Radiation therapy for heterotopic ossification prophylaxis acutely after elbow trauma: A prospective randomized study

Journal of Bone and Joint Surgery

Volumn 92, Issue 11, 2010, Pages 2032-2038

  Hamid, Nady ^a   Ashraf, Nomaan ^a   Bosse, Michael J ^a   Connor, Patrick M ^b   Kellam, James F ^a   Sims, Stephen H ^a   Stull, Douglass E ^c   Jeray, Kyle J ^d   Hymes, Robert A ^e   Lowe, Timothy J ^a  

^a CAROLINAS MEDICAL CENTER   (United States)

^b ORTHOCAROLINA HIP AND KNEE CENTER   (United States)

^c 2nd Floor Support Tower ^*  (United States)

^d GREENVILLE HOSPITAL SYSTEM   (United States)

^e INOVA FAIRFAX HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; ELBOW DISLOCATION; ELBOW INJURY; FEMALE; FRACTURE NONUNION; HETEROTOPIC OSSIFICATION; HUMAN; HUMERUS FRACTURE; MALE; POSTOPERATIVE PERIOD; PREVALENCE; PRIORITY JOURNAL; RADIATION DOSE; RANGE OF MOTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ELBOW; FRACTURE; INJURY; JOINT CHARACTERISTICS AND FUNCTIONS; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; RADIOTHERAPY; RANDOMIZED CONTROLLED TRIAL;

ADULT; EARLY TERMINATION OF CLINICAL TRIALS; ELBOW; FEMALE; FRACTURES, BONE; FRACTURES, UNUNITED; HUMANS; MALE; MIDDLE AGED; OSSIFICATION, HETEROTOPIC; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RANGE OF MOTION, ARTICULAR; YOUNG ADULT;

EID: 77956626586     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.I.01435     Document Type: Article

References (28)

1. Iorio R, Healy WL. Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. J Am Acad Orthop Surg. 2002;10:409-16.
2. Heyd R, Strassmann G, Schopohl B, Zamboglou N. Radiation therapy for the prevention of heterotopic ossification at the elbow. J Bone Joint Surg Br. 2001;83:332-4. (Pubitemid 32390342)
3. Summerfield SL, DiGiovanni C, Weiss AP. Heterotopic ossification of the elbow. J Shoulder Elbow Surg. 1997;6:321-32.
4. Thompson HC 3rd, Garcia A. Myositis ossificans: aftermath of elbow injuries. Clin Orthop Relat Res. 1967;50:129-34.
5. Ilahi OA, Strausser DW, Gabel GT. Post-traumatic heterotopic ossification about the elbow. Orthopedics. 1998;21:265-8.
6. Mazurek MT, Trenholm JAI, Connor PM, Sims SH, Bosse MJ, Kellam JF. Incidence of heterotopic ossification after open reduction and internal fixation of intraarticular distal humerus fractures. Presented as a poster exhibit at the Annual Meeting of the Orthopaedic Trauma Association; 2002 Oct 11-13; Toronto, ON, Canada. Poster no. 87.
7. Ring D, Jupiter JB. Operative release of ankylosis of the elbow due to heterotopic ossification. Surgical technique. J Bone Joint Surg Am. 2004;86 Suppl 1:2-10. (Pubitemid 38269049)
8. Stein DA, Patel R, Egol KA, Kaplan FT, Tejwani NC, Koval KJ. Prevention of heterotopic ossification at the elbow following trauma using radiation therapy. Bull Hosp Jt Dis. 2003;61:151-4.
9. Robinson C, Lyons J, Evans P, Lawton J, Graham T, Polster J, Suh J. Postoperative single fraction radiation for prevention of heterotopic ossification after elbow surgery [abstract]. Int J Radiat Oncol Biol Phys. 2007;69 Suppl 1:S545.
10. Moher D, Schulz KF, Altman D; CONSORT Group (Consolidated Standards of Reporting Trials). The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285:1987-91.
11. Murphy WM, Leu D. Fracture classification: biological significance. In: Rüedi TP, Murphy WM, editors. AO principles of fracture management. New York: AO Publishing/Thieme; 2000. p 45-58.
12. Healy WL, Lo TC, DeSimone AA, Rask B, Pfeifer BA. Single-dose irradiation for the prevention of heterotopic ossification after total hip arthroplasty. A comparison of doses of five hundred and fifty and seven hundred centigray. J Bone Joint Surg Am. 1995;77:590-5.
13. Morrey BF, editor. The elbow and its disorders. 3rd ed. Philadelphia: Saunders; 2000.
14. Callaghan JJ, Rosenberg AG, Rubash HE, editors. The adult hip. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007.
15. Ilahi OA, Bennett JB, Gabel GT, Mehlhoff TL, Kohl HW 3rd. Classification of heterotopic ossification about the elbow. Orthopedics. 2001;24:1075-8.
16. Frölke JP, Patka P. Definition and classification of fracture non-unions. Injury. 2007;38 Suppl 2:S19-22. Erratum in: Injury. 2007;38:1224.
17. Dudziak ME, Saadeh PB, Mehrara BJ, Steinbrech DS, Greenwald JA, Gittes GK, Longaker MT. The effects of ionizing radiation on osteoblast-like cells in vitro. Plast Reconstr Surg. 2000;106:1049-61.
18. Konski A, Weiss C, Rosier R, Poulter C, Pelligrini V, Anthony P, Evarts CM, Richardson M, Henzler M, Rubin P. The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: an animal model. Int J Radiat Oncol Biol Phys. 1990;18:861-5.
19. Coventry MB, Scanlon PW. The use of radiation to discourage ectopic bone. A nine-year study in surgery about the hip. J Bone Joint Surg Am. 1981;63:201-8.
20. Baker SA, Fitzgerald RH Jr, Coventry MB. Treatment of nonunion of the greater trochanter. Hip. 1981;15-24.
21. Pellegrini VD Jr, Konski AA, Gastel JA, Rubin P, Evarts CM. Prevention of heterotopic ossification with irradiation after total hip arthroplasty. Radiation therapy with a single dose of eight hundred centigray administered to a limited field. J Bone Joint Surg Am. 1992;74:186-200.
22. Chen TH, Huang CK, Chen WM, Chiang CC, Lo WH. Heterotopic ossification after cemented or uncemented Bateman bipolar hemiarthroplasty. Zhonghua Yi Xue Za Zhi (Taipei). 1998;61:520-3.
23. Jasty M, Schutzer S, Tepper J, Willett C, Stracher MA, Harris WH. Radiationblocking shields to localize periarticular radiation precisely for prevention of heterotopic bone formation around uncemented total hip arthroplasties. Clin Orthop Relat Res. 1990;257:138-45. (Pubitemid 20246734)
24. Hastings H 2nd, Graham TJ. The classification and treatment of heterotopic ossification about the elbow and forearm. Hand Clin. 1994;10:417-37.
25. Rubenstein JH, Salenius SA, Blitzer PH, Katin MJ, Dosoretz DE. Prevention of heterotopic bone formation with low dose radiation therapy. J Fla Med Assoc. 1992;79:828-32.
26. Tsionos I, Leclercq C, Rochet JM. Heterotopic ossification of the elbow in patients with burns. Results after early excision. J Bone Joint Surg Br. 2004;86:396-403.
27. Cullen JP, Pellegrini VD Jr, Miller RJ, Jones JA. Treatment of traumatic radioulnar synostosis by excision and postoperative low-dose irradiation. J Hand Surg Am. 1994;19:394-401.
28. McAuliffe JA, Wolfson AH. Early excision of heterotopic ossification about the elbow followed by radiation therapy. J Bone Joint Surg Am. 1997;79:749-55.