Impaired insulin sensitivity and secretion in normoglycemic patients with spinocerebellar ataxia type 1

Movement Disorders

Volumn 25, Issue 12, 2010, Pages 1976-1980

  Lalić, Nebojša M ^a   Dragašević, Nataš A ^a   Stefanova, Elka ^a   Jotić, Aleksandra ^a   Lalić, Katarina ^a   Miličić, Tanja ^a   Petrović, Igor ^a   Maćešić, Marija ^a   Kostić, Vladimir S ^a  

^a CLINICAL CENTER OF SERBIA   (Serbia)

Author keywords

Insulin resistance; Spinocerebellar ataxia

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DIET RESTRICTION; DISEASE DURATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HOMEOSTASIS; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESPONSE; INSULIN SENSITIVITY; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SPINOCEREBELLAR ATAXIA TYPE 1; SPINOCEREBELLAR DEGENERATION; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

BLOOD GLUCOSE; CHOLESTEROL, LDL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; SPINOCEREBELLAR ATAXIAS;

EID: 77956830673     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.23176     Document Type: Article

References (13)

1. Orr HT, Zoghbi HY. Trinucleotide repeat disorders. Annu Rev Neurosci 2007;30:575-621.
2. Cohen E, Dillin A. The insulin paradox: proteotoxicity and neurodegeneration. Nat Rev Neurosci 2008;9:759-767.
3. Lalić NM, Marić J, Svetel M, et al. Glucose homeostasis in Huntington disease. Abnormalities in insulin sensitivity and early-phase insulin secretion. Arch Neurol 2008;65:476-480.
4. World Health Organization, Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia: report of a WHO/IDF consultation. Geneva: World Health Org; 2006.
5. Schwab RS, England AC. Parkinsonism due to various specific causes. In: Vinken PJ, Bruyn GW, editors. Handbook of clinical neurology, Vol. 6. Amsterdam, North Holland: 1968. p 203-233.
6. Dragašević N, Čuljković B, Klein C, et al. Frequency analysis and clinical characterization of different types of spinocerebellar ataxia in Serbian patients. Mov Disord 2006;21:187-191.
7. Ferrannini E, Mari A. How to measure insulin sensitivity. J Hypertens 1998;16:895-906.
8. Uchihara T, Takeda Y, Kobayashi T, et al. Unexpected clinico-pathological phenotype linked to small elongation of CAG repeat in SCA1 gene. J Neurol 2006;253:396-398.
9. van der Burg JMM, Björqvist M, Brundin P. Beyond the brain: widespread pathology in Huntington's disease. Lancet Neurol 2009;8:765-774.
10. Sathasivam K, Bobbs C, Turmaine M, et al. Formation of polyglutamine insclusions in non-CNS tissue. Hum Mol Genet 1999;8:813-822.
11. Andreassen DA, Dedeoglu A, Stanojevic V, et al. Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis 2002;11:410-424.
12. Servadio A, Koshy B, Armstrong D, Antalffy B, Orr HT, Zoghbi HY. Expression analysis of the ataxin-1 protein in tissues from normal and spinocerebellar ataxia type 1 individuals. Nat Genet 1995;10:94-98.
13. Chen H-K, Fernandez-Funez P, Acevedo SF, et al. Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1. Cell 2003;113:457-468.