The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway

Molecular Cell

Volumn 39, Issue 6, 2010, Pages 950-962

  Mitchell, Sarah F ^a   Walker, Sarah E ^a   Algire, Mikkel A ^a,c   Park, Eun Hee ^b   Hinnebusch, Alan G ^b   Lorsch, Jon R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c J CRAIG VENTER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' 7 METHYLGUANOSINE; 7 METHYLGUANOSINE; INITIATION FACTOR; INITIATION FACTOR 3; INITIATION FACTOR 4A; INITIATION FACTOR 4G; MESSENGER RNA; SINGLE STRANDED RNA; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANISOTROPY; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; COMPETITIVE INHIBITION; EUKARYOTE; FLUORESCENCE ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; RIBOSOMAL PREINITIATION COMPLEX; RIBOSOME; RNA CAPPING; RNA STRUCTURE; TRANSLATION INITIATION;

CELL-FREE SYSTEM; EUKARYOTIC INITIATION FACTOR-3; EUKARYOTIC INITIATION FACTOR-4A; EUKARYOTIC INITIATION FACTOR-4E; EUKARYOTIC INITIATION FACTOR-4F; EUKARYOTIC INITIATION FACTOR-4G; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION, FUNGAL; GUANOSINE; KINETICS; NUCLEIC ACID CONFORMATION; PEPTIDE CHAIN INITIATION, TRANSLATIONAL; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; RIBOSOMAL PROTEINS; RIBOSOME SUBUNITS, SMALL, EUKARYOTIC; RNA CAP ANALOGS; RNA CAPS; RNA, FUNGAL; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA;

EID: 77956940474     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2010.08.021     Document Type: Article

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