Greater reduction of striatal dopamine transporter availability during the symptomatic than asymptomatic phase of Kleine-Levin syndrome

Sleep Medicine

Volumn 11, Issue 9, 2010, Pages 959-

  Hoexter, Marcelo Q ^a   Shih, Ming C ^a   Felício, André C ^a,b   Tufik, Sergio ^c   Bressan, Rodrigo A ^a,b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL ISRAELITA ALBERT EINSTEIN   (Brazil)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER;

BRAIN SIZE; EVOKED CORTICAL RESPONSE; HUMAN; HYPERSOMNIA; LETTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRIATE CORTEX; SYMPTOMATOLOGY; VOLUMETRY;

CORPUS STRIATUM; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; KLEINE-LEVIN SYNDROME; MALE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; YOUNG ADULT;

EID: 77956801378     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2010.03.002     Document Type: Letter

References (5)

1. Arnulf I., Lin L., Gadoth N., File J., Lecendreux M., Franco P., et al. Kleine-Levin syndrome: a systematic study of 108 patients. Ann Neurol 2008, 63(4):482-493.
2. Koerber R.K., Torkelson R., Haven G., Donaldson J., Cohen S.M., Case M. Increased cerebrospinal fluid 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in Kleine-Levin syndrome. Neurology 1984, 34:1597-1600.
3. Chesson A.L., Levine S.N., Kong L.S., Lee S.C. Neuroendocrine evaluation in Kleine-Levin syndrome: evidence of reduced dopaminergic tone during periods of hypersomnolence. Sleep 1991, 14:226-232.
4. Hoexter M.Q., Shih M.C., Mendes D.D., Godeiro-Junior C., Felicio A.C., Fu Y.K., et al. Lower dopamine transporter density in an asymptomatic patient with Kleine-Levin syndrome. Acta Neurol Scand 2008, 117(5):370-373.
5. Szobot C.M., Shih M.C., Schaefer T., Júnior N., Hoexter M.Q., Fu Y.K., et al. Methylphenidate DAT binding in adolescents with attention-deficit/hyperactivity disorder comorbid with substance use disorder - a single photon emission computed tomography with [Tc(99m)]TRODAT-1 study. Neuroimage 2008, 40(3):1195-1201.