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Volumn 51, Issue 8, 2010, Pages 2032-2057

Genetic causes of high and low serum HDL-cholesterol

Author keywords

Coronary artery disease; Genetic determinant; Genome wide association studies; High density lipoprotein cholesterol; Hypoalphalipoproteinemia; Lipid; Lipoprotein; Polymorphism

Indexed keywords

ABC TRANSPORTER; ACYL COENZYME A DESATURASE 1; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIVER TRIACYLGLYCEROL LIPASE; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

EID: 77956812723     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R004739     Document Type: Review
Times cited : (171)

References (240)
  • 1
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
    • Gordon, T., W. P. Castelli, M. C. Hjortland, W. B. Kannel, and T. R. Dawber. 1977. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62: 707-714.
    • (1977) Am. J. Med. , vol.62 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 2
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • 2001. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 285: 2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 3
    • 70450081001 scopus 로고    scopus 로고
    • Major lipids, apolipoproteins, and risk of vascular disease
    • The Emerging Risk Factors Collaboration
    • The Emerging Risk Factors Collaboration. 2009. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 302: 1993-2000.
    • (2009) JAMA , vol.302 , pp. 1993-2000
  • 4
    • 0035806916 scopus 로고    scopus 로고
    • Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study
    • Sharrett, A. R., C. M. Ballantyne, S. A. Coady, G. Heiss, P. D. Sorlie, D. Catellier, and W. Patsch. 2001. Coronary heart disease prediction from lipoprotein cholesterol levels, triglycerides, lipoprotein(a), apolipoproteins A-I and B, and HDL density subfractions: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 104: 1108-1113.
    • (2001) Circulation , vol.104 , pp. 1108-1113
    • Sharrett, A.R.1    Ballantyne, C.M.2    Coady, S.A.3    Heiss, G.4    Sorlie, P.D.5    Catellier, D.6    Patsch, W.7
  • 5
    • 60449094498 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2009 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones, D., R. Adams, M. Carnethon, G. De Simone, T. Ferguson, K. Flegal, E. Ford, K. Furie, A. Go, K. Greenlund, et al. 2009. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 119: 480-486.
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    De Simone, G.4    Ferguson, T.5    Flegal, K.6    Ford, E.7    Furie, K.8    Go, A.9    Greenlund, K.10
  • 6
    • 4344665253 scopus 로고    scopus 로고
    • Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: The role of nicotinic acid-a position paper developed by the European Consensus Panel on HDL-C
    • Chapman, M. J., G. Assmann, J. Fruchart, J. Shepherd, and C. Sirtori. 2004. Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid-a position paper developed by the European Consensus Panel on HDL-C. Curr. Med. Res. Opin. 20: 1253-1268.
    • (2004) Curr. Med. Res. Opin. , vol.20 , pp. 1253-1268
    • Chapman, M.J.1    Assmann, G.2    Fruchart, J.3    Shepherd, J.4    Sirtori, C.5
  • 7
    • 0035574654 scopus 로고    scopus 로고
    • Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease
    • Kareinen, A., L. Viitanen, P. Halonen, S. Lehto, and M. Laakso. 2001. Cardiovascular risk factors associated with insulin resistance cluster in families with early-onset coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 21: 1346-1352.
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1346-1352
    • Kareinen, A.1    Viitanen, L.2    Halonen, P.3    Lehto, S.4    Laakso, M.5
  • 8
    • 66349137054 scopus 로고    scopus 로고
    • The metabolism and anti-atherogenic properties of HDL
    • Rye, K. A., C. A. Bursill, G. Lambert, F. Tabet, and P. J. Barter. 2009. The metabolism and anti-atherogenic properties of HDL. J. Lipid Res. 50 ( Suppl. ): S195-S200.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Rye, K.A.1    Bursill, C.A.2    Lambert, G.3    Tabet, F.4    Barter, P.J.5
  • 9
    • 0038173268 scopus 로고    scopus 로고
    • High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions
    • Barter, P., J. Kastelein, A. Nunn, and R. Hobbs. 2003. High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions. Atherosclerosis. 168: 195-211.
    • (2003) Atherosclerosis , vol.168 , pp. 195-211
    • Barter, P.1    Kastelein, J.2    Nunn, A.3    Hobbs, R.4
  • 12
    • 0030868848 scopus 로고    scopus 로고
    • Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L
    • Duchateau, P. N., C. R. Pullinger, R. E. Orellana, S. T. Kunitake, J. Naya-Vigne, P. M. O'Connor, M. J. Malloy, and J. P. Kane. 1997. Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L. J. Biol. Chem. 272: 25576-25582.
    • (1997) J. Biol. Chem. , vol.272 , pp. 25576-25582
    • Duchateau, P.N.1    Pullinger, C.R.2    Orellana, R.E.3    Kunitake, S.T.4    Naya-Vigne, J.5    O'Connor, P.M.6    Malloy, M.J.7    Kane, J.P.8
  • 14
    • 33845320131 scopus 로고    scopus 로고
    • Molecular regulation of HDL metabolism and function: Implications for novel therapies
    • Rader, D. J. 2006. Molecular regulation of HDL metabolism and function: implications for novel therapies. J. Clin. Invest. 116: 3090-3100.
    • (2006) J. Clin. Invest. , vol.116 , pp. 3090-3100
    • Rader, D.J.1
  • 15
    • 33947114419 scopus 로고    scopus 로고
    • Genetic factors affecting HDL levels, structure, metabolism and function
    • Sviridov, D., and P. J. Nestel. 2007. Genetic factors affecting HDL levels, structure, metabolism and function. Curr. Opin. Lipidol. 18: 157-163.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 157-163
    • Sviridov, D.1    Nestel, P.J.2
  • 16
    • 33750127491 scopus 로고    scopus 로고
    • Variations on a gene: Rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis
    • Brunham, L. R., R. R. Singaraja, and M. R. Hayden. 2006. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Annu. Rev. Nutr. 26: 105-129.
    • (2006) Annu. Rev. Nutr. , vol.26 , pp. 105-129
    • Brunham, L.R.1    Singaraja, R.R.2    Hayden, M.R.3
  • 17
    • 0030933460 scopus 로고    scopus 로고
    • The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes
    • Kuivenhoven, J. A., H. Pritchard, J. Hill, J. Frohlich, G. Assmann, and J. Kastelein. 1997. The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes. J. Lipid Res. 38: 191-205.
    • (1997) J. Lipid Res. , vol.38 , pp. 191-205
    • Kuivenhoven, J.A.1    Pritchard, H.2    Hill, J.3    Frohlich, J.4    Assmann, G.5    Kastelein, J.6
  • 18
    • 6344257092 scopus 로고    scopus 로고
    • Insight into the role of LCAT from mouse models
    • Ng, D. S. 2004. Insight into the role of LCAT from mouse models. Rev. Endocr. Metab. Disord. 5: 311-318.
    • (2004) Rev. Endocr. Metab. Disord. , vol.5 , pp. 311-318
    • Ng, D.S.1
  • 19
    • 0032812981 scopus 로고    scopus 로고
    • Remodelling of high density lipoproteins by plasma factors
    • Rye, K. A., M. A. Clay, and P. J. Barter. 1999. Remodelling of high density lipoproteins by plasma factors. Atherosclerosis. 145: 227-238.
    • (1999) Atherosclerosis , vol.145 , pp. 227-238
    • Rye, K.A.1    Clay, M.A.2    Barter, P.J.3
  • 20
    • 34250195008 scopus 로고    scopus 로고
    • Genetic determinants of HDL: Monogenic disorders and contributions to variation
    • Klos, K. L. E., and I. J. Kullo. 2007. Genetic determinants of HDL: monogenic disorders and contributions to variation. Curr. Opin. Cardiol. 22: 344-351.
    • (2007) Curr. Opin. Cardiol. , vol.22 , pp. 344-351
    • Klos, K.L.E.1    Kullo, I.J.2
  • 21
    • 33646394603 scopus 로고    scopus 로고
    • Human genetics of variation in high-density lipoprotein cholesterol
    • Qasim, A., and D. J. Rader. 2006. Human genetics of variation in high-density lipoprotein cholesterol. Curr. Atheroscler. Rep. 8: 198-205.
    • (2006) Curr. Atheroscler. Rep. , vol.8 , pp. 198-205
    • Qasim, A.1    Rader, D.J.2
  • 22
    • 0141988913 scopus 로고    scopus 로고
    • Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis
    • Trigatti, B. L., M. Krieger, and A. Rigotti. 2003. Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23: 1732-1738.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1732-1738
    • Trigatti, B.L.1    Krieger, M.2    Rigotti, A.3
  • 23
    • 34247619743 scopus 로고    scopus 로고
    • HDL cholesterol: Physiology, pathophysiology, and management
    • Link, J. J., A. Rohatgi, and J. A. de Lemos. 2007. HDL cholesterol: physiology, pathophysiology, and management. Curr. Probl. Cardiol. 32: 268-314.
    • (2007) Curr. Probl. Cardiol. , vol.32 , pp. 268-314
    • Link, J.J.1    Rohatgi, A.2    De Lemos, J.A.3
  • 26
    • 0031802046 scopus 로고    scopus 로고
    • Epidemiological aspects of high density lipoprotein cholesterol
    • de Backer, G., D. de Bacquer, and M. Kornitzer. 1998. Epidemiological aspects of high density lipoprotein cholesterol. Atherosclerosis. 137 ( Suppl. ): S1-S6.
    • (1998) Atherosclerosis , vol.137 , Issue.SUPPL.
    • De Backer, G.1    De Bacquer, D.2    Kornitzer, M.3
  • 27
    • 34547858847 scopus 로고    scopus 로고
    • High-density lipoprotein as a therapeutic target: A systematic review
    • Singh, I. M., M. H. Shishehbor, and B. J. Ansell. 2007. High-density lipoprotein as a therapeutic target: a systematic review. JAMA. 298: 786-798.
    • (2007) JAMA , vol.298 , pp. 786-798
    • Singh, I.M.1    Shishehbor, M.H.2    Ansell, B.J.3
  • 28
    • 0034700637 scopus 로고    scopus 로고
    • Nonpharmacologic management of low levels of high-density lipoprotein cholesterol
    • Ginsberg, H. N. 2000. Nonpharmacologic management of low levels of high-density lipoprotein cholesterol. Am. J. Cardiol. 86: 41L-45L.
    • (2000) Am. J. Cardiol. , vol.86
    • Ginsberg, H.N.1
  • 29
    • 0028068650 scopus 로고
    • Familial lipoprotein disorders and premature coronary artery disease
    • Schaefer, E. J., J. J. Genest, J. M. Ordovas, D. N. Salem, and P. W. Wilson. 1994. Familial lipoprotein disorders and premature coronary artery disease. Atherosclerosis. 108 ( Suppl. ): S41-S54.
    • (1994) Atherosclerosis , vol.108 , Issue.SUPPL.
    • Schaefer, E.J.1    Genest, J.J.2    Ordovas, J.M.3    Salem, D.N.4    Wilson, P.W.5
  • 34
    • 34247899094 scopus 로고    scopus 로고
    • Familial occurrence of abnormalities of high-density lipoprotein cholesterol
    • Kral, B. G., and D. M. Becker. 2007. Familial occurrence of abnormalities of high-density lipoprotein cholesterol. J. Clin. Lipidol. 1: 31-40.
    • (2007) J. Clin. Lipidol. , vol.1 , pp. 31-40
    • Kral, B.G.1    Becker, D.M.2
  • 35
    • 42449130136 scopus 로고    scopus 로고
    • Low high-density lipoprotein cholesterol: An important consideration in coronary heart disease risk assessment
    • Majeed, F., and M. Miller. 2008. Low high-density lipoprotein cholesterol: an important consideration in coronary heart disease risk assessment. Curr. Opin. Endocrinol. Diabetes Obes. 15: 175-181.
    • (2008) Curr. Opin. Endocrinol. Diabetes Obes. , vol.15 , pp. 175-181
    • Majeed, F.1    Miller, M.2
  • 36
    • 3142782906 scopus 로고    scopus 로고
    • Genetic determinants of low high-density lipoprotein cholesterol
    • Miller, M., and M. Zhan. 2004. Genetic determinants of low high-density lipoprotein cholesterol. Curr. Opin. Cardiol. 19: 380-384.
    • (2004) Curr. Opin. Cardiol. , vol.19 , pp. 380-384
    • Miller, M.1    Zhan, M.2
  • 37
    • 0033816683 scopus 로고    scopus 로고
    • Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia
    • Yamashita, S., T. Maruyama, K. Hirano, N. Sakai, N. Nakajima, and Y. Matsuzawa. 2000. Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. Atherosclerosis. 152: 271-285.
    • (2000) Atherosclerosis , vol.152 , pp. 271-285
    • Yamashita, S.1    Maruyama, T.2    Hirano, K.3    Sakai, N.4    Nakajima, N.5    Matsuzawa, Y.6
  • 38
    • 0028111063 scopus 로고
    • Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins
    • Ishigami, M., S. Yamashita, N. Sakai, T. Arai, I. K. Hirano, H. Hiraoka, K. Kameda-Takemura, and Y. Matsuzawa. 1994. Large and cholesteryl ester-rich high-density lipoproteins in cholesteryl ester transfer protein (CETP) deficiency can not protect macrophages from cholesterol accumulation induced by acetylated low-density lipoproteins. J. Biochem. 116: 257-262.
    • (1994) J. Biochem. , vol.116 , pp. 257-262
    • Ishigami, M.1    Yamashita, S.2    Sakai, N.3    Arai, T.4    Hirano, I.K.5    Hiraoka, H.6    Kameda-Takemura, K.7    Matsuzawa, Y.8
  • 39
    • 71749086157 scopus 로고    scopus 로고
    • The effects of cholesterol ester transfer protein inhibition on cholesterol efflux
    • Tall, A. R. 2009. The effects of cholesterol ester transfer protein inhibition on cholesterol efflux. Am. J. Cardiol. 104: 39E-45E.
    • (2009) Am. J. Cardiol. , vol.104
    • Tall, A.R.1
  • 40
    • 0037453064 scopus 로고    scopus 로고
    • Cellular phospholipid and cholesterol efflux in high-density lipoprotein deficiency
    • Marcil, M., R. Bissonnette, J. Vincent, L. Krimbou, and J. Genest. 2003. Cellular phospholipid and cholesterol efflux in high-density lipoprotein deficiency. Circulation. 107: 1366-1371.
    • (2003) Circulation , vol.107 , pp. 1366-1371
    • Marcil, M.1    Bissonnette, R.2    Vincent, J.3    Krimbou, L.4    Genest, J.5
  • 41
    • 48549090621 scopus 로고    scopus 로고
    • Clinical presentation, laboratory values, and coronary heart disease risk in marked high-density lipoprotein-deficiency states
    • Santos, R. D., B. F. Asztalos, L. R. Martinez, M. H. Miname, E. Polisecki, and E. J. Schaefer. 2008. Clinical presentation, laboratory values, and coronary heart disease risk in marked high-density lipoprotein-deficiency states. J. Clin. Lipidol. 2: 237-247.
    • (2008) J. Clin. Lipidol. , vol.2 , pp. 237-247
    • Santos, R.D.1    Asztalos, B.F.2    Martinez, L.R.3    Miname, M.H.4    Polisecki, E.5    Schaefer, E.J.6
  • 42
    • 33646433424 scopus 로고    scopus 로고
    • Differential diagnosis of familial high density lipoprotein deficiency syndromes
    • von Eckardstein, A. 2006. Differential diagnosis of familial high density lipoprotein deficiency syndromes. Atherosclerosis. 186: 231-239.
    • (2006) Atherosclerosis , vol.186 , pp. 231-239
    • Von Eckardstein, A.1
  • 45
    • 9144250425 scopus 로고    scopus 로고
    • A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease
    • Ikewaki, K., A. Matsunaga, H. Han, H. Watanabe, A. Endo, J. Tohyama, M. Kuno, J. Mogi, K. Sugimoto, N. Tada, et al. 2004. A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease. Atherosclerosis. 172: 39-45.
    • (2004) Atherosclerosis , vol.172 , pp. 39-45
    • Ikewaki, K.1    Matsunaga, A.2    Han, H.3    Watanabe, H.4    Endo, A.5    Tohyama, J.6    Kuno, M.7    Mogi, J.8    Sugimoto, K.9    Tada, N.10
  • 48
    • 0022559945 scopus 로고
    • Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia
    • Ordovas, J. M., E. Schaefer, D. Salem, R. Ward, C. Glueck, C. Vergani, P. Wilson, and S. Karathanasis. 1986. Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. N. Engl. J. Med. 314: 671-677.
    • (1986) N. Engl. J. Med. , vol.314 , pp. 671-677
    • Ordovas, J.M.1    Schaefer, E.2    Salem, D.3    Ward, R.4    Glueck, C.5    Vergani, C.6    Wilson, P.7    Karathanasis, S.8
  • 50
    • 0025127088 scopus 로고
    • Human apolipoprotein A-I gene promoter polymorphism: Association with hyperalphalipoproteinemia
    • Pagani, F., A. Sidoli, G. A. Giudici, L. Barenghi, C. Vergani, and F. E. Baralle. 1990. Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia. J. Lipid Res. 31: 1371-1377.
    • (1990) J. Lipid Res. , vol.31 , pp. 1371-1377
    • Pagani, F.1    Sidoli, A.2    Giudici, G.A.3    Barenghi, L.4    Vergani, C.5    Baralle, F.E.6
  • 51
    • 0025172876 scopus 로고
    • G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations
    • Jeenah, M., A. Kessling, N. Miller, and S. Humphries. 1990. G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations. Mol. Biol. Med. 7: 233-241.
    • (1990) Mol. Biol. Med. , vol.7 , pp. 233-241
    • Jeenah, M.1    Kessling, A.2    Miller, N.3    Humphries, S.4
  • 52
    • 0027428860 scopus 로고
    • Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia
    • Rader, D. J., J. R. Schaefer, P. Lohse, K. Ikewaki, F. Thomas, W. A. Harris, L. A. Zech, C. A. Dujovne, and H. B. Brewer. 1993. Increased production of apolipoprotein A-I associated with elevated plasma levels of high-density lipoproteins, apolipoprotein A-I, and lipoprotein A-I in a patient with familial hyperalphalipoproteinemia. Metabolism. 42: 1429-1434.
    • (1993) Metabolism , vol.42 , pp. 1429-1434
    • Rader, D.J.1    Schaefer, J.R.2    Lohse, P.3    Ikewaki, K.4    Thomas, F.5    Harris, W.A.6    Zech, L.A.7    Dujovne, C.A.8    Brewer, H.B.9
  • 56
    • 33748743543 scopus 로고    scopus 로고
    • Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo
    • Singaraja, R. R., M. Van Eck, N. Bissada, F. Zimetti, H. L. Collins, R. B. Hildebrand, A. Hayden, L. R. Brunham, M. H. Kang, J. Fruchart, et al. 2006. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation. 114: 1301-1309.
    • (2006) Circulation , vol.114 , pp. 1301-1309
    • Singaraja, R.R.1    Van Eck, M.2    Bissada, N.3    Zimetti, F.4    Collins, H.L.5    Hildebrand, R.B.6    Hayden, A.7    Brunham, L.R.8    Kang, M.H.9    Fruchart, J.10
  • 59
    • 33750927892 scopus 로고    scopus 로고
    • ATP-binding cassette cholesterol transporters and cardiovascular disease
    • Oram, J. F., and A. M. Vaughan. 2006. ATP-binding cassette cholesterol transporters and cardiovascular disease. Circ. Res. 99: 1031-1043.
    • (2006) Circ. Res. , vol.99 , pp. 1031-1043
    • Oram, J.F.1    Vaughan, A.M.2
  • 61
    • 0037150282 scopus 로고    scopus 로고
    • Novel ABCA1 compound variant associated with HDL cholesterol deficiency
    • Ho Hong, S., J. Rhyne, K. Zeller, and M. Miller. 2002. Novel ABCA1 compound variant associated with HDL cholesterol deficiency. Biochim. Biophys. Acta. 1587: 60-64.
    • (2002) Biochim. Biophys. Acta , vol.1587 , pp. 60-64
    • Ho Hong, S.1    Rhyne, J.2    Zeller, K.3    Miller, M.4
  • 62
    • 0034672281 scopus 로고    scopus 로고
    • Lecithin cholesterol acyltransferase
    • Jonas, A. 2000. Lecithin cholesterol acyltransferase. Biochim. Biophy.s Acta. 1529: 245-256.
    • (2000) Biochim. Biophy.s Acta , vol.1529 , pp. 245-256
    • Jonas, A.1
  • 66
    • 0035344214 scopus 로고    scopus 로고
    • Genetic determinants of plasma triglycerides: Impact of rare and common mutations
    • Talmud, P. J. 2001. Genetic determinants of plasma triglycerides: impact of rare and common mutations. Curr. Atheroscler. Rep. 3: 191-199.
    • (2001) Curr. Atheroscler. Rep. , vol.3 , pp. 191-199
    • Talmud, P.J.1
  • 67
    • 0029920693 scopus 로고    scopus 로고
    • Lipoprotein lipase and lipolysis: Central roles in lipoprotein metabolism and atherogenesis
    • Goldberg, I. J. 1996. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 37: 693-707.
    • (1996) J. Lipid Res. , vol.37 , pp. 693-707
    • Goldberg, I.J.1
  • 72
    • 0028135441 scopus 로고
    • Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol
    • Inazu, A., X. C. Jiang, T. Haraki, K. Yagi, N. Kamon, J. Koizumi, H. Mabuchi, R. Takeda, K. Takata, and Y. Moriyama. 1994. Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J. Clin. Invest. 94: 1872-1882.
    • (1994) J. Clin. Invest. , vol.94 , pp. 1872-1882
    • Inazu, A.1    Jiang, X.C.2    Haraki, T.3    Yagi, K.4    Kamon, N.5    Koizumi, J.6    Mabuchi, H.7    Takeda, R.8    Takata, K.9    Moriyama, Y.10
  • 73
    • 0142010558 scopus 로고    scopus 로고
    • Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease
    • Boekholdt, S. M., and J. F. Thompson. 2003. Natural genetic variation as a tool in understanding the role of CETP in lipid levels and disease. J. Lipid Res. 44: 1080-1093.
    • (2003) J. Lipid Res. , vol.44 , pp. 1080-1093
    • Boekholdt, S.M.1    Thompson, J.F.2
  • 74
    • 2142763867 scopus 로고    scopus 로고
    • A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly
    • Curb, J. D., R. D. Abbott, B. L. Rodriguez, K. Masaki, R. Chen, D. S. Sharp, and A. R. Tall. 2004. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J. Lipid Res. 45: 948-953.
    • (2004) J. Lipid Res. , vol.45 , pp. 948-953
    • Curb, J.D.1    Abbott, R.D.2    Rodriguez, B.L.3    Masaki, K.4    Chen, R.5    Sharp, D.S.6    Tall, A.R.7
  • 75
    • 17444448251 scopus 로고    scopus 로고
    • A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency
    • Moriyama, Y., T. Okamura, A. Inazu, M. Doi, H. Iso, Y. Mouri, Y. Ishikawa, H. Suzuki, M. Iida, J. Koizumi, et al. 1998. A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency. Prev. Med. 27: 659-667.
    • (1998) Prev. Med. , vol.27 , pp. 659-667
    • Moriyama, Y.1    Okamura, T.2    Inazu, A.3    Doi, M.4    Iso, H.5    Mouri, Y.6    Ishikawa, Y.7    Suzuki, H.8    Iida, M.9    Koizumi, J.10
  • 76
  • 78
    • 0142105905 scopus 로고    scopus 로고
    • Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians
    • Ruel, I. L., P. Couture, C. Gagne, Y. Deshaies, J. Simard, R. A. Hegele, and B. Lamarche. 2003. Characterization of a novel mutation causing hepatic lipase deficiency among French Canadians. J. Lipid Res. 44: 1508-1514.
    • (2003) J. Lipid Res. , vol.44 , pp. 1508-1514
    • Ruel, I.L.1    Couture, P.2    Gagne, C.3    Deshaies, Y.4    Simard, J.5    Hegele, R.A.6    Lamarche, B.7
  • 81
    • 0036739254 scopus 로고    scopus 로고
    • Hepatic lipase: A pro- or anti-atherogenic protein?
    • Jansen, H., A. J. M. Verhoeven, and E. J. G. Sijbrands. 2002. Hepatic lipase: a pro- or anti-atherogenic protein? J. Lipid Res. 43: 1352-1362.
    • (2002) J. Lipid Res. , vol.43 , pp. 1352-1362
    • Jansen, H.1    Verhoeven, A.J.M.2    Sijbrands, E.J.G.3
  • 82
    • 38349181769 scopus 로고    scopus 로고
    • Lipases as modulators of atherosclerosis in murine models
    • Brown, R. J., and D. J. Rader. 2007. Lipases as modulators of atherosclerosis in murine models. Curr. Drug Targets. 8: 1307-1319.
    • (2007) Curr. Drug Targets , vol.8 , pp. 1307-1319
    • Brown, R.J.1    Rader, D.J.2
  • 83
    • 0142074269 scopus 로고    scopus 로고
    • Hepatic lipase and dyslipidemia: Interactions among genetic variants, obesity, gender, and diet
    • Deeb, S. S., A. Zambon, M. C. Carr, A. F. Ayyobi, and J. D. Brunzell. 2003. Hepatic lipase and dyslipidemia: interactions among genetic variants, obesity, gender, and diet. J. Lipid Res. 44: 1279-1286.
    • (2003) J. Lipid Res. , vol.44 , pp. 1279-1286
    • Deeb, S.S.1    Zambon, A.2    Carr, M.C.3    Ayyobi, A.F.4    Brunzell, J.D.5
  • 84
    • 13144306071 scopus 로고    scopus 로고
    • Genome-wide association studies for common diseases and complex traits
    • Hirschhorn, J. N., and M. J. Daly. 2005. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6: 95-108.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 95-108
    • Hirschhorn, J.N.1    Daly, M.J.2
  • 85
    • 1842612038 scopus 로고    scopus 로고
    • Genetics of familial combined hyperlipidemia and risk of coronary heart disease
    • Shoulders, C., E. Jones, and R. Naoumova. 2004. Genetics of familial combined hyperlipidemia and risk of coronary heart disease. Hum. Mol. Genet. 13: R149-160.
    • (2004) Hum. Mol. Genet. , vol.13
    • Shoulders, C.1    Jones, E.2    Naoumova, R.3
  • 87
    • 0036980843 scopus 로고    scopus 로고
    • HDL genetics: Candidate genes, genome wide scans and gene-environment interactions
    • Ordovas, J. M. 2002. HDL genetics: candidate genes, genome wide scans and gene-environment interactions. Cardiovasc. Drugs Ther. 16: 273-281.
    • (2002) Cardiovasc. Drugs Ther. , vol.16 , pp. 273-281
    • Ordovas, J.M.1
  • 88
    • 11844280278 scopus 로고    scopus 로고
    • Genetics of variation in HDL cholesterol in humans and mice
    • Wang, X., and B. Paigen. 2005. Genetics of variation in HDL cholesterol in humans and mice. Circ. Res. 96: 27-42.
    • (2005) Circ. Res. , vol.96 , pp. 27-42
    • Wang, X.1    Paigen, B.2
  • 89
    • 10044225895 scopus 로고    scopus 로고
    • Compendium of genome-wide scans of lipid-related phenotypes: Adding a new genome-wide search of apolipoprotein levels
    • Bosse, Y., Y. C. Chagnon, J. Despres, T. Rice, D. C. Rao, C. Bouchard, L. Perusse, and M. Vohl. 2004. Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels. J. Lipid Res. 45: 2174-2184.
    • (2004) J. Lipid Res. , vol.45 , pp. 2174-2184
    • Bosse, Y.1    Chagnon, Y.C.2    Despres, J.3    Rice, T.4    Rao, D.C.5    Bouchard, C.6    Perusse, L.7    Vohl, M.8
  • 92
    • 0037385395 scopus 로고    scopus 로고
    • Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q
    • Pajukanta, P., H. Allayee, K. Krass, A. Kuraishy, A. Soro, H. Lilja, R. Mar, M. Taskinen, I. Nuotio, M. Laakso, et al. 2003. Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q. Am. J. Hum. Genet. 72: 903-917.
    • (2003) Am. J. Hum. Genet. , vol.72 , pp. 903-917
    • Pajukanta, P.1    Allayee, H.2    Krass, K.3    Kuraishy, A.4    Soro, A.5    Lilja, H.6    Mar, R.7    Taskinen, M.8    Nuotio, I.9    Laakso, M.10
  • 95
    • 13144265739 scopus 로고    scopus 로고
    • Genome-wide association studies: Theoretical and practical concerns
    • Wang, W. Y. S., B. J. Barratt, D. G. Clayton, and J. A. Todd. 2005. Genome-wide association studies: theoretical and practical concerns. Nat. Rev. Genet. 6: 109-118.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 109-118
    • Wang, W.Y.S.1    Barratt, B.J.2    Clayton, D.G.3    Todd, J.A.4
  • 97
    • 59649092852 scopus 로고    scopus 로고
    • Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: A systematic in-depth review
    • Boes, E., S. Coassin, B. Kollerits, I. M. Heid, and F. Kronenberg. 2009. Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review. Exp. Gerontol. 44: 136-160.
    • (2009) Exp. Gerontol. , vol.44 , pp. 136-160
    • Boes, E.1    Coassin, S.2    Kollerits, B.3    Heid, I.M.4    Kronenberg, F.5
  • 99
    • 19944431793 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: Individual patient meta-analysis of 13 677 subjects
    • Boekholdt, S. M., F. Sacks, J. Jukema, J. Shepherd, D. Freeman, A. McMahon, F. Cambien, V. Nicaud, G. de Grooth, P. Talmud, et al. 2005. Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13 677 subjects. Circulation. 111: 278-287.
    • (2005) Circulation , vol.111 , pp. 278-287
    • Boekholdt, S.M.1    Sacks, F.2    Jukema, J.3    Shepherd, J.4    Freeman, D.5    McMahon, A.6    Cambien, F.7    Nicaud, V.8    De Grooth, G.9    Talmud, P.10
  • 101
    • 0033536024 scopus 로고    scopus 로고
    • Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis
    • Wittrup, H. H., A. Tybjaerg-Hansen, and B. G. Nordestgaard. 1999. Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis. Circulation. 99: 2901-2907.
    • (1999) Circulation , vol.99 , pp. 2901-2907
    • Wittrup, H.H.1    Tybjaerg-Hansen, A.2    Nordestgaard, B.G.3
  • 102
    • 30944449662 scopus 로고    scopus 로고
    • Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    • Hutter, C. M., M. A. Austin, F. M. Farin, H. Viernes, K. L. Edwards, D. L. Leonetti, M. J. McNeely, and W. Y. Fujimoto. 2006. Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. Atherosclerosis. 185: 78-86.
    • (2006) Atherosclerosis , vol.185 , pp. 78-86
    • Hutter, C.M.1    Austin, M.A.2    Farin, F.M.3    Viernes, H.4    Edwards, K.L.5    Leonetti, D.L.6    McNeely, M.J.7    Fujimoto, W.Y.8
  • 103
    • 0344406740 scopus 로고    scopus 로고
    • Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    • Ma, K., M. Cilingiroglu, J. D. Otvos, C. M. Ballantyne, A. J. Marian, and L. Chan. 2003. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc. Natl. Acad. Sci. USA. 100: 2748-2753.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2748-2753
    • Ma, K.1    Cilingiroglu, M.2    Otvos, J.D.3    Ballantyne, C.M.4    Marian, A.J.5    Chan, L.6
  • 104
    • 38949176388 scopus 로고    scopus 로고
    • Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population
    • Tang, N. P., L. Wang, L. Yang, B. Zhou, H. Gu, Q. Sun, R. Cong, H. Zhu, and B. Wang. 2008. Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population. J. Lipid Res. 49: 369-375.
    • (2008) J. Lipid Res. , vol.49 , pp. 369-375
    • Tang, N.P.1    Wang, L.2    Yang, L.3    Zhou, B.4    Gu, H.5    Sun, Q.6    Cong, R.7    Zhu, H.8    Wang, B.9
  • 105
    • 34147109232 scopus 로고    scopus 로고
    • Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol
    • Paré, G., D. Serre, D. Brisson, S. S. Anand, A. Montpetit, G. Tremblay, J. C. Engert, T. J. Hudson, and D. Gaudet. 2007. Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol. Am. J. Hum. Genet. 80: 673-682.
    • (2007) Am. J. Hum. Genet. , vol.80 , pp. 673-682
    • Paré, G.1    Serre, D.2    Brisson, D.3    Anand, S.S.4    Montpetit, A.5    Tremblay, G.6    Engert, J.C.7    Hudson, T.J.8    Gaudet, D.9
  • 108
    • 0031923075 scopus 로고    scopus 로고
    • Linkage of the apo CIII microsatellite with isolated low high-density lipoprotein cholesterol
    • Devlin, C. M., V. L. Prenger, and M. Miller. 1998. Linkage of the apo CIII microsatellite with isolated low high-density lipoprotein cholesterol. Hum. Genet. 102: 273-281.
    • (1998) Hum. Genet. , vol.102 , pp. 273-281
    • Devlin, C.M.1    Prenger, V.L.2    Miller, M.3
  • 109
    • 0242690899 scopus 로고    scopus 로고
    • Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment
    • Gagnon, F., G. P. Jarvik, A. G. Motulsky, S. S. Deeb, J. D. Brunzell, and E. M. Wijsman. 2003. Evidence of linkage of HDL level variation to APOC3 in two samples with different ascertainment. Hum. Genet. 113: 522-533.
    • (2003) Hum. Genet. , vol.113 , pp. 522-533
    • Gagnon, F.1    Jarvik, G.P.2    Motulsky, A.G.3    Deeb, S.S.4    Brunzell, J.D.5    Wijsman, E.M.6
  • 110
    • 0037389235 scopus 로고    scopus 로고
    • Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice
    • Pennacchio, L. A., and E. M. Rubin. 2003. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler. Thromb. Vasc. Biol. 23: 529-534.
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 529-534
    • Pennacchio, L.A.1    Rubin, E.M.2
  • 111
    • 33644759250 scopus 로고    scopus 로고
    • Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I
    • Blatter Garin, M. C., X. Moren, and R. W. James. 2006. Paraoxonase-1 and serum concentrations of HDL-cholesterol and apoA-I. J. Lipid Res. 47: 515-520.
    • (2006) J. Lipid Res. , vol.47 , pp. 515-520
    • Blatter Garin, M.C.1    Moren, X.2    James, R.W.3
  • 113
    • 0036766742 scopus 로고    scopus 로고
    • ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans
    • Weggemans, R. M., P. L. Zock, E. S. Tai, J. M. Ordovas, H. O. F. Molhuizen, and M. B. Katan. 2002. ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans. Clin. Genet. 62: 226-229.
    • (2002) Clin. Genet. , vol.62 , pp. 226-229
    • Weggemans, R.M.1    Zock, P.L.2    Tai, E.S.3    Ordovas, J.M.4    Molhuizen, H.O.F.5    Katan, M.B.6
  • 115
    • 0026771986 scopus 로고
    • The MspI restriction fragment length polymorphism 3′ to the apolipoprotein A-II gene: Relationships with lipids, apolipoproteins, and premature coronary artery disease
    • Civeira, F., J. Genest, M. Pocovi, D. N. Salem, P. N. Herbert, P. W. Wilson, E. J. Schaefer, and J. M. Ordovas. 1992. The MspI restriction fragment length polymorphism 3′ to the apolipoprotein A-II gene: relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis. 92: 165-176.
    • (1992) Atherosclerosis , vol.92 , pp. 165-176
    • Civeira, F.1    Genest, J.2    Pocovi, M.3    Salem, D.N.4    Herbert, P.N.5    Wilson, P.W.6    Schaefer, E.J.7    Ordovas, J.M.8
  • 116
    • 0023880090 scopus 로고
    • DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: A study in men selected for differences in high-density-lipoprotein cholesterol concentration
    • Kessling, A. M., J. Rajput-Wiliams, D. Bainton, J. Scott, N. E. Miller, I. Baker, and S. E. Humphries. 1988. DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: a study in men selected for differences in high-density-lipoprotein cholesterol concentration. Am. J. Hum. Genet. 42: 458-467.
    • (1988) Am. J. Hum. Genet. , vol.42 , pp. 458-467
    • Kessling, A.M.1    Rajput-Wiliams, J.2    Bainton, D.3    Scott, J.4    Miller, N.E.5    Baker, I.6    Humphries, S.E.7
  • 119
    • 34347371806 scopus 로고    scopus 로고
    • WWOX in biological control and tumorigenesis
    • Aqeilan, R. I., and C. Croce. 2007. WWOX in biological control and tumorigenesis. J. Cell. Physiol. 212: 307-310.
    • (2007) J. Cell. Physiol. , vol.212 , pp. 307-310
    • Aqeilan, R.I.1    Croce, C.2
  • 125
    • 14644420598 scopus 로고    scopus 로고
    • Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population
    • Frikke-Schmidt, R., B. Nordestgaard, G. Jensen, and A. Tybjaerg-Hansen. 2004. Genetic variation in ABC transporter A1 contributes to HDL cholesterol in the general population. J. Clin. Invest. 114: 1343-1353.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1343-1353
    • Frikke-Schmidt, R.1    Nordestgaard, B.2    Jensen, G.3    Tybjaerg-Hansen, A.4
  • 126
    • 66349110548 scopus 로고    scopus 로고
    • The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis
    • Masson, D., X. Jiang, L. Lagrost, and A. R. Tall. 2009. The role of plasma lipid transfer proteins in lipoprotein metabolism and atherogenesis. J. Lipid Res. 50: S201-S206.
    • (2009) J. Lipid Res. , vol.50
    • Masson, D.1    Jiang, X.2    Lagrost, L.3    Tall, A.R.4
  • 131
    • 33751213896 scopus 로고    scopus 로고
    • Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
    • Sukonina, V., A. Lookene, T. Olivecrona, and G. Olivecrona. 2006. Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc. Natl. Acad. Sci. USA. 103: 17450-17455.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 17450-17455
    • Sukonina, V.1    Lookene, A.2    Olivecrona, T.3    Olivecrona, G.4
  • 132
    • 26844540456 scopus 로고    scopus 로고
    • Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: Regulation of triglyceride metabolism
    • Köster, A., Y. B. Chao, M. Mosior, A. Ford, P. A. Gonzalez-DeWhitt, J. E. Hale, D. Li, Y. Qiu, C. C. Fraser, D. D. Yang, et al. 2005. Transgenic angiopoietin-like (angptl)4 overexpression and targeted disruption of angptl4 and angptl3: regulation of triglyceride metabolism. Endocrinology. 146: 4943-4950.
    • (2005) Endocrinology , vol.146 , pp. 4943-4950
    • Köster, A.1    Chao, Y.B.2    Mosior, M.3    Ford, A.4    Gonzalez-DeWhitt, P.A.5    Hale, J.E.6    Li, D.7    Qiu, Y.8    Fraser, C.C.9    Yang, D.D.10
  • 133
    • 34047177395 scopus 로고    scopus 로고
    • Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
    • Romeo, S., L. Pennacchio, Y. Fu, E. Boerwinkle, A. Tybjaerg-Hansen, H. Hobbs, and J. Cohen. 2007. Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat. Genet. 39: 513-516.
    • (2007) Nat. Genet. , vol.39 , pp. 513-516
    • Romeo, S.1    Pennacchio, L.2    Fu, Y.3    Boerwinkle, E.4    Tybjaerg-Hansen, A.5    Hobbs, H.6    Cohen, J.7
  • 135
    • 7244245762 scopus 로고    scopus 로고
    • Finishing the euchromatic sequence of the human genome
    • International Human Genome Sequencing Consortium
    • International Human Genome Sequencing Consortium. 2004. Finishing the euchromatic sequence of the human genome. Nature. 431: 931-945.
    • (2004) Nature , vol.431 , pp. 931-945
  • 137
    • 41649089532 scopus 로고    scopus 로고
    • Defining the spectrum of alleles that contribute to blood lipid concentrations in humans
    • Kathiresan, S., K. Musunuru, and M. Orho-Melander. 2008. Defining the spectrum of alleles that contribute to blood lipid concentrations in humans. Curr. Opin. Lipidol. 19: 122-127.
    • (2008) Curr. Opin. Lipidol. , vol.19 , pp. 122-127
    • Kathiresan, S.1    Musunuru, K.2    Orho-Melander, M.3
  • 140
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler, D., M. J. Daly, and E. S. Lander. 2008. Genetic mapping in human disease. Science. 322: 881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 141
    • 43249125992 scopus 로고    scopus 로고
    • Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
    • Pe'er, I., R. Yelensky, D. Altshuler, and M. Daly. 2008. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet. Epidemiol. 32: 381-385.
    • (2008) Genet. Epidemiol. , vol.32 , pp. 381-385
    • Pe'er, I.1    Yelensky, R.2    Altshuler, D.3    Daly, M.4
  • 142
    • 36248975593 scopus 로고    scopus 로고
    • Optimal designs for two-stage genome-wide association studies
    • Skol, A. D., L. Scott, G. Abecasis, and M. Boehnke. 2007. Optimal designs for two-stage genome-wide association studies. Genet. Epidemiol. 31: 776-788.
    • (2007) Genet. Epidemiol. , vol.31 , pp. 776-788
    • Skol, A.D.1    Scott, L.2    Abecasis, G.3    Boehnke, M.4
  • 143
    • 73149103718 scopus 로고    scopus 로고
    • Prioritizing GWAS results: A review of statistical methods and recommendations for their application
    • Cantor, R. M., K. Lange, and J. S. Sinsheimer. 2010. Prioritizing GWAS results: a review of statistical methods and recommendations for their application. Am. J. Hum. Genet. 86: 6-22.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 6-22
    • Cantor, R.M.1    Lange, K.2    Sinsheimer, J.S.3
  • 144
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan, S., O. Melander, C. Guiducci, A. Surti, N. Burtt, M. Rieder, G. Cooper, C. Roos, B. Voight, A. Havulinna, et al. 2008. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat. Genet. 40: 189-197.
    • (2008) Nat. Genet. , vol.40 , pp. 189-197
    • Kathiresan, S.1    Melander, O.2    Guiducci, C.3    Surti, A.4    Burtt, N.5    Rieder, M.6    Cooper, G.7    Roos, C.8    Voight, B.9    Havulinna, A.10
  • 145
    • 34547622688 scopus 로고    scopus 로고
    • Imputation-based analysis of association studies: Candidate regions and quantitative traits
    • Servin, B., and M. Stephens. 2007. Imputation-based analysis of association studies: candidate regions and quantitative traits. PLoS Genet. 3: e114.
    • (2007) PLoS Genet. , vol.3
    • Servin, B.1    Stephens, M.2
  • 146
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • Marchini, J., B. Howie, S. Myers, G. McVean, and P. Donnelly. 2007. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39: 906-913.
    • (2007) Nat. Genet. , vol.39 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 153
    • 58149214774 scopus 로고    scopus 로고
    • Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and apolipoprotein B among 6382 white women in genome-wide analysis with replication
    • Chasman, D. I., G. Pare, R. Y. Zee, A. N. Parker, N. R. Cook, J. E. Buring, D. J. Kwiatkowski, L. M. Rose, J. D. Smith, P. T. Williams, et al. 2008. Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ Cardiovasc Genet. 1: 21-30.
    • (2008) Circ Cardiovasc Genet. , vol.1 , pp. 21-30
    • Chasman, D.I.1    Pare, G.2    Zee, R.Y.3    Parker, A.N.4    Cook, N.R.5    Buring, J.E.6    Kwiatkowski, D.J.7    Rose, L.M.8    Smith, J.D.9    Williams, P.T.10
  • 154
    • 67649367650 scopus 로고    scopus 로고
    • Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study
    • Ridker, P. M., G. Paré, A. N. Parker, R. Y. L. Zee, J. P. Miletich, and D. I. Chasman. 2009. Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study. Circ Cardiovasc Genet. 2: 26-33.
    • (2009) Circ Cardiovasc Genet. , vol.2 , pp. 26-33
    • Ridker, P.M.1    Paré, G.2    Parker, A.N.3    Zee, R.Y.L.4    Miletich, J.P.5    Chasman, D.I.6
  • 155
    • 58549109632 scopus 로고    scopus 로고
    • Plasma lipoproteins: Genetic influences and clinical implications
    • Hegele, R. A. 2009. Plasma lipoproteins: genetic influences and clinical implications. Nat. Rev. Genet. 10: 109-121.
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 109-121
    • Hegele, R.A.1
  • 156
    • 33846868388 scopus 로고    scopus 로고
    • Alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction
    • Baylin, A., E. Ruiz-Narvaez, P. Kraft, and H. Campos. 2007. alpha-Linolenic acid, Delta6-desaturase gene polymorphism, and the risk of nonfatal myocardial infarction. Am. J. Clin. Nutr. 85: 554-560.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 554-560
    • Baylin, A.1    Ruiz-Narvaez, E.2    Kraft, P.3    Campos, H.4
  • 157
    • 0035141324 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
    • Hayhurst, G. P., Y. H. Lee, G. Lambert, J. M. Ward, and F. J. Gonzalez. 2001. Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol. Cell. Biol. 21: 1393-1403.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1393-1403
    • Hayhurst, G.P.1    Lee, Y.H.2    Lambert, G.3    Ward, J.M.4    Gonzalez, F.J.5
  • 158
    • 33847090730 scopus 로고    scopus 로고
    • Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism
    • Murphy, C., A. M. Murray, S. Meaney, and M. Gåfvels. 2007. Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism. Biochem. Biophys. Res. Commun. 355: 359-364.
    • (2007) Biochem. Biophys. Res. Commun. , vol.355 , pp. 359-364
    • Murphy, C.1    Murray, A.M.2    Meaney, S.3    Gåfvels, M.4
  • 160
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer, N., and P. Tontonoz. 2006. Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116: 607-614.
    • (2006) J. Clin. Invest. , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 163
    • 0343060983 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation
    • Yoon, J. C., T. W. Chickering, E. D. Rosen, B. Dussault, Y. Qin, A. Soukas, J. M. Friedman, W. E. Holmes, and B. M. Spiegelman. 2000. Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation. Mol. Cell. Biol. 20: 5343-5349.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5343-5349
    • Yoon, J.C.1    Chickering, T.W.2    Rosen, E.D.3    Dussault, B.4    Qin, Y.5    Soukas, A.6    Friedman, J.M.7    Holmes, W.E.8    Spiegelman, B.M.9
  • 164
    • 33744736614 scopus 로고    scopus 로고
    • Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    • Schaeffer, L., H. Gohlke, M. Müller, I. M. Heid, L. J. Palmer, I. Kompauer, H. Demmelmair, T. Illig, B. Koletzko, and J. Heinrich. 2006. Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids. Hum. Mol. Genet. 15: 1745-1756.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1745-1756
    • Schaeffer, L.1    Gohlke, H.2    Müller, M.3    Heid, I.M.4    Palmer, L.J.5    Kompauer, I.6    Demmelmair, H.7    Illig, T.8    Koletzko, B.9    Heinrich, J.10
  • 166
    • 0842349501 scopus 로고    scopus 로고
    • An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia
    • Calabresi, L., B. Villa, M. Canavesi, C. R. Sirtori, R. W. James, F. Bernini, and G. Franceschini. 2004. An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. Metabolism. 53: 153-158.
    • (2004) Metabolism , vol.53 , pp. 153-158
    • Calabresi, L.1    Villa, B.2    Canavesi, M.3    Sirtori, C.R.4    James, R.W.5    Bernini, F.6    Franceschini, G.7
  • 167
    • 0024334111 scopus 로고
    • Fish oils and plasma lipid and lipoprotein metabolism in humans: A critical review
    • Harris, W. S. 1989. Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review. J. Lipid Res. 30: 785-807.
    • (1989) J. Lipid Res. , vol.30 , pp. 785-807
    • Harris, W.S.1
  • 168
    • 0027227341 scopus 로고
    • N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients
    • Connor, W. E., C. A. DeFrancesco, and S. L. Connor. 1993. N-3 fatty acids from fish oil. Effects on plasma lipoproteins and hypertriglyceridemic patients. Ann. N. Y. Acad. Sci. 683: 16-34.
    • (1993) Ann. N. Y. Acad. Sci. , vol.683 , pp. 16-34
    • Connor, W.E.1    DeFrancesco, C.A.2    Connor, S.L.3
  • 169
    • 0028268518 scopus 로고
    • Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors
    • Dagnelie, P. C., J. D. Bell, S. C. Williams, T. E. Bates, P. D. Abel, and C. S. Foster. 1994. Effect of fish oil on cancer cachexia and host liver metabolism in rats with prostate tumors. Lipids. 29: 195-203.
    • (1994) Lipids , vol.29 , pp. 195-203
    • Dagnelie, P.C.1    Bell, J.D.2    Williams, S.C.3    Bates, T.E.4    Abel, P.D.5    Foster, C.S.6
  • 170
    • 10544236911 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    • DOI 10.1038/384458a0
    • Yamagata, K., H. Furuta, N. Oda, P. Kaisaki, S. Menzel, N. Cox, S. Fajans, S. Signorini, M. Stoffel, and G. Bell. 1996. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature. 384: 458-460. (Pubitemid 26414661)
    • (1996) Nature , vol.384 , Issue.6608 , pp. 458-460
    • Yamagata, K.1    Furuta, H.2    Oda, N.3    Kaisaki, P.J.4    Menzel, S.5    Cox, N.J.6    Fajans, S.S.7    Signorini, S.8    Stoffel, M.9    Bell, G.I.10
  • 173
    • 0038632115 scopus 로고    scopus 로고
    • T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects
    • Zhu, Q., K. Yamagata, A. Miura, N. Shihara, Y. Horikawa, J. Takeda, J. Miyagawa, and Y. Matsuzawa. 2003. T130I mutation in HNF-4alpha gene is a loss-of-function mutation in hepatocytes and is associated with late-onset Type 2 diabetes mellitus in Japanese subjects. Diabetologia. 46: 567-573.
    • (2003) Diabetologia , vol.46 , pp. 567-573
    • Zhu, Q.1    Yamagata, K.2    Miura, A.3    Shihara, N.4    Horikawa, Y.5    Takeda, J.6    Miyagawa, J.7    Matsuzawa, Y.8
  • 175
    • 0017809430 scopus 로고
    • Characterization of the oligosaccharide side chain of apolipoprotein C-III from human plasma very low density lipoproteins
    • Vaith, P., G. Assmann, and G. Uhlenbruck. 1978. Characterization of the oligosaccharide side chain of apolipoprotein C-III from human plasma very low density lipoproteins. Biochim. Biophys. Acta. 541: 234-240.
    • (1978) Biochim. Biophys. Acta , vol.541 , pp. 234-240
    • Vaith, P.1    Assmann, G.2    Uhlenbruck, G.3
  • 176
    • 0032909677 scopus 로고    scopus 로고
    • The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell
    • Magrané, J., R. P. Casaroli-Marano, M. Reina, M. Gåfvels, and S. Vilaró. 1999. The role of O-linked sugars in determining the very low density lipoprotein receptor stability or release from the cell. FEBS Lett. 451: 56-62.
    • (1999) FEBS Lett. , vol.451 , pp. 56-62
    • Magrané, J.1    Casaroli-Marano, R.P.2    Reina, M.3    Gåfvels, M.4    Vilaró, S.5
  • 177
    • 0028962142 scopus 로고
    • Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:Cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion
    • Schindler, P. A., C. A. Settineri, X. Collet, C. J. Fielding, and A. L. Burlingame. 1995. Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion. Protein Sci. 4: 791-803.
    • (1995) Protein Sci. , vol.4 , pp. 791-803
    • Schindler, P.A.1    Settineri, C.A.2    Collet, X.3    Fielding, C.J.4    Burlingame, A.L.5
  • 179
    • 34248325296 scopus 로고    scopus 로고
    • Mevalonate kinase deficiencies: From mevalonic aciduria to hyperimmunoglobulinemia D syndrome
    • Haas, D., and G. F. Hoffmann. 2006. Mevalonate kinase deficiencies: from mevalonic aciduria to hyperimmunoglobulinemia D syndrome. Orphanet J. Rare Dis. 1: 13.
    • (2006) Orphanet J. Rare Dis. , vol.1 , pp. 13
    • Haas, D.1    Hoffmann, G.F.2
  • 181
    • 0037503924 scopus 로고    scopus 로고
    • Liver X receptor signaling pathways in cardiovascular disease
    • Tontonoz, P., and D. J. Mangelsdorf. 2003. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17: 985-993.
    • (2003) Mol. Endocrinol. , vol.17 , pp. 985-993
    • Tontonoz, P.1    Mangelsdorf, D.J.2
  • 182
    • 0344496513 scopus 로고    scopus 로고
    • The tetratricopeptide repeat: A structural motif mediating protein-protein interactions
    • Blatch, G. L., and M. Lässle. 1999. The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays. 21: 932-939.
    • (1999) Bioessays , vol.21 , pp. 932-939
    • Blatch, G.L.1    Lässle, M.2
  • 184
    • 65949107547 scopus 로고    scopus 로고
    • Common genetic variation and human traits
    • Goldstein, D. B. 2009. Common genetic variation and human traits. N. Engl. J. Med. 360: 1696-1698.
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1696-1698
    • Goldstein, D.B.1
  • 186
    • 58049218775 scopus 로고    scopus 로고
    • 1000 Genomes Project promises closer look at variation in human genome
    • Kuehn, B. M. 2008. 1000 Genomes Project promises closer look at variation in human genome. JAMA. 300: 2715.
    • (2008) JAMA , vol.300 , pp. 2715
    • Kuehn, B.M.1
  • 187
    • 58149156386 scopus 로고    scopus 로고
    • Cohort studies and the genetics of complex disease
    • Manolio, T. 2009. Cohort studies and the genetics of complex disease. Nat. Genet. 41: 5-6.
    • (2009) Nat. Genet. , vol.41 , pp. 5-6
    • Manolio, T.1
  • 189
    • 71849106791 scopus 로고    scopus 로고
    • Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers
    • Ioannidis, J. P. 2009. Prediction of cardiovascular disease outcomes and established cardiovascular risk factors by genome-wide association markers. Circ Cardiovasc Genet. 2: 7-15.
    • (2009) Circ Cardiovasc Genet. , vol.2 , pp. 7-15
    • Ioannidis, J.P.1
  • 190
    • 77949320494 scopus 로고    scopus 로고
    • Association of blood lipids with common DNA sequence variants at 19 genetic loci in the Multiethnic United States National Health and Nutrition Examination Survey III
    • Keebler, M. E., C. L. Sanders, A. Surti, C. Guiducci, N. P. Burtt, and S. Kathiresan. 2009. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the Multiethnic United States National Health and Nutrition Examination Survey III. Circ Cardiovasc Genet. 2: 238-243.
    • (2009) Circ Cardiovasc Genet. , vol.2 , pp. 238-243
    • Keebler, M.E.1    Sanders, C.L.2    Surti, A.3    Guiducci, C.4    Burtt, N.P.5    Kathiresan, S.6
  • 194
    • 1842452952 scopus 로고    scopus 로고
    • Ethnic differences in atherosclerosis, cardiovascular disease and lipid metabolism
    • Kuller, L. H. 2004. Ethnic differences in atherosclerosis, cardiovascular disease and lipid metabolism. Curr. Opin. Lipidol. 15: 109-113.
    • (2004) Curr. Opin. Lipidol. , vol.15 , pp. 109-113
    • Kuller, L.H.1
  • 197
    • 62549121231 scopus 로고    scopus 로고
    • Copy number variation in metabolic phenotypes
    • Lanktree, M., and R. A. Hegele. 2008. Copy number variation in metabolic phenotypes. Cytogenet. Genome Res. 123: 169-175.
    • (2008) Cytogenet. Genome Res. , vol.123 , pp. 169-175
    • Lanktree, M.1    Hegele, R.A.2
  • 198
    • 0344189687 scopus 로고
    • DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis
    • Karathanasis, S. K., E. Ferris, and I. A. Haddad. 1987. DNA inversion within the apolipoproteins AI/CIII/AIV-encoding gene cluster of certain patients with premature atherosclerosis. Proc. Natl. Acad. Sci. USA. 84: 7198-7202.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 7198-7202
    • Karathanasis, S.K.1    Ferris, E.2    Haddad, I.A.3
  • 199
    • 0024443049 scopus 로고
    • Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11
    • Ordovas, J. M., D. K. Cassidy, F. Civeira, C. L. Bisgaier, and E. J. Schaefer. 1989. Familial apolipoprotein A-I, C-III, and A-IV deficiency and premature atherosclerosis due to deletion of a gene complex on chromosome 11. J. Biol. Chem. 264: 16339-16342.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16339-16342
    • Ordovas, J.M.1    Cassidy, D.K.2    Civeira, F.3    Bisgaier, C.L.4    Schaefer, E.J.5
  • 200
    • 33947153916 scopus 로고    scopus 로고
    • Genomic copy number variation and its potential role in lipoprotein and metabolic phenotypes
    • Pollex, R. L., and R. A. Hegele. 2007. Genomic copy number variation and its potential role in lipoprotein and metabolic phenotypes . Curr. Opin. Lipidol. 18: 174-180.
    • (2007) Curr. Opin. Lipidol. , vol.18 , pp. 174-180
    • Pollex, R.L.1    Hegele, R.A.2
  • 201
    • 34347353237 scopus 로고    scopus 로고
    • Copy-number variation and association studies of human disease
    • McCarroll, S. A., and D. M. Altshuler. 2007. Copy-number variation and association studies of human disease. Nat. Genet. 39: S37-S42.
    • (2007) Nat. Genet. , vol.39
    • McCarroll, S.A.1    Altshuler, D.M.2
  • 204
    • 68249092574 scopus 로고    scopus 로고
    • Massively parallel sequencing: The next big thing in genetic medicine
    • Tucker, T., M. Marra, and J. M. Friedman. 2009. Massively parallel sequencing: the next big thing in genetic medicine. Am. J. Hum. Genet. 85: 142-154.
    • (2009) Am. J. Hum. Genet. , vol.85 , pp. 142-154
    • Tucker, T.1    Marra, M.2    Friedman, J.M.3
  • 205
    • 39649117755 scopus 로고    scopus 로고
    • The impact of next-generation sequencing technology on genetics
    • Mardis, E. R. 2008. The impact of next-generation sequencing technology on genetics. Trends Genet. 24: 133-141.
    • (2008) Trends Genet. , vol.24 , pp. 133-141
    • Mardis, E.R.1
  • 206
    • 50649105955 scopus 로고    scopus 로고
    • Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers
    • Yeager, M., N. Xiao, R. B. Hayes, P. Bouffard, B. Desany, L. Burdett, N. Orr, C. Matthews, L. Qi, A. Crenshaw, et al. 2008. Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers. Hum. Genet. 124: 161-170.
    • (2008) Hum. Genet. , vol.124 , pp. 161-170
    • Yeager, M.1    Xiao, N.2    Hayes, R.B.3    Bouffard, P.4    Desany, B.5    Burdett, L.6    Orr, N.7    Matthews, C.8    Qi, L.9    Crenshaw, A.10
  • 212
    • 50949095168 scopus 로고    scopus 로고
    • Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data
    • Li, B., and S. M. Leal. 2008. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am. J. Hum. Genet. 83: 311-321.
    • (2008) Am. J. Hum. Genet. , vol.83 , pp. 311-321
    • Li, B.1    Leal, S.M.2
  • 215
    • 33646054594 scopus 로고    scopus 로고
    • Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: Cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study
    • Wittrup, H. H., R. V. Andersen, A. Tybjaerg-Hansen, G. B. Jensen, and B. G. Nordestgaard. 2006. Combined analysis of six lipoprotein lipase genetic variants on triglycerides, high-density lipoprotein, and ischemic heart disease: cross-sectional, prospective, and case-control studies from the Copenhagen City Heart Study. J. Clin. Endocrinol. Metab. 91: 1438-1445.
    • (2006) J. Clin. Endocrinol. Metab. , vol.91 , pp. 1438-1445
    • Wittrup, H.H.1    Andersen, R.V.2    Tybjaerg-Hansen, A.3    Jensen, G.B.4    Nordestgaard, B.G.5
  • 216
    • 77950791661 scopus 로고    scopus 로고
    • The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study
    • Epub ahead of print. August 17, 2009
    • Junyent, M., K. L. Tucker, C. E. Smith, J. M. Lane, J. Mattei, C. Q. Lai, L. D. Parnell, and J. M. Ordovas. 2009. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc Dis. Epub ahead of print. August 17, 2009.
    • (2009) Nutr Metab Cardiovasc Dis.
    • Junyent, M.1    Tucker, K.L.2    Smith, C.E.3    Lane, J.M.4    Mattei, J.5    Lai, C.Q.6    Parnell, L.D.7    Ordovas, J.M.8
  • 217
    • 33644664451 scopus 로고    scopus 로고
    • The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population
    • Sorlí, J. V., D. Corella, F. Francés, J. B. Ramírez, J. I. González, M. Guillén, and O. Portolés. 2006. The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population. Clin. Chim. Acta. 366: 196-203.
    • (2006) Clin. Chim. Acta , vol.366 , pp. 196-203
    • Sorlí, J.V.1    Corella, D.2    Francés, F.3    Ramírez, J.B.4    González, J.I.5    Guillén, M.6    Portolés, O.7
  • 218
    • 33745079199 scopus 로고    scopus 로고
    • The challenge for genetic epidemiologists: How to analyze large numbers of SNPs in relation to complex diseases
    • Heidema, A. G., J. M. A. Boer, N. Nagelkerke, E. C. M. Mariman, D. L. van der A, and E. J. M. Feskens. 2006. The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases. BMC Genet. 7: 23.
    • (2006) BMC Genet. , vol.7 , pp. 23
    • Heidema, A.G.1    Boer, J.M.A.2    Nagelkerke, N.3    Mariman, E.C.M.4    Van Der A, D.L.5    Feskens, E.J.M.6
  • 221
    • 70349428501 scopus 로고    scopus 로고
    • Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study
    • Smith, C. E., D. K. Arnett, M. Y. Tsai, C. Lai, L. D. Parnell, J. Shen, M. Laclaustra, M. Junyent, and J. M. Ordovás. 2009. Physical inactivity interacts with an endothelial lipase polymorphism to modulate high density lipoprotein cholesterol in the GOLDN study. Atherosclerosis. 206: 500-504.
    • (2009) Atherosclerosis , vol.206 , pp. 500-504
    • Smith, C.E.1    Arnett, D.K.2    Tsai, M.Y.3    Lai, C.4    Parnell, L.D.5    Shen, J.6    Laclaustra, M.7    Junyent, M.8    Ordovás, J.M.9
  • 222
    • 45149095026 scopus 로고    scopus 로고
    • The -250G>a promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects
    • Grarup, N., C. H. Andreasen, M. K. Andersen, A. Albrechtsen, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, T. Jørgensen, O. Schmitz, T. Hansen, et al. 2008. The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects. J. Clin. Endocrinol. Metab. 93: 2294-2299.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 2294-2299
    • Grarup, N.1    Andreasen, C.H.2    Andersen, M.K.3    Albrechtsen, A.4    Sandbaek, A.5    Lauritzen, T.6    Borch-Johnsen, K.7    Jørgensen, T.8    Schmitz, O.9    Hansen, T.10
  • 223
    • 0037195149 scopus 로고    scopus 로고
    • Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: Evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study
    • Ordovas, J. M., D. Corella, S. Demissie, L. A. Cupples, P. Couture, O. Coltell, P. W. F. Wilson, E. J. Schaefer, and K. L. Tucker. 2002. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation. 106: 2315-2321.
    • (2002) Circulation , vol.106 , pp. 2315-2321
    • Ordovas, J.M.1    Corella, D.2    Demissie, S.3    Cupples, L.A.4    Couture, P.5    Coltell, O.6    Wilson, P.W.F.7    Schaefer, E.J.8    Tucker, K.L.9
  • 224
    • 34848825888 scopus 로고    scopus 로고
    • Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults
    • Nettleton, J. A., L. M. Steffen, C. M. Ballantyne, E. Boerwinkle, and A. R. Folsom. 2007. Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. Atherosclerosis. 194: e131-e140.
    • (2007) Atherosclerosis , vol.194
    • Nettleton, J.A.1    Steffen, L.M.2    Ballantyne, C.M.3    Boerwinkle, E.4    Folsom, A.R.5
  • 225
    • 70349563932 scopus 로고    scopus 로고
    • Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study
    • Junyent, M., L. D. Parnell, C. Lai, Y. Lee, C. E. Smith, D. K. Arnett, M. Y. Tsai, E. K. Kabagambe, R. J. Straka, M. Province, et al. 2009. Novel variants at KCTD10, MVK, and MMAB genes interact with dietary carbohydrates to modulate HDL-cholesterol concentrations in the Genetics of Lipid Lowering Drugs and Diet Network Study. Am. J. Clin. Nutr. 90: 686-694.
    • (2009) Am. J. Clin. Nutr. , vol.90 , pp. 686-694
    • Junyent, M.1    Parnell, L.D.2    Lai, C.3    Lee, Y.4    Smith, C.E.5    Arnett, D.K.6    Tsai, M.Y.7    Kabagambe, E.K.8    Straka, R.J.9    Province, M.10
  • 226
    • 37849054350 scopus 로고    scopus 로고
    • Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women
    • Jensen, M. K., K. J. Mukamal, K. Overvad, and E. B. Rimm. 2008. Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur. Heart J. 29: 104-112.
    • (2008) Eur. Heart J. , vol.29 , pp. 104-112
    • Jensen, M.K.1    Mukamal, K.J.2    Overvad, K.3    Rimm, E.B.4
  • 227
    • 33646547266 scopus 로고    scopus 로고
    • Genotype-by-sex interaction in the regulation of high-density lipoprotein: The Framingham Heart Study
    • Mosher, M. J., L. J. Martin, L. A. Cupples, Q. Yang, T. D. Dyer, J. T. Williams, and K. E. North. 2005. Genotype-by-sex interaction in the regulation of high-density lipoprotein: the Framingham Heart Study. Hum. Biol. 77: 773-793.
    • (2005) Hum. Biol. , vol.77 , pp. 773-793
    • Mosher, M.J.1    Martin, L.J.2    Cupples, L.A.3    Yang, Q.4    Dyer, T.D.5    Williams, J.T.6    North, K.E.7
  • 228
    • 49749136629 scopus 로고    scopus 로고
    • Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: The Strong Heart Family Study
    • Mosher, M. J., L. A. Lange, B. V. Howard, E. T. Lee, L. G. Best, R. R. Fabsitz, J. W. Maccluer, and K. E. North. 2008. Sex-specific interaction between APOE genotype and carbohydrate intake affects plasma HDL-C levels: the Strong Heart Family Study. Genes Nutr. 3: 87-97.
    • (2008) Genes Nutr. , vol.3 , pp. 87-97
    • Mosher, M.J.1    Lange, L.A.2    Howard, B.V.3    Lee, E.T.4    Best, L.G.5    Fabsitz, R.R.6    Maccluer, J.W.7    North, K.E.8
  • 230
    • 34250219608 scopus 로고    scopus 로고
    • Inconsistencies in the genetic prediction of HDL cholesterol versus atherosclerosis
    • Carlquist, J., and J. L. Anderson. 2007. Inconsistencies in the genetic prediction of HDL cholesterol versus atherosclerosis. Curr. Opin. Cardiol. 22: 352-358.
    • (2007) Curr. Opin. Cardiol. , vol.22 , pp. 352-358
    • Carlquist, J.1    Anderson, J.L.2
  • 233
    • 33748111733 scopus 로고    scopus 로고
    • Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration
    • Rea, T. J., C. M. Brown, and C. F. Sing. 2006. Complex adaptive system models and the genetic analysis of plasma HDL-cholesterol concentration. Perspect. Biol. Med. 49: 490-503.
    • (2006) Perspect. Biol. Med. , vol.49 , pp. 490-503
    • Rea, T.J.1    Brown, C.M.2    Sing, C.F.3
  • 234
    • 33748749272 scopus 로고    scopus 로고
    • A thematic review series: Systems biology approaches to metabolic and cardiovascular disorders
    • Lusis, A. J. 2006. A thematic review series: systems biology approaches to metabolic and cardiovascular disorders. J. Lipid Res. 47: 1887-1890.
    • (2006) J. Lipid Res. , vol.47 , pp. 1887-1890
    • Lusis, A.J.1
  • 238
    • 54249156545 scopus 로고    scopus 로고
    • Metabolic syndrome: From epidemiology to systems biology
    • Lusis, A., A. Attie, and K. Reue. 2008. Metabolic syndrome: from epidemiology to systems biology. Nat. Rev. Genet. 9: 819-830.
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 819-830
    • Lusis, A.1    Attie, A.2    Reue, K.3


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