The Study of Protein Conformation in Solution Via Direct Sampling by Desorption Electrospray Ionization Mass Spectrometry

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 10, 2010, Pages 1730-1736

  Miao, Zhixin ^a   Wu, Shiyong ^a   Chen, Hao ^a  

^a OHIO UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMMONIUM ACETATE; CONFORMATIONAL CHANGE; DESORPTION ELECTROSPRAY IONIZATION; DESORPTION ELECTROSPRAY IONIZATION MASS SPECTROMETRIES; DIRECT SAMPLING; LIQUID SAMPLE; NATIVE PROTEINS; NEW APPROACHES; ONLINE MONITORING; PROTEIN CONFORMATION; PROTEIN IONS; PROTEIN SOLUTION; SAMPLE PRETREATMENT; SPECTROSCOPIC DATA; UBIQUITIN;

AMMONIUM COMPOUNDS; CONFORMATIONS; DESORPTION; ELECTROSPRAY IONIZATION; IONIZATION; LIQUIDS; MASS SPECTROMETRY; PARTICLE DETECTORS;

PROTEINS;

ACID; AMMONIUM ACETATE; BETA ENDORPHIN; CYTOCHROME C; LYSOZYME; MYOGLOBIN; ORGANIC SOLVENT; PROTEIN; UBIQUITIN; WATER;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HEATING; ONLINE MONITORING; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; SPECTROSCOPY;

ACETATES; HUMANS; METHANOL; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TEMPERATURE; WATER;

EID: 77956875402     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2010.06.003     Document Type: Article

References (42)

1. Zhang Y. Progress and Challenges in Protein Structure Prediction. Curr. Opin. Struct. Biol 2008, 18:342-348.
2. Przybylski M., Glocker M.O. Electrospray Mass Spectrometry of Biomacromolecular Complexes with Noncovalent Interactions-New Analytical Perspectives for Supramolecular Chemistry and Molecular Recognition Processes. Angew. Chem. Int. Ed 1996, 35:806-826.
3. Kaltashov I.A., Abzalimov R.R. Do Ionic Charges in ESI MS Provide Useful Information on Macromolecular Structure?. J. Am. Soc. Mass Spectrom 2008, 19:1239-1246.
4. Grandori R. Electrospray-Ionization Mass Spectrometry for Protein Conformational Studies. Curr. Org. Chem 2003, 7:1589-1603.
5. Fenn J.B., Mann M., Meng C.K., Wong S.F., Whitehouse C.M. Electrospray Ionization for Mass Spectrometry of Large Biomolecules. Science 1989, 246:64-71.
6. Konermann L., Collings B.A., Douglas D.J. Cytochrome c Folding Kinetics Studied by Time-Resolved Electrospray Ionization Mass Spectrometry. Biochemistry 1997, 36:5554-5559.
7. Katta V., Chait B.T. Observation of the Hemoglobin Complex in Native Myoglobin by Electrospray-Ionization Mass Spectrometry. J. Am. Chem. Soc 1991, 113:8534-8535.
8. Loo J.A., Edmonds C.G., Udseth H.R., Smith R.D. Effect of Reducing Disulfide-Containing Proteins on Electrospray Ionization Mass Spectra. Anal. Chem 1990, 62:693-698.
9. Chowdhury S.K., Katta V., Chait B.T. Probing Conformational Changes in Proteins by Mass Spectrometry. J. Am. Chem. Soc 1990, 112:9012-9013.
10. Nemirovskiy O., Giblin D.E., Gross M.L. Electrospray Ionization Mass Spectrometry and Hydrogen/Deuterium Exchange for Probing the Interaction of Calmodulin with Calcium. J. Am. Soc. Mass Spectrom 1999, 10:711-718.
11. Simmons D.A., Konermann L. Characterization of Transient Protein Folding Intermediates during Myoglobin Reconstitution by Time-Resolved Electrospray Mass Spectrometry with On-Line Isotopic Pulse Labeling. Biochemistry 2002, 41:1906-1914.
12. Cooks R.G., Ouyang Z., Takats Z., Wiseman J.M. Ambient Mass Spectrometry. Science 2006, 311:1566-1570.
13. Takats Z.W., Gologan B., Cooks R.G. Mass Spectrometry Sampling Under Ambient Conditions with Desorption Electrospray Ionization. Science 2004, 306:471-473. J. M.
14. Cody R.B., Laramee J.A., Durst H.D. Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions. Anal. Chem 2005, 77:2297-2302.
15. Denes J., Katona M., Hosszu A., Czuczy N., Takats Z. Analysis of Biological Fluids by Direct Combination of Solid Phase Extraction and Desorption Electrospray Ionization Mass Spectrometry. Anal. Chem 2009, 81:1669-1675.
16. Kauppila T., Wiseman J.M., Ketola R.A., Kotiaho T., Cooks R.G., Kostiainen R. Desorption Electrospray Ionization Mass Spectrometry for the Analysis of Pharmaceuticals and Metabolites. Rapid Commun. Mass Spectrom 2006, 20:387-392.
17. Cotte-Rodriguez I., Chen H., Cooks R.G. Rapid Trace Detection of Triacetone Triperoxide (TATP) by Complexation Reactions during Desorption Electrospray Ionization. Chem. Commun 2006, 953-955.
18. Miao, Z.; Chen, H. Analysis of Continuous-Flow Liquid Samples by Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS). Proceedings of the 56th Annual American Society for Mass Spectrometry Conference on Mass Spectrometry; Denver, CO, June, 2008.
19. Miao Z., Chen H. Direct Analysis of Liquid Samples by Desorption Electrospray Ionization-Mass Spectrometry (DESI-MS). J. Am. Soc. Mass Spectrom 2009, 20:10-19.
20. Ma X., Zhao M., Lin Z., Zhang S., Yang C., Zhang X. Versatile Platform Employing Desorption Electrospray Ionization Mass Spectrometry for High-Throughput Analysis. Anal. Chem 2008, 80:6131-6136.
21. Chipuk J.E., Brodbelt J.S. Transmission Mode Desorption Electrospray Ionization. J. Am. Soc. Mass Spectrom 2008, 19:1612-1620.
22. Zhang Y., Chen H. Detection of Saccharides by Reactive Desorption Electrospray Ionization (DESI) Using Modified Phenylboronic Acids. Int. J. Mass Spectrom 2010, 289:98-107.
23. Li J., Dewald H.D., Chen H. Online Coupling of Electrochemical Reactions with Liquid Sample Desorption Electrospray Ionization-Mass Spectrometry. Anal. Chem 2009, 81:9716-9722.
24. Van den Heuvel R.H.H., Heck A.J.R. Native Protein Mass Spectrometry: From Intact Oligomers to Functional Machineries. Curr. Opin. Chem. Biol 2004, 8:519-526.
25. Takáts Z., Wiseman J.M., Gologan B., Cooks R.G. Electrosonic Spray Ionization-a Gentle Technique or Generating Folded Proteins and Protein Complexes in the Gas Phase and Studying Ion-Molecule Reactions at Atmospheric Pressure. Anal. Chem 2004, 76:4050-4058.
26. Liu J., Konermann L. Irreversible Thermal Denaturation of Cytochrome c Studied by Electrospray Mass Spectrometry. J. Am. Soc. Mass Spectrom 2009, 20:819-828.
27. Mirza U.A., Cohen S.L., Chait B.T. Heat-Induced Conformational Changes in Proteins Studied by Electrospray Ionization Mass Spectrometry. Anal. Chem 1993, 65:1-6.
28. Laskin J., Laskin A., Roach P.J., Slysz G.W., Anderson G.A., Nizkorodov S.A., Bones D.L., Nguyen L.Q. High-Resolution Desorption Electrospray Ionization Mass Spectrometry for Chemical Characterization of Organic Aerosols. Anal. Chem 2010, 82:2048-2058.
29. Shiea J., Wang C.H. Applications of Multiple Channel Electrospray Ionization Sources for Biological Sample Analysis. J. Mass Spectrom 1997, 32:247-250.
30. Myung S., Wiseman J.M., Valentine S.J., Takats Z., Cooks R.G., Clemmer D.E. Coupling Desorption Electrospray Ionization with Ion Mobility/Mass Spectrometry for Analysis of Protein Structure: Evidence for Desorption of Folded and Denatured States. J. Phys. Chem. B 2006, 110:5045-5051.
31. Costa A.B., Cooks R.G. Simulated Splashes: Elucidating the Mechanism of Desorption Electrospray Ionization Mass Spectrometry. Chem. Phys. Lett 2008, 464:1-8.
32. Lane A., Nyadong L., Galhena A.S., Shearer T.L., Stout E.P., Parry R.M., Kwasnik M., Wang M.D., Hay M.E., Fernandez F.M., Kubanek J. Desorption Electrospray Ionization Mass Spectrometry Reveals Surface-Mediated Antifungal Chemical Defense of a Tropical Seaweed. Proc. Natl. Acad. Sci. U.S.A 2009, 106:7314-7319.
33. Shiea J., Yuan C.-H., Huang M.-Z., Cheng S.-C., Ma Y.-L., Tseng W.-L., Chang H.-C., Hung W.-C. Detection of Native Protein Ions in Aqueous Solution under Ambient Conditions by Electrospray Laser Desorption/Ionization Mass Spectrometry. Anal. Chem 2008, 80:4845-4852.
34. Mao D., Ding C., Douglas D.J. Hydrogen/Deuterium Exchange of Myoglobin Ions in a Linear Quadrupole Ion Trap. Rapid Commun. Mass Spectrom 2002, 16:1941-1945.
35. Babu K.R., Douglas D.J. Methanol-Induced Conformations of Myoglobin at pH 4.0. Biochemistry 2000, 39:14702-14710.
36. Konermann L., Rosell F.I., Mauk A.G., Douglas D.J. Acid-Induced Denaturation of Myoglobin Studied by Time-Resolved Electrospray Ionization Mass Spectrometry. Biochemistry 1997, 36:6448-6454.
37. Peng I.X., Loo R.O., Shiea J., Loo J.A. Reactive-Electrospray-Assisted Laser Desorption/Ionization for Characterization of Peptides and Proteins. Anal. Chem 2008, 80:6995-7003.
38. Konermann L., Douglas D.J. Acid-Induced Unfolding of Cytochrome c at Different Methanol Concentrations: Electrospray Ionization Mass Spectrometry Specifically Monitors Changes in the Tertiary Structure. Biochemistry 1997, 36:12296-12302.
39. Lin H., Dass C. Conformational Changes in β-endorphin as Studied by Electrospray Ionization Mass Spectrometry. Rapid Commun. Mass Spectrom 2001, 15:2341-2346.
40. Konermann L., Douglas D.J. Unfolding of Proteins Monitored by Electrospray Ionization Mass Spectrometry: A Comparison of Positive and Negative Ion Modes. J. Am. Soc. Mass Spectrom 1998, 9:1248-1254.
41. Miao, Z.; Wu, Q.; Wu, S.; Chen, H. Generation of Native Protein Ions and Ultrafast H/D Exchange in Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS). Proceedings of the 57th Annual American Society for Mass Spectrometry Conference on Mass Spectrometry; Philadelphia, PA, May, 2009.
42. Chen H., Yang S., Li M., Hu B., Li J., Wang J. Sensitive Detection of Native Proteins Using Extractive Electrospray Ionization Mass Spectrometry. Angew. Chem. Int. Ed 2010, 49:3053-3056.