The unsolved cyclosporine-induced kidney injury: Is paricalcitol a feasible new renoprotective option

Kidney International

Volumn 77, Issue 12, 2012, Pages 1055-1057

  Reis, Flávio N F ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; CALCIUM CHANNEL BLOCKING AGENT; CREATININE; CYCLOSPORIN A; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PARICALCITOL; RAPAMYCIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; VITAMIN D; BONE DENSITY CONSERVATION AGENT; CYCLOSPORIN; ERGOCALCIFEROL; PROTECTIVE AGENT;

APOPTOSIS; CREATININE CLEARANCE; CYCLOSPORINE INDUCED KIDNEY INJURY; DRUG INDUCED DISEASE; HUMAN; KIDNEY ALLOGRAFT; KIDNEY BLOOD FLOW; KIDNEY DISEASE; KIDNEY FUNCTION; KIDNEY INJURY; KIDNEY TRANSPLANTATION; LIVER FIBROSIS; NEPHROTOXICITY; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; CHEMICALLY INDUCED DISORDER; FIBROSIS; NOTE;

BONE DENSITY CONSERVATION AGENTS; CYCLOSPORINE; ERGOCALCIFEROLS; FIBROSIS; HUMANS; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; PROTECTIVE AGENTS;

EID: 77956930803     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.93     Document Type: Note

References (10)

1. Naesens M, Kuypers DR, Sarwal M. Calcineurin inhibitor nephrotoxicity. C lin J Am Soc Nephrol 2009; 4 : 4 81-5 08.
2. Textor SC, Taler SJ, Canzanello VJ e t al. Posttransplantation hypertension related to calcineurin inhibitors. L iver Transpl 2000; 6 : 521-530.
3. Mange KC, Cizman B, Joffe M et al. Arterial hypertension and renal allograft survival. JAMA 2000; 2 83: 6 33-6 38. (Pubitemid 30069179)
4. Flechner SM, Kobashigawa J, Klintmalm G. Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant 2008 ; 2 2 : 1-15. (Pubitemid 351149996)
5. Rangan GK. Sirolimus-associated proteinuria and renal dysfunction. D rug Saf 2006 ; 2 9 : 1153-1161. (Pubitemid 44904830)
6. Park JW, Bae EH, Kim IJ et al. Paricalcitol attenuates cyclosporine-induced kidney injury in rats. Kidney Int 2010; 7 7: 1 076-1 085.
7. Li M, Batuman V. Vitamin D: a new hope for chronic kidney disease? Kidney Int 2009 ; 7 6: 1 219-1 221.
8. Doorenbos CR, van den Born J, Navis G et al. Possible renoprotection by vitamin D in chronic renal disease: beyond mineral metabolism. Nat Rev Nephrol 2009; 5 : 6 91-7 00.
9. Park JW, Bae EH, Kim IJ et al. Renoprotective effects of paricalcitol on gentamicin-induced kidney injury in rats. A m J Physiol Renal Physiol 2010 ; 2 98 : F301-F313.
10. McNally PG, Feehally J. Pathophysiology of cyclosporin A nephrotoxicity: experimental and clinical observations. N ephrol Dial Transplant 1992; 7 : 791-804.