Neurosteroid pregnenolone and sigma-1 receptor function

Clinical Psychopharmacology and Neuroscience

Volumn 8, Issue 2, 2010, Pages 115-

  Hashimoto, Kenji ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 4 (3 PHENYLPROPYL)PIPERAZINE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; CALCIUM ION; PHENCYCLIDINE; PLACEBO; PRASTERONE SULFATE; PREGNENOLONE; SIGMA 1 OPIATE RECEPTOR;

CLINICAL TRIAL; COGNITIVE DEFECT; CORRELATION ANALYSIS; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG TOLERABILITY; ENDOPLASMIC RETICULUM; HUMAN; INTRACELLULAR SIGNALING; LETTER; NEGATIVE SYNDROME; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE;

EID: 77956644583     PISSN: 17381088     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (7)

1. Marx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34:1885-1903.
2. 2+ signaling and cell survival. Cell 2007;131:596-610.
3. Hashimoto K, Ishiwata K. Sigma receptor ligands: possible applications as therapeutic drugs and as radiopharmaceuticals. Curr Pharm Des 2006;12:3857-3876.
4. Hayashi T, Stahl SM. The sigma-1 receptor and its role in the treatment of mood disorders. Drugs Future 2009;34:137-146.
5. Hashimoto K. Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. Cent Nerv Syst Agents Med Chem 2009;9:197-204..
6. Hashimoto K, Fujita Y, Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors. Neuropsychopharmacology 2007;32:514-521. (Pubitemid 46271046)
7. Maurice T, Urani A, Phan VL, Romieu P. The interaction between neuroactive steroids and the sigma-1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res Brain Res Rev 2001;37:116-132. (Pubitemid 34020726)