Pulsatile intermittent intravenous insulin therapy for attenuation of retinopathy and nephropathy in type 1 diabetes mellitus

Metabolism: Clinical and Experimental

Volumn 59, Issue 10, 2010, Pages 1429-1434

  Weinrauch, Larry A ^a   Sun, Jennifer ^a   Gleason, Ray E ^a   Boden, Guenther H ^f   Creech, R H ^e   Dailey, George ^d   Kennedy, Frank P ^c   Weir, Matthew R ^b   D'Elia, John A ^a  

^a JOSLIN DIABETES CENTER   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c MAYO CLINIC   (United States)

^d Pediatric/Adolescent Sports Medicine Program   (United States)

^e Medical Center   (United States)

^f TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOSYLATED HEMOGLOBIN; INSULIN;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DISEASE COURSE; DISEASE DURATION; DRUG MEGADOSE; DRUG PULSE THERAPY; FEMALE; FOLLOW UP; GLUCOSE OXIDATION; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY QUOTIENT; RETINA; SEX RATIO; COMPLICATION; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; INTRAVENOUS DRUG ADMINISTRATION; PERIODICITY; PHYSIOLOGY; PULSATILE FLOW;

ADULT; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DIABETIC RETINOPATHY; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; INSULIN; MALE; PERIODICITY; PULSATILE FLOW;

EID: 77956959700     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2010.01.004     Document Type: Article

References (30)

1. Aoki T.T., Vlachokosta F.V., Foss M.C., and Meistas M.T. Evidence for restoration of hepatic glucose processing in type I diabetes mellitus J Clin Invest 71 1983 837 839
2. Paolisso G., Scheen A.J., Giugliano D., Sgambato S., Albert A., and Varrichio M. Pulsatile insulin delivery has greater metabolic effects than continuous hormone administration in man: importance of pulse frequency J Clin Endocrinol Metab 72 1991 607 615
3. Paolisso G., Sgambato S., Giunta R., Varrichio M., and D'Onofrio F. Pulsatile rather than continuous glucagon infusion leads to greater metabolic derangements in insulin-dependent diabetic subjects Diabete Metab 16 1990 42 47
4. Pal B.R., Phillips P.E., Matthews D.R., and Dunger D.B. Contrasting metabolic effects of continuous and pulsatile growth hormone administration in young adults with type 1 (insulin-dependent) diabetes mellitus Diabetelogia 35 1992 542 549
5. Siragy H.M., Vieweg W.V., Pincus S., and Veldhuis J.D. Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism J Clin End Metabol 80 1995 28 33
6. Stagner J.I., Samols E., and Weir G.C. Sustained oscillations of insulin, glucagon and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration J Clin Invest 65 1980 939 942
7. Schmitt C.P., Löcken S., Mehls O., Veldhuis J.D., Lehnert T., and Ritz E. PTH pulsatility but not calcium sensitivity is restored after total parathyroidectomy with heterotopic autotransplantation J Am Soc Nephrol 14 2003 407 414
8. Aoki T.T., Benbarka M.M., and Okimura M.C. Long-term intermittent intravenous insulin therapy and type 1 diabetes mellitus Lancet 342 1993 525 528
9. Aoki T.T., Grecu E.O., and Arcangeli M.A. Chronic intermittent intravenous insulin therapy corrects orthostatic hypotension of diabetes Am J Med 99 1995 683 684
10. Dailey G., Boden G., Creech R., Johnson D., Gleason R.E., and Kennedy F.P. Effects of pulsatile intravenous insulin therapy (PIVIT) on the progression of diabetic nephropathy Metabolism 49 2000 1491 1495
11. Weinrauch L.A., Burger A.J., Aepfelbacher F., Lee A.T., Gleason R.E., and D'Elia J.A. A pilot study to test the effect of pulsatile insulin infusion on cardiovascular mechanisms that might contribute to attenuation of renal compromise in type 1 diabetic patients with proteinuria Metabolism 56 2007 1453 1457
12. Trudeau K., Roy S., Molina A., Shirihai O., and Sayon R. Insulin reverses high glucose-induced changes of mitochondrial morphology and membrane potential heterogeneity in retinal endothelial cells Diabetes S 2009 A 231
13. Early Treatment Diabetic Retinopathy Study Research Group Fundus photographic risk factors for progression of diabetic retinopathy. EDTRS report number 12 Ophthalmology 98 1991 823 833
14. Lewis E.J., Hunsicker L.G., Bain R.P., and Rohde R.D. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group N Engl J Med 329 1993 1456
15. Mauer M., Zinman B., Gardiner R., Suissa S., Sinaiko A., and Strand T. Renal and retinal effects of enalapril and losartan in type 1 diabetes N Engl J Med 361 2009 40 51
16. Weinrauch L.A., Bayliss G., Gleason R.E., Lee A.T., and D'Elia J.A. Utilization of an abbreviated diabetes impact management scale to assess change in subjective disability during a trial of pulsatile insulin delivery demonstrates benefit Metabolism 58 2009 488 491
17. Aepfelbacher F., Yeon S.B., Weinrauch L.A., D'Elia J., and Burger A.J. Effect of improved glycemic control on left ventricular structure and function in patients with type 1 diabetes mellitus Int J Cardiol 94 2004 47 51
18. Weinrauch L.A., Burger A., Gleason R.E., Lee A.T., and D'Elia J.A. Left ventricular mass reduction in type 1 diabetic patients with nephropathy J Clin Hypertens 7 2005 159 164
19. D'Elia J., Weinrauch L., Gleason R., Lipinska I., Keough J., and Pendse S. Fibrinogen and factor VII levels improve with glycemic control in type 1 diabetic patients with microvascular complications Arch Int Med 161 2001 98 101
20. Weinrauch L.A., Kennedy F.J., Burger A., Gleason R.E., Keough J., and D'Elia J.A. Prospective evaluation of autonomic dysfunction in aggressive management of diabetic microangiopathy Am J Hypertens 12 1999 1135 1139
21. Weinrauch L.A., Burger A., Aronson D., Gleason R.E., Lee A.T., and D'Elia J.A. Regression of left ventricular hypertrophy in diabetic nephropathy: loss of parasympathetic function predicts response to treatment J Clin Hypertens 8 2006 330 335
22. Burger A.J., D'Elia J.A., Weinrauch L.A., Lerman I., and Gaur A. Marked abnormalities in heart rate variability are associated with progressive deterioration of renal function in type 1 diabetic patients with overt nephropathy Int J Cardiol 86 2002 281 287
23. Burger A.J., Weinrauch L.A., D'Elia J.A., and Aronson D. Effects of glycemic control on heart rate variability in type 1 diabetic patients with cardiac autonomic neuropathy Am J Cardiol 84 1999 687 691
24. Roshon B., Tofler G., Weinrauch L., Gleason R., Keough J., and Lipinska I. Improved glycemic control and platelet function abnormalities in diabetic patients with microvascular disease Metabolism 49 2000 88 91
25. Roest P., Molin D., Schralkwijk C., van Iperen M., Wentzel P., and Eriksson V. Specific local cardiovascular changes of N (carboxymethyl) lysine, vascular endothelial growth factor and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects Diabetes 58 2009 1222 1228
26. Geltman J., Sun J., Keenan H., Whelan L., Monnier V., and Aiello L.P. Unexpected high prevalence of cardiovascular complications in type 1 diabetes of extreme duration Diabetes 58 2009 A199
27. Hummel S., Pfluger M., Krieichauf S., Hummel M., and Ziegler A. Predictors of overweight during childhood in offspring of parents with type 1 diabetes Diabetes Care 32 2009 921 925
28. Kaufman F., Hirst K., Linder B., Baranowski T., Cooper D., Foster G. Health Study Writing Group Risk factors for type 2 diabetes in a sixth grade multiracial cohort Diabetes Care 32 2009 953 955
29. Gardner T.W. An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the astemizole retinopathy trial Curr Eye Res 31 2006 535 547
30. Silva K., Rosales M., Lopes de Faria J.B., and Lopes de Faria J.M. Diabetic retinal neurodegeneration is associated with myocardial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes Diabetes 58 2009 1382 1390