Increased blood flow by insulin infusion targeting normoglycemia in patients with severe sepsis: Friend or foe?

Critical Care

Volumn 14, Issue 1, 2010, Pages

  Berghe, Greet V D ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; ANTIDIABETIC AGENT;

BLOOD FLOW VELOCITY; CLINICAL PRACTICE; CRITICAL ILLNESS; ENDOTHELIUM; FOREARM BLOOD FLOW; GLUCOSE BLOOD LEVEL; HEMODYNAMICS; HUMAN; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN TREATMENT; INTENSIVE CARE; NONHUMAN; NOTE; ORGAN PERFUSION; PRIORITY JOURNAL; SEPSIS; BLOOD; BLOOD FLOW; DRUG EFFECT; FOREARM; INTRAVENOUS DRUG ADMINISTRATION; VASCULARIZATION;

BLOOD GLUCOSE; FOREARM; HUMANS; HYPOGLYCEMIC AGENTS; INFUSIONS, INTRAVENOUS; INSULIN; REGIONAL BLOOD FLOW; SEPSIS;

EID: 77956631776     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc8228     Document Type: Note

References (11)

1. Žuran I, Poredoš P, Skale R, Voga G, Gabršček L, Parežnik R. Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial. Crit Care 2009, 13:R198. 2811932, 20003200, 10.1186/cc8202.
2. Dandona P, Aljada A, Mohanty P, Ghanim H, Bandyopadhyay A, Chaudhuri A. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care 2003, 26:3310-3314. 10.2337/diacare.26.12.3310, 14633819.
3. Dandona P, Aljada A, Chaudhuri A, Mohanty P. Endothelial dysfunction, inflammation and diabetes. Rev Endocr Metab Disord 2004, 5:189-197. 10.1023/B:REMD.0000032407.88070.0a, 15211090.
4. Dandona P, Aljada A, Chaudhuri A, Bandyopadhyay A. The potential influence of inflammation and insulin resitance on the pathogenesis and treatment of atherosclorosis-related complications in type 2 diabetes. J Clin Endocrinol Metab 2003, 88:2422-2429. 10.1210/jc.2003-030178, 12788837.
5. Ellger B, Debaveye Y, Vanhorebeek I, Langouche L, Giulietti A, Van Etten E, Herijgers P, Mathieu C, Berghe G. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes 2006, 55:1096-1105. 10.2337/diabetes.55.04.06.db05-1434, 16567534.
6. Su H, Sun X, Ma H, Zhang H-F, Yu Q-J, Huang C, Wang X-M, Luan R-H, Jia G-L, Wang H-G, Gao F. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab 2007, 293:E629-E635. 10.1152/ajpendo.00221.2007, 17519283.
7. Stegenga ME, Crabben SN, Blümer RM, Levi M, Meijers JC, Serlie MJ, Tanck MW, Sauerwein HP, Poll T. Hyperglycemia enhances coagulation and reduces neurophil degranulation, whereas hyeprinsulinemia inhibits fibrinlysis during human endotoxinemia. Blood 2008, 112:82-89. 2435690, 18316629, 10.1182/blood-2007-11-121723.
8. Blümer RM, Crabben SN, Stegenga ME, Tanck MW, Ackermans MT, Endert E, Poll T, Sauerwein HP. Hyperglycemia prevents the suppressive effect of hyperinsulinemia on plasma adiponectin levels in healthy humans. Am J Physiol Endocrinol Metab 2008, 295:E613-E617. 10.1152/ajpendo.90288.2008, 18577692.
9. Berghe G, Wouters PJ, Weekers F, Verwaest C, Bruyninckx F, Schetz M, Vlasselaers D, Ferdinande P, Lauwers P, Bouillon R. Intensive insulin therapy in critically ill patients. N Engl J Med 2001, 345:1359-1367. 10.1056/NEJMoa011300, 11794168.
10. Langouche L, Vanhorebeek I, Vlasselaers D, Perre S, Wouters PJ, Skogstrand K, Hansen TK, Berghe G. Intensive insulin therapy protects the endothelium of critically ill patients. J Clin Invest 2005, 115:2277-2286. 1180545, 16075063, 10.1172/JCI25385.
11. Berghe G, Schetz M, Vlasselaers D, Hermans G, Wilmer A, Bouillon R, Mesotten D. Clinical review: Intensive insulin therapy in critically ill patients: NICE-SUGAR or Leuven blood glucose target?. J Clin Endocrinol Metab 2009, 94:3163-3170. 10.1210/jc.2009-0663, 19531590.