Progesterone receptor gene polymorphism and recurrent spontaneous abortion;Polimorfismo do gene dos receptores de progesterona e o aborto espontâneo de repetição

Revista Brasileira de Ginecologia e Obstetricia

Volumn 32, Issue 5, 2010, Pages 229-233

  Traina, Évelyn ^a   Daher, Silvia ^a   Franchim, Camila Sommerauer ^a   Fuziy, Juliana Aoki ^a   Moron, Antônio Fernandes ^a   Banzato, Priscilla Chamelete Andrade ^a   Mattar, Rosiane ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Abortion; Genetic; Habitual; Polymorphism; Pregnancy; Progesterone

Indexed keywords

PROGESTERONE RECEPTOR;

ADOLESCENT; ADULT; ARTICLE; CASE CONTROL STUDY; FEMALE; GENETIC POLYMORPHISM; GENETICS; HUMAN; PREGNANCY; RECURRENT ABORTION;

ABORTION, HABITUAL; ADOLESCENT; ADULT; CASE-CONTROL STUDIES; FEMALE; HUMANS; POLYMORPHISM, GENETIC; PREGNANCY; RECEPTORS, PROGESTERONE; YOUNG ADULT;

EID: 77956973001     PISSN: 01007203     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Ford HB, Schust DJ. Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol. 2009;2(2):76-83.
2. Szekeres-Bartho J, Balasch J. Progestagen therapy for recurrent miscarriage. Hum Reprod Update. 2008;14(1):27-35.
3. Toth B, Jeschke U, Rogenhofer N, Scholz C, Würfel W, Thaler CJ, et al. Recurrent miscarriage: current concepts in diagnosis and treatment. J Reprod Immunol. 2010;85(1):25-32.
4. Check JH. A practical approach to the prevention of miscarriage: Part 1 - Progesterone therapy. Clin Exp Obstet Gynecol. 2009;36(4):203-8.
5. Scarpin KM, Grahan JD, Mote PA, Clarke CL. Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nucl Recept Signal. 2009;7:e009.
6. Rousseau-Merck MF, Misrahi M, Loosfelt H, Milgrom E, Berger R. Localization of the human progesterone receptor gene to chromosome 11q22-q23. Hum Genet. 1987;77(3):280-2.
7. Kim JJ, Choi YM, Choung SH, Yoon SH, Lee GH, Moon SY. Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome. Fertil Steril. 2010;93(6):1942-7.
8. Aléssio AM, Siqueira LH, de Carvalho EC, Barini R, Mansur AP, Hoehr NF, et al. Estrogen receptor alpha and beta gene polymorphisms are not risk factors for recurrent miscarriage in a Brazilian population. Clin Appl Thromb Hemost. 2008;14(2):180-5.
9. Goodman C, Hur J, Goodman CS, Jeyendran RS, Coulam C. Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages? Am J Reprod Immunol. 2009;62(6):365-70.
10. Kurz C, Tempfer CB, Boecskoer S, Unfried G, Nagele F, Hefler LA. The PROGINS progesterone receptor gene polymorphism and idiopathic recurrent miscarriage. J Soc Gynecol Investig. 2001;8(5):295-8.
11. Schweikert A, Rau T, Berkholz A, Allera A, Daufeldt S, Wildt L. Association of progesterone receptor polymorphism with recurrent abortions. Eur J Obstet Gynecol Reprod Biol. 2004;113(1): 67-72.
12. Carvalho CV, D'Amora P, Sato H, Girão MJBC, Lima GR, Silva IDCG, et al. Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com endometriose pélvica. Rev Bras Ginecol Obstet. 2004;26(8):613-7.
13. Gomes MT, Castro RA, Villanova FE, da Silva ID, Baracat EC, de Lima GR, et al. The progesterone receptor gene polymorphism, PROGINS, may be a factor related to the development of uterine fibroids. Fertil Steril. 2007;87(5):1116-21.
14. Junqueira MG, da Silva ID, Nogueira-de-Souza NC, Carvalho CV, Leite DB, Gomes MT, et al. Progesterone receptor (PROGINS) polymorphism and the risk of endometrial cancer development. Int J Gynecol Cancer. 2007;17(1):229-32.
15. Linhares JJ, Silva IDCG, Souza NCN, Noronha EC, Ferraro O, Baracat FF. Polimorfismo do gene do receptor de progesterona (PROGINS) em mulheres com câncer de mama: estudo casocontrole. Rev Bras Ginecol Obstet. 2005;27(8):473-8.
16. Instituto Brasileiro de Geografia e Estatística (IBGE). Síntese de Indicadores Sociais: uma análise das condições de vida da população brasileira 2007 [Internet]. Rio de Janeiro; 2007 [citado 2010 Jan 10]. Disponível em:
17. Gustincich S, Manfioletti G, Del Sal G, Schneider C, Carninci P. A fast method for high-quality genomic DNA extraction from whole human blood. Biotechniques. 1991;11(3):298-300, 302.
18. Romano A, Delvoux B, Fischer DC, Groothuis P. The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone. J Mol Endocrinol. 2007;38(1-2):331-50.
19. Romero R, Kuivaniemi H, Tromp G, Olson J. The design, execution, and interpretation of genetic association studies to decipher complex diseases. Am J Obstet Gynecol. 2002;187(5):1299-312.
20. Pearson TA, Manolio TA. How to interpret a genome-wide association study. JAMA. 2008;299(11):1335-44.
21. Bombell S, McGuire W. Cytokine polymorphisms in women with recurrent pregnancy loss: meta-analysis. Aust N Z J Obstet Gynaecol. 2008;48(2):147-54.
22. Pena SDJ, Carvalho-Silva DR, Alves-Silva J, Prado VF, Santos FR. Retrato molecular do Brasil. Ciênc Hoje. 2000;27(159):16-25.