Considerations in using US-based laboratory toxicity tables to evaluate laboratory toxicities among healthy Malawian and Ugandan infants

Journal of Acquired Immune Deficiency Syndromes

Volumn 55, Issue 1, 2010, Pages 58-64

  Lubega, Irene R ^a   Fowler, Mary Glenn ^a,d   Musoke, Philippa M ^a   Elbireer, Ali ^a,d   Bagenda, Danstan ^a   Kafulafula, George ^b   Ko, Jeanne ^c   Mipando, Linda ^b   Mubiru, Mike ^a   Kumwenda, Newton ^c   Taha, Taha ^c   Jackson, J Brooks ^d   Guay, Laura ^e  

^a MAKERERE UNIVERSITY   (Uganda)

^b UNIVERSITY OF MALAWI   (Malawi)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e GEORGE WASHINGTON UNIVERSITY   (United States)

Author keywords

Division of AIDS; Infants; Malawian; Non HIV exposed; Normal laboratory reference values; Toxicity tables; Ugandan

Indexed keywords

BILIRUBIN; HEMOGLOBIN; SODIUM;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; INFANT; LABORATORY TEST; LEUKOCYTE; MALAWI; MALE; NEUTROPENIA; NEUTROPHIL COUNT; NEWBORN; NORMAL HUMAN; PRENATAL EXPOSURE; PRIORITY JOURNAL; THROMBOCYTE; UGANDA; BLOOD ANALYSIS; BLOOD EXAMINATION; COMPARATIVE STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; PATHOLOGY; UNITED STATES;

BLOOD CHEMICAL ANALYSIS; CROSS-SECTIONAL STUDIES; FEMALE; HEMATOLOGIC TESTS; HIV INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; MALAWI; MALE; UGANDA; UNITED STATES;

EID: 77956625678     PISSN: 15254135     EISSN: 10779450     Source Type: Journal    
DOI: 10.1097/QAI.0b013e3181db059d     Document Type: Article

References (22)

1. Nduka N, Aneke C, Maxwell-Owhochuku S. Comparison of some haematological indices of Africans and Caucasians resident in the same Nigerian environment. Haematologia (Budap). 1988;21:57-63.
2. Lisse I, Aaby P, Whittle H, et al. T-lymphocyte subsets in West African children: impact of age, sex, and season. J Pediatr. 1997;130:77-85. (Pubitemid 27492722)
3. National Institute for Allergy and Infectious Disease (NIAID). Division of AIDS toxicity table for grading the severity of Adult and Pediatric adverse experiences publish date December 2004. Available at: http://rcc.tech-res.com/ Document/safetyandpharmacovigilance/DAIDS-AE-GradingTable-Clarification- August2009-Final.doc. Accessed January 18, 2009.
4. Clinical Laboratory Standards Institute. Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Proposed Guideline-Third Edition; Proposed Guideline. C28-P3. Available at: http://www.clsi.org/source/orders/free/c28-p3.pdf. Accessed June 18, 2008.
5. Robertson SE, Anker M, Roisin AJ, et al. The lot quality technique: a global review of applications in the assessment of health services and disease surveillance. World Health Stat Q. 1997;50:199-209. (Pubitemid 28133361)
6. R Development Core Team (2007). R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2007. Available at: http://www.r-project.org. Accessed January 5, 2008.
7. Stata Corp. Stata Statistical Software: Release 8. College Station, Texas: StataCorp LP; 2003.
8. Bain BJ. Ethnic and sex differences in the total and differential white cell count and platelet count. J Clin Pathol. 1996;49:664-666. (Pubitemid 26264395)
9. Scott-Emuakpor AB, Okolo AA, Omene JA, et al. Normal haematological values of the African neonate. Blut. 1985;51:11-18. (Pubitemid 15068079)
10. Mukiibi JM, Mtimavalye LAR, Broadhead RL, et al. Some haematological parameters in Malawian neonates. East Afr Med J. 1995;72:10-14.
11. Lugada ES, Mermin J, Kaharuza F, et al. Population-based hematologic and immunologic reference values for a healthy Uganda population. Clin Diagn Lab Immunol. 2004;11:29-34. (Pubitemid 38090648)
12. Neser ML. The leucocyte picture in white, Bantu colored and Indian school children 6-15 years as observed during the Pretoria Nutrition Status Surveys of 1962-1965. S Afr Med J. 1968;42:444-450.
13. Haddy TB, Rana SR, Castro O. Benign ethnic neutropenia: what is a normal absolute neutrophil count? J Lab Clin Med. 1999;133:15-22. (Pubitemid 29032412)
14. Bedri, Saad BO, Gudetta B, et al. Neutropenia among infants in a perinatal intervention trial. Presented at: 12th Conference on Retroviruses and Opportunistic Infections; February 25, 2005; Boston, MA. p. 367; Abstract 814.
15. Taha T, Kumwenda N, Gibbons A, et al. Effect of HIV-1 antiretroviral prophylaxis on hepatic and hematological parameters of African infants. AIDS. 2002;16:851-858. (Pubitemid 34409008)
16. European Collaborative Study. Are there gender and race differences in cellular immunity patterns over age in infected and uninfected children born to HIV-infected women? J Acquir Immune Defic Syndr. 2003;33:635-641.
17. Wells J, Shetty AK, Stranix L, et al. Range of normal neutrophil counts in healthy Zimbabwean infants: implications for monitoring antiretroviral drug toxicity. J Acquir Immune Defic Syndr. 2006;4:460-463. (Pubitemid 44050894)
18. Taha ET, Kumwenda N, Kafulafula G, et al. Hematological changes in African children who received short-term prophylaxis with nevirapine and zidovudine at birth. Ann Trop Paed. 2004;24:301-309. (Pubitemid 40045360)
19. Kourtis A, Van der Horst C, Kazembe P, et al. Low absolute neutrophil counts in African infants. J Int Assoc Physicians AIDS Care (Chic Ill). 2005;4:73-76.
20. + and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda. Ann Trop Paed. 2006;26:169-179. (Pubitemid 47054027)
21. Quintó L, Aponte JJ, Sacarlal J, et al. Haematological and biochemical indices in young African children: in search of reference intervals. Trop Med Int Health. 2006;11:1741-1748. (Pubitemid 44624378)
22. Chou VB, Omer SB, Hussain H, et al. The costs associated with adverse event procedures for an International HIV Clinical Trial determined by activity-based costing. J Acquir Immune Defic Syndr. 2007;46:426-432. (Pubitemid 350098693)