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Volumn 6, Issue 4, 2010, Pages 469-477

Preclinical and clinical evidence of nephro- and cardiovascular protective effects of glycosaminoglycans

Author keywords

Cardiovascular diseases; Diabetic nephropathy; Glycosaminoglycans; Proteinuria; Sulodexide

Indexed keywords

AGRIN; ANGIOTENSIN II; ANTICOAGULANT AGENT; ANTILIPEMIC AGENT; COLLAGEN TYPE 18; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCOSAMINOGLYCAN; GROWTH FACTOR; HEPARIN; LIPOPROTEIN LIPASE; PERLECAN; SULODEXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77956833209     PISSN: 17341922     EISSN: None     Source Type: Journal    
DOI: 10.5114/aoms.2010.14456     Document Type: Review
Times cited : (10)

References (89)
  • 1
    • 0042073223 scopus 로고    scopus 로고
    • Clinical Epidemiology of Cardiovascular Disease in Chronic Kidney Disease Prior to Dialysis
    • DOI 10.1046/j.1525-139X.2003.16025.x
    • Levin A. Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis. Semin Dial 2003; 16: 101-5. (Pubitemid 37361072)
    • (2003) Seminars in Dialysis , vol.16 , Issue.2 , pp. 101-105
    • Levin, A.1
  • 2
    • 0001822934 scopus 로고    scopus 로고
    • Epidemiology of cardiac disease in dialysis patients
    • Sarnak MJ, Levey AS. Epidemiology of cardiac disease in dialysis patients. Semin Dial 1999; 12: 69-76.
    • (1999) Semin Dial , vol.12 , pp. 69-76
    • Sarnak, M.J.1    Levey, A.S.2
  • 3
    • 57349105118 scopus 로고    scopus 로고
    • Rationale and strategies for early detection and management of diabetic kidney disease
    • Radbill B, Murphy B, LeRoith D. Rationale and strategies for early detection and management of diabetic kidney disease. Mayo Clin Proc 2008; 83: 1373-81.
    • (2008) Mayo Clin Proc , vol.83 , pp. 1373-1381
    • Radbill, B.1    Murphy, B.2    LeRoith, D.3
  • 4
    • 55949124252 scopus 로고    scopus 로고
    • Advances in diabetes mellitus, diabetic nephropathy, metabolic syndrome and cardiovascular-renal risk
    • Martínez Castelao A. Advances in diabetes mellitus, diabetic nephropathy, metabolic syndrome and cardiovascular-renal risk. Nefrologia 2008; 28 Suppl 5: 79-84.
    • (2008) Nefrologia , vol.28 , Issue.SUPPL. 5 , pp. 79-84
    • Martínez Castelao, A.1
  • 5
    • 34547814203 scopus 로고    scopus 로고
    • Does early insulin treatment decrease the risk of microangiopathy in non-obese adults with diabetes
    • Rogowicz A, Litwinowicz M, Pilacinski S, Zozulinska D, Wierusz-Wysocka B. Does early insulin treatment decrease the risk of microangiopathy in non-obese adults with diabetes. Arch Med Sci 2007; 3: 129-35.
    • (2007) Arch Med Sci , vol.3 , pp. 129-135
    • Rogowicz, A.1    Litwinowicz, M.2    Pilacinski, S.3    Zozulinska, D.4    Wierusz-Wysocka, B.5
  • 6
    • 55949127699 scopus 로고    scopus 로고
    • The relationship between proteinuria and coronary risk: A systematic review and meta-analysis
    • Perkovic V, Verdon C, Ninomiya T, et al. The relationship between proteinuria and coronary risk: a systematic review and meta-analysis. PLoS Med 2008; 5: e207.
    • (2008) PLoS Med , vol.5
    • Perkovic, V.1    Verdon, C.2    Ninomiya, T.3
  • 7
    • 60249095827 scopus 로고    scopus 로고
    • Decreased kidney function as a risk factor for cardiovascular events in subjects with metabolic syndrome - A pilot study
    • Barylski M, Banach M, Mikhailidis DP, Pawlicki L, Kowalski J. Decreased kidney function as a risk factor for cardiovascular events in subjects with metabolic syndrome - a pilot study. Arch Med Sci 2008; 4: 417-23.
    • (2008) Arch Med Sci , vol.4 , pp. 417-423
    • Barylski, M.1    Banach, M.2    Mikhailidis, D.P.3    Pawlicki, L.4    Kowalski, J.5
  • 8
    • 34748862301 scopus 로고    scopus 로고
    • Microalbuminuria and cardiovascular disease
    • Weir MR. Microalbuminuria and cardiovascular disease. Clin J Am Soc Nephrol 2007; 2: 581-90.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 581-590
    • Weir, M.R.1
  • 10
    • 0343201238 scopus 로고
    • Presence of heparan sulphate in the glomerular basement membranes
    • Kanwar YS, Farquhar MG. Presence of heparan sulphate in the glomerular basement membranes. Proc Natl Acad Sci U S A 1979; 76: 1303-7.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 1303-1307
    • Kanwar, Y.S.1    Farquhar, M.G.2
  • 11
    • 0018320289 scopus 로고
    • Isolation of glycosaminoglycans (heparin sulphate) from glomerular basement membranes
    • Kanwar YS, Farquhar MG. Isolation of glycosaminoglycans (heparin sulphate) from glomerular basement membranes. Proc Natl Acad Sci U S A 1979; 76: 4493.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 4493
    • Kanwar, Y.S.1    Farquhar, M.G.2
  • 12
    • 0019304713 scopus 로고
    • Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans heparin sulphate by enzyme digestion
    • Kanwar YS, Linker A, Farquhar MG. Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans heparin sulphate) by enzyme digestion. J Cell Biol 1980; 86: 688-93.
    • (1980) J Cell Biol , vol.86 , pp. 688-693
    • Kanwar, Y.S.1    Linker, A.2    Farquhar, M.G.3
  • 13
    • 15744403559 scopus 로고    scopus 로고
    • Structural Insights into biological roles of protein-glycosaminoglycan interactions
    • DOI 10.1016/j.chembiol.2004.11.020
    • Raman R, Sasisekharan V, Sasisekharan R. Structural insights into biological roles of protein-glycosaminoglycan interactions. Chem Biol 2005; 12: 267-77. (Pubitemid 40406273)
    • (2005) Chemistry and Biology , vol.12 , Issue.3 , pp. 267-277
    • Raman, R.1    Sasisekharan, V.2    Sasisekharan, R.3
  • 15
    • 55249098128 scopus 로고    scopus 로고
    • Revisiting the glomerular charge barrier in the molecular era
    • Harvey SJ, Miner JH. Revisiting the glomerular charge barrier in the molecular era. Curr Opin Nephrol Hypertens 2008; 17: 393-8.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 393-398
    • Harvey, S.J.1    Miner, J.H.2
  • 16
    • 47349130832 scopus 로고    scopus 로고
    • Glomerular filtration: The charge debate charges ahead
    • Miner JH. Glomerular filtration: the charge debate charges ahead. Kidney Int 2008; 74: 259-61.
    • (2008) Kidney Int , vol.74 , pp. 259-261
    • Miner, J.H.1
  • 17
    • 0027312478 scopus 로고
    • Distribution of GBM heparin sulphate proteoglycan core protein and side chanins in human glomerular disease
    • van der Born J, van del Havuel L, Bakker M, et al. Distribution of GBM heparin sulphate proteoglycan core protein and side chanins in human glomerular disease. Kidney Int 1993; 43: 454-63.
    • (1993) Kidney Int , vol.43 , pp. 454-463
    • Van Der Born, J.1    Van Del Havuel, L.2    Bakker, M.3
  • 18
    • 0028297289 scopus 로고
    • Expression of glomerular extracellular matrix components in human diabetic nephropathy: Decrease of heparin sulphate in the glomerular basal membrane
    • Tamsma J, van der Born J, Bruijn J, et al. Expression of glomerular extracellular matrix components in human diabetic nephropathy: decrease of heparin sulphate in the glomerular basal membrane. Diabetologia 1994; 37: 313-20.
    • (1994) Diabetologia , vol.37 , pp. 313-320
    • Tamsma, J.1    Van Der Born, J.2    Bruijn, J.3
  • 19
    • 0032842107 scopus 로고    scopus 로고
    • Reduction in glomerular heparin sulphate correlates with complement deposition and albuminuria in active Heymann nephritis
    • Raats C, Luca M, Bakker M, et al. Reduction in glomerular heparin sulphate correlates with complement deposition and albuminuria in active Heymann nephritis. J Am Soc Nephrol 1999; 10: 1689-99.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1689-1699
    • Raats, C.1    Luca, M.2    Bakker, M.3
  • 20
    • 0028891176 scopus 로고
    • Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparin sulphate
    • van den Born J, van Kraats AA, Bakker MA, et al. Selective proteinuria in diabetic nephropathy in the rat is associated with a relative decrease in glomerular basement membrane heparin sulphate. Diabetologia 1995; 38: 161-72.
    • (1995) Diabetologia , vol.38 , pp. 161-172
    • Van Den Born, J.1    Van Kraats, A.A.2    Bakker, M.A.3
  • 21
    • 47349084411 scopus 로고    scopus 로고
    • Loss of heparin sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria
    • Chen S, Wassenhove-McCarthy DJ, Yamaguchi Y, et al. Loss of heparin sulfate glycosaminoglycan assembly in podocytes does not lead to proteinuria. Kidney Int 2008; 74: 289-99.
    • (2008) Kidney Int , vol.74 , pp. 289-299
    • Chen, S.1    Wassenhove-McCarthy, D.J.2    Yamaguchi, Y.3
  • 22
    • 0029013068 scopus 로고
    • Charge selectivity in kidney ultrafiltration
    • Comper WD, Glascow EF. Charge selectivity in kidney ultrafiltration. Kidney Int 1995; 47: 1242-51.
    • (1995) Kidney Int , vol.47 , pp. 1242-1251
    • Comper, W.D.1    Glascow, E.F.2
  • 24
    • 26944476342 scopus 로고    scopus 로고
    • Heparan sulphate of perlecan is involved in glomerular filtration
    • Morita H, Yoshimura A, Inui K, et al. Heparan sulphate of perlecan is involved in glomerular filtration. J Am Soc Nephrol 2005; 16: 1703-10.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 1703-1710
    • Morita, H.1    Yoshimura, A.2    Inui, K.3
  • 25
    • 5744238949 scopus 로고    scopus 로고
    • Structurally altered besement membranes and hydrocephalus in a type XVIII collagen deficient mouse line
    • Utriainen A, Sormunen R, Kettunen M, et al. Structurally altered besement membranes and hydrocephalus in a type XVIII collagen deficient mouse line. Hum Mol Genet 2004; 13: 2089-99.
    • (2004) Hum Mol Genet , vol.13 , pp. 2089-2099
    • Utriainen, A.1    Sormunen, R.2    Kettunen, M.3
  • 26
    • 33645384150 scopus 로고    scopus 로고
    • Podocyte derived agrin is responsible for glomerular basement membrane anionic charge
    • Abstract
    • Harvey S, Burgess R, Miner J. Podocyte derived agrin is responsible for glomerular basement membrane anionic charge [Abstract]. J Am Soc Nephrol 2005; 16: 1A.
    • (2005) J Am Soc Nephrol , vol.16
    • Harvey, S.1    Burgess, R.2    Miner, J.3
  • 27
    • 67651089928 scopus 로고    scopus 로고
    • Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulphate from the glomerular basement membrane
    • Goldberg S, Harvey SJ, Cunningham J, Tryggvason K, Miner JH. Glomerular filtration is normal in the absence of both agrin and perlecan-heparan sulphate from the glomerular basement membrane. Nephrol Dial Transplant 2009; 24: 2044-51.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 2044-2051
    • Goldberg, S.1    Harvey, S.J.2    Cunningham, J.3    Tryggvason, K.4    Miner, J.H.5
  • 28
    • 33947254378 scopus 로고    scopus 로고
    • In vivo degradation of heparan sulphates in the glomerular basement membrane does not result in proteinuria
    • Winjhoven TJ, Lensen JF, Wismans RG, et al. In vivo degradation of heparan sulphates in the glomerular basement membrane does not result in proteinuria. J Am Soc Nephrol 2007; 18: 823-32.
    • (2007) J Am Soc Nephrol , vol.18 , pp. 823-832
    • Winjhoven, T.J.1    Lensen, J.F.2    Wismans, R.G.3
  • 29
    • 38349013416 scopus 로고    scopus 로고
    • Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria
    • Celie JW, Reijmers RM, Slot EM, et al. Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria. Am J Physiol Renal Physiol 2008; 294: F253-63.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Celie, J.W.1    Reijmers, R.M.2    Slot, E.M.3
  • 30
    • 0037968713 scopus 로고    scopus 로고
    • Collagen XVIII a basement membrane heparin sulphate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1
    • Kawashima H, Watanabe N, Hirose M, et al. Collagen XVIII a basement membrane heparin sulphate proteoglycan, interacts with L-selectin and monocyte chemoattractant protein-1. J Biol Chem 2003; 278: 13069-76.
    • (2003) J Biol Chem , vol.278 , pp. 13069-13076
    • Kawashima, H.1    Watanabe, N.2    Hirose, M.3
  • 31
    • 33748048179 scopus 로고    scopus 로고
    • Role of heparin sulphate I in inflammation
    • Parish CR. Role of heparin sulphate I in inflammation. Nat Rev Immunol 2006; 6: 633-43.
    • (2006) Nat Rev Immunol , vol.6 , pp. 633-643
    • Parish, C.R.1
  • 32
    • 24944451114 scopus 로고    scopus 로고
    • Endothelial heparan sulfate deficiency impairs L-selectin- And chemokine-mediated neutrophil trafficking during inflammatory responses
    • DOI 10.1038/ni1233, PII N1233
    • Wang L, Fuster M, Sriramarao P, Esko JD. Endothelial heparin sulphate deficiency impairs L-selectin - and chemokine-mediated neutrophile trafficking during inflammatory responses. Nat Immunol 2005; 6: 902-10. (Pubitemid 43090445)
    • (2005) Nature Immunology , vol.6 , Issue.9 , pp. 902-910
    • Wang, L.1    Fuster, M.2    Sriramarao, P.3    Esko, J.D.4
  • 33
    • 37249038716 scopus 로고    scopus 로고
    • Heparan sulphate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking
    • Rops AL, van der Hoven MJ, Baselmans MM, et al. Heparan sulphate domains on cultured activated glomerular endothelial cells mediate leukocyte trafficking. Kidney Int 2008; 73: 52-62.
    • (2008) Kidney Int , vol.73 , pp. 52-62
    • Rops, A.L.1    Van Der Hoven, M.J.2    Baselmans, M.M.3
  • 34
    • 0034529045 scopus 로고    scopus 로고
    • Lipoprotein modulation of seubendothelial heparin sulphate proteoglycans (perlecan) and atherogenicity
    • Pillarisetti S. Lipoprotein modulation of seubendothelial heparin sulphate proteoglycans (perlecan) and atherogenicity. Trends Cardiovasc Med 2000; 10: 60-5.
    • (2000) Trends Cardiovasc Med , vol.10 , pp. 60-65
    • Pillarisetti, S.1
  • 35
    • 34447312221 scopus 로고    scopus 로고
    • Subendothelial heparan sulphate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion
    • Celie JW, Rutjes NW, Keuning ED, et al. Subendothelial heparan sulphate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion. Am J Pathol 2007; 170: 1865-78.
    • (2007) Am J Pathol , vol.170 , pp. 1865-1878
    • Celie, J.W.1    Rutjes, N.W.2    Keuning, E.D.3
  • 36
    • 34047111300 scopus 로고    scopus 로고
    • Heparan sulphate on activated glomerular endothelial cells and exogenious heparinoids influence the rolling and adhesion of leuckocytes
    • Rops AL, Jacobs CW, Linssen PC, et al. Heparan sulphate on activated glomerular endothelial cells and exogenious heparinoids influence the rolling and adhesion of leuckocytes. Nephrol Dial Transplant 2007; 22: 1070-7.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 1070-1077
    • Rops, A.L.1    Jacobs, C.W.2    Linssen, P.C.3
  • 37
    • 0034677943 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action
    • Jones M, Tussey M, Athanasou N, Jackson DG. Heparan sulphate proteoglycan isoforms of the CD44 hyaluronan receptor induced in human inflammatory macrophages can function as paracrine regulators of fibroblast growth factor action. J Biol Chem 2000; 275: 7964-74.
    • (2000) J Biol Chem , vol.275 , pp. 7964-7974
    • Jones, M.1    Tussey, M.2    Athanasou, N.3    Jackson, D.G.4
  • 38
    • 30744451472 scopus 로고    scopus 로고
    • Glycosaminoglycans and their proteoglycans; host-associated molecular aptterns for initiation and modulation of inflammation
    • Taylor KR, Gallo RL. Glycosaminoglycans and their proteoglycans; host-associated molecular aptterns for initiation and modulation of inflammation. FASEB J 2006; 20: 9-22.
    • (2006) FASEB J , vol.20 , pp. 9-22
    • Taylor, K.R.1    Gallo, R.L.2
  • 40
    • 41149087185 scopus 로고    scopus 로고
    • Abnormal glomerular permeability characteristics in diabetic nephropathy, implications for the therapeutic use of low-molecular weight heparin
    • Lewis EJ, Xu X. Abnormal glomerular permeability characteristics in diabetic nephropathy, implications for the therapeutic use of low-molecular weight heparin. Diabetes Care 2008; 31 Suppl 2: S202-7.
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2
    • Lewis, E.J.1    Xu, X.2
  • 41
    • 34347375504 scopus 로고    scopus 로고
    • Heparanase upregulation in high glucose-treated endothelial cells is prevented by insulin and heparin
    • Han J, Woytowitch AE, Mandal AK, Hiebert LM. Heparanase upregulation in high glucose-treated endothelial cells is prevented by insulin and heparin. Exp Biol Med (Maywood) 2007; 232: 927-34. (Pubitemid 47026799)
    • (2007) Experimental Biology and Medicine , vol.232 , Issue.7 , pp. 927-934
    • Han, J.1    Woytowich, A.E.2    Mandal, A.K.3    Hiebert, L.M.4
  • 42
    • 37548999851 scopus 로고    scopus 로고
    • Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy
    • Wijnhoven TJ, van den Hoven MJ, Ding H, et al. Heparanase induces a differential loss of heparan sulphate domains in overt diabetic nephropathy. Diabetologia 2008; 51: 372-82.
    • (2008) Diabetologia , vol.51 , pp. 372-382
    • Wijnhoven, T.J.1    Van Den Hoven, M.J.2    Ding, H.3
  • 43
    • 0030921674 scopus 로고    scopus 로고
    • Pathogenesis of diabetic vascular disease, evidence for the role of reduced heparin sulphate proteoglycan
    • Jensen T. Pathogenesis of diabetic vascular disease, evidence for the role of reduced heparin sulphate proteoglycan. Diabetes 1997; 46 Suppl 2: S98-100.
    • (1997) Diabetes , vol.46 , Issue.SUPPL. 2
    • Jensen, T.1
  • 44
    • 34547887952 scopus 로고    scopus 로고
    • Anti-proteinuric effects of glycosaminoglycan-based drugs
    • Wijnhoven TJ, Lensen JF, Rops AL, et al. Anti-proteinuric effects of glycosaminoglycan-based drugs. Curr Opin Mol Ther 2007; 9: 364-77.
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 364-377
    • Wijnhoven, T.J.1    Lensen, J.F.2    Rops, A.L.3
  • 45
    • 34548522237 scopus 로고    scopus 로고
    • Proteinuria-lowering effect of heparin therapy in diabetic nephropathy without affecting the renin-angiotensinaldosterone system
    • Benck U, Haeckel S, Clorius JH, van der Woude FJ. Proteinuria-lowering effect of heparin therapy in diabetic nephropathy without affecting the renin-angiotensinaldosterone system. Clin J Am Soc Nephrol 2007; 2: 58-67.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 58-67
    • Benck, U.1    Haeckel, S.2    Clorius, J.H.3    Van Der Woude, F.J.4
  • 46
    • 39449132487 scopus 로고    scopus 로고
    • Emerging therapeutic strategies in diabetic nephropathy
    • Ravera M, Re M, Weiss U, Deferrari L, Deferrari G. Emerging therapeutic strategies in diabetic nephropathy. J Nephrol 2007; 20 Suppl 12: S23-32.
    • (2007) J Nephrol , vol.20 , Issue.SUPPL. 12
    • Ravera, M.1    Re, M.2    Weiss, U.3    Deferrari, L.4    Deferrari, G.5
  • 47
    • 0347994931 scopus 로고    scopus 로고
    • Angiotensin II Type 1-Receptor Mediated Changes in Heparan Sulfate Proteoglycans in Human SV40 Transformed Podocytes
    • DOI 10.1097/01.ASN.0000102476.50041.44
    • Brinkkoetter PT, Holtgrefe S, van der Woude FJ, Yard BA. Angiotensin II type-1 receptor mediated changes in heparan sulphate proteoglycans in human SV40 transformed podocytes. J Am Soc Nephrol 2004; 15: 33-40. (Pubitemid 38020695)
    • (2004) Journal of the American Society of Nephrology , vol.15 , Issue.1 , pp. 33-40
    • Brinkkoetter, P.-T.1    Holtgrefe, S.2    Van Der Woude, F.J.3    Yard, B.A.4
  • 49
    • 0029000397 scopus 로고
    • Heparin induced aldosterone suppression and hyperkalemia
    • Oster JR, Singer I, Fishman LM. Heparin induced aldosterone suppression and hyperkalemia. Am J Med 1995; 98: 575-86.
    • (1995) Am J Med , vol.98 , pp. 575-586
    • Oster, J.R.1    Singer, I.2    Fishman, L.M.3
  • 50
    • 53549090148 scopus 로고    scopus 로고
    • Agents in development for the treatment of diabetic nephropathy
    • Goh SY, Jasik M, Cooper ME. Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs 2008; 13: 447-63.
    • (2008) Expert Opin Emerg Drugs , vol.13 , pp. 447-463
    • Goh, S.Y.1    Jasik, M.2    Cooper, M.E.3
  • 51
    • 36849053427 scopus 로고    scopus 로고
    • The role of sulodexide in the treatment of diabetic nephropathy
    • Weiss R, Niecestro R, Raz I. The role of sulodexide in the treatment of diabetic nephropathy. Drugs 2007; 67: 2681-96.
    • (2007) Drugs , vol.67 , pp. 2681-2696
    • Weiss, R.1    Niecestro, R.2    Raz, I.3
  • 52
    • 0022413890 scopus 로고
    • Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part II: Organ distribution in rats
    • Ruggeri A, Guizzardi S, Franchi M, Morocutti M, Mastacchi R. Pharmacokinetics and distribution of a fluoresceinated glycosaminoglycan, sulodexide, in rats. Part II: Organ distribution in rats. Arzneimittelforschung 1985; 35: 1517-9.
    • (1985) Arzneimittelforschung , vol.35 , pp. 1517-1519
    • Ruggeri, A.1    Guizzardi, S.2    Franchi, M.3    Morocutti, M.4    Mastacchi, R.5
  • 53
    • 0030634791 scopus 로고    scopus 로고
    • The efficacy of sulodexide - A low-molecular heparin - In the therapy of diabetic nephropathy
    • Shestakova MV, Chugunova LA, Vorontsov AV, Dedov II. The efficacy of sulodexide - a low-molecular heparin - in the therapy of diabetic nephropathy. Ter Arkh 1997; 69: 34-7.
    • (1997) Ter Arkh , vol.69 , pp. 34-37
    • Shestakova, M.V.1    Chugunova, L.A.2    Vorontsov, A.V.3    Dedov, I.I.4
  • 54
    • 58649103570 scopus 로고    scopus 로고
    • Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes
    • Campo GM, Avenoso A, Campo S, et al. Glycosaminoglycans modulate inflammation and apoptosis in LPS-treated chondrocytes. J Cell Biochem 2009; 106: 83-92.
    • (2009) J Cell Biochem , vol.106 , pp. 83-92
    • Campo, G.M.1    Avenoso, A.2    Campo, S.3
  • 57
    • 45849133109 scopus 로고    scopus 로고
    • Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats
    • Kristová V, Lísková S, Sotníková R, Vojtko R, Kurtanský A. Sulodexide improves endothelial dysfunction in streptozotocin-induced diabetes in rats. Physiol Res 2008; 57: 491-4.
    • (2008) Physiol Res , vol.57 , pp. 491-494
    • Kristová, V.1    Lísková, S.2    Sotníková, R.3    Vojtko, R.4    Kurtanský, A.5
  • 58
    • 0034931606 scopus 로고    scopus 로고
    • Glycosaminoglycans, airways inflammation and bronchial hyperresponsiveness
    • Lever R, Page C. Glycosaminoglycans, airways inflammation and bronchial hyperresponsiveness. Pulm Pharmacol Ther 2001; 14: 249-54.
    • (2001) Pulm Pharmacol Ther , vol.14 , pp. 249-254
    • Lever, R.1    Page, C.2
  • 59
    • 0030071492 scopus 로고    scopus 로고
    • Effect of sulphated glycosaminoglycans on proteinuria in patients with overt diabetic (type 1) nephropathy
    • Tamsma JT, van der Woude FJ, Lemkes HH. Effect of sulphated glycosaminoglycans on proteinuria in patients with overt diabetic (type 1) nephropathy. Nephrol Dial Transplant 1996; 11: 182-5.
    • (1996) Nephrol Dial Transplant , vol.11 , pp. 182-185
    • Tamsma, J.T.1    Van Der Woude, F.J.2    Lemkes, H.H.3
  • 60
    • 0036014944 scopus 로고    scopus 로고
    • Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric and type 1 and type 2 diabetic patients; the Di.N.A.S. randomized trial
    • Gambaro G, Kinalska Oksa A, Pont'uch P, et al. Oral sulodexide reduces albuminuria in microalbuminuric and macroalbuminuric and type 1 and type 2 diabetic patients; the Di.N.A.S. randomized trial. J Am Soc Nephr 2002; 13: 1615-25.
    • (2002) J Am Soc Nephr , vol.13 , pp. 1615-1625
    • Gambaro, G.1    Kinalska Oksa, A.2    Pont'uch, P.3
  • 61
    • 33846443180 scopus 로고    scopus 로고
    • Effect of sulodexide on albuminuria, NAG excretion and glomerular filtration response to dopamine in diabetic patients
    • Sulikowska B, Olejniczak H, Muszynska M, et al. Effect of sulodexide on albuminuria, NAG excretion and glomerular filtration response to dopamine in diabetic patients. Am J Nephrol 2006; 26: 621-8.
    • (2006) Am J Nephrol , vol.26 , pp. 621-628
    • Sulikowska, B.1    Olejniczak, H.2    Muszynska, M.3
  • 62
    • 10644232891 scopus 로고    scopus 로고
    • Effect of 12-month therapy with omega-3 polyunsaturated acids on glomerular filtration response to dopamine in IgA nephropathy
    • DOI 10.1159/000080670
    • Sulikowska B, Nieweglowski T, Manitius J, Lisiak-Szydlowska W, Rutkowski B. Effect of 12 month therapy with omega-3 polyunsaturated acids on glomerular filtration response to dopamine in IgA nephropathy. Am J Nephrol 2004; 24: 474-82. (Pubitemid 39656661)
    • (2004) American Journal of Nephrology , vol.24 , Issue.5 , pp. 474-482
    • Sulikowska, B.1    Nieweglowski, T.2    Manitius, J.3    Lysiak-Szydlowska, W.4    Rutkowski, B.5
  • 63
    • 0031005065 scopus 로고    scopus 로고
    • A pilot study of the effect of the glycosaminoglycan sulodexide on microalbuminuria in type I diabetic patients
    • Szelachowska M, Poplawska A, Topolska J, Kinalska I, Grimaldi M. A pilot study of the effect of the glycosaminoglycan sulodexide on microalbuminuria in type I diabetic patients. Curr Med Res Opin 1997; 13: 539-45.
    • (1997) Curr Med Res Opin , vol.13 , pp. 539-545
    • Szelachowska, M.1    Poplawska, A.2    Topolska, J.3    Kinalska, I.4    Grimaldi, M.5
  • 64
    • 0030931210 scopus 로고    scopus 로고
    • Glycosaminoglycans as a possible tool for micro- and macroalbuminuria in diabetic patients. A pilot study
    • Sorrenti G, Grimaldi M, Canova N, Palazzini E, Melchionda N. Glycosaminoglycans as a possible tool for micro- and macroalbuminuria in diabetic patients. A pilot study. J Int Med Res 1997; 25: 81-6.
    • (1997) J Int Med Res , vol.25 , pp. 81-86
    • Sorrenti, G.1    Grimaldi, M.2    Canova, N.3    Palazzini, E.4    Melchionda, N.5
  • 65
    • 0030957881 scopus 로고    scopus 로고
    • Glycosaminoglycans delay the progression of nephropathy in NIDDM
    • Solini A, Vergnani L, Ricci F, Crepaldi G. Glycosaminoglycans delay the progression of nephropathy in NIDDM. Diabetes Care 1997; 20: 819-23. (Pubitemid 27202534)
    • (1997) Diabetes Care , vol.20 , Issue.5 , pp. 819-823
    • Solini, A.1    Vergnani, L.2    Ricci, F.3    Crepaldi, G.4
  • 66
    • 0342327339 scopus 로고    scopus 로고
    • Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients
    • Skrha J, Perusicová J, Pont'uch P, Oksa A. Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients. Diabetes Res Clin Pract 1997; 38: 25-31.
    • (1997) Diabetes Res Clin Pract , vol.38 , pp. 25-31
    • Skrha, J.1    Perusicová, J.2    Pont'uch, P.3    Oksa, A.4
  • 67
    • 0030719936 scopus 로고    scopus 로고
    • A randomized, controlled study of sulodexide therapy for the treatment of diabetic nephropathy
    • Dedov I, Shestakova M, Vorontzov A, Palazzini E. A randomized, controlled study of sulodexide therapy for the treatment of diabetic nephropathy. Nephrol Dial Transplant 1997; 12: 2295-300.
    • (1997) Nephrol Dial Transplant , vol.12 , pp. 2295-2300
    • Dedov, I.1    Shestakova, M.2    Vorontzov, A.3    Palazzini, E.4
  • 68
    • 0031408776 scopus 로고    scopus 로고
    • Effect of glycosaminoglycans on urinary albumin excretion in insulin-dependent diabetic patients with micro- or macroalbuminuria
    • Poplawska A, Szelachowska M, Topolska J, Wysocka-Solowie B, Kinalska I. Effect of glycosaminoglycans on urinary albumin excretion in insulin-dependent diabetic patients with micro- or macroalbuminuria. Diabetes Res Clin Pract 1997; 38: 109-14.
    • (1997) Diabetes Res Clin Pract , vol.38 , pp. 109-114
    • Poplawska, A.1    Szelachowska, M.2    Topolska, J.3    Wysocka-Solowie, B.4    Kinalska, I.5
  • 69
    • 0031265478 scopus 로고    scopus 로고
    • The effect of sulodexide, a glycosaminoglycan, on albuminuria in diabetic patients
    • Perusicová J, Skrha J. The effect of sulodexide, a glycosaminoglycan, on albuminuria in diabetic patients. Vnitr Lek 1997; 43: 748-52.
    • (1997) Vnitr Lek , vol.43 , pp. 748-752
    • Perusicová, J.1    Skrha, J.2
  • 70
    • 0031627018 scopus 로고    scopus 로고
    • A trial of the use of the low-molecular heparin sulodexide in the therapy of diabetic nephropathy
    • Zalevskaia AG, Astamirova KhS, Karpova IA, Popova SG. A trial of the use of the low-molecular heparin sulodexide in the therapy of diabetic nephropathy. Ter Arkh 1998; 70: 71-4.
    • (1998) Ter Arkh , vol.70 , pp. 71-74
    • Zalevskaia, A.G.1    Astamirova, Kh.S.2    Karpova, I.A.3    Popova, S.G.4
  • 72
    • 0032253183 scopus 로고    scopus 로고
    • The effect of glycosaminoglycan sulodexide on oxidative stress and fibrinolysis in diabetes mellitus
    • Skrha J, Perusicová J, Kvasnicka J, Hilgertová J. The effect of glycosaminoglycan sulodexide on oxidative stress and fibrinolysis in diabetes mellitus. Sb Lek 1998; 99: 103-9.
    • (1998) Sb Lek , vol.99 , pp. 103-109
    • Skrha, J.1    Perusicová, J.2    Kvasnicka, J.3    Hilgertová, J.4
  • 73
    • 0033182928 scopus 로고    scopus 로고
    • The effect of glycosaminoglycan sulodexide on albuminuria in patients with diabetes mellitus
    • Oksa A, Pontuch P, Kratochvilova H. The effect of glycosaminoglycan sulodexide on albuminuria in patients with diabetes mellitus. Bratisl Lek Listy 1999; 100: 486-9.
    • (1999) Bratisl Lek Listy , vol.100 , pp. 486-489
    • Oksa, A.1    Pontuch, P.2    Kratochvilova, H.3
  • 74
  • 75
    • 44449145518 scopus 로고    scopus 로고
    • Effects of sulodexide in patients with type 2 diabetes and persistent albuminuria
    • Collaborative Study Group
    • Heerspink HL, Greene T, Lewis JB, et al.; Collaborative Study Group. Effects of sulodexide in patients with type 2 diabetes and persistent albuminuria. Nephrol Dial Transplant 2008; 23: 1946-54.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 1946-1954
    • Heerspink, H.L.1    Greene, T.2    Lewis, J.B.3
  • 76
    • 35448943234 scopus 로고    scopus 로고
    • Rationale for and study design of the sulodexide trials in Type 2 diabetic, hypertensive patients with microalbuminuria or overt nephropathy
    • Collaborative Study Group
    • Lambers Heerspink HJ, Fowler MJ, Volgi J, et al.; Collaborative Study Group. Rationale for and study design of the sulodexide trials in Type 2 diabetic, hypertensive patients with microalbuminuria or overt nephropathy. Diabet Med 2007; 24: 1290-5.
    • (2007) Diabet Med , vol.24 , pp. 1290-1295
    • Lambers Heerspink, H.J.1    Fowler, M.J.2    Volgi, J.3
  • 77
    • 70349243437 scopus 로고    scopus 로고
    • Emerging therapies for chronic kidney disease: What is their role?
    • Vilayur E, Harris DC. Emerging therapies for chronic kidney disease: what is their role? Nat Rev Nephrol 2009; 5: 375-83.
    • (2009) Nat Rev Nephrol , vol.5 , pp. 375-383
    • Vilayur, E.1    Harris, D.C.2
  • 78
    • 33746614761 scopus 로고    scopus 로고
    • Interactions between heparan sulphate and proteins: The concept of specificity
    • Kreguger J, Spillmann D, Li J, Lindahl U. Interactions between heparan sulphate and proteins: the concept of specificity. J Cell Biol 2006; 174: 323-7.
    • (2006) J Cell Biol , vol.174 , pp. 323-327
    • Kreguger, J.1    Spillmann, D.2    Li, J.3    Lindahl, U.4
  • 79
    • 0022687523 scopus 로고
    • Proteoglycans and hypertension 1. A biochemical and ultrastructural study of arta glycosaminoglycans in spontaneously hypertensive rats
    • Reynertson RH, Parmley RT, Rodén L, Oparil S. Proteoglycans and hypertension 1. A biochemical and ultrastructural study of arta glycosaminoglycans in spontaneously hypertensive rats. Coll Relat Res 1986; 6: 77-101.
    • (1986) Coll Relat Res , vol.6 , pp. 77-101
    • Reynertson, R.H.1    Parmley, R.T.2    Rodén, L.3    Oparil, S.4
  • 80
    • 76049101885 scopus 로고    scopus 로고
    • Effect of sulodexide on plasma transforming growth factor-beta1 in healthy volunteers
    • Borawski J, Dubowski M, Pawlak K, Mysliwiec M. Effect of sulodexide on plasma transforming growth factor-beta1 in healthy volunteers. Clin Appl Thromb Hemost 2010; 16: 60-5.
    • (2010) Clin Appl Thromb Hemost , vol.16 , pp. 60-65
    • Borawski, J.1    Dubowski, M.2    Pawlak, K.3    Mysliwiec, M.4
  • 81
    • 0022648042 scopus 로고
    • The use of sulodexide in the treatment of peripheral vasculopathy accompanying metabolic diseases. Controlled study in hyperlipidemic and diabetic subjects
    • Pisano L, Moronesi F, Falco F, et al. The use of sulodexide in the treatment of peripheral vasculopathy accompanying metabolic diseases. Controlled study in hyperlipidemic and diabetic subjects. Thromb Res 1986; 41: 23-31.
    • (1986) Thromb Res , vol.41 , pp. 23-31
    • Pisano, L.1    Moronesi, F.2    Falco, F.3
  • 82
    • 0025264190 scopus 로고
    • Double-blind multicenter trial on a new medium molecular weight glycosaminoglycan. Current therapeutic effects and perspectives for clinical use
    • Crepaldi G, Fellin R, Calabró A, et al. Double-blind multicenter trial on a new medium molecular weight glycosaminoglycan. Current therapeutic effects and perspectives for clinical use. Atherosclerosis 1990; 81: 233-43.
    • (1990) Atherosclerosis , vol.81 , pp. 233-243
    • Crepaldi, G.1    Fellin, R.2    Calabró, A.3
  • 83
    • 0021861851 scopus 로고
    • Effect of sulodexide on hemorheological parameters in a group of patients with peripheral atherosclerotic vascular disease
    • Calabrò A, Rossi A, Baiocchi MR, Coscetti G, Fellin R, Crepaldi G. Effect of sulodexide on hemorheological parameters in a group of patients with peripheral atherosclerotic vascular disease. Ric Clin Lab 1985; 15 Suppl 1: 455-63.
    • (1985) Ric Clin Lab , vol.15 , Issue.SUPPL. 1 , pp. 455-463
    • Calabrò, A.1    Rossi, A.2    Baiocchi, M.R.3    Coscetti, G.4    Fellin, R.5    Crepaldi, G.6
  • 84
    • 34547632760 scopus 로고    scopus 로고
    • Effects of sulodexide on hemostatic factors, lipid profile and inflammation in chronic peritoneal dialysis patients
    • Kim SB, Kim SH, Lee MS, Chang JW, Lee SK, Park JS. Effects of sulodexide on hemostatic factors, lipid profile and inflammation in chronic peritoneal dialysis patients. Perit Dial Int 2007; 27: 456-60.
    • (2007) Perit Dial Int , vol.27 , pp. 456-460
    • Kim, S.B.1    Kim, S.H.2    Lee, M.S.3    Chang, J.W.4    Lee, S.K.5    Park, J.S.6
  • 85
    • 0036660264 scopus 로고    scopus 로고
    • Sulodexide in the treatment of intermittent claudication. Results of a randomized, double-blind, multicentre, placebo-controlled study
    • Arterial Arm of the Suavis (Sulodexide Arterial Venous Italian Study Group)
    • Coccheri S, Scondotto G, Agnelli G, Palazzini E, Zamboni V; Arterial Arm of the Suavis (Sulodexide Arterial Venous Italian Study Group). Sulodexide in the treatment of intermittent claudication. Results of a randomized, double-blind, multicentre, placebo-controlled study. Eur Heart J 2002; 23: 1057-65.
    • (2002) Eur Heart J , vol.23 , pp. 1057-1065
    • Coccheri, S.1    Scondotto, G.2    Agnelli, G.3    Palazzini, E.4    Zamboni, V.5
  • 86
    • 0031974383 scopus 로고    scopus 로고
    • Review of pharmacodynamics, pharmacokinetics, and therapeutic properties of sulodexide
    • DOI 10.1002/(SICI)1098-1128(199801)18:1<1::AID-MED1>3.0.CO;2-4
    • Harenberg J. Review of pharmacodynamics, pharmacokinetics and therapeutic properties of sulodexide. Med Res Rev 1998; 18: 1-20. (Pubitemid 28037477)
    • (1998) Medicinal Research Reviews , vol.18 , Issue.1 , pp. 1-20
    • Harenberg, J.1
  • 87
    • 33847767217 scopus 로고    scopus 로고
    • Sulodexide a renewed interest in this glycosaminoglycan
    • Lauver DA, Lucchesi BR. Sulodexide a renewed interest in this glycosaminoglycan. Cardiovasc Drug Rev 2006; 24: 214-26.
    • (2006) Cardiovasc Drug Rev , vol.24 , pp. 214-226
    • Lauver, D.A.1    Lucchesi, B.R.2
  • 88
    • 0038006792 scopus 로고    scopus 로고
    • Additive thrombin inhibition by fast moving heparin and dermatan sulphate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans
    • Cosmi B, Cini M, Legnani C, Pancani C, Calanni F, Coccheri S. Additive thrombin inhibition by fast moving heparin and dermatan sulphate explains the anticoagulant effect of sulodexide, a natural mixture of glycosaminoglycans. Thromb Res 2003; 109: 333-9.
    • (2003) Thromb Res , vol.109 , pp. 333-339
    • Cosmi, B.1    Cini, M.2    Legnani, C.3    Pancani, C.4    Calanni, F.5    Coccheri, S.6
  • 89
    • 0028200016 scopus 로고
    • Prevention of thrombus formation and growth by antithrombin III and heparin cofactor-II dependent thrombin inhibitors: Importance of heparin cofactor II
    • Buchanan MR, Liao P, Smith LJ, Ofosu FA. Prevention of thrombus formation and growth by antithrombin III and heparin cofactor-II dependent thrombin inhibitors: importance of heparin cofactor II. Thromb Res 1994; 74: 463-75.
    • (1994) Thromb Res , vol.74 , pp. 463-475
    • Buchanan, M.R.1    Liao, P.2    Smith, L.J.3    Ofosu, F.A.4


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