The relationship between circulating Fibroblast growth factor 23 and bone metabolism factors in Korean hemodialysis patients

Clinical and Experimental Nephrology

Volumn 14, Issue 3, 2010, Pages 239-243

  Park, So Youn ^a   Jeong, Kyung Hwan ^a   Moon, Ju Young ^a   Lee, Sang Ho ^a   Ihm, Chun Gyoo ^a   Rhee, Sang Youl ^a   Woo, Jeong Taek ^a   Oh, In Hwan ^a   Lee, Tae Won ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

Bone demineralization, pathologic; Bone density; Fibroblast growth factor 23; Renal dialysis

Indexed keywords

CALCIUM PHOSPHATE; FIBROBLAST GROWTH FACTOR 23; PHOSPHATE; VITAMIN D; FIBROBLAST GROWTH FACTOR;

ADULT; ARTICLE; BLOOD LEVEL; BONE DEMINERALIZATION; BONE DENSITY; BONE METABOLISM; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; FEMALE; GENDER; HEMODIALYSIS PATIENT; HUMAN; HYPOTHESIS; KOREA; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PHOSPHATE BLOOD LEVEL; PROTEIN BLOOD LEVEL; SCORING SYSTEM; VITAMIN D METABOLISM; AGED; BLOOD; BONE; DRUG EFFECT; MIDDLE AGED; PATHOPHYSIOLOGY; RENAL REPLACEMENT THERAPY;

AGED; BONE AND BONES; BONE DEMINERALIZATION, PATHOLOGIC; BONE DENSITY; CROSS-SECTIONAL STUDIES; FEMALE; FIBROBLAST GROWTH FACTORS; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PHOSPHATES; RENAL DIALYSIS;

EID: 77956621570     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-010-0272-5     Document Type: Article

References (26)

1. Yamashita T, Yoshioka M, Itoh N. Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain. Biochem Biophys Res Commun. 2000;277:494-498
2. Weber TJ, Liu S, Indridason OS, Quarles LD. Serum FGF23 levels in normal and disordered phosphorus homeostasis. J Bone Miner Res. 2003;18:1227-1234
3. Imanishi Y, Inaba M, Nakatsuka K, Nagasue K, Okuno S, Yoshihara A, et al. FGF-23 in patients with end-stage renal disease on hemodialysis. Kidney Int. 2004;65:1943-1946
4. Mirams M, Robinson BG, Mason RS, Nelson AE. Bone as a source of FGF23: regulation by phosphate? Bone. 2004; 35:1192-1199
5. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD. Pathogenic role of FGF23 in Hyp mice. Am J Physiol Endocrinol Metab. 2006;291:E38-49.
6. Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, et al. Homozygous ablation of fibroblast growth factor- 23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004;23:421-432
7. Saito H, Kusano K, Kinosaki M, Kinosaki M, Ito H, Hirata M, et al. Human fibroblast growth factor-23 mutants suppress Na?- dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production. J Biol Chem. 2003;278:2206-2211
8. Inoue Y, Segawa H, Kaneko I, Yamanaka S, Kusano K, Kawakami E, et al. Role of the vitamin D receptor in FGF23 action on phosphate metabolism. Biochem J. 2005;390:325-331
9. Baum M, Schiavi S, Dwarakanath V, Quigley R. Effect of fibroblast growth factor-23 on phosphate transport in proximal tubules. Kidney Int. 2005;68:1148-1153
10. Shimada T, Yamazaki Y, Takahashi M, Hasegawa H, Urakawa I, Oshima T, et al. Vitamin D receptor independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol. 2005;289:F1088-95.
11. Kuro OM. Klotho as a regulator of fibroblast growth factor signaling and phosphate/calcium metabolism. Curr Opin Nephrol Hypertens. 2006;15:437-441
12. National Kidney Foundation. K/DOQI clinical practice guidelines for hemodialysis adequacy, 2000. Am J Kidney Dis. 2001; 37(Suppl 1):S7-64.
13. Marsell R, Mirza MAI, Mallmin H, Karlsson M, Mellström D, Orwoll E, et al. Relation between fibroblast growth factor-23, body weight and bone mineral density in elderly men. Osteoporos Int. 2009;20:1167-1173
14. Portale AA, Booth BE, Halloran BP, Morris RC Jr. Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest. 1984;73:1580-1589
15. Nagano N, Miyata S, Abe M, Kobayashi N, Wakita S, Yamashita T, et al. Effect of manipulating serum phosphorus with phosphate binder on circulating PTH and FGF23 in renal failure rats. Kidney Int. 2006;69:531-537
16. Khachigian LM. Early growth response-1 in cardiovascular pathobiology. Circ Res. 2006;98:186-191
17. Qunibi WY, Abouzahr F, Mizani MR, Nolan CR, Arya R, Hunt KJ. Cardiovascular calcification in Hispanic Americans (HA) with chronic kidney disease (CKD) due to type 2 diabetes. Kidney Int. 2005;68:271-277
18. Mehrotra R. Disordered mineral metabolism and vascular calcification in nondialyzed chronic kidney disease patients. J Ren Nutr. 2006;16:100-108
19. Larsson T, Nisbeth U, Ljunggren Ö , Jüppner H, Jonsson KB. Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers. Kidney Int. 2003;64:2272-2279
20. Gutierrez O, Isakova T, Rhee E, Shah A, Holmes J, Collerone G, et al. Fibroblast growth factor-23 mitigates hyperphosphatemia but accentuates calcitriol deficiency in chronic kidney disease. J Am Soc Nephrol. 2005;16:2205-2215
21. Shigematsu T, Kazama JJ, Yamashita T, Fukumoto S, Hosoya T, Gejyo F, et al. Possible involvement of circulating fibroblast growth factor 23 in the development of secondary hyperparathyroidism associated with renal insufficiency. Am J Kidney Dis. 2004;44:250-256
22. Torres PU, Friedlander G, Vernejoul MC, Silve C, Prié D. Bonemass does not correlate with the serum fibroblast growth factor 23 in hemodialysis patients. Kidney Int. 2008;73:102-107
23. Stubbs J, Liu S, Quarles LD. Role of fibroblast growth factor 23 in phosphate homeostasis and pathogenesis of disordered mineral metabolism in chronic kidney disease. Semin Dial. 2007;20:302-308
24. Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, et al. Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis. N Engl J Med. 2008;359:584-592
25. Sitara D, Kim S, Razzaque, Bergwitz C, Taguchi T, Schüler C, et al. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet. 2008;4:e1000154.
26. Stubbs JR, Liu S,Tang W,Zhou J, Wang Y,Yao X, et al. Role of hyperphosphatemia and 1,25 dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice J Am Soc Nephrol. 2007 18 2116-2124