Prophylactic and therapeutic benefits of a monoclonal antibody against the fusion protein of human metapneumovirus in a mouse model

Antiviral Research

Volumn 88, Issue 1, 2010, Pages 31-37

  Hamelin, Marie Eve ^a   Gagnon, Constance ^a   Prince, Gregory A ^b   Kiener, Peter ^c   Suzich, JoAnn ^c   Ulbrandt, Nancy ^c   Boivin, Guy ^a  

^a LAVAL UNIVERSITY   (Canada)

^b Virion Systems Inc   (United States)

^c MEDIMMUNE   (United States)

Author keywords

Fusion; Human metapneumovirus; Monoclonal antibody; Mouse; Treatment

Indexed keywords

METHACHOLINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1A7; MONOCLONAL ANTIBODY 338; UNCLASSIFIED DRUG; VIRUS FUSION PROTEIN;

AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; DRUG EFFICACY; HISTOPATHOLOGY; HUMAN METAPNEUMOVIRUS; LUNG FUNCTION; MOUSE; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROPHYLAXIS; PROVOCATION TEST; REAL TIME POLYMERASE CHAIN REACTION; VIRAL RESPIRATORY TRACT INFECTION; VIRUS TITRATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; DISEASE MODELS, ANIMAL; LUNG; LUNG DISEASES, OBSTRUCTIVE; METAPNEUMOVIRUS; MICE; MICE, INBRED BALB C; PARAMYXOVIRIDAE INFECTIONS; PNEUMONIA; POLYMERASE CHAIN REACTION; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY SYSTEM; RESPIRATORY TRACT INFECTIONS; VIRAL FUSION PROTEINS;

HUMAN METAPNEUMOVIRUS; MUS; PARAMYXOVIRIDAE;

EID: 77956942876     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2010.07.001     Document Type: Article

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