Intralesional chemotherapy for nonmelanoma skin cancer: A practical review

Journal of the American Academy of Dermatology

Volumn 63, Issue 4, 2010, Pages 689-702

  Kirby, Joslyn S ^a   Miller, Christopher J ^b  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

basal cell carcinoma; bleomycin; chemotherapy; fluorouracil; interferon; intralesional; keratoacanthoma; methotrexate; squamous cell carcinoma

Indexed keywords

ALCOHOL; ALPHA INTERFERON; ALPHA2A INTERFERON; ALPHA2B INTERFERON; BETA INTERFERON; BLEOMYCIN; BUPIVACAINE; CREATININE; DAPSONE; DIPYRIDAMOLE; FLUOROURACIL; GAMMA INTERFERON; INTERFERON; LIDOCAINE; METHOTREXATE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PENICILLIN DERIVATIVE; PHENOTHIAZINE DERIVATIVE; PHENYTOIN; PROBENECID; RETINOID; SALICYLIC ACID; SULFONAMIDE; SULFONYLUREA; TETRACYCLINE; TRIMETHOPRIM; ANTINEOPLASTIC AGENT;

ALOPECIA; BASAL CELL CARCINOMA; BLOOD CELL COUNT; BREAST FEEDING; CANCER CHEMOTHERAPY; CANCER GROWTH; CANCER SURGERY; CANCER THERAPY; CLINICAL STUDY; CLINICAL TRIAL; CREATININE BLOOD LEVEL; CRUSTING; CYTOPENIA; CYTOTOXICITY; DIARRHEA; DNA SYNTHESIS INHIBITION; DRUG COST; DRUG HYPERSENSITIVITY; DRUG MECHANISM; EAR; EMOTIONAL DISORDER; ERYTHEMA; FACE; FEVER; FOLATE METABOLISM; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GOLD STANDARD; HAND; HEADACHE; HEMODIALYSIS; HISTOPATHOLOGY; HUMAN; INFORMATION RETRIEVAL; INJECTION SITE PAIN; INOCULATION; KERATOACANTHOMA; KIDNEY FAILURE; LEG; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FUNCTION TEST; LIVER TOXICITY; LUNG FIBROSIS; LUNG TOXICITY; MALAISE; MEDLINE; MULTIPLE CANCER; MYALGIA; NAUSEA; NECROSIS; NEPHROTOXICITY; OUTCOME ASSESSMENT; PAIN; PANCYTOPENIA; PREGNANCY; PRIORITY JOURNAL; RAYNAUD PHENOMENON; REVIEW; SCALP; SCLERODERMA; SKIN CANCER; SKIN DISEASE; SQUAMOUS CELL CARCINOMA; STOMATITIS; SUSTAINED RELEASE FORMULATION; SYRINGE; TERATOGENICITY; THORAX; TREATMENT CONTRAINDICATION; TREATMENT RESPONSE; TUMOR BIOPSY; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR VOLUME; ULCER; UREA NITROGEN BLOOD LEVEL; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIAL (TOPIC); DRUG COMBINATION; FEMALE; INTRALESIONAL DRUG ADMINISTRATION; MALE; PATHOLOGY; PRACTICE GUIDELINE; RISK ASSESSMENT; SKIN NEOPLASMS; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLEOMYCIN; CARCINOMA, BASAL CELL; CARCINOMA, SQUAMOUS CELL; CLINICAL TRIALS AS TOPIC; DRUG THERAPY, COMBINATION; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRALESIONAL; INTERFERONS; MALE; METHOTREXATE; PRACTICE GUIDELINES AS TOPIC; RISK ASSESSMENT; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 77956738766     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaad.2009.09.048     Document Type: Review

References (60)

1. Miller SJ, Anderson J, Berg D, Bichakjian CK, Bowen G, Cheney RT, et al. NCCN clinical practice guidelines in oncology. Basal cell and squamous cell skin cancers. Available from: http://www.nccn.org/professionals/physician-gls. Accessed March 25, 2009.
2. N.M. Annest, M.J. VanBeek, C.J. Arpey, and D.C. Whitaker Intralesional methotrexate treatment for keratoacanthoma tumors: A retrospective study and review of the literature J Am Acad Dermatol 56 2007 989 993
3. D.K. Goette Keratoacanthoma and its treatment J Assoc Milit Dermatol 10 1984 3 10
4. J.L. Melton, B.R. Nelson, D.B. Stough, M.D. Brown, N.A. Swanson, and T.M. Johnson Treatment of keratoacanthomas with intralesional methotrexate J Am Acad Dermatol 25 1991 1017 1023
5. K. Spieth, J. Gille, and R. Kaufmann Intralesional methotrexate as effective treatment in solitary giant keratoacanthoma of the lower lip Dermatology 200 2000 317 319
6. C. Cuesta-Romero, and J. de Grado-Pena Intralesional methotrexate in solitary keratoacanthoma Arch Dermatol 134 1998 513 514
7. M. Goebeler, C. Lurz, M.E. Kolve-Goebeler, and E.B. Brocker Pancytopenia after treatment of keratoacanthoma by single lesional methotrexate infiltration Arch Dermatol 137 2001 1104 1105
8. J.G. de Visscher, K.G. van der Wal, R. Blanken, and F. Willemse Treatment of giant keratoacanthoma of the skin of the lower lip with intralesional methotrexate: A case report J Oral Maxillofac Surg 60 2002 93 95
9. P.R. Cohen, K.E. Schulze, and B.R. Nelson Pancytopenia after a single intradermal infiltration of methotrexate J Drugs Dermatol 4 2005 648 651
10. P.R. Cohen, K.E. Schulze, C.F. Teller, and B.R. Nelson Intralesional methotrexate for keratoacanthoma of the nose Skinmed 4 2005 393 395
11. A. Singal, S. Mohanty, S.N. Bhattacharya, M.C. Baruah, and N. Singh Unusual multiple keratoacanthoma in a child successfully treated with 5-fluorouracil J Dermatol 24 1997 546 548
12. B. Kurtis, and T. Rosen Treatment of cutaneous neoplasms by intralesional injections of 5-fluorouracil (5-FU) J Dermatol Surg Oncol 6 1980 122 127
13. C.M. Parker, and C.W. Hanke Large keratoacanthomas in difficult locations treated with intralesional 5-fluorouracil J Am Acad Dermatol 14 1986 770 777
14. A.L. Leonard, and C.W. Hanke Treatment of giant keratoacanthoma with intralesional 5-fluorouracil J Drugs Dermatol 5 2006 454 456
15. D.K. Goette, and R.B. Odom Successful treatment of keratoacanthoma with intralesional fluorouracil J Am Acad Dermatol 2 1980 212 216
16. R.B. Odom, and D.K. Goette Treatment of keratoacanthomas with intralesional fluorouracil Arch Dermatol 114 1978 1779 1783
17. E. Klein, F. Helm, H. Milgrom, H.L. Stoll Jr., and H.L. Traenkle Tumors of the skin, II: keratoacanthoma; local effect of 5-fluorouracil Skin 1 1962 153 156
18. L.G. Morse, C. Kendrick, D. Hooper, H. Ward, and E. Parry Treatment of squamous cell carcinoma with intralesional 5-fluorouracil Dermatol Surg 29 2003 1150 1153
19. S.W. Eubanks, R.H. Gentry, J.W. Patterson, and D.L. May Treatment of multiple keratoacanthomas with intralesional fluorouracil J Am Acad Dermatol 7 1982 126 129
20. B. Kurtis, and T. Rosen Squamous cell carcinoma arising in a basal cell epithelioma treated with 5-fluorouracil J Dermatol Surg Oncol 5 1979 394 396
21. W.H. Avant, and R.C. Huff Intradermal 5-fluorouracil in the treatment of basal cell carcinoma of the face South Med J 69 1976 561 563
22. S. Sayama, and H. Tagami Treatment of keratoacanthoma with intralesional bleomycin Br J Dermatol 109 1983 449 452
23. C. de la Torre, A. Losada, and M.J. Cruces Keratoacanthoma centrifugum marginatum: treatment with intralesional bleomycin J Am Acad Dermatol 37 1997 1010 1011
24. A. Andreassi, E. Pianigiani, P. Taddeucci, G. Lorenzini, M. Fimiani, and M. Biagioli Guess what! Keratoacanthoma treated with intralesional bleomycin Eur J Dermatol 9 1999 403 405
25. M.S. Gyurova, M.Z. Stancheva, M.N. Arnaudova, and R.K. Yankova Intralesional bleomycin as alternative therapy in the treatment of multiple basal cell carcinomas Dermatol Online J 12 2006 25
26. Y. Mishima, and M. Matunaka Effect of bleomycin on benign and malignant cutaneous tumors Acta Derm Venereol 52 1972 211 215
27. D. Dyall-Smith Intralesional bleomycin Australas J Dermatol 39 1998 123 124
28. L. Kowalzick, T. Rogozinski, C. Schober, G. Fierlbeck, H. Mensing, and S. Jablonska Treatment of basal cell carcinoma with intralesional recombinant interferon beta: A dose-finding study Eur J Dermatol 4 1994 430 433
29. L. Kowalzick, T. Rogozinski, R. Wimheuer, J. Pilz, U. Manske, and A. Scholz Intralesional recombinant interferon beta-1a in the treatment of basal cell carcinoma: results of an open-label multicenter study Eur J Dermatol 12 2002 558 561
30. B. Tank, J.M. Habets, B. Naafs, O. Damsma, E. Stolz, and T. van Joost Intralesional treatment of basal cell carcinoma with low-dose recombinant interferon gamma J Am Acad Dermatol 21 1989 734 735
31. L. Edwards, D. Whiting, D. Rogers, K. Luck, and K.A. Smiles The effect of intralesional interferon gamma on basal cell carcinomas J Am Acad Dermatol 22 1990 496 500 (Pubitemid 20212405)
32. B. Dogan, Y. Harmanyeri, H. Baloglu, and I. Oztek Intralesional alfa-2a interferon therapy for basal cell carcinoma Cancer Lett 91 1995 215 219
33. P. LeGrice, E. Baird, and L. Hodge Treatment of basal cell carcinoma with intralesional interferon alpha-2a N Z Med J 108 1995 206 207
34. J.J. Grob, A.M. Collet, M.H. Munoz, and J.J. Bonerandi Treatment of large basal-cell carcinomas with intralesional interferon-alpha-2a Lancet 1 1988 878 879
35. E. Alpsoy, E. Yilmaz, E. Basaran, and S. Yazar Comparison of the effects of intralesional interferon alfa-2a, 2b and the combination of 2a and 2b in the treatment of basal cell carcinoma J Dermatol 23 1996 394 396
36. S. Bostanci, P. Kocyigit, A. Alp, C. Erdem, and E. Gurgey Treatment of basal cell carcinoma located in the head and neck region with intralesional interferon a-2a Clin Drug Invest 25 2005 661 667
37. L. Edwards, S.B. Tucker, D. Perednia, K.A. Smiles, E.L. Taylor, and D.J. Tanner The effect of an intralesional sustained release formulation of interferon alfa-2b on basal cell carcinomas Arch Dermatol 126 1990 1029 1032
38. A. Pizarro, and E. Fonseca Treatment of basal cell carcinoma with intralesional interferon alpha-2b: evaluation of efficacy with emphasis on tumors located on "H" zone on face Eur J Dermatol 4 1994 287 290
39. V. Boneschi, L. Brambilla, G. Chiappino, N. Mozzanica, and A.F. Finzi Intralesional alpha 2b recombinant interferon for basal cell carcinomas Int J Dermatol 30 1991 220 224
40. N. Mozzanica, A. Cattaneo, V. Boneschi, L. Brambilla, E. Melotti, and A.F. Finzi Immunohistological evaluation of basal cell carcinoma immunoinfiltrate during intralesional treatment with alpha 2-interferon Arch Dermatol Res 282 1990 311 317
41. S.A. Buechner Intralesional interferon alfa-2b in the treatment of basal cell carcinoma: immunohistochemical study on cellular immune reaction leading to tumor regression J Am Acad Dermatol 24 1991 731 734
42. D. Kopera, L. Cerroni, R. Fink-Puches, and H. Kerl Different treatment modalities for the management of a patient with the nevoid basal cell carcinoma syndrome J Am Acad Dermatol 34 1996 937 939
43. M.F. Healsmith, J. Berth-Jones, A. Fletcher, and R.A. Graham-Brown Treatment of basal cell carcinoma with intralesional interferon alpha-2b J R Soc Med 84 1991 524 526
44. B. Stenquist, A.M. Wennberg, H. Gisslen, and O. Larko Treatment of aggressive basal cell carcinoma with intralesional interferon: evaluation of efficacy by Mohs surgery J Am Acad Dermatol 27 1992 65 69
45. S. Chimenti, K. Peris, S. Di Cristofaro, M.C. Fargnoli, and G. Torlone Use of recombinant interferon alfa-2b in the treatment of basal cell carcinoma Dermatology 190 1995 214 217
46. K. Thestrup-Pedersen, I.E. Jacobsen, and G. Frentz Intralesional interferon-alpha 2b treatment of basal cell carcinoma Acta Derm Venereol 70 1990 512 514
47. K.H. Kim, R.M. Yavel, V.L. Gross, and N. Brody Intralesional interferon alpha-2b in the treatment of basal cell carcinoma and squamous cell carcinoma: revisited Dermatol Surg 30 2004 116 120
48. R.R. McDonald, and K. Georgouras Treatment of basal cell carcinoma with intralesional interferon alpha: A case report and literature review [see comment] Australas J Dermatol 33 1992 81 86
49. S.B. Tucker, J.W. Polasek, A.J. Perri, and E.A. Goldsmith Long-term follow-up of basal cell carcinomas treated with perilesional interferon alfa 2b as monotherapy J Am Acad Dermatol 54 2006 1033 1038
50. R.C. Cornell, H.T. Greenway, S.B. Tucker, L. Edwards, S. Ashworth, and J.C. Vance Intralesional interferon therapy for basal cell carcinoma [see comment] J Am Acad Dermatol 23 1990 694 700 (Pubitemid 20336398)
51. L. Wickramasinghe, T.C. Hindson, and H. Wacks Treatment of neoplastic skin lesions with intralesional interferon J Am Acad Dermatol 20 1989 71 74
52. H.T. Greenway, R.C. Cornell, D.J. Tanner, E. Peets, G.M. Bordin, and C. Nagi Treatment of basal cell carcinoma with intralesional interferon J Am Acad Dermatol 15 1986 437 443
53. L. Edwards, B. Berman, R.P. Rapini, D.A. Whiting, S. Tyring, and H.T. Greenway Treatment of cutaneous squamous cell carcinomas by intralesional interferon alfa-2b therapy Arch Dermatol 128 1992 1486 1489
54. R.F. Wagner, and R.L. Sanchez Presentation of sebaceous carcinoma and dermatofibromasarcoma protuberans subsequent to intralesional interferon alfa-2b for the treatment of in situ squamous cell carcinoma Arch Dermatol 127 1991 272
55. J.J. Grob, F. Suzini, M.A. Richard, M. Weiller, H. Zarour, and C. Noe Large keratoacanthomas treated with intralesional interferon alfa-2a J Am Acad Dermatol 29 1993 237 241
56. C.K. Oh, H.S. Son, J.B. Lee, H.S. Jang, and K.S. Kwon Intralesional interferon alfa-2b treatment of keratoacanthomas [erratum appears in J Am Acad Dermatol 2004;51:1040] J Am Acad Dermatol 51 Suppl 2004 S177 S180
57. J.C. Martinez, and C.C. Otley The management of melanoma and nonmelanoma skin cancer: A review for the primary care physician Mayo Clin Proc 76 2001 1253 1265
58. N. Smeets, D.I. Kuijpers, P. Nelemans, J.U. Ostertag, M.E. Verhaegh, and G.A. Krekels Mohs' micrographic surgery for treatment of basal cell carcinoma of the face-results of a retrospective study and review of the literature Br J Dermatol 151 2004 141 147 (Pubitemid 39061291)
59. P.O. Larson Keratoacanthomas treated with Mohs' micrographic surgery (chemosurgery): a review of forty-three cases J Am Acad Dermatol 16 1987 1040 1044
60. A. Stefanou, and J. Siderov Medical errors. Dosage nomenclature of bleomycin needs to be standardised to avoid errors Br Med J 322 2001 1423 1424