Process development for a large scale stereoselective synthesis of (Z)-(1-bromobut-1-ene-1,2-diyl)dibenzene, a key intermediate of a selective estrogen receptor modulator

Organic Process Research and Development

Volumn 14, Issue 5, 2010, Pages 1147-1152

  Cann, Reginald O ^a   Waltermire, Robert E ^a   Chung, Jihchin ^a,b   Oberholzer, Matthew ^a,c   Kasparec, Jiri ^a,d   Ye, Yun K ^a   Wethman, Robert ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c DUPONT COMPANY   (United States)

^d GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOMETALATION; KEY FEATURE; LARGE SCALE SYNTHESIS; NICKEL ACETYLACETONATE; PHENYLBORONIC ACIDS; PHENYLETHYNYL; PROCESS DEVELOPMENT; PROCESS SCALE-UP; SAFETY PRECAUTIONS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; STEREO-SELECTIVE; STEREOSELECTIVE SYNTHESIS; STEREOSPECIFIC; SUZUKI COUPLINGS; SYNTHETIC SEQUENCE; TRIMETHYL; VINYL BROMIDES; VINYLTRIMETHYLSILANE;

BROMINE COMPOUNDS; OLEFINS; ORGANIC ACIDS; STEREOSELECTIVITY;

SYNTHESIS (CHEMICAL);

EID: 77956945058     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100112r     Document Type: Article

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