Use of disposable reactors to generate inoculum cultures for E. coli production fermentations

Biotechnology Progress

Volumn 26, Issue 4, 2010, Pages 1200-1203

  Mahajan, Ekta ^a   Matthews, Timothy ^a   Hamilton, Ryan ^a   Laird, Michael W ^a  

^a GENENTECH INC   (United States)

Author keywords

Disposable Bioreactor; E. coli; Fermentation; WAVE Bioreactor

Indexed keywords

BIOTECHNOLOGY INDUSTRY; CAPITAL INVESTMENT; CHINESE HAMSTER OVARY; CONTROL DATA; DISPOSABLE BIOREACTOR; DISPOSABLE TECHNOLOGY; E. COLI; FERMENTORS; GAS FEED; HIGH CELL DENSITY; INOCULA; LABORATORY SCALE; MAINTENANCE REQUIREMENT; OPERATING EXPENSE; OPTICAL DENSITIES; OXYGEN DEMAND; PRODUCTION CULTURE; PRODUCTION PROCESS; PRODUCTION SYSTEM; RECOMBINANT PROTEIN PRODUCTIONS; WAVE SYSTEM; WORKING VOLUME;

BIOCONVERSION; CELL CULTURE; CORROSION RESISTANT ALLOYS; ECONOMIC ANALYSIS; ESCHERICHIA COLI; FERMENTATION; FERMENTERS; INVESTMENTS; OXYGEN; PRODUCTION ENGINEERING; PROTEINS;

STAINLESS STEEL;

ANIMAL; ARTICLE; BIOREACTOR; CHO CELL; CRICETULUS; ESCHERICHIA COLI; FERMENTATION; GROWTH, DEVELOPMENT AND AGING; HAMSTER; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; BIOREACTORS; CHO CELLS; CRICETINAE; CRICETULUS; ESCHERICHIA COLI; FERMENTATION;

CRICETULUS GRISEUS; ESCHERICHIA COLI;

EID: 77956956137     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.414     Document Type: Article

References (9)

1. Sinclair A. Disposable Bioreactors: the next generation. Bio-Pharm Int. 2008;21(4):21.
2. Mirasol F. Disposable use grows in commercial production. ICIS Chemical Business. 2008.
3. Sinclair A, Leveen L, Monge M, Lim J, Cox S. The environmental impact of disposable technologies. BioPharm Int Suppl. Nov 2, 2008.
4. Wells B, Boehm J, Cardona M, Gettings R, Gupta V, Hockstad M, Kossay B. Guide to disposal of single use bioprocess systems. BioProcess Int. 2007;22-28.
5. Boodhoo K, Vicevic M, Cartwright CD, Ndlovu T, Toogood EC, Intensification of gas-liquid mass transfer using a rotating bed of porous packings for application to an E.coli batch fermentation process. Chem Eng J. 2008;135:141-150.
6. Mikola M, Seto J, Amanullah A. Evaluation of a novel wave bioreactor cellbag for aerobic yeast cultivation. Bioprocess Biosyst Eng. 2007;30:231-241.
7. Hill CW, Harnish BW. Inversions between ribosomal RNA genes of Escherichia coli, Proc Natl Acad Sci USA. 1981;78:7069-7072.
8. Andersen DC, Swartz J, Ryll T, Lin N, Metabolic oscillations in an E. coli fermentation. Biotechnol Bioeng. 2001;75:212-218.
9. Laura C. Simmons, Dorothea Reilly, Laura Klimowski, T. Shantha Raju, Paul Sims, Kyu Hong, Robert L. Shields, Lisa A. Damico, Ptricia Rancatore, Daniel G. Yansura. Expression of fulllength immunoglobulins in Escherichia coli: rapid and efficient production of aglycosylated antibodies. J Immunol Meth. 2002; 263:133-147.