Gender differences in the genetic and environmental determinants of adolescent depression

Depression and Anxiety

Volumn 27, Issue 7, 2010, Pages 658-666

  Uddin, Monica ^a   Koenen, Karestan C ^b   De Los Santos, Regina ^a   Bakshis, Erin ^a   Aiello, Allison E ^a   Galea, Sandro ^c  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c Mailman School of Public Health ^*  (United States)

Author keywords

Gene environment interaction; Macrosocial environment; Serotonin transporter promoter; Social epidemiology

Indexed keywords

5 HTTLPR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; DEPRESSION; FAMILY FUNCTIONING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENOTYPE; HEALTH SURVEY; HUMAN; PRIORITY JOURNAL; PROMOTER REGION; RACE; RISK ASSESSMENT; SEX DIFFERENCE; SOCIAL ASPECT; SOCIAL SUPPORT; ADOLESCENT BEHAVIOR; ADULT; CHILD; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; PSYCHOLOGY; SOCIAL CLASS; UNITED STATES; YOUNG ADULT;

ADOLESCENT; ADOLESCENT BEHAVIOR; ADULT; CHILD; DEPRESSION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS; SOCIAL CLASS; SOCIAL SUPPORT; UNITED STATES; YOUNG ADULT;

EID: 77956805401     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.20692     Document Type: Article

References (43)

1. Rice F. The genetics of depression in childhood and adolescence. Curr Psychiatry Rep 2009;11:167-173.
2. Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders. Int Rev Psychiatry 2004;16:260-283.
3. Rice F, Harold G, Thapar A. The genetic aetiology of childhood depression: A review. J Child Psychol Psychiatry 2002;43:65-79.
4. Eley TC, Stevenson J. Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. J Child Psychol Psychiatry 1999;40:1273-1282.
5. Silberg J, Pickles A, Rutter M et al. The influence of genetic factors and life stress on depression among adolescent girls. Arch Gen Psychiatry 1999;56:225-232.
6. Moffitt TE, Caspi A, Rutter M. Strategy for investigating interactiosn between measured genes and measured environments. Arch Gen Psychiatry.2005;62: 473-481.
7. Tao-Cheng JH, Zhou FC. Differential polarization of serotonin transporters in axons versus soma-dendrites: An immunogold electron microscopy study. Neuroscience 1999;94: 821-830.
8. Hariri AR, Weinberger DR. Functional neuroimaging of genetic variation in serotonergic neurotransmission. Genes Brain Behav 2003;2:341-349.
9. Lesch KP, Bengel D, Heils A et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996;274:1527-1531.
10. Caspi A, Sugden K, Moffitt TE et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386-389.
11. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Mol Psychiatry 2008;13:131-146.
12. Risch N, Herrell R, Lehner T et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. JAMA 2009;301: 2462-2471.
13. Chipman P, Jorm AF, Prior M et al. No interaction between the serotonin transporter polymorphism (5-HTTLPR) and childhood adversity or recent stressful life events on symptoms of depression: Results from two community surveys. Am J Med Genet B Neuropsychiatr Genet 2007;144B:561-565.
14. Laucht M, Treutlein J, Blomeyer D et al. Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: Evidence from a high-risk community sample of young adults. Int J Neuropsychopharmacol 2009:1-11.
15. Cicchetti D, Rogosch FA, Sturge-Apple ML. Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds. Dev Psychopathol 2007;19:1161-1180.
16. Eley TC, Sugden K, Corsico A et al. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 2004;9:908-915.
17. Sjoberg RL, Nilsson KW, Nordquist N et al. Development of depression: Sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 2006;9:443-449.
18. Carlsson M, Carlsson A. A regional study of sex differences in rat brain serotonin. Prog Neuropsychopharmacol Biol Psychiatry 1988;12:53-61.
19. Barr CS, Newman TK, Schwandt M et al. Sexual dichotomy of an interaction between early adversity and the serotonin transporter gene promoter variant in rhesus macaques. Proc Natl Acad Sci USA 2004;101:12358-12363.
20. Jorm AF, Prior M, Sanson A et al. Association of a functional polymorphism of the serotonin transporter gene with anxietyrelated temperament and behavior problems in children: A longitudinal study from infancy to the mid-teens. Mol Psychiatry 2000;5:542-547.
21. Kaufman J, Yang BZ, Douglas-Palumberi H et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 2006;59:673-680.
22. Kaufman J, Yang BZ, Douglas-Palumberi H et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proc Natl Acad Sci USA 2004;101: 17316-17321.
23. Leventhal T, Brooks-Gunn J. Moving to opportunity: An experimental study of neighborhood effects on mental health. Am J Public Health 2003;93:1576-1582.
24. Kling JR, Jeffrey JB, Katz LF. Experimental analysis of neighborhood effects. Econometrica 2007;75:83-119.
25. Harris KM. The National Longitudinal Study of Adolescent Health (Add Health), Waves I & II, 1994-1996; Wave III, 2001-2002 [machine-readable data file and documentation]. Chapell Hill, NC: Carolina Population Center, University of North Carolina at Chapel Hill; 2008.
26. Harris KM, Halpern CT, Smolen A et al. The National Longitudinal Study of Adolescent Health (Add Health) twin data. Twin Res Hum Genet 2006;9:988-997.
27. Radloff L. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Meas 1977; 1:385-401.
28. Heils A, Teufel A, Petri S et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996;66: 2621-2624.
29. Robert SA. Community-level socioeconomic status effects on adult health. J Health Soc Behav 1998;39:18-37.
30. Guo G, Wang J. The mixed or multilevel model for behavior genetic analysis. Behav Genet 2002;32:37-49.
31. Gelernter J, Kranzler H, Cubells JF. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Hum Genet 1997;101:243-246.
32. Rodriguez S, Gaunt TR, Day IN. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol 2009;169:505-514.
33. Jacobs N, Kenis G, Peeters F et al. Stress-related negative affectivity and genetically altered serotonin transporter function: Evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 2006;63:989-996.
34. Tuvblad C, Grann M, Lichtenstein P. Heritability for adolescent antisocial behavior differs with socioeconomic status: Geneenvironment interaction. J Child Psychol Psychiatry 2006;47: 734-743.
35. Tajima F. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 1989;123: 585-595.
36. Hinds DA, Stuve LL, Nilsen GB et al. Whole-genome patterns of common DNA variation in three human populations. Science 2005;307:1072-1079.
37. Nakamura M, Ueno S, Sano A et al. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 2000;5:32-38.
38. Stein MB, Seedat S, Gelernter J. Serotonin transporter gene promoter polymorphism predicts SSRI response in generalized social anxiety disorder. Psychopharmacology (Berl) 2006;187: 68-72.
39. Hu X, Oroszi G, Chun J et al. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin Exp Res 2005;29: 8-16.
40. Tang H, Quertermous T, Rodriguez B et al. Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet 2005;76:268-275.
41. Philibert RA, Sandhu H, Hollenbeck N et al. The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet 2008;147B:543-549.
42. Philibert R, Madan A, Andersen A et al. Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet 2007;144B:101-105.
43. Koenen KC, Aiello AE, Bakshis E et al. Modification of the association between serotonin transporter genotype and risk of posttraumatic stress disorder in adults by county-level social environment. Am J Epidemiol 2009;169:704-711.