A novel measure to characterise optimality of diameter relationships at retinal vascular bifurcations

Artery Research

Volumn 4, Issue 3, 2010, Pages 75-80

  Witt, Nicholas W ^a   Chapman, Neil ^a   Thom, Simon A McG ^a   Stanton, Alice V ^a   Parker, Kim H ^a   Hughes, Alun D ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Bifurcation optimality; Junction exponent; Microvascular diameter; Retina; Vascular bifurcation

Indexed keywords

N(G) METHYLARGININE; PLACEBO; SODIUM CHLORIDE; TROPICAMIDE;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIAGNOSTIC ACCURACY; DOUBLE BLIND PROCEDURE; DRUG INFUSION; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERTENSION; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; REFRACTION INDEX; RETINA ARTERY; RETINA BLOOD VESSEL; RETINA VASCULITIS; RETINAL VASCULAR BIFURCATION; SIGNAL NOISE RATIO; TOPOGRAPHY;

EID: 77956650312     PISSN: 18729312     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.artres.2010.06.003     Document Type: Article

References (16)

1. Murray C.D. The physiological principle of minimum work: the vascular system and the cost of blood volume. Proc Natl Acad Sci U S A 1926, 12:207-214.
2. Sherman T.F. On connecting large vessels to small. J Gen Physiol 1981, 78:431-453.
3. LaBarbera M. Principles of design of fluid transport systems in zoology. Science 1990, 249:992-1000.
4. Hutchins G.M., Miner M.A., Boitnott J.K. Vessel calibre and branch angle of human coronary artery branch points. Circ Res 1976, 38:572-576.
5. Stanton A.V., Wasan B., Cerutti A., Ford S., Marsh R., Sever P.P., et al. Vascular network changes in the retina with age and hypertension. J Hypertens 1995, 13:1724-1728.
6. Chapman N., Dell'Omo G., Sartini M.S., Witt N., Hughes A., Thom S., et al. Peripheral vascular disease is associated with abnormal arteriolar diameter relationships at bifurcations in the human retina. Clin Sci 2002, 103:111-116.
7. Woldenberg M.J., Horsfield K. Relation of branching angles to optimality for four cost principles. J Theor Biol 1986, 122:187-204.
8. Zamir M. Nonsymmetrical bifurcations in arterial branching. J Gen Physiol 1978, 72:837-845.
9. Chapman N., Witt N., Gao X., Bharath A.A., Stanton A.V., Thom S.A., et al. Computer algorithms for the automated measurement of retinal arteriolar diameters. Br J Ophthalmol 2001, 85:74-79.
10. Cnaan A., Laird N.M., Slasor P. Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data. Stat Med 1997, 16(20):2349-2380.
11. Moncada S., Palmer R., Higgs E. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991, 43:109-142.
12. Griffith T.M., Edwards D.H. Basal EDRF activity helps to keep the geometrical configuration of arterial bifurcations close to the Murray optimum. J Theor Biol 1990, 146:545-573.
13. Griffith T., Edwards D., Randall M. Blood flow and optimal vascular topography: role of the endothelium. Basic Cardiol Res 1991, 86(Suppl. 2):89-96.
14. Haynes W., Noon J., Walker B., Webb D. Inhibition of nitric oxide synthesis increases blood pressure in healthy humans. J Hypertens 1993, 11:1375-1380.
15. Schmetterer L., Krejcy K., Kastner J., Wolzt M., Gouya G., Findl O., et al. The effect of systemic nitric oxide-synthase inhibition on ocular fundus pulsations in man. Exp Eye Res 1997, 64:305-312.
16. Chapman N., Haimes G., Stanton A., Thom S., Hughes A. Acute effects of oxygen and carbon dioxide on retinal vascular network geometry in hypertensive and normotensive subjects. Clin Sci 2000, 99:483-488.