Chapter 3.1.5 The use of targeted point mutants in the study of learning and memory

Techniques in the Behavioral and Neural Sciences

Volumn 13, Issue C, 1999, Pages 305-314

  Giese, Karl Peter ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77956671164     PISSN: 09210709     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0921-0709(99)80027-3     Document Type: Article

References (52)

1. Adelman J.P., Bond C.T., Pessia M., and Maylie J. Episodic ataxia results from voltage-dependent potassium channels with altered functions. Neuron 15 (1995) 1449-1454
2. Araki K., Imaizumi T., Okuyama K., Oike Y., and Yamamura K. Efficiency of recombination by Cretransient expression in embryonic stem cells: Comparison of various promoters. J. Biochem. 122 (1997) 977-982
3. Askew G.R., Doetschman T., and Lingrel J.B. Site-directed point mutations in embryonic stem cells: a gene targeting tag-and-exchange strategy. Mol. Cell. Biol. 13 (1993) 4115-4124
4. Bach M.E., Hawkins R.D., Osman M., Kandel E.R., and Mayford M. Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the 0 frequency. Cell 81 (1995) 905-915
5. Browne D.L., Gancher S.T., Nutt J.G., Brunt E.R.P., Smith E.A., Kramer P., and Litt M. Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1. Nat. Genet. 8 (1994) 136-140
6. Brusa R., Zimmermann F., Koh D.-S., Gass P., Seeburg P.H., and Sprengel R. Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluRB allele in mice. Science 270 (1995) 1677-1680
7. Chapman P.F., Frenguelli B., Smith A., Chen C.-M., and Silva A.J. The α-calcium-calmodulin kinase II: a bidirectional modulator of pre-synaptic plasticity. Neuron 14 (1995) 591-597
8. αΔ- mice. Science 279 (1998) 867-869
9. Deng C., Thomas K.R., and Capecchi M.R. Location of crossovers during gene targeting with insertion and replacement vectors. Mol. Cell. Biol. 13 (1993) 2134-2140
10. 2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 264 (1989) 16759-16763
11. 286 of the α calcium-calmodulin kinase II in LTP and learning. Science 279 (1998) 870-873
12. Grant S.G.N., O'Dell T.J., Karl K.A., Stein P.L., Soriano P., and Kandel E.R. Impaired long-term potentiation, spatial learning and hippocampal development in fyn mutant mice. Science 258 (1992) 1903-1910
13. 2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation. Neuron 3 (1989) 59-70
14. 2+/calmodulin-dependent protein kinases. Annu. Rev. Biochem. 61 (1992) 559-601
15. Hasty P., Ramirez-Solis R., Krumlauf R., and Bradley A. Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells. Nature 350 (1991) 243-246
16. Hasty P., Rivera-Perez J., and Bradley A. The length of homology required for gene targeting in embryonic stem cells. Mol. Cell. Biol. 11 (1991) 5586-5591
17. P. H., Rivera-Perez J., Chang C., and Bradley A. Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol. Cell. Biol. 11 (1991) 4509-4517
18. Hemsley A., Arnheim N., Toney M.D., Cortopassi G., and Galas D.J. A simple method for site-directed mutagenesis using the polymerase chain reaction. Nucl. Acids Res. 17 (1989) 6545-6551
19. Herrup K., and Noebels J. Ion channel mutants and their impact on behavior and disease. Society for Neuroscience Short Course 2 Syllabus (1997)
20. Joyner A.L. Gene targeting: A practical approach (1993), IRL Press, Oxford
21. Kellendonk C., Tronche F., Monaghan A.P., Angrand P.O., Stewart F., and Schlitz G. Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucl. Acids. Res. 24 (1996) 1404-1411
22. Lakhlani P.P., MacMillan L.B., Guo T.Z., McCool B.A., Lovinger D.M., Maze M., and Limbird L.E. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc. Natl. Acad. Sci. USA 94 (1997) 9950-9955
23. 2+/calmodulin-dependent protein kinase molecules of the postsynaptic density. Proc. Natl. Acad. Sci. USA 85 (1988) 5320-5324
24. Lisman J. The CaM kinase II hypothesis for the storage of synaptic memory. Trends Neurosci. 17 (1994) 406-412
25. Lledo P.-M., Hjelmstad G.O., Mukherji S., Soderling T.R., Malenka R.C., and Nicoll R.A. Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. Proc. Natl. Acad. Sci. USA 92 (1995) 11175-11179
26. Mansour S.L., Thomas K.R., and Capecchi M.R. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336 (1988) 348-352
27. Mayford M., Wang J., Kandel E.R., and O'Dell T.J. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81 (1995) 891-904
28. Mayford M., Bach M.E., Huang Y.-Y., Wang L., Hawkins R.D., and Kandel E.R. Control of memory formation through regulated expression of a CaMKII transgene. Science 274 (1996) 1678-1683
29. 2+-triggered molecular switch. Cell 44 (1986) 861-870
30. Nagy A., Rossant J., Nagy R., Abramow-Newerly W., and Roder J.C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 90 (1993) 8424-8428
31. 2+-independent activity of calmodulin-dependent protein kinase II α subunit. J. Biochem. 109 (1991) 137-143
32. Olson E.N., Arnold H.-H., Rigby P.W.J., and Wold B.J. Know your neighbors: three phenotypes in null mutants of the myogenic bHLH gene MRF4. Cell 85 (1996) 1-4
33. Pettit D.L., Perlman S., and Malinow R. Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons. Science 266 (1994) 1881-1885
34. Ramirez-Solis R., Zheng H., Whiting J., Krumlauf R., and Bradley A. Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell 73 (1993) 279-294
35. Reaume A.G., Howland D.S., Trusko S.P., Savage M.J., Lang D.M., Greenberg B.D., Siman R., and Scott R.W. Enhanced amyloidgenic processing of the ?-amyloid precursor protein in gene-targeted mice bearing the Swedish familial alzheimer's disease mutations and a "humanized" a? sequence. J. Biol. Chem. 271 (1996) 23380-23388
36. Rotenberg A., Mayford M., Hawkins R.D., Kandel E.R., and Muller R.U. Mice expressing activated CaMKII lack low frequency LTP and do not form stable place cells in the CA1 region of the hippocampus. Cell 87 (1996) 1351-1361
37. Sambrook J., Fritsch E.F., and Maniatis T. Molecular cloning: A laboratory manual (1989), CSHL Press
38. Sauer B. Manipulation of transgenes by site-specific recombination: use of Cre recombinase. Methods Enzymol. 225 (1993) 890-900
39. Silva A.J., Stevens C.F., Tonegawa S., and Wang Y. Deficient hippocampal long-term potentiation in alpha-calcium calmodulin kinase II mutant mice. Science 257 (1992) 201-206
40. Silva A.J., Paylor R., Wehner J.M., and Tonegawa S. Impaired spatial learning in alpha-calcium calmodulin kinase II mutant mice. Science 257 (1992) 206-211
41. Silva A.J., Smith A., and Giese K.P. Gene targeting and the biology of learning and memory. Annu. Rev. Genet. 31 (1997) 527-546
42. Silva A.J., Simpson E.M., Takahashi J.S., Lipp H.-P., Nakanishi S., Wehner J.M., Giese K.P., Tully T., Abel T., Chapman P.F., Fox K., Grant S., Itohara S., Lathe R., Mayford M., McNamara J.O., Morris R.J., Picciotti M., Roder J., Shin H.-S., Schlesinger P.A., Storm D.R., Stryker M.P., Wang Y., and Wolfer D.P. Mutant mice and neuroscience: recommendations concerning genetic background. Neuron 9 (1997) 755-759
43. Soriano P., Montgomery C., Geske R., and Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64 (1991) 693-702
44. Stacey A., Schnieke A., McWhir J., Cooper J., Colman A., and Melton D.W. Use of double-replacement gene targeting to replace the murine α-lactalbumin gene with its human counterpart in embryonic stem cells and mice. Mol. Cell. Biol. 14 (1994) 1009-1016
45. TeRiele H., Maandag E.R., and Berns A. Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs. Proc. Natl. Acad. Sei. USA 89 (1992) 5128-5132
46. Thomas K.R., and Capecchi M.R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51 (1987) 503-512
47. Van Doorninck J.H., French P.J., Verbeek E., Peters R.H.P.C., Morreau H., Bijman J., and Scholte B.J. A mouse model for the cystic fibrosis AF508 mutation. EMBO J. 14 (1995) 4403-4411
48. Vazquez J.C., Nogues C., Rucker E.B., and Piedrahita J.A. Factors affecting the efficiency of introducing precise genetic changes in ES cells by homologous recombination: tag-and-exchange versus the Cre-loxP system. Transgenic Res. 7 (1998) 181-193
49. 2+/calmodulin-independent activity. Proc. Natl. Aead. Sci. USA 87 (1990) 1273-1277
50. Wu H., Liu X., and Jaenisch R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Colla-1 gene by homologous recombination in embryonic stem cells. Proc. Natl. Acad. Sci. USA 91 (1994) 2819-2823
51. Zerr P., Adelman J.P., and Maylie J. Episodic ataxia mutations in Kvl.1 alter potassium channel function by dominant negative effects or haploinsufficiency. J. Neurosci. 18 (1998) 2842-2848
52. Zucker R.S. Short-term synaptic plasticity. Annu. Rev. Neurosei. 12 (1989) 13-31