Impurity profiling of acetylspiramycin by liquid chromatography-ion trap mass spectrometry

Journal of Chromatography A

Volumn 1217, Issue 42, 2010, Pages 6531-6544

  Wang, Ming juan ^a,b   Pendela, Murali ^b   Hu, Chang qin ^a   Jin, Shao hong ^a   Hoogmartens, Jos ^b   Van Schepdael, Ann ^b   Adams, Erwin ^b  

^a NATIONAL INSTITUTE FOR THE CONTROL OF PHARMACEUTICAL AND BIOLOGICAL PRODUCTS   (China)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

16 Membered macrolide; Acetylspiramycin; Impurity profile; Liquid chromatography tandem mass spectrometry

Indexed keywords

ACETYLSPIRAMYCIN; COLLISION-INDUCED DISSOCIATION SPECTRA; COMMERCIAL SAMPLE; IMPURITIES IN; IMPURITY PROFILE; IMPURITY PROFILING; LIQUID CHROMATOGRAPHY-ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; MACROLIDES; POSITIVE ION MODE; QUADRUPOLE ION TRAP MASS SPECTROMETERS; RELATED SUBSTANCES; REVERSED PHASE; STARTING MATERIALS; SYNTHESIS PROCESS;

COMPLEXATION; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; ION CHROMATOGRAPHY; IONS; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; QUALITY CONTROL;

IMPURITIES;

ACETYLSPIRAMYCIN;

ARTICLE; CHEMICAL STRUCTURE; COLLISIONALLY ACTIVATED DISSOCIATION; DRUG IMPURITY; DRUG MANUFACTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ION TRAP MASS SPECTROMETRY; MASS SPECTROMETER; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUALITY CONTROL; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY;

ACETYLATION; CHROMATOGRAPHY, REVERSE-PHASE; DRUG CONTAMINATION; SPIRAMYCIN; TANDEM MASS SPECTROMETRY;

EID: 77957018828     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2010.08.061     Document Type: Article

References (12)

1. Liu X.P., Xiangtan J. Min. Institut. 1997, 12:65.
2. Hu M., Hu C.Q. Anal. Chim. Acta 2005, 535:89.
3. Shi X.G., Zhang S.Q., Fawcett J.P., Zhong D.F. J. Pharm. Biomed. Anal. 2004, 36:593.
4. Pendela M., Govaerts C., Diana J., Hoogmartens J., Van Schepdael A., Adams E. Rapid Commun. Mass Spectrom. 2007, 21:599.
5. Kondo A., Nakatani T., Kuzuya Y., Suzuki H., Sano H., Yamaguchi K., Shirahata K., Takahashi K., Kita K., Nishiie Y. Jpn. J. Antibiot. 1990, 43:1152.
6. Kondo A., Sato K., Shuto K., Yamashita K., Ichikawa S., Takahashi K., Kita K., Nishiie Y., Sano H., Yamaguchi K. Jpn. J. Antibiot. 1990, 43:1521.
7. Li S.Y., Nelson D.S. Int. J. Immunopharmacol. 1985, 7:881.
8. Takahashi H., Yoshida K., Matsuda T., Komatsu H., Toyoda K., Morita M., Nuka O., Sera N. Jpn. J. Antibiot. 1981, 34:1082.
9. Song Z.H., Wang C.N. Mikrochim. Acta 2005, 149:117.
10. Espinas F.M., Odakura Y., Suzuki N., Sasaki H. Jpn. J. Antibiot. 1981, 34:1141.
11. The State Pharmacopoeia Commission of PR China, Pharmacopoeia of the People's Republic of China, Edition 2005, Chemical Industry Press, Beijing, 2005, p. 6.
12. Govaerts C., Chepkwony H.K., Van Schepdael A., Adams E., Roets E., Hoogmartens J. J. Mass Spectrom. 2004, 39:437.