An electro-amalgamation approach to isolate no-carrier-added 177Lu from neutron irradiated Yb for biomedical applications

Nuclear Medicine and Biology

Volumn 37, Issue 7, 2010, Pages 811-820

  Chakravarty, Rubel ^a   Das, Tapas ^a   Dash, Ashutosh ^a   Venkatesh, Meera ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

Author keywords

177Lu from Yb; DOTA TATE; Electrochemical separation; Mercury cathode; NCA 177Lu

Indexed keywords

1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; DEXTRO PHENYLALANYLTYROSINE OCTREOTATE; LITHIUM CITRATE; LUTETIUM 177; MERCURY; PLATINUM; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; YTTERBIUM;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; ELECTROAMALGAMATION; ELECTROCHEMICAL ANALYSIS; ELECTRODE; ELECTROLYSIS; GAMMA SPECTROMETRY; ISOLATION PROCEDURE; ISOTOPE LABELING; NEUTRON RADIATION; PH; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE;

COMPUTER SIMULATION; ELECTROCHEMISTRY; ELECTRODES; ELECTROLYSIS; MERCURY; NEUTRONS; OCTREOTIDE; ORGANOMETALLIC COMPOUNDS; RADIOPHARMACEUTICALS; YTTERBIUM;

EID: 77957007863     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2010.04.082     Document Type: Article

References (20)

1. 177Lu for radionuclide therapy. Appl Radiat Isot 2003, 59:109-118.
2. Knapp F.F., Mirzadeh S., Beets A.L., Du M. Production of therapeutic radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for applications in nuclear medicine, oncology and interventional cardiology. J Radioanal Nucl Chem 2005, 263(2):503-509.
3. Firestone R. Table of Isotopes 1996, Wiley, New York. 8th ed.
4. 177Lu in medium flux reactor. Appl Radiat Isot 2007, 65:301-308.
5. Mirzadeh S, Du M, Beets AL, Knapp FF. Method for preparing high specific activity 177Lu. United States Patent 6716353 (2004).
6. 177Lu radioisotope separation, Part I. Multi-column chromatographic process for clinically applicable. J Radioanal Nucl Chem 2008, 277(3):663-673.
7. 177Lu radioisotope separation Part II. The conventional column chromatographic separation combined with HPLC for high purity. J Radioanal Nucl Chem 2008, 277(3):675-683.
8. 176Yb targets. Appl Radiat Isot 2005, 63:23-36.
9. 177Lu process. J Radioanal Nucl Chem 2003, 255(3):575-579.
10. 177Lu process. Appl Radiat Isot 2000, 53:421-425.
11. Lahiri S., Nayak D., Nandy M., Das N.R. Separation of carrier free lutetium produced in proton activated ytterbium with HDEHP. Appl Radiat Isot 1998, 49(8):911-913.
12. 177Lu process. J Radioanal Nucl Chem 2009, 280(1):167-169.
13. Marsh J.K. Rare earth metal amalgams, Part 1. J Chem Soc 1942, 1:398-401.
14. Marsh J.K. Rare earth metal amalgams, Part 2. J Chem Soc 1942, 1:523-526.
15. Marsh J.K. Rare earth metal amalgams, Part 3. J Chem Soc 1943, 2:8-10.
16. Marsh J.K. Rare earth metal amalgams, Part 4. J Chem Soc 1943, 2:531-535.
17. Barrett M.F., Topp N.E. Extraction of lanthanons with alkali metal amalgams II: a counter-current process for the extraction of samarium or ytterbium. J Appl Chem 1962, 13(1):7-12.
18. Kwekkeboom D.J., Krenning E.P., de Jong M. Peptide receptor imaging and therapy. J Nucl Med 2000, 41:1704-1713.
19. 111In-DTPA)octreotide in patients. Eur J Nucl Med 2001, 28:1319-1325.
20. Khomutov N.E. Table of molal standard electrode potentials and their temperature coefficients in aqueous solutions at 25°C. Electrochemistry: electrodeposition of metals and alloys. Achievements in Science: Chemistry Series 1969, 2-27. Referativnyi Zhurnal Khimiya, Baltiiskaya ul., Moskow. N.E. Khomutov (Ed.).