Mass Spectrometry Guided In Situ Proteolysis to Obtain Crystals for X-Ray Structure Determination

Journal of the American Society for Mass Spectrometry

Volumn 21, Issue 10, 2010, Pages 1795-1801

  Gheyi, Tarun ^a   Rodgers, Logan ^a   Romero, Richard ^a   Sauder, J Michael ^a   Burley, Stephen K ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTAL FORMATION; HIGH RESOLUTION; IN-SITU; POLYPEPTIDE CHAIN; PROTEOLYTIC DIGESTION; PURIFIED PROTEIN; RELATIVE CONCENTRATION; STRUCTURE DETERMINATION; TARGET PROTEINS; TIME-SCALES; X-RAY STRUCTURE;

CRYSTAL STRUCTURE; CRYSTALLIZATION; MASS SPECTROMETRY;

PROTEINS;

PROTEINASE;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ANALYSIS; X RAY ANALYSIS;

CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; MASS SPECTROMETRY; PEPTIDE FRAGMENTS; PEPTIDE HYDROLASES; PROTEIN CONFORMATION; PROTEINS;

EID: 77956873612     PISSN: 10440305     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jasms.2010.06.015     Document Type: Article

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