis. Rev Physiol Biochem Pharmacol 147:75-121.
7. Eckert JH, Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116:3623-3634.
8. Stone SL, et al. (2005) Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Plant Physiol 137:13-30.
9. Warren DS, Morrell JC, Moser HW, Valle D, Gould SJ (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63:347-359.
10. Schumann U, Wanner G, Veenhuis M, Schmid M, Gietl C (2003) AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis. Proc Natl Acad Sci USA 100:9626-9631.
11. Kiel JAK, Emmrich K, Meyer HE, Kunau W-H (2005) Ubiquitination of the peroxisomal targeting signal type 1 receptor, Pex5p, suggests the presence of a quality control mechanism during peroxisomal matrix protein import. J Biol Chem 280:1921-1930.
12. Kragt A, Voorn-Brouwer T, van den Berg M, Distel B (2005) The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem 280:7867-7874.
13. Platta HW, et al. (2007) Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol 177:197-204.
14. Chang CC, Warren DS, Sacksteder KA, Gould SJ (1999) PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import. J Cell Biol 147:761-774.
15. Okumoto K, Abe I, Fujiki Y (2000) Molecular anatomy of the peroxin Pex12p: Ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p. J Biol Chem 275:25700-25710.
16. Hu JP, et al. (2002) A role for peroxisomes in photomorphogenesis and development of Arabidopsis. Science 297:405-409.
17. Sparkes IA, et al. (2003) An Arabidopsis pex10 null mutant is embryo lethal, implicating peroxisomes in an essential role during plant embryogenesis. Plant Physiol 133:1809-1819.
18. Fan JL, et al. (2005) The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development. Plant Physiol 139:231-239.
19. Schumann U, et al. (2007) Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts. Proc Natl Acad Sci USA 104:1069-1074.
20. Mano S, et al. (2002) Distribution and characterization of peroxisomes in Arabidopsis by visualization with GFP: Dynamic morphology and actin-dependent movement. Plant Cell Physiol 43:331-341.
21. Timm S, et al. (2008) A cytosolic pathway for the conversion of hydroxypyruvate to glycerate during photorespiration in Arabidopsis. Plant Cell 20:2848-2859.
22. Sinclair AM, Trobacher CP, Mathur N, Greenwood JS, Mathur J (2009) Peroxule extension over ER-defined paths constitutes a rapid subcellular response to hydroxyl stress. Plant J 59:231-242.
23. Williams C, van den Berg M, Geers E, Distel B (2008) Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun 374:620-624.
24. Mano S, Nakamori C, Nito K, Kondo M, Nishimura M (2006) The Arabidopsis pex12 and pex13 mutants are defective in both PTS1- and PTS2-dependent protein transport to peroxisomes. Plant J 47:604-618.
25. Nito K, Kamigaki A, Kondo M, Hayashi M, Nishimura M (2007) Functional classification of Arabidopsis peroxisome biogenesis factors proposed from analyses of knockdown mutants. Plant Cell Physiol 48:763-774.