Contrast-enhanced ultrasound for imaging vasa vasorum: Comparison with histopathology in a swine model of atherosclerosis

European Journal of Echocardiography

Volumn 11, Issue 8, 2010, Pages 659-664

  Schinkel, Arend F L ^a,b   Krueger, Chris G ^c   Tellez, Armando ^d   Granada, Juan F ^d   Reed, Jess D ^c   Hall, Anne ^e   Zang, William ^e   Owens, Cindy ^e   Kaluza, Greg L ^d   Staub, Daniel ^a   Coll, Blai ^a   Ten Cate, Folkert J ^b   Feinstein, Steven B ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d CARDIOVASCULAR RESEARCH FOUNDATION   (United States)

^e Ge Vingmed Ultrasound AS   (Norway)

Author keywords

Atherosclerosis; Contrast enhanced ultrasound; Vasa vasorum; Vulnerable plaque

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CLINICAL EFFECTIVENESS; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE SEVERITY; EARLY DIAGNOSIS; ECHOGRAPHY; FEMORAL ARTERY; FOLLOW UP; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; IMAGE ANALYSIS; INTERMETHOD COMPARISON; NONHUMAN; PRIORITY JOURNAL; SWINE; VASA VASORUM;

ANIMALS; ARTERIOSCLEROSIS; CONTRAST MEDIA; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HYPERLIPOPROTEINEMIA TYPE II; SWINE; TIME FACTORS; TUNICA INTIMA; TUNICA MEDIA; VASA VASORUM;

EID: 77956838337     PISSN: 15252167     EISSN: 15322114     Source Type: Journal    
DOI: 10.1093/ejechocard/jeq048     Document Type: Article

References (21)

1. Viles-Gonzalez JF, Fuster V, Badimon JJ. Atherothrombosis: a widespread disease with unpredictable and life-threatening consequences. Eur Heart J 2004;25: 1197-207.
2. Schaar JA, Muller JE, Falk E, Virmani R, Fuster V, Serruys PW et al. Terminology for high-risk and vulnerable coronary artery plaques. Eur Heart J 2004;25:1077-82.
3. Gurfinkel E, Vigliano C, Janavel JV, Fornoni D, Caponi G, Meckert PC et al. Presence of vulnerable coronary plaques in middle-aged individuals who suffered a brain death. Eur Heart J 2009;30:2845-53.
4. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN et al. Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 2005;25:2054-61.
5. Barger AC, Beeuwkes R 3rd, Lainey LL, Silverman KJ. Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med 1984;310:175-7.
6. Fleiner M, Kummer M, Mirlacher M, Sauter G, Cathomas G, Krapf R et al. Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation 2004;110:2843-50.
7. Feinstein SB. Contrast ultrasound imaging of the carotid artery vasa vasorum and atherosclerotic plaque neovascularization. J Am Coll Cardiol 2006;48:236-43.
8. DeMaria AN, Narula J, Mahmud E, Tsimikas S. Imaging vulnerable plaque by ultrasound. J Am Coll Cardiol 2006;47:C32-C39.
9. Shah F, Balan P, Weinberg M, Reddy V, Neems R, Feinstein M et al. Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis? Vasc Med 2007;12: 291-7.
10. Coli S, Magnoni M, Sangiorgi G, Marrocco-Trischitta MM, Melisurgo G, Mauriello A et al. Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J Am Coll Cardiol 2008;52:223-30.
11. Giannoni MF, Vicenzini E, Citone M, Ricciardi MC, Irace L, Laurito A et al. Contrast carotid ultrasound for the detection of unstable plaques with neoangiogenesis: a pilot study. Eur J Vasc Endovasc Surg 2009;37:722-7.
12. Hasler-Rapacz J, Ellegren H, Fridolfsson AK, Kirkpatrick B, Kirk S, Andersson L et al. Identification of a mutation in the low density lipoprotein receptor gene associated with recessive familial hypercholesterolemia in swine. Am J Med Genet 1998;76:379-86.
13. Hasler-Rapacz J, Kempen HJ, Princen HM, Kudchodkar BJ, Lacko A, Rapacz J. Effects of simvastatin on plasma lipids and apolipoproteins in familial hypercholesterolemic swine. Arterioscler Thromb Vasc Biol 1996;16:137-43.
14. Institute of Laboratory Animal Resources. Guide for the Care and use of Laboratory Animals. Washington, DC: National Academy Press; 1996.
15. Granada JF, Wallace-Bradley D, Win HK, Alviar CL, Builes A, Lev EI et al. In vivo plaque characterization using intravascular ultrasound-virtual histology in a porcine model of complex coronary lesions. Arterioscler Thromb Vasc Biol 2007; 27:387-93.
16. Gerhard-Herman M, Gardin JM, Jaff M, Mohler E, Roman M, Naqvi TZ, American Society of Echocardiography; Society of Vascular Medicine, Biology. Guidelines for noninvasive vascular laboratory testing: a report from the American Society of Echocardiography and the Society of Vascular Medicine and Biology. J Am Soc Echocardiogr 2006;19:955-72.
17. Moreno PR, Purushothaman KR, Zias E, Sanz J, Fuster V. Neovascularization in human atherosclerosis. Curr Mol Med 2006;6:457-77.
18. Sluimer JC, Kolodgie FD, Bijnens AP, Maxfield K, Pacheco E, Kutys B et al. Thinwalled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol 2009;53:1517-27.
19. Hasler-Rapacz J, Prescott MF, Von Linden-Reed J, Rapacz JM Jr, Hu Z, Rapacz J. Elevated concentrations of plasma lipids and apolipoproteins B, C-III, and E are associated with the progression of coronary artery disease in familial hypercholesterolemic swine. Arterioscler Thromb Vasc Biol 1995;15:583-92.
20. Sahler LG, Davis D, Saad WE, Patel NC, Lee DE, Waldman DL. Comparison of vasa vasorum after intravascular stent placement with sirolimis drug-eluting and bare metal stents. J Med Imaging Radiat Oncol 2008;52:570-5.
21. Feinstein SB, Coll B, Staub D, Adam D, Schinkel AF, ten Cate FJ et al. Contrast enhanced ultrasound imaging. J Nucl Cardiol 2010;17:106-15.