Prehospital high-dose tirofiban in patients undergoing primary percutaneous intervention. the AGIR-2 study

Archives of Cardiovascular Diseases

Volumn 103, Issue 5, 2010, Pages 285-292

  El Khoury, Carlos ^a   Dubien, Pierre Yves ^b   Mercier, Catherine ^b   Belle, Loic ^c   Debaty, Guilaume ^d   Capel, Olivier ^b   Perret, Thibault ^e   Savary, Dominique ^c   Serre, Patrice ^f   Bonnefoy, Eric ^b  

^a Hussel Hospital   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c RESURCOR Réseau des Urgences Coronaires Network   (France)

^d GRENOBLE UNIVERSITY HOSPITAL   (France)

^e Cardiology Department   (France)

^f Hopital Fleyriat   (France)

Author keywords

Acute myocardial infarction; Glycoprotein IIb IIIa inhibitor; Prehospital care; Primary angioplasty; Tirofiban

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; HEPARIN; TIROFIBAN; TROPONIN I; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; CREATINE KINASE; TICLOPIDINE; TYROSINE;

AMBULANCE; ANGIOCARDIOGRAPHY; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MEGADOSE; EMERGENCY CARE; FEMALE; HEART CATHETERIZATION; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PERCUTANEOUS CORONARY INTERVENTION; RANDOMIZED CONTROLLED TRIAL; ST SEGMENT ELEVATION; ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; STENT THROMBOSIS; ANALOGS AND DERIVATIVES; BLOOD; COMPARATIVE STUDY; CORONARY ARTERY BLOOD FLOW; DRUG ADMINISTRATION; DRUG COMBINATION; EMERGENCY HEALTH SERVICE; FRANCE; MYOCARDIAL INFARCTION; PATHOPHYSIOLOGY; TIME; TRANSLUMINAL CORONARY ANGIOPLASTY; TREATMENT OUTCOME;

AMBULANCES; ANGIOPLASTY, BALLOON, CORONARY; BIOLOGICAL MARKERS; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CREATINE KINASE; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; EMERGENCY MEDICAL SERVICES; FEMALE; FRANCE; HUMANS; MALE; MYOCARDIAL INFARCTION; PLATELET AGGREGATION INHIBITORS; TICLOPIDINE; TIME FACTORS; TREATMENT OUTCOME; TROPONIN I; TYROSINE;

EID: 77956651449     PISSN: 18752136     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acvd.2010.04.005     Document Type: Article

References (15)

1. W.E. Boden, J. Hoekstra, and C.D. Miller ST-elevation myocardial infarction: the role of adjunctive antiplatelet therapy Am J Emerg Med 26 2008 212 220
2. F. Van de Werf, J. Bax, and A. Betriu Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology Eur Heart J 29 2008 2909 2945
3. G. De Luca, C.M. Gibson, and F. Bellandi Early glycoprotein IIb-IIIa inhibitors in primary angioplasty (EGYPT) cooperation: an individual patient data meta-analysis Heart 94 2008 1548 1558
4. N. von Beckerath, D. Taubert, G. Pogatsa-Murray, E. Schömig, A. Kastrati, and A. Schömig Absorption metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (intracoronary stenting and antithrombotic regimen: choose between 3 high oral doses for immediate clopidogrel effect) trial Circulation 112 2005 2946 2950
5. A.W.J. Van't Hof, J. Ten Berg, and T. Heestermans Prehospital initiation of tirofiban in patients with ST-elevation myocardial infarction undergoing primary angioplasty (On-TIME 2): a multicentre, double-blind, randomised controlled trial Lancet 372 2008 537 546
6. G. Montalescot, M. Borentain, L. Payot, J.P. Collet, and D. Thomas Early vs late administration of glycoprotein IIb/IIIa inhibitors in primary percutaneous coronary intervention of acute ST-segment elevation myocardial infarction: a meta-analysis JAMA 292 2004 362 366
7. G.W. Stone, D. Cox, and E. Garcia Normal flow (TIMI-3) before mechanical reperfusion therapy is an independent determinant of survival in acute myocardial infarction: analysis from the primary angioplasty in myocardial infarction trials Circulation 104 2001 636 641
8. B.R. Brodie, T.D. Stuckey, C. Hansen, and D. Muncy Benefit of coronary reperfusion before intervention on outcomes after primary angioplasty for acute myocardial infarction Am J Cardiol 85 2000 13 18
9. D.P. Lee, N.A. Herity, and B.L. Hiatt Adjunctive platelet glycoprotein IIb/IIIa receptor inhibition with tirofiban before primary angioplasty improves angiographic outcomes: results of the tirofiban given in the emergency room before primary angioplasty (TIGER-PA) pilot trial Circulation 107 2003 1497 1501
10. J. Mehilli, A. Kastrati, and S. Schulz Abciximab in patients with acute ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention after clopidogrel loading: a randomized double-blind trial Circulation 119 2009 1933 1940
11. G.B. Danzi, C. Capuano, M. Sesana, and R. Baglini Preliminary experience with a high bolus dose of tirofiban during percutaneous coronary intervention Curr Med Res Opin 19 2003 28 33
12. Z. Huczek, K.J. Filipiak, and J. Kochman Baseline platelet reactivity in acute myocardial infarction treated with primary angioplasty - influence on myocardial reperfusion, left ventricular performance, and clinical events Am Heart J 154 2007 62 70
13. T. Bilsel, T. Akbulut, and K. Yesilcimen Single high-dose bolus tirofiban with high-loading-dose clopidogrel in primary coronary angioplasty Heart Vessels 21 2006 102 107
14. S.G. Ellis, M. Tendera, and M.A. de Belder Facilitated PCI in patients with ST-elevation myocardial infarction N Engl J Med 358 2008 2205 2217
15. C.M. Gibson, A.J. Kirtane, and S.A. Murphy Early initiation of eptifibatide in the emergency department before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: results of the Time to integrilin therapy in acute myocardial infarction (TITAN)-TIMI 34 trial Am Heart J 152 2006 668 675