Why is p53-inducible gene 3 rarely affected in cancer

Oncogene

Volumn 29, Issue 37, 2010, Pages 5220-

  Kotsinas, A ^a   Pateras, I S ^a   Galanos, P S ^a   Karamouzis, M V ^a   Sfikakis, P P ^a   Gorgoulis, V G ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN P53; REACTIVE OXYGEN METABOLITE; ONCOPROTEIN; SIGNAL PEPTIDE; TP53I3 PROTEIN, HUMAN;

CANCER CELL; CANCER SUSCEPTIBILITY; DNA DAMAGE; GENE; HETEROZYGOSITY LOSS; LETTER; LUNG TUMOR; MICROSATELLITE INSTABILITY; NEOPLASM; P53 INDUCIBLE GENE 3; POSITIVE FEEDBACK; PRIORITY JOURNAL; SURVIVAL; GENETICS; HUMAN;

HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOSS OF HETEROZYGOSITY; NEOPLASMS; PROTO-ONCOGENE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77956928317     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.263     Document Type: Letter

References (5)

1. Contente A, Dittmer A, Koch MC, Roth J, Dobbelstein M. (2002). A polymorphic microsatellite that mediates induction of PIG3 by p53. Nat Genet 30: 315-320.
2. Gorgoulis VG, Liloglou T, Sigala T, Korkolis D, Yannoukakos D, Papalambros E et al. (2004). Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas. Mutat Res 556: 143-150.
3. Lee JH, Kang Y, Khare V, Jin ZY, Kang MY, Yoon Y et al. (2010). The p53-inducible gene 3 (PIG3) contributes to early cellular response to DNA damage. Oncogene 29: 1431-1450.
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5. Nicholls CD, Shields MA, Lee PW, Robbins SM, Beattie TL. (2004). UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. J Biol Chem 279: 24171-24178.